The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the desert island book of all medical pharmacology - if you can own just one pharmacology book, this is it.

    The American Dream champions individualism.  But at what price?  In this timely revision of The Wilding of America, Charles Derber chronicles the latest incidents of "wilding" - extreme acts of self-interested violence and greed - that signal an eroding of the moral landscape of American society.  Despite this ever-increasing emphasis on individualism in America, Derber offers a communitarian alternative that is as inspiring as it is instructive.

    Organized by body system, the book presents the latest information on over 100 critical care disorders. Key information is highlighted in numerous quick-scan tables, illustrations, and flow charts, and icons and sidebars draw attention to essential information. Features include a glossary of important critical care terms and an appendix of web resources.

    An Introduction to Meteorology (13th Edition)

    Mt. Lockley, who observed rabbits in Wales over a 5 year period, shows that they have a complex community life little understood by the world in general. These vegetarian creatures posses both dignity and 'animality'; psychological factors play as large a part in shaping their lives as they do in ours. One finds, too, that their reputation for promiscuity and wanton reproduction is really undeserved. Lockley built an artificial warren with glass sides and several tracts of natural habitat-an open plain, a woodlot, a lushly vegetated savannah were enclosed and arranged for maximum ease of observation with minimum interference. This controlled rabbit colony was observed every day and night in every season and in all kinds of weather. In Lockley's account, rabbits emerge with characteristics and personalities of their own. The nicknames he gives them (Weary Willie, Timid Timothy, Bold Benjamin, for example) in no way lessen the objective and scientific accuracy of his findings. In fact, this touch of individuality reinforces the observation that rabbits are creatures with interests, wills, and preferences of their own. Female conservatism, scent setting or 'chinning' by dominant males, the ability of the female to absorb her fertilized embryo, the stress of subordinate status...and more, are revealed here.

    New BIG IDEAs help all students focus on the most important concepts. Students explore concepts through engaging narrative, frequent use of analogies, familiar examples, and clear and instructional graphics. Now, with Success Tracker™ online, teachers can choose from a variety of diagnostic and benchmark tests to gauge student comprehension. Targeted remediation is available too! Whether using the text alone or in tandem with exceptional ancillaries and technology, teachers can meet the needs of every student at every learning level.With unparalleled reading support, resources to reach every student, and a proven research-based approach, authors Kenneth Miller and Joseph Levine continue to set the standard.Prentice Hall Biology delivers:-Clear, accessible writing-Up-to-date content-A student friendly approach-A powerful framework for connecting key concepts

    This is a sustainable source of advantage in today’s turbulent global marketplace, where demand is difficult to predict and supply chains need to be more flexible as a result. In fact, the real competition today is not between companies, but between supply chains. The winning approach to supply chains is an integrated perspective that takes account of networks of relationships, sustainability and product design, as well as the logistics of procurement, distribution, and fulfilment. Logistics and Supply Chain Management examines the tools, core processes and initiatives that ensure businesses gain and maintain their competitive advantage. The fourth edition has been completely updated and now contains four new chapters covering:· managing supply chain relationships· product design in the supply chain· matching supply and demand · creating a sustainable supply chain Front Flap The updated 4th edition of the bestselling Logistics and Supply Chain Management is the practical guide to all the key topics in an integrated approach to supply chains, including: The link between logistics and customer value Logistics and the bottom line – measuring costs and performance Creating a responsive supply chain Managing the global pipeline Managing supply chain relationships Managing risk in the supply chain Matching supply and demand Creating a sustainable supply chain Product design in the supply chain Back Flap About the author Martin Christopher is Chairman of the Centre for Logistics and Supply Chain Management. He has written numerous books and articles and is on the editorial advisory board of a several professional journals. Until recently he was co-editor of The International Journal of Logistics Management and his latest books have focused upon relationship marketing, logistics and supply chain management. He has held appointments as Visiting Professor at the Universities of British Columbia, Canada, New South Wales, Australia and South Florida, USA. Professor Christopher is a Fellow of the Chartered Institute of Marketing, the Chartered Institute of Logistics and Transport and the Chartered Institute of Purchasing and Supply. In 1987 he was awarded the Sir Robert Lawrence medal of the Institute of Logistics and Transport for his contribution to the development of logistics education in Britain. In 2005 he was awarded the Distinguished Service Award of the USA Council for Supply Chain Management Professionals. In 2007 he was designated as Foundation Professor by the Chartered Institute of Purchasing and Supply. Martin has also worked as a consultant for major international companies in North America, Europe, the Far East and Australasia.

    It has been developed specifically for emerging courses in astrobiology, though it can also be used for introductory astronomy.

    Daft addresses themes and issues directly relevant to both the everyday demands and significant challenges facing businesses today. Comprehensive coverage helps develop managers able to look beyond traditional techniques and ideas to tap into a full breadth of management skills. With the best in proven management and new competencies that harness creativity, D.A.F.T. is Management.

    Part One presents the general principles of pathophysiology and discusses the influence of the environment and the role of genetics in the development of disease. Part Two, organized by body system, examines normal anatomy and physiology, alterations of function in adults, and alterations of function in children.

    Goljan, MD, makes it easy for you to master all of the pathology material covered on the USMLE™ Step 1 Exam. It combines an outline-format review of key concepts with over 400 hundred USMLE-style practice questions - online - that give you all the practice you need to succeed! Book • Outline format: Concise, high-yield subject matter is presented in a study-friendly format.• High-yield margin notes: Key content that is most likely to appear on the exam is reinforced in the margin notes.• Visual elements: Full-color photographs are utilized to enhance your study and recognition of key pathology images. Abundant two-color schematics and summary tables enhance your study experience.• Two-color design: Colored text and headings make studying more efficient and pleasing.New! Online Study and Testing Tool• A minimum of 350 USMLE Step 1–type MCQs: Clinically oriented, multiple-choice questions that mimic the current USMLE format, including high-yield images and complete rationales for all answer options. • Online benefits: New review and testing tool delivered via the USMLE Consult platform, the most realistic USMLE review product on the market. Online feedback includes results analyzed to the subtopic level (discipline and organ system). • Test mode: Create a test from a random mix of questions or by subject or keyword using the timed test mode. USMLE Consult simulates the actual test-taking experience using NBME’s FRED interface, including style and level of difficulty of the questions and timing information. Detailed feedback and analysis shows your strengths and weaknesses and allows for more focused study. • Practice mode: Create a test from randomized question sets or by subject or keyword for a dynamic study session. The practice mode features unlimited attempts at each question, instant feedback, complete rationales for all answer options, and a detailed progress report. • Online access: Online access allows you to study from an internet-enabled computer wherever and whenever it is convenient. This access is activated through registration on www.studentconsult.com with the pin code printed inside the front cover.Student Consult• Full online access: You can access the complete text and illustrations of this book on www.studentconsult.com. • Save content to your PDA: Through our unique Pocket Consult platform, you can clip selected text and illustrations and save them to your PDA for study on the fly! • Free content: An interactive community center with a wealth of additional valuable resources is available.

    Traditional topics are supplemented by several newly-emerging disciplines, such as the probabilistic basis for structural analysis, and matrix methods.KEY TOPICS: Although retaining its character as a complete traditional book on mechanics of solids with advanced overtones from the first edition, the second edition of Engineering Mechanics of Solids has been significantly revised. The book reflects an emphasis on the SI system of units and presents a simpler approach for calculations of axial stress that provides a more obvious, intuitive approach. It also now includes a greater number of chapters as well as an expanded chapter on Mechanical Properties of Materials and introduces a number of avant-garde topics. Among these topics are an advanced analytic expression for cyclic loading and a novel failure surface for brittle material. MARKET: An essential reference book for civil, mechanical, and aeronautical engineers.

    Chosen as a Main Selection of the Military Book Club.

    The text incorporates examples from around the world and from everyday life to make the material relevant to a wide range of students. Research methods are emphasized throughout in order to demonstrate how cultural psychologists study the close-knit relationship between culture and the ways we think and behave. Three unique chapters bring an interdisciplinary dimension to the text, examining cultural evolution, mental health, and morality from the perspective of cultural psychology.