This edition retains the essence of the original, but has been updated with new features and integrated colour illustrations.

    This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop.Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

    The latest version is far superior, both in content and presentation, to previous versions. I give it my highest recommendation."--"Doody's Review Service"From the authors of "Basic and Clinical Pharmacology," the leading pharmacology textbook, here is the newest edition of the best review book available for medical pharmacology course exams and board examinations. This skill-building guide comes with over 1000 review questions and answers -- far more than most other pharmacology reviews -- and a chapter-based approach that facilitates use with course notes or larger texts. Features: A new full-color presentation Organized to reflect course syllabi, focusing on the clinical use and pharmacology of drug categories, rather than individual drugs Two complete practice exams A valuable appendix of test-taking strategies Chapters that include valuable learning aids such as: --Short discussion of the major concepts that underlie basic principles or drug groups--Explanatory figures and tables--Review questions followed by answers and explanations--Drug Trees in drug-oriented chapters that visually organize drug groups--A list of high-yield terms and definitions you need to know Skill Keeper questions that prompt you to review previous material to understand links between related topics A checklist of tasks you should be able to do, once you have finished the chapter Summary Tables that list the important drugs and include key information about their mechanisms of action, effects, clinical uses, pharmacokinetics, drug interactions, and toxicities

    The book concisely reviews key physiological principles and includes clinical correlations throughout to emphasize connections between basic physiology and clinical medicine. Numerous illustrations, tables, and flow charts help students visualize material quickly and aid in long-term retention. End-of-chapter USMLE-style questions and a comprehensive end-of-book exam test the student's problem-solving skills, and clearly explained answers guide the student through the correct steps in reasoning. This edition features increased coverage of pathophysiology, new questions, and a new two-color design and artwork.

    The text is written in straightforward language and is complemented by extensive clear, full-colour illustrations. Each chapter provides an explanation of the normal structure and functions of the human body and what occurs when disease or illness disrupts the normal processes.Carefully refined, clear and unambiguous textExcellent layout ensures the text and relevant illustrations are close togetherHighly illustrated with clear line diagrams, mostly in colourText uses regular sequences of headings, lists, and bullet points to help with learning and revisionOmits the unnecessary detail which can confuse the student new to the subjectA glossary of common prefixes, suffixes and roots commonly used in anatomy and physiologyAn Appendix containing useful biological values for easy referenceLearning outcomes related to the sections within each chapterAccompanying Colouring and workbook that facilitates structured learning and revision of the material in this bookAccess to an Evolve companion website offering animations, MCQs, a full image bank, an audio pronunciation guide as well as useful web links.- text revised and updated, including one chapter integrating the musculoskeletal system and a new chapter on genetics to reflect the increasing importance of this topic - new and revised artwork/illustrations - enhanced features on the Evolve website for students: -High quality animations -Multiple-choice questions -Web links to supplementary websites -An audio pronunciation guideand for Lecturers: -Image bank: the complete collection of images from the book.

    Beginning in the 1950s when doctors still paid house calls but regularly withheld the truth from their patients, Amy Gutmann and Jonathan D. Moreno explore an unprecedented revolution in health care and explain the problem with America’s wanting everything that medical science has to offer without debating its merits and its limits. The result: Americans today pay far more for health care while having among the lowest life expectancies and highest infant mortality of any affluent nation.Gutmann and Moreno—“incisive, influential, and pragmatic thinkers” (Arthur Caplan)—demonstrate that the stakes have never been higher for prolonging and improving life. From health care reform and death-with-dignity to child vaccinations and gene editing, they explain how bioethics came to dominate the national spotlight, leading and responding to a revolution in doctor-patient relations, a burgeoning world of organ transplants, and new reproductive technologies that benefit millions but create a host of legal and ethical challenges.With striking examples, the authors show how breakthroughs in cancer research, infectious disease, and drug development provide Americans with exciting new alternatives, yet often painful choices. They address head-on the most fundamental challenges in American health care: Why do we pay so much for health care while still lacking universal coverage? How can medical studies adequately protect individuals who volunteer for them? What’s fair when it comes to allocating organs for transplants in truly life-and-death situations?A lucid and provocative blend of history and public policy, this urgent work exposes the American paradox of wanting to have it all without paying the price.

    This clear, concise look at the basic principles and concepts of genetics uses a human genetics perspective to discuss the methods and experiments upon which genetic principles are based, such as DNA replication.

    In his hallmark friendly style, he explores the universal impact of being the right size. By examining stories ranging from Alice in Wonderland to Gulliver's Travels, he shows that humans have always been fascinated by things big and small. Why then does size always reside on the fringes of science and never on the center stage? Why do biologists and others ponder size only when studying something else--running speed, life span, or metabolism? Why Size Matters, a pioneering book of big ideas in a compact size, gives size its due by presenting a profound yet lucid overview of what we know about its role in the living world. Bonner argues that size really does matter--that it is the supreme and universal determinant of what any organism can be and do. For example, because tiny creatures are subject primarily to forces of cohesion and larger beasts to gravity, a fly can easily walk up a wall, something we humans cannot even begin to imagine doing.Bonner introduces us to size through the giants and dwarfs of human, animal, and plant history and then explores questions including the physics of size as it affects biology, the evolution of size over geological time, and the role of size in the function and longevity of living things.As this elegantly written book shows, size affects life in its every aspect. It is a universal frame from which nothing escapes.

    With extensive treatment of the heart of epidemiology-from study designs to descriptive epidemiology to quantitative measures-this reader-friendly text is accessible and interesting to a wide range of beginning students in all health-related disciplines. A unique focus is given to real-world applications of epidemiology and the development of skills that students can apply in subsequent course work and in the field. The text is also accompanied by a complete package of instructor and student resources available through a companion Web site.

    Turn to any page, and you'll find essential point-of-care guidance on all the major conditions seen in clinical medicine. Completely updated to reflect all the major advances and new clinical developments, the new edition of the Manual is the most indispensable yet. It continues to focus on diagnosis and therapy with an emphasis on patient care and offers authoritative, high-yield coverage of: Etiology and epidemiology Clinically relevant pathophysiology Signs & Symptoms o Differential Diagnosis Physical and Laboratory Findings Therapeutics o Practice GuidelinesNEW FEATURESFull-color presentation for the first time!Full-color images of clinical conditions encountered in dermatology, cardiology, and eye diseases New chapters on end-of-life care, congenital heart disease in the adult patient, non-invasive cardiac examination, and metabolic syndromeLook for these other great Harrison's titles:Harrison's Principles of Internal Medicine, 17eHarrison's Online available through Accessmedicine.com

    It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species births, deaths, disease, war, famine, migration, and a lot of sex. Since scientists first read the human genome in 2001, it has been subject to all sorts of claims, counterclaims, and myths. In fact, as Adam Rutherford explains, our genomes should be read not as instruction manuals, but as epic poems. DNA determines far less than we have been led to believe about us as individuals, but vastly more about us as a species. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about history, and what history tells us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be."

    The beginning chapters introduce basic chemical and biological concepts to provide students with the framework they need to comprehend physiological principles. The chapters that follow promote conceptual understanding rather than rote memorization of facts. Health applications are included throughout the book to heighten interest, deepen understanding of physiological concepts, and help students relate the material to their individual career goals. Every effort has been made to help students integrate related concepts and understand the relationships between anatomical structures and their functions.

    The Haywire Heart is the first book to examine heart conditions in athletes. Intended for anyone who competes in endurance sports like cycling, triathlon, running races of all distances, and cross-country skiing, The Haywire Heart presents the evidence that going too hard or too long can damage your heart forever. You’ll find what to watch out for, what to do about it, and how to protect your heart so you can enjoy the sports you love for years to come. The Haywire Heart shares the developing research into a group of conditions known as “athlete’s heart”, starting with a wide-ranging look at the warning signs, symptoms, and how to recognize your potential risk. Leading cardiac electrophysiologist and masters athlete Dr. John Mandrola explores the prevention and treatment of heart conditions in athletes like arrhythmia, atrial fibrillation and flutter, tachycardia, hypertrophy, and coronary artery disease. He reviews new research about exercise intensity and duration, recovery, inflammation and calcification, and the ways athletes inflict lasting harm. These heart problems are appearing with alarming frequency among masters athletes who are pushing their bodies harder than ever in the hope that exercise will keep them healthy and strong into their senior years. The book is complete with gripping case studies of elite and age-group athletes from journalist Chris Case—like the scary condition that nearly killed cyclist and coauthor Lennard Zinn—and includes a frank discussion of exercise addiction and the mental habits that prevent athletes from seeking medical help when they need it.Dr. Mandrola explains why many doctors misdiagnose heart conditions in athletes and offers an invaluable guide on how to talk with your doctor about your condition and its proven treatments. He covers known heart irritants, training and rest modifications, effective medicines, and safe supplements that can reduce the likelihood of heart damage from exercise. Heart conditions affect hardcore athletes as well as those who take up sports seeking better health and weight loss. The Haywire Heart is a groundbreaking and critically important guide to heart care for athletes. By protecting your heart now and watching for the warning signs, you can avoid crippling heart conditions and continue to exercise and compete for years to come.

    It provides the background needed to understand related drugs currently on the market, as well as drugs yet to be released. In simplifying a complex subject, this text focuses on the essentials of pharmacology. Large print is used to show need-to-know information, and small print is used for nice to know material. At the end of each chapter, a summary of major nursing implications helps in applying the material to real-world situations. This edition includes a new companion CD-ROM featuring NCLEX(R) examination-style review questions, a variety of electronic calculators, and animations depicting drug mechanisms and effects.Uses a prototype drug approach that places a strong emphasis on understanding over memorization - equipping students with the knowledge to learn not only about related drugs currently on the market, but also about those drugs that will be released once the student begins practice.Summaries of Major Nursing Implications at the end of each chapter provide an in-depth look at assessment, implementation, and ongoing evaluations.Utilizes large print for essential information and small print for nice-to-know information to help both faculty and students focus their limited classroom and study time on understanding the essentials.Concise drug summary tables present detailed information on individual drugs, including class, generic and trade names, dosages, routes, and indications.Key Points at the end of each chapter summarize content in a bulleted format to help students review important concepts.Prototype drug discussions employ a clear and consistent format with separate headings for Mechanism of Action; Pharmacologic Effects; Pharmacokinetics; Therapeutic Uses; Adverse Effects; Drug Interactions; and Preparations, Dosage, and Administration.An attractive full-color design adds visual interest, highlights key information, and facilitates student learning.Drugs for Multiple Sclerosis and Drugs for Hemophilia chapters.Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia chapter covers newsworthy drugs such as Viagra and Levitra.Special Interest Topics boxes on current issues in pharmacology, such as Medication-Overuse Headache: Too Much of a Good Thing and Face Time with Botox.Adult Immunization appendix summarizes the latest information on immunizations.Numerous new illustrations show drug mechanisms and effects, and depict topics such as histologic changes in Alzheimer's disease and the movement of drugs following GI absorption.

    The newly revised Fifth Edition has been significantly updated throughout and features substantially revised art and Running Problems in the book and on the reader Companion Website. Recognized as an extraordinary educator and active learning enthusiast, Dr. Silverthorn incorporates time-tested classroom techniques throughout the book and presents thorough, up-to-date coverage of new scientific discoveries, biotechnology techniques, and treatments of disorders. Dr. Silverthorn also co-authored the accompanying Student Workbook and Instructor Manual, ensuring that these ancillaries reinforce the pedagogical approach of the book.The Fifth Edition includes access to Interactive Physiology(R) 10-System Suite (IP-10), PhysioEx(TM) 8.0, A&P Flix animations in 3D, and The Physiology Place Companion Website. Key Topics: Introduction to Physiology, Molecular Interactions, Compartmentation: Cells and Tissues, Energy and Cellular Metabolism, Membrane Dynamics, Communication, Integration, Homeostasis, Introduction to the Endocrine System, Neurons: Cellular and Network Properties, The Central Nervous System, Sensory Physiology, Efferent Division: Autonomic and Somatic Motor Control, Muscles, Integrative Physiology I: Control of Body Movement, Cardiovascular Physiology, Blood Flow and the Control of Blood Pressure, Blood, Mechanics of Breathing, Gas Exchange and Transport, The Kidneys, Integrative Physiology II: Fluid and Electrolyte Balance, Digestion, Energy Balance and Metabolism, Endocrine Control of Growth and Metabolism, The Immune System, Integrative Physiology III: Exercise, Reproduction and DevelopmentMarket: Intended for those interested in learning the basics of human physiology