The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Its dramatically updated art program, more streamlined presentation of material, and integration of chapter objectives will help you better visualize and understand the structure and function of the human body. Elaine Marieb's clear and friendly writing style emphasizes the relevance of anatomy & physiology to your life and future career. The book clarifies concepts, defines key terms, and offers just the right balance of anatomy, physiology, and clinical coverage to make the content complete without being overwhelming. Elaine Marieb wrote this book specifically for the one-semester course and continues to carefully select a range of material that proves just right for the shorter course. New information on hot topics like the HPV Vaccine, Infantile Polycystic Kidney disease, and Sudden Infant Death Syndrome (SIDS) draws students into the material. This package contains: Essentials of Human Anatomy and Physiology, Tenth Edition

    Provides a chronology of seven thousand years of significant moments in history, religion, science, and the arts in an accessible format designed for quick reference.

    The only reference text to identify the top resources in major subject areas and genres, it shows students how to approach the reference query by matching specific types of questions to the most appropriate format (when answering questions that require handy facts, for example, go first to ready reference sources; for questions about current events and issues, start with indexes). The book begins with the essentials -- interviewing patrons, determining the information need, and developing a basic search strategy. It then gives a thorough overview of the materials, print and electronic, most frequently used to answer questions -- from government information to bibliographic resources, dictionaries, encyclopedias, biographical information sources, atlases, and more. A section on special topics in reference includes chapters on when and how to use the Internet as a reference tool, suggestions on user instruction at the reference desk, and reader's advisory work, as well as a chapter on service to children and youth authored by acclaimed expert Mary K. Chelton. Finally, the book addresses reference management basics: selection and evaluation of material, management of the reference department, assessing and improving reference services, and future trends. Guided by an advisory board and a focus group, the authors have achieved an ideal balance between practical elements and guiding principles. This landmark text is sure to be of interest to LIS educators, students, and both novice and experienced reference professionals.

    In this unconventional introduction, physicist Leonard Susskind and hacker-scientist George Hrabovsky offer a first course in physics and associated math for the ardent amateur. Unlike most popular physics books—which give readers a taste of what physicists know but shy away from equations or math—Susskind and Hrabovsky actually teach the skills you need to do physics, beginning with classical mechanics, yourself. Based on Susskind's enormously popular Stanford University-based (and YouTube-featured) continuing-education course, the authors cover the minimum—the theoretical minimum of the title—that readers need to master to study more advanced topics.An alternative to the conventional go-to-college method, The Theoretical Minimum provides a tool kit for amateur scientists to learn physics at their own pace.

    Major retailers are predicting everything from when their customers are pregnant to when they want a new pair of Chuck Taylors. It's a brave new world where seemingly meaningless data can be transformed into valuable insight to drive smart business decisions.But how does one exactly do data science? Do you have to hire one of these priests of the dark arts, the "data scientist," to extract this gold from your data? Nope.Data science is little more than using straight-forward steps to process raw data into actionable insight. And in Data Smart, author and data scientist John Foreman will show you how that's done within the familiar environment of a spreadsheet. Why a spreadsheet? It's comfortable! You get to look at the data every step of the way, building confidence as you learn the tricks of the trade. Plus, spreadsheets are a vendor-neutral place to learn data science without the hype. But don't let the Excel sheets fool you. This is a book for those serious about learning the analytic techniques, the math and the magic, behind big data.Each chapter will cover a different technique in a spreadsheet so you can follow along: - Mathematical optimization, including non-linear programming and genetic algorithms- Clustering via k-means, spherical k-means, and graph modularity- Data mining in graphs, such as outlier detection- Supervised AI through logistic regression, ensemble models, and bag-of-words models- Forecasting, seasonal adjustments, and prediction intervals through monte carlo simulation- Moving from spreadsheets into the R programming languageYou get your hands dirty as you work alongside John through each technique. But never fear, the topics are readily applicable and the author laces humor throughout. You'll even learn what a dead squirrel has to do with optimization modeling, which you no doubt are dying to know.

    It begins with an overview of film production, moves on to a consideration of the formal elements and techniques, covers film criticism and concludes with a brief section highlighting the key moments in film history. Illustrated with over 500 frame enlargements, many in colour, "Film Art" has been updated to include analysis of some of the most interesting films of recent years including "Raging Bull" and "Desperately Seeking Susan".

    Fully revised and featuring lots of new material, this fourth edition provides an unparalleled introduction to 2,000 years of Christian thought. A fully revised new edition of the bestselling introductory textbook in Christian theologyFeatures new sections on monastic schools of theology, the English Reformation, and Radical OrthodoxyIncludes increased discussion of women in the early Church, feminist theology, Eastern Orthodox theology and history, and Catholic teachings on the Doctrine of the ChurchIncorporates user-friendly key terms sections, and study questionsSupported by a website at www.blackwellpublishing.com/mcgrath, containing additional lecturer resources.

    Today, unfortunately, the traditional place of mathematics in education is in grave danger. The teaching and learning of mathematics has degenerated into the realm of rote memorization, the outcome of which leads to satisfactory formal ability but does not lead to real understanding or to greater intellectual independence. This new edition of Richard Courant's and Herbert Robbins's classic work seeks to address this problem. Its goal is to put the meaning back into mathematics.Written for beginners and scholars, for students and teachers, for philosophers and engineers, What is Mathematics? Second Edition is a sparkling collection of mathematical gems that offers an entertaining and accessible portrait of the mathematical world. Covering everything from natural numbers and the number system to geometrical constructions and projective geometry, from topology and calculus to matters of principle and the Continuum Hypothesis, this fascinating survey allows readers to delve into mathematics as an organic whole rather than an empty drill in problem solving. With chapters largely independent of one another and sections that lead upward from basic to more advanced discussions, readers can easily pick and choose areas of particular interest without impairing their understanding of subsequent parts.Brought up to date with a new chapter by Ian Stewart, What is Mathematics? Second Edition offers new insights into recent mathematical developments and describes proofs of the Four-Color Theorem and Fermat's Last Theorem, problems that were still open when Courant and Robbins wrote this masterpiece, but ones that have since been solved.Formal mathematics is like spelling and grammar - a matter of the correct application of local rules. Meaningful mathematics is like journalism - it tells an interesting story. But unlike some journalism, the story has to be true. The best mathematics is like literature - it brings a story to life before your eyes and involves you in it, intellectually and emotionally. What is Mathematics is like a fine piece of literature - it opens a window onto the world of mathematics for anyone interested to view.

    Now William Dunham gives them the attention they deserve.Dunham places each theorem within its historical context and explores the very human and often turbulent life of the creator — from Archimedes, the absentminded theoretician whose absorption in his work often precluded eating or bathing, to Gerolamo Cardano, the sixteenth-century mathematician whose accomplishments flourished despite a bizarre array of misadventures, to the paranoid genius of modern times, Georg Cantor. He also provides step-by-step proofs for the theorems, each easily accessible to readers with no more than a knowledge of high school mathematics.A rare combination of the historical, biographical, and mathematical, Journey Through Genius is a fascinating introduction to a neglected field of human creativity.

    Sections group tales together by theme or juxtapose variations of individual tales, inviting comparison and analysis across cultures and genres. An accessible section of critical selections provides a foundation for readers to analyze, debate, and interpret the tales for themselves. An expanded introduction by the editors looks at the history of folk and fairy tales and distinguishes between the genres, while revised introductions to individual sections provide more detailed history of particular tellers and tales, paying increased attention to the background and cultural origin of each tale. A selection of illustrations from editions of classic tales from the 19th to the 21st centuries is also included.

    This new edition has been thoroughly revised and updated, with thirty new essays and a new section on anti-globalization movements. The editors have replaced several abstract articles from the first edition with livelier, more accessible essays that reflect the current scholarship. With new case studies, and a more international focus, this second edition is an even better introduction to globalization studies.Fully revised and updated - includes 30 new essays and a new section on anti-globalization movements.Wide-ranging - across economic, political, cultural, and experiential dimensions of social change.Inclusive - covering a wide variety of perspectives on globalization and capturing some of the fault lines in current debates.Stimulating - not only by including well-written, provocative, and contemporary works but also by structuring sections around arguments that serve as connecting themes.

    Offers students with the tools necessary to do ethical research in psychology and to understand the research they learn about in psychology courses and in the media.

    Its organization and thoroughness are unsurpassed, putting it above similar review books. Students who thoroughly read this book should have no trouble successfully completing their psychiatry clerkship and passing the shelf exam. As course director for the core psychiatry clerkship at my institution, I will recommend this book to students."--Doody's Review Service"First Aid for the Psychiatry Clerkship" gives you the core information needed to impress on the wards and pass the psychiatry clerkship exam. Written by students who know what it takes to succeed, and based on the national guidelines for the psychiatry clerkship, the book is filled with mnemonics, ward and exam tips, tables, clinical images, algorithms, and newly added mini-cases.Features Completely revised based on the psychiatry clerkship's core competencies Written by medical students who passed and reviewed by faculty for accuracy NEW integrated mini-cases illustrate classic patient presentations and/or commonly tested scenarios NEW illustrations and management algorithms Updated throughout with enhanced sections on medications, depression/anxiety, and child psychiatry Helps students hone in on the most important concepts for the clerkship and the examThe content you need to ace the clerkship: Section I: How to Succeed in the Psychiatry Clerkship Section II: High-Yield Facts; Examination and Diagnosis; Psychotic Disorders; Mood Disorders; Anxiety and Adjustment Disorders; Personality Disorders; Substance-Related Disorders; Cognitive Disorders; Geriatric Disorders; Psychiatric Disorders in Children; Dissociative Disorders; Somataform and Factitious Disorders; Impulse Control Disorders; Eating Disordes; Disorders; Sleep Disorders; Sexual Disorders; Psychtherapies; Psychopharmacology; Legal Issues; Section III: Awards and Opportunities.

    To meet it, you need a fully integrated text and supplements package that sets the stage for a perfectly choreographed learning experience.