It’s called autophagy, and when it’s turned on, the complex operation not only can slow down the aging process, it can optimize biological function as a whole, helping to stave off all manner of diseases and affording us the healthy life spans we never thought possible. It’s the body’s ultimate switch to life. So how can we positively activate this switch? How frequently should we fast and for how long? Which foods dial up autophagy or, conversely, turn it down? How much exercise and what types are recommended? What’s the sweet spot between intermittent fasting, protein cycling, and ketogenic eating? Backed by a wealth of scientific data and featuring a gallery of guidelines to follow for lasting results, The Switch decodes the science of autophagy and teaches you how to control it and maximize its profound impact.

    And it is ignorance--not knowledge--that is the true engine of science.Most of us have a false impression of science as a surefire, deliberate, step-by-step method for finding things out and getting things done. In fact, says Firestein, more often than not, science is like looking for a black cat in a dark room, and there may not be a cat in the room. The processis more hit-or-miss than you might imagine, with much stumbling and groping after phantoms. But it is exactly this not knowing, this puzzling over thorny questions or inexplicable data, that gets researchers into the lab early and keeps them there late, the thing that propels them, the verydriving force of science. Firestein shows how scientists use ignorance to program their work, to identify what should be done, what the next steps are, and where they should concentrate their energies. And he includes a catalog of how scientists use ignorance, consciously or unconsciously--aremarkable range of approaches that includes looking for connections to other research, revisiting apparently settled questions, using small questions to get at big ones, and tackling a problem simply out of curiosity. The book concludes with four case histories--in cognitive psychology, theoreticalphysics, astronomy, and neuroscience--that provide a feel for the nuts and bolts of ignorance, the day-to-day battle that goes on in scientific laboratories and in scientific minds with questions that range from the quotidian to the profound.Turning the conventional idea about science on its head, Ignorance opens a new window on the true nature of research. It is a must-read for anyone curious about science.

    We pride ourselves on our ability to multitask--read work email, reply to a text, check Facebook, watch a video clip. Talk on the phone, send a text, drive a car. Enjoy family dinner with a glowing smartphone next to our plates. We can do it all, 24/7! Never mind the errors in the email, the near-miss on the road, and the unheard conversation at the table. In The Distracted Mind, Adam Gazzaley and Larry Rosen--a neuroscientist and a psychologist--explain why our brains aren't built for multitasking, and suggest better ways to live in a high-tech world without giving up our modern technology.The authors explain that our brains are limited in their ability to pay attention. We don't really multitask but rather switch rapidly between tasks. Distractions and interruptions, often technology-related--referred to by the authors as "interference"--collide with our goal-setting abilities. We want to finish this paper/spreadsheet/sentence, but our phone signals an incoming message and we drop everything. Even without an alert, we decide that we "must" check in on social media immediately.Gazzaley and Rosen offer practical strategies, backed by science, to fight distraction. We can change our brains with meditation, video games, and physical exercise; we can change our behavior by planning our accessibility and recognizing our anxiety about being out of touch even briefly. They don't suggest that we give up our devices, but that we use them in a more balanced way.

    Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely--technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future--is now within reach.In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage.  As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars.  We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage.  By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

    After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

    It's all what Dr Joshua Wolrich defines as 'nutribollocks' and he is on a mission to set the record straight.As an NHS doctor with personal experience of how damaging diets can be, he believes every one of us deserves to have a happy, healthy relationship with food and with our bodies. His message is clear: we need to fight weight stigma, call out the lies of diet culture and give ourselves permission to eat all foods.Food Isn't Medicine wades through nutritional science (both good and bad) to demystify the common diet myths that many of us believe without questioning. If you have ever wondered whether you should stop eating sugar, try fasting, juicing or 'alkaline water', or struggled through diet after diet (none of which seem to work), this book will be a powerful wake-up call. Drawing on the latest research and delivered with a dose of humour, it not only liberates us from the destructive belief that weight defines health but also explains how to spot the misinformation we are bombarded with every day.Dr Joshua Wolrich will empower you to escape the diet trap and call out the bad health advice for what it really is: complete nutribollocks.

    We will directly and indirectly determine what lives, what dies, where, and when. We are in a different phase of evolution; the future of life is now in our hands.”Why are rates of conditions like autism, asthma, obesity, and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter, and having far fewer kids? How might your lifestyle affect your unborn children and grandchildren? How will gene-editing technologies like CRISPR steer the course of human evolution? If Darwin were alive today, how would he explain this new world? Could our progeny eventually become a different species—or several?In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution—sometimes intentionally, sometimes not. For example:   •  Globally, rates of obesity in humans nearly doubled between 1980 and 2014. What’s more, there’s evidence that other species, from pasture-fed horses to lab animals to house cats, are also getting fatter.    •  As reported by U.S. government agencies, the rate of autism rose by 131 percent from 2001 to 2010, an increase that cannot be attributed simply to increases in diagnosis rates.    •  Three hundred years ago, almost no one with a serious nut allergy lived long enough to reproduce. Today, despite an environment in which food allergies have increased by 50 percent in just over a decade, 17 million Americans who suffer from food allergies survive, thrive, and pass their genes and behaviors on to the next generation.    •  In the pre-Twinkie era, early humans had quite healthy mouths. As we began cooking, bathing, and using antibiotics, the bacteria in our bodies changed dramatically and became far less diverse. Today the consequences are evident not only in our teeth but throughout our bodies and minds. Though these harbingers of change are deeply unsettling, the authors argue that we are also in an epoch of tremendous opportunity. New advances in biotechnology help us mitigate the cruel forces of natural selection, from saving prematurely born babies to gene therapies for sickle cell anemia and other conditions. As technology like CRISPR enables us to take control of our genes, we will be able to alter our own species and many others—a good thing, given that our eventual survival will require space travel and colonization, enabled by a fundamental redesign of our bodies.Future humans could become great caretakers of the planet, as well as a more diverse, more resilient, gentler, and more intelligent species—but only if we make the right choices now.Intelligent, provocative, and optimistic, Evolving Ourselves is the ultimate guide to the next phase of life on Earth.

    Frank Lipman, the definitive guide to total wellnessIn his best-selling book, The New Health Rules, Dr. Frank Lipman laid out a modern manifesto for living a healthy and fulfilling life. How to Be Well is the essential follow up: a hands-on manual to mastering the habits, routines, and tactics that will help readers improve their health and establish the pillars of lifelong vitality.    In How to Be Well, Lipman has created The Good Medicine Mandala—a new map for a new era of medicine. The Good Medicine Mandala is illustrated by a circular system of six rings that contain simple steps to what really works to improve and strengthen resilience, functioning, and overall health. The Six Rings are: How to Eat: Mastering the very building blocks of life: food How to Sleep: Restoring one of our most fundamental needs How to Move: Helping the body move in the ways that nature intended How to Protect: Mitigating and preventing the invisible assaults of everyday toxins How to Unwind: Consciously switching off to allow for mental reprieve How to Connect: Awakening and enhancing a sense of belonging and meaning For anyone interested in health, wellness, and happiness, this gorgeously illustrated book is a must-have.

    We can now pin down the neurons that fire when a person reports becoming aware of a piece of information and understand the crucial role unconscious computations play in how we make decisions. The emerging theory enables a test of consciousness in animals, babies, and those with severe brain injuries.A joyous exploration of the mind and its thrilling complexities, Consciousness and the Brain will excite anyone interestedin cutting-edge science and technology and the vast philosophical, personal, and ethical implications of finally quantifyingconsciousness.

    Far from preparing them for fulfilling relationships, viewing an endless stream of porn videos led to unexpected symptoms. Perhaps most surprisingly, for the first time in history erectile dysfunction was becoming a significant problem for young men. This led to one of the largest informal experiments in the history of science. Tens of thousands of people have tried abstaining from sexually stimulating material in a process they call ‘rebooting’. Many of them reported startling changes, from improved concentration and elevated mood to a greater capacity for real-life intimacy. Gary Wilson has listened to the stories of those who have tried giving up internet porn and related them to an account of how the reward system of the brain interacts with its environment. And now a growing body of research in neuroscience is confirming what these pioneers have discovered for themselves – internet pornography can be seriously addictive and damaging. In Your Brain on Porn Wilson provides a concise introduction to the phenomenon of internet porn addiction that draws on both first-person accounts and the findings of cognitive neuroscience. In a voice that is generous and humane, he also offers advice for those who want to stop using internet pornography. The publication of Your Brain on Porn is a landmark in our attempts to understand, and remain balanced in, a world where addiction is big business.

    Howard Murad, M.D., FAAD is one today's foremost authorities on health and skincare, and his philosophies have helped men and women around the world look and feel as young and healthy as possible. With The Water Secret, Dr. Murad shares a new, scientifically proven strategy, cultivated over years of practice and treating over 50,000 patients, to help you look and feel better from the inside out.The Water Secret will:• Reveal groundbreaking secrets to help you take years off your looks, feel better and healthier• Debunk health myths through cutting-edge research and tell the truth about how inflammation, hydration, and other factors really affect your health• Explain how damaged cells that leak water can sabotage your looks• Introduces an integrated, multidisciplinary "Inclusive Health" approach to help optimize cellular strength• Give you a complete 10-step action plan with recipes and meal plans to start you on the path to clear skin, fewer wrinkles, more energy, and better overall healthDiscover The Water Secret and learn to take control of the process of aging by improving the health of every cell in the body. Begin the program and you will see and feel the difference your healthy new lifestyle will make in as soon as one week!

    Alongside this lifestyle, depression rates have skyrocketed: approximately 1 in 4 Americans will suffer from major depression at some point in their lives. Where have we gone wrong? Dr. Stephen Ilardi sheds light on our current predicament and reminds us: our bodies were never designed for the sleep-deprived, poorly nourished, frenzied pace of twenty-first century life. In fact, our genes have changed very little since the days of our hunter-gatherer ancestors and are still building, in effect, Stone Age bodies. Herein lies the key to breaking the cycle of depression.Inspired by the extraordinary resilience of aboriginal groups like the Kaluli of Papua New Guinea (who rarely suffer from depression), Dr. Ilardi prescribes an easy-to-follow, clinically proven program that harks back to what our bodies were originally made for-and need. Here you can find the road back to lasting health by integrating the following 6 elements into your life: an omega-3 rich diet; exercise; plenty of natural sunlight; ample sleep; social connections; and participation in meaningful tasks that leave little time for negative thoughts-all things that our ancestors had in abundance.Already, The Depression Cure program has delivered dramatic results, helping even those who have failed to respond to traditional medications. Interweaving the stories of many who have fought-and won-the battle against this debilitating illness, this groundbreaking book can illuminate the path to lifting the fog once and for all for you or a loved one.

    Why We Get Sick compels readers to reexamine the age-old attitudes toward sickness. Line drawings.

    “The Clean program works….The wisdom and information contained in this book is deeply helpful and life changing.” —Gwyneth PaltrowAs featured on Goop.com!From Alejandro Junger, Eastern medicine specialist, cardiologist, and head of the Integrative Medicine program at Lenox Hill Hospital (as well as a doctor at New York City’s renowned Eleven Eleven Wellness Center), comes the New York Times bestseller, Clean—a medically-proven program that teaches how to remove toxins, rejuvenate our bodies, and restore our natural health.

    With fresh insight, Martie Haselton explains how the fertility cycle has evolved over millions of years into a fine-tuned signaling system. Among the fascinating findings: During ovulation, women's attractiveness peaks because their "mate search effort" is turned on. Their walking gait, voice, skin condition, and dance moves are more alluring, and they wear more revealing clothes. They also tend to shop more. Being on the Pill affects women's preferences in men, and PMS may have evolved to get rid of boyfriends with unfit sperm. The research is provocative, but Haselton also presents practical advice for women to use their hormonal cycles to their advantage, helping them achieve success in their relationships, careers, and lives. Groundbreaking and counter-intuitive, HORMONAL will empower women everywhere to embrace their biology.