You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

    

    is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it. "A whole new crop of chemicals is radically changing the recreational drug landscape," writes Ben Westhoff. "These are known as Novel Psychoactive Substances (NPS) and they include replacements for known drugs like heroin, cocaine, ecstasy, and marijuana. They are synthetic, made in a laboratory, and are much more potent than traditional drugs"--and all-too-often tragically lethal. Drugs like fentanyl, K2, and Spice--and those with arcane acronyms like 25i-NBOMe-- were all originally conceived in legitimate laboratories for proper scientific and medicinal purposes. Their formulas were then hijacked and manufactured by rogue chemists, largely in China, who change their molecular structures to stay ahead of the law, making the drugs' effects impossible to predict. Westhoff has infiltrated this shadowy world, becoming the first journalist to report from inside an illicit Chinese fentanyls lab and providing startling and original reporting on how China's vast chemical industry operates, and how the Chinese government subsidizes it. He tracks down the little-known scientists who invented these drugs and inadvertently killed thousands, as well as a mysterious drug baron who turned the law upside down in his home country of New Zealand. Poignantly, Westhoff chronicles the lives of addicted users and dealers, families of victims, law enforcement officers, and underground drug awareness organizers in the U.S. and Europe. Together they represent the shocking and riveting full anatomy of a calamity we are just beginning to understand. From its depths, as Westhoff relates, are emerging new strategies that may provide essential long-term solutions to the drug crisis that has affected so many.

    Singapore ranks sixth in the world in healthcare outcomes, yet spends proportionally less on healthcare than any other high-income country. This is the first book to set out a comprehensive system-level description of healthcare in Singapore, with a view to understanding what can be learned from its unique system design and development path.The lessons from Singapore will be of interest to those currently planning the future of healthcare in emerging economies, as well as those engaged in the urgent debates on healthcare in the wealthier countries faced with serious long-term challenges in healthcare financing. Policymakers, legislators, public health officials responsible for healthcare systems planning, finance and operations, as well as those working on healthcare issues in universities and think tanks should understand how the Singapore system works to achieve affordable excellence.

    . . If what we want in this moment is insight from this brilliant doctor about pandemics, he wants us to see that they do not occur in isolation. --Carolyn Kellogg, The Boston GlobeIn 2014, Sierra Leone, Liberia, and Guinea suffered the worst epidemic of Ebola in history. The brutal virus spread rapidly through a clinical desert where basic health-care facilities were few and far between. Causing severe loss of life and economic disruption, the Ebola crisis was a major tragedy of modern medicine. But why did it happen, and what can we learn from it?Paul Farmer, the internationally renowned doctor and anthropologist, experienced the Ebola outbreak firsthand--Partners in Health, the organization he founded, was among the international responders. In Fevers, Feuds, and Diamonds, he offers the first substantive account of this frightening, fast-moving episode and its implications. In vibrant prose, Farmer tells the harrowing stories of Ebola victims while showing why the medical response was slow and insufficient. Rebutting misleading claims about the origins of Ebola and why it spread so rapidly, he traces West Africa's chronic health failures back to centuries of exploitation and injustice. Under formal colonial rule, disease containment was a priority but care was not - and the region's health care woes worsened, with devastating consequences that Farmer traces up to the present.This thorough and hopeful narrative is a definitive work of reportage, history, and advocacy, and a crucial intervention in public-health discussions around the world.

    Orwell gives an anecdotal account of his experiences in a french public hospital which triggers a contemplation of hospital literature in the context of 19th-century medicine.

    Spanning continents and centuries, it is an in-depth look into the history and science of manliness. From speed and strength, to beauty and sex appeal, to bravado and wit, it examines how man today compares to his masculine ancestors. Peter McAllister set out to rebut the claim that man today is suffering from feminization and emasculation. He planned to use his skills as a paleoanthropologist and journalist to write a book demonstrating unequivocally that man today is a triumph---the result of a hard-fought evolutionary struggle toward greatness. As you will see, he failed. In nearly every category of manliness, modern man turned out to be not just matched, but bested, by his ancestors. Stung, McAllister embarked on a new mission. If his book couldn’t be a testament to modern male achievement, he decided, it would be a record of his failures. Manthropology, then, is a globe-spanning tour of the science of masculinity. It kicks off in Ice Age France, where a biomechanical analysis demonstrates that La Ferrassie 2, a Neanderthal woman discovered in the early 1900s, would cream 2004 World Arm Wrestling Federation champion Alexey Voyevoda in an arm wrestle. Then it moves on to medieval Serbia, showing how Slavic guslar poets (who were famously able to repeat a two thousand-line verse after just one hearing) would have destroyed Curtis Jackson, aka 50 Cent, in a battle rap. Finally, it takes the reader to the steaming jungles of modern equatorial Africa, where Aka Pygmy men are such super-dads, they even grow breasts to suckle their children. Now, that’s commitment. For modern man, the results of these investigations aren’t always pretty. But in its look at the history of men, Manthropology is unfailingly smart, informative, surprising, and entertaining.                         *** HOW DOES MODERN MAN STACK UP? Russian arm wrestling champion Alexey Voyevoda has a twenty-two-inch bicep and has curled more than two hundred and fifty pounds---with just one arm. But could he stand up in an arm wrestling match with an average Neanderthal male? Or, for that matter, a female? (p. 10)                       *** Today’s Ultimate Fighters compete in a sport where bouts routinely end with an unconscious loser splayed out on a blood-soaked canvas. But what would a match in the Octagon look like next to the Pankration bouts of the Ancient Greeks: a battleground or a playground? (p. 77)                       *** A modern army goes into battle with state-of-the-art technology and centuries of strategical insight. But for sheer determination, could they have bested Nero’s legions, who marched nearly two marathons a day for six days straight---each legionary carrying hundred-pound packs? (p. 99)                       *** There’s philological evidence that suggests Homer may not have written the Iliad; he may have rapped it. If 50 Cent had to face Homer in a rap battle, would he come out on top? (p. 160)                       *** Wilt Chamberlain is known for scoring on more than just the court. He claimed to have had as many as twenty thousand sexual encounters in his lifetime. Such conquest could only be matched by one of the world’s greatest conquerors: There is the evidence that approximately 32 million people are descended from Genghis Khan. (p. 248)

    Have it powdered or granulated, by the teaspoon or cube, dark brown or light brown, refined or raw. Taste it in a thick slice of birthday cake, a palmful of chocolate candies, or a snifter of dark rum. Whatever the form, whatever the treat - sugar drives us wild like nothing else. It’s lingered on our tongues for millennia and found its way into almost every household in the world. Alas, the history of sugar is far from sweet. Long before it was linked to America’s obesity epidemic, sugar was fueling the dark forces of exploitation, colonization, conquest, and slavery. More than just candy and cake, sugar has drastically altered the diets, cultures, and economies of the modern world. How can we love sugar while having a healthy relationship with its bittersweet history? From the earliest cultivation of sugarcane in Asia, to the brutal conditions on colonial sugar plantations, to the multibillion-dollar industry that dominates our grocery aisles today, The History of Sugar offers you a host of surprising insights into human nature. As historian Kelley Fanto Deetz reveals in her fascinating Audible Original, our relationship to this commodity showcases its incredible capacity to lure, to addict, to transform humans to bow to its sweetness at almost all costs - and still bring us together in moments of undeniably delicious joy and celebration.

    Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

    Doctor, Harvard professor, renowned infectious-disease specialist, anthropologist, the recipient of a MacArthur "genius" grant, world-class Robin Hood, Farmer was brought up in a bus and on a boat, and in medical school found his life’s calling: to diagnose and cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most.Mountains Beyond Mountains takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes minds and practices through his dedication to the philosophy that "the only real nation is humanity"—a philosophy that is embodied in the small public charity he founded, Partners in Health. He enlists the help of the Gates Foundation, George Soros, the U.N.’s World Health Organization, and others in his quest to cure the world. At the heart of this book is the example of a life based on hope, and on an understanding of the truth of the Haitian proverb "Beyond mountains there are mountains": as you solve one problem, another problem presents itself, and so you go on and try to solve that one too.

    Uzzi Reiss shows the way for women who want to turn back the effects of time through natural hormone therapy, but who wonder: is it safe? Does it work? Is hormone therapy right for me?Natural Hormone Balance for Women is Dr. Reiss's breakthrough, step-by-step program for women who want to take control of their lives by restoring hormonal balance. This revolutionary, commonsense natural hormone replacement program is designed to meet the individual needs of most women looking to rejuvenate body and mind—and offers astounding benefits for women of all ages: More energy and stamina * Improved memory * Healthier, more youthful skin * Balanced moods * Less depression and anxiety * Stabilization of weight and more muscle definition * Better sleep patterns * PMS and menopausal symptoms reduced or eliminated * Enhanced sexuality Dr. Reiss takes the confusion out of the medical information you need to know. In clear, nontechnical language, he thoroughly explains: -the important difference between standard chemical hormone prescriptions and natural hormone replacements -which hormone replacements are best for you and how to adjust them to your maximum individual benefit -how to take hormones without worry -how to choose the most effective hormonal gel, cream, pill, or sublingual drops, and when to use them. Dr. Reiss has helped thousands of women transform their lives by achieving natural hormone balance. Now you can tap into the replenishing "fountain of youthfulness" that is not only essential for better life, but easier and safer to achieve than ever before.

    With extensive treatment of the heart of epidemiology-from study designs to descriptive epidemiology to quantitative measures-this reader-friendly text is accessible and interesting to a wide range of beginning students in all health-related disciplines. A unique focus is given to real-world applications of epidemiology and the development of skills that students can apply in subsequent course work and in the field. The text is also accompanied by a complete package of instructor and student resources available through a companion Web site.

    While the narrative predominately revolves around Meyer's story, it also includes vignettes from interviews with several other doctors, nurses, and medical assistants, to indicate the wide range of U.S. health care workers' experiences. Meyer recounts the pandemic from the period before it was identified, through its emergence in the United States, the virus's terrifying uncontrolled community spread, and concern about the long-term repercussions of COVID-19. The co-authors argue that forging personal connections is vital to practicing emergency medicine, and they impart health care providers' efforts to compensate for the myriad ways that personal connection was hampered by pandemic precautionary measures. The book isn't only a document of trauma; it also notes moments of joy, like when medical staff discovered new treatments with better patient outcomes, or when Meyer's mentor survived after contracting the virus.

    But American Overdose exposes the powerful forces they were up against, including the pharmaceutical industry's coopting of the Food and Drug Administration and Congress in the drive to push painkillers--resulting in the resurgence of heroin cartels in the American heartland. McGreal tells the story, in terms both broad and intimate, of people hit by a catastrophe they never saw coming. Years in the making, its ruinous consequences will stretch years into the future.

    Over the past few years, we ve seen facial hair sprouting up on faces everywhere. Men want to experiment with their facial gardens, but it s not always just as easy as putting the razor to rest Any man will surely go back to shaving when his beard starts to itch. When a goatee or mustache looks bad, he ll shave it off, discouraged and unaware of his options. Marginalized facial hair stereotypes prevent every day, normal guys from making facial hair part of their personal style. Men have forgotten about their beards, let alone how to wear and care for them. Until now. The Facial Hair Handbook is a hilarious and informative guide to all aspects of facial hair, for men of all ages and all faces. From making the decision to wear facial hair, to the best way to take it off, all men can finally be stylish and care for their appearance while staying true to who they are: Men.