The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Women thirty and older who wish to conceive naturally are often told it is a "bit too late" for easy conception, or they are forced to turn to invasive, expensive treatments. But there is a better way! With How to Concieve Naturally: And Have a Healthy Pregnancy After 30 readers will discover that it's possible to have a healthy pregnancy in your thirties or early forties. Experts Christa Orecchio and Willow Buckley share their vast knowledge of holistic health, nutrition, and fertility in this powerful program that has helped thousands of women conceive naturally and quickly. From a 12-week preconception fertility detox to a postpartum plan to rebalance hormones, this book empowers women to take charge of their fertility at any age. Orecchio and Buckley present the most current research in nutrition and homeopathy to equip women with the wide-ranging knowledge they'll need on each step of the journey to having a baby naturally, from preconception to postpartum.

    Thankfully there is a better way: The Way of the Productivity Ninja.Using techniques including Ruthlessness, Mindfulness, Zen-like Calm and Stealth & Camouflage you will get your inbox down to zero, make the most of your attention, beat procrastination and learn to work smarter, not harder.Written by one of the UK’s foremost productivity experts, How to be a Productivity Ninja is a fun, accessible and practical guide to staying cool, calm and collected, getting more done, and learning to love your work again.

    The Anatomy of Peace asks, What if conflicts at home, conflicts at work, and conflicts in the world stem from the same root cause? What if we systematically misunderstand that cause? And what if, as a result, we unwittingly perpetuate the very problems we think we are trying to solve? Through an intriguing story we learn how and why we contribute to the divisions and problems we blame on others and the surprising way that these problems can be solved. Yusuf al-Falah, an Arab, and Avi Rozen, a Jew, each lost his father at the hands of the other's ethnic cousins. The Anatomy of Peace is the story of how they came together, how they help warring parents and children come together, and how we too can find our way out of the struggles that weigh us down. This second edition includes new sections enabling readers to go deeper into the book's key concepts; access to free digital study and discussion guides; and information about The Reconciliation Project, a highly successful global peace initiative based on concepts in The Anatomy of Peace.

    We’re told that learning is all self-discipline, that we must confine ourselves to designated study areas, turn off the music, and maintain a strict ritual if we want to ace that test, memorize that presentation, or nail that piano recital.   But what if almost everything we were told about learning is wrong? And what if there was a way to achieve more with less effort?   In How We Learn, award-winning science reporter Benedict Carey sifts through decades of education research and landmark studies to uncover the truth about how our brains absorb and retain information. What he discovers is that, from the moment we are born, we are all learning quickly, efficiently, and automatically; but in our zeal to systematize the process we have ignored valuable, naturally enjoyable learning tools like forgetting, sleeping, and daydreaming. Is a dedicated desk in a quiet room really the best way to study? Can altering your routine improve your recall? Are there times when distraction is good? Is repetition necessary? Carey’s search for answers to these questions yields a wealth of strategies that make learning more a part of our everyday lives—and less of a chore.   By road testing many of the counterintuitive techniques described in this book, Carey shows how we can flex the neural muscles that make deep learning possible. Along the way he reveals why teachers should give final exams on the first day of class, why it’s wise to interleave subjects and concepts when learning any new skill, and when it’s smarter to stay up late prepping for that presentation than to rise early for one last cram session. And if this requires some suspension of disbelief, that’s because the research defies what we’ve been told, throughout our lives, about how best to learn.   The brain is not like a muscle, at least not in any straightforward sense. It is something else altogether, sensitive to mood, to timing, to circadian rhythms, as well as to location and environment. It doesn’t take orders well, to put it mildly. If the brain is a learning machine, then it is an eccentric one. In How We Learn, Benedict Carey shows us how to exploit its quirks to our advantage.  Praise for How We Learn“This book is a revelation. I feel as if I’ve owned a brain for fifty-four years and only now discovered the operating manual.”—Mary Roach, bestselling author of Stiff and Gulp“A welcome rejoinder to the faddish notion that learning is all about the hours put in.” —The New York Times Book Review   “A valuable, entertaining tool for educators, students and parents.” —Shelf Awareness   “How We Learn is more than a new approach to learning; it is a guide to making the most out of life. Who wouldn’t be interested in that?” —Scientific American   “I know of no other source that pulls together so much of what we know about the science of memory and couples it with practical, practicable advice.”—Daniel T. Willingham, professor of psychology at the University of Virginia

    ABOUT THE AUTHOR: In the mid-1990's, Deborah Taylor-Hough set up one of the first Charlotte Mason homeschooling websites and edited The Charlotte Mason Monthly ezine. Debi currently edits The Charlotte Mason eMagazine and blogs at CharlotteMasonHome.com

    Moms in particular will welcome this trend.  A full 60% wish they had a flexible work option. But companies see advantages too in the way remote work increases their talent pool, reduces turnover, lessens their real estate footprint, and improves the ability to conduct business across multiple time zones, to name just a few advantages.  In Remote, inconoclastic authors Fried and Hansson will convince readers that letting all or part of work teams function remotely is a great idea--and they're going to show precisely how a remote work setup can be accomplished.

    An exclusive first look at May Martin’s Sewing Bible, due out in August.May has been teaching sewing for over 40 years. Now for the first time she shares her tips and tricks, offering the ultimate beginners’ guide to sewing.Beautifully styled and simple-to-follow, this authoritative sewing e-short, taken from May Martin’s Sewing Bible, gives readers information on everything they need to know to get started with sewing.

    From Isaac Newton to Mark Zuckerberg, these visionary, determined INTJs have made an impact. But what drives these self-possessed, sometimes mysterious Masterminds? What makes them so uniquely equipped to improve the systems we live with every day?This book is for INTJs and those who live with them, work with them, or just want to know more about them. With an eye toward the INTJ's natural strengths, The True INTJ takes an in-depth look at the talents, motivations, values, and unique qualities of the INTJ. You'll discover what drives the INTJ, and how this innovative, dedicated personality type can use their gifts to change the world.

    Headlee is a talented, honest storyteller, and her advice has helped me become a better spouse, friend, and mother.”  (Jessica Lahey, author of New York Times bestseller The Gift of Failure)Today most of us communicate from behind electronic screens, and studies show that Americans feel less connected and more divided than ever before. The blame for some of this disconnect can be attributed to our political landscape, but the erosion of our conversational skills as a society lies with us as individuals.And the only way forward, says Headlee, is to start talking to each other. In We Need to Talk, she outlines the strategies that have made her a better conversationalist—and offers simple tools that can improve anyone’s communication. For example: BE THERE OR GO ELSEWHERE. Human beings are incapable of multitasking, and this is especially true of tasks that involve language. Think you can type up a few emails while on a business call, or hold a conversation with your child while texting your spouse? Think again.CHECK YOUR BIAS. The belief that your intelligence protects you from erroneous assumptions can end up making you more vulnerable to them. We all have blind spots that affect the way we view others. Check your bias before you judge someone else.HIDE YOUR PHONE. Don’t just put down your phone, put it away. New research suggests that the mere presence of a cell phone can negatively impact the quality of a conversation.Whether you’re struggling to communicate with your kid’s teacher at school, an employee at work, or the people you love the most—Headlee offers smart strategies that can help us all have conversations that matter.

    Thousands of people, all over the world, are trading Forex and making tons of money. Why not you?All you need to start trading Forex is a computer and an Internet connection. You can do it from the comfort of your home, in your spare time without leaving your day job.And you don't need a large sum of money to start, you can trade initially with a minimal sum, or better off, you can start practicing with a demo account without the need to deposit any money.Forex Trading is very simple and straightforward, we only deal with a pair of currencies, and it has quite a high profit potential.Forex allows even beginners the opportunity to succeed with financial trading. Actually people that have minimum financial track record can easily make money by learning how to trade currencies online. This book features the in and outs of currency trading as well as strategies needed to achieve success in the trading.Here are some of the topics you'll discover while reading the book:* The single most critical factor to Forex trading success - ignore it at your own perils.* Simple, easy to copy ideas that will enhance your chances of winning trades.* What you need to succeed in currency trading.* Advantages of trading Forex.* Effective risk management strategies to help you minimize your risk and conserve your capital.* Key factors to successful financial Forex trading.* How to develop Forex trading strategies and entry and exit signals that work.* A list of easy-to-follow tips to help you improve your trading successes.* All this and much much more.Table of Contents1. Making Money in Forex Trading2. What is Forex Trading3. How to Control Losses with "Stop Loss"4. How to Use Forex for Hedging5. Advantages of Forex Over Other Investment Assets6. The Basic Forex Trading Strategy7. Forex Trading Risk Management8. What You Need to Succeed in Forex9. Technical Analysis As a Tool for Forex Trading Success10. Developing a Forex Strategy and Entry and Exit Signals11. A Few Trading Tips for DessertTags: Forex trading strategies, Forex scalping, Forex trading secrets, Forex trading manual, currency trading for dummies, Forex trading for beginners, day trading the currency market, Forex trading system, Forex for dummies, foreign currency trading.

    Covey, bestselling author of The 8th Habit: From Effectiveness to Greatness, comes the accompanying personal workbook that will help you further realize the power of this new habit. The world has changed dramatically since Covey's classic The 7 Habits of Highly Effective People was published. The challenges we all face in our relationships, families, professional lives and communities are of an entirely new order of magnitude. In order to thrive in what Covey calls the new Knowledge Worker Age, we need to build on and move beyond effectiveness -- to greatness. Accessing the higher reaches of human genius and motivation in today's reality requires a whole new habit. The questionnaires, tests, self-assessments, and other exercises in this workbook provide a hands-on approach to developing the mind-set, skill-set and tool-set for achieving greatness in the Knowledge Worker Age. The 8th Habit will transform the way you think about yourself and your purpose in life, about your organization and about humankind.

    It provides the background needed to understand related drugs currently on the market, as well as drugs yet to be released. In simplifying a complex subject, this text focuses on the essentials of pharmacology. Large print is used to show need-to-know information, and small print is used for nice to know material. At the end of each chapter, a summary of major nursing implications helps in applying the material to real-world situations. This edition includes a new companion CD-ROM featuring NCLEX(R) examination-style review questions, a variety of electronic calculators, and animations depicting drug mechanisms and effects.Uses a prototype drug approach that places a strong emphasis on understanding over memorization - equipping students with the knowledge to learn not only about related drugs currently on the market, but also about those drugs that will be released once the student begins practice.Summaries of Major Nursing Implications at the end of each chapter provide an in-depth look at assessment, implementation, and ongoing evaluations.Utilizes large print for essential information and small print for nice-to-know information to help both faculty and students focus their limited classroom and study time on understanding the essentials.Concise drug summary tables present detailed information on individual drugs, including class, generic and trade names, dosages, routes, and indications.Key Points at the end of each chapter summarize content in a bulleted format to help students review important concepts.Prototype drug discussions employ a clear and consistent format with separate headings for Mechanism of Action; Pharmacologic Effects; Pharmacokinetics; Therapeutic Uses; Adverse Effects; Drug Interactions; and Preparations, Dosage, and Administration.An attractive full-color design adds visual interest, highlights key information, and facilitates student learning.Drugs for Multiple Sclerosis and Drugs for Hemophilia chapters.Drugs for Erectile Dysfunction and Benign Prostatic Hyperplasia chapter covers newsworthy drugs such as Viagra and Levitra.Special Interest Topics boxes on current issues in pharmacology, such as Medication-Overuse Headache: Too Much of a Good Thing and Face Time with Botox.Adult Immunization appendix summarizes the latest information on immunizations.Numerous new illustrations show drug mechanisms and effects, and depict topics such as histologic changes in Alzheimer's disease and the movement of drugs following GI absorption.

    Philip Bailey describes in depth the personality profiles of some 35 polychrests. The last pages of the book cover a mix of psychological astrology and homeopathy when he explores the elements and some polychrests. Bailey provides detailed information on 35 major types, giving insight on diagnosis, mental and emotional traits, and physical characteristics. His broad profiles of major constitutional remedies give the reader a good overall picture of the personality type and therefore ways of remembering facts about the archetype, by having a unifying theory for each remedy.

    Hadoop allowed small and medium sized companies to store huge amounts of data on cheap commodity servers in racks. The introduction of Big Data has allowed businesses to make decisions based on quantifiable analysis. Hadoop is now implemented in major organizations such as Amazon, IBM, Cloudera, and Dell to name a few. This book introduces you to Hadoop and to concepts such as ‘MapReduce’, ‘Rack Awareness’, ‘Yarn’ and ‘HDFS Federation’, which will help you get acquainted with the technology.