Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    We know, for example, that there are a few core truths to science of happiness. We know that being kind and altruistic makes us happy, that turning off devices, talking to people, forging relationships, living with meaning and delving into the concerns of others offer our best chance at achieving happiness. But how do we retain happiness? It often slips out of our hands as quickly as we find it. So, when we are exposed to, or learn, good things, how do we continue to burn with them?And more than that, when our world goes dark, when we're overwhelmed by illness or heartbreak, loss or pain, how do we survive, stay alive or even bloom? In the muck and grit of a daily existence full of disappointments and a disturbing lack of control over many of the things that matter most - finite relationships, fragile health, fraying economies, a planet in peril - how do we find, nurture and carry our own inner, living light - a light to ward off the darkness?Absorbing, achingly beautiful, inspiring and deeply moving, Julia Baird has written exactly the book we need for these times.

    After years of failed diets Dr Nadja Hermann weighed over 23 stone at the age of 30. All her life, she had heard and read about hundreds of reasons why diets wouldn't work for her. But when her weight started to seriously affect her health, she took a hard look at the science and realised that most of what she believed about dieting was a myth. What was more, those very myths were preventing her from losing weight.Forget clean eating, paleo, or fasting — it was conquering these elements of ‘Fat Logic’ that finally led to Hermann achieving a healthy weight. One and a half years later, she weighed 10 stone, and has maintained that weight to this day. Now, using humour, the insight she’s acquired, and a dose of science, Hermann debunks widespread lies about weight loss, and shows how it is possible to attain a healthy weight.

    Wherever there is greenery, photosynthesis isworking to make oxygen, release energy, and create living matter from the raw material of sunlight, water, and carbon dioxide. Without photosynthesis, there would be an empty world, an empty sky, and a sun that does nothing more than warm the rocks and reflect off the sea. With photosynthesis, we have a living world with three billion years of sunlight-fed history to relish.Eating the Sun is a bottom-up account of our planet, a celebration of how the smallest things, enzymes and pigments, influence the largest things­­—the oceans, the rainforests, and the fossil fuel economy. From the physics, chemistry, and cellular biology that make photosynthesis possible, to the quirky and competitive scientists who first discovered the beautifully honed mechanisms of photosynthesis, to the modern energy crisis we face today, Oliver Morton offers a complete biography of the earth through the lens of this mundane and most important of processes.More than this, Eating the Sun is a call to arms. Only by understanding photosynthesis and the flows of energy it causes can we hope to understand the depth and subtlety of the current crisis in the planet's climate. What's more, nature's greatest energy technology may yet inspire the breakthroughs we need to flourish without such climatic chaos in the century to come.Entertaining, thought-provoking, and deeply illuminating, Eating the Sun reveals that photosynthesis is not only the key to humanity's history; it is also vital to confronting and understanding contemporary realities like climate change and the global food shortage. This book will give you a new and perhaps troubling way of seeing the world, but it also explains how we can change our situation—for the better or the worse.

    The CEO of Nestlé, purveyor of bottled water, heartily agrees. It is important to give water a market value, he says in a promotional video, so “we're all aware that it has a price.” But for those who have no access to clean water, a fifth of the world's population, the price is thirst. This is the frightening landscape that Karen Piper conducts us through in The Price of Thirst—one where thirst is political, drought is a business opportunity, and more and more of our most necessary natural resource is controlled by multinational corporations.In visits to the hot spots of water scarcity and the hotshots in water finance, Piper shows us what happens when global businesses with mafia-like powers buy up the water supply and turn off the taps of people who cannot pay: border disputes between Iraq and Turkey, a “revolution of the thirsty” in Egypt, street fights in Greece, an apartheid of water rights in South Africa. The Price of Thirst takes us to Chile, the first nation to privatize 100 percent of its water supplies, creating a crushing monopoly instead of a thriving free market in water; to New Delhi, where the sacred waters of the Ganges are being diverted to a private water treatment plant, fomenting unrest; and to Iraq, where the U.S.-mandated privatization of water resources destroyed by our military is further destabilizing the volatile region. And in our own backyard, where these same corporations are quietly buying up water supplies, Piper reveals how “water banking” is drying up California farms in favor of urban sprawl and private towns.The product of seven years of investigation across six continents and a dozen countries, and scores of interviews with CEOs, activists, environmentalists, and climate change specialists, The Price of Thirst paints a harrowing picture of a world out of balance, with the distance between the haves and have-nots of water inexorably widening and the coming crisis moving ever closer.

    Containing the renowned artist's superbly lucid and comprehensive text, this guide features more than 6,500 of his detailed paintings. Full color.

    The experienced author team have reviewed the core text, expanded the Applications of Biology chapters, and added two new chapters on practical skills. Each chapter now has a set of exam-style practice questions, as well as questions to help review the material. Also included are advice on how to revise and prepare for the examinations, multiple choice questions, revision summaries and answers to all book questions.

    Bartlett builds upon his popular seminars to teach us how to access the discovery he has made -- a process that merges the science of subtle energy with our innate imaginations to produce measurable results. By applying forces known to modern physics, you will learn to tap into states of healthy awarenes from different moments -- in essence, travel in time -- and bring them into the present for immediate, profound results. As Dr. Bartlett shows, this practice requires no special training and produces transformation in the blink of an eye, giving you the key to a whole new level of power, awareness, and potential in your life. Filled with stories of success and discussing seemingly implausible topics such as alternate universes, invisibility, and levitation, The Physics of Miracles is not only fascinating but also instantly applicable. For millions of people looking for empowerment in an increasingly disconnected, impersonal world, Dr. Bartlett shares his experience with these phenomena that will reshape the way people think about their own place in the universe.

    Randall never gave sleep much thought. That is, until he began sleepwalking. One midnight crash into a hallway wall sent him on an investigation into the strange science of sleep.In Dreamland, Randall explores the research that is investigating those dark hours that make up nearly a third of our lives. Taking readers from military battlefields to children’s bedrooms, Dreamland shows that sleep isn't as simple as it seems. Why did the results of one sleep study change the bookmakers’ odds for certain Monday Night Football games? Do women sleep differently than men? And if you happen to kill someone while you are sleepwalking, does that count as murder?This book is a tour of the often odd, sometimes disturbing, and always fascinating things that go on in the peculiar world of sleep. You’ll never look at your pillow the same way again.

    The Complete Book of Cacti & Succulents is a feast of in-depth information and over 600 eye-catching photographs. This book has everything you need to make your plant arrangements healthy and spectacular no matter what kinds of succulents you use. Using this guide, you will quickly discover just how bold and creative you can be with these arrangements, and understand why so many decorators can recommend succulents for almost every occasion.Whether you're just thinking about decorating with these beautiful, easy-to-care-for plants, or you've been a sucker for succulents for a good long while, this book contains ideas and inspiration for beginners and masters alike. Through step-by-step full-color sequences and expert guidance, this book gives in-depth information on the history, cultivation, and creative use of hundreds of strikingly handsome specimens of cacti and provides practical information for use in both house and garden.

    And now he's showing the way to build the very foundation of well-being: Resilience. Today, people feel rattled by political and economic forces, and realize that they need to be able to rely on their own inner guidance systems in order to stay happy and calm. Not simply about weathering negative experiences, Resilient's groundbreaking program shows you how to harness the power of positive experiences in order to build an unshakeable core.In this succinct guide to lasting happiness, Dr. Hanson has distilled 40 years of clinical work and teaching into the tools that actually work. Each of these 12 tools grows a key inner strength for resilience, allowing you to enter a positive cycle in which resilience creates a sense of well-being, which creates even more resilience, and so on. Developed from his incredibly popular online course called The Foundations of Well-Being, this essential book offers everything you need to shore up these powerful inner strengths. In his inimitable friendly, warm, straightforward tone, Dr. Hanson shares stories, support, and simple thoughts and actions that lead to deeply rooted change. Here is the groundwork that will allow you to meet life with a whole heart.

    The introduction contains illustrations of the main leaves, buds, and firs you are likely to find, and these provide the starting point for identification by leading you to a 'key' species.Within each tree family there is a list of key species and a guide to the most important features to look for when identifying a particular tree from that family. Then individual species are clearly described and a detailed illustration is given on the same page.Covering all the tree species found outside the major arboretums, from the olive tree to the eucalyptus, this is one of the most important tree guides to have appeared in the last 20 years. The illustrations are annotated with essential identification features, and the text highlights the most important things to look for to aid fast and accurate identification. There is also coverage of all the species native to Southern Europe.

    Emoto demonstrates how water's unique role in transporting the natural vibration of these words can help you welcome change and live a more positive and happy life. Dr. Emoto also explores the significance of words and language, their origins, and their impact on water. He introduces and explains the key concept of resonance -- the vehicle through which life-force energy is transmitted. From this knowledge, he draws out lessons that we can apply to our lives to reap the benefits of positive resonance, including more harmonious relationships, restored health, and improved communications. This thoughtful book includes new and extraordinary water-crystal photographs that provide convincing reasons for all of us to choose positive words and strive for perfect resonance for a more healthy, peaceful, and happy life.

    He shows that by consciously opening the doors of perception, we can reconnect with the living intelligences in Nature as kindred beings, become again wild scientists, nondomesticated explorers of a Gaian world just as Goethe, Barbara McClintock, James Lovelock, and others have done. For as Einstein commented, “We cannot solve the problems facing us by using the same kind of thinking that created them.” Buhner explains how to use analogical thinking and imaginal perception to directly experience the inherent meanings that flow through the world, that are expressed from each living form that surrounds us, and to directly initiate communication in return. He delves deeply into the ecological function of invasive plants, bacterial resistance to antibiotics, psychotropic plants and fungi, and, most importantly, the human species itself. He shows that human beings are not a plague on the planet, they have a specific ecological function as important to Gaia as that of plants and bacteria. Buhner shows that the capacity for depth connection and meaning-filled communication with the living world is inherent in every human being. It is as natural as breathing, as the beating of our own hearts, as our own desire for intimacy and love. We can change how we think and in so doing begin to address the difficulties of our times.

    Let's face it, comparing cats and dogs is like, well, like comparing apples and oranges. They are different, and they have different needs. A dog is a pack animal that needs a leader. By nature a dog expects to get rubbed and wrestled with. Dogs like to horse around. A cat does not. A cat is a solitary predator and needs its space. But what both cats and dogs do need is your love and attention. Just because a cat is, by nature, independent doesn't mean that he or she doesn't need your praise or physical affection. There are a lot of myths about cats -- like the one above -- that lead to their mistreatment. By learning more about what makes a cat a cat, you will be better able to give your feline the space, care, and love that he or she needs. And this sentiment couldn't be truer when it comes to training your cat. Hitting or yelling at your cat when he scratches his claws on your nice new couch just doesn't make sense. Your cat is only being a cat. He needs to scratch his nails so they can stay healthy and strong. Also, scratching helps a cat relieve stress and relax. Imagine being yelled at and hit for sprawling out on the couch with a magazine and a glass of nice red wine after a long day's work. You must align your training expectations with your cat's needs if you want to have a happy, well-trained cat. Johnson-Bennett advises you to "get on her level emotionally, physically, and mentally in order to map out an effective training plan." She outlines three basic methods for training: positive reinforcement (rewarding kitty for good behavior), remote control (spraying kitty with a water gun when she jumps on the kitchen counter), and redirection (getting kitty to scratch on a scratching post instead of your expensive couch). By using these training methods in the first place, you will get a head start in establishing good behavior, and in the process you and your cat will become closer.If you want to learn more about your cat and what you can do to strengthen and enjoy your relationship with each other, then Think Like a Cat should really be on your reading list. From years of experience as a vet technician and as an adoring cat owner, Johnson-Bennett knows her stuff. And she covers it all in this book -- from grooming, training, health, and nutrition to emergency care, games, and toys. So get ready to hear a lot more purring around the house!—Jen Forman