Today, says Dale Purves, the dominant research agenda may have taken us as far as it can--and neuroscientists may be approaching a paradigm shift. In this highly personal book, Purves reveals how we got to this point and offers his notion of where neuroscience may be headed next. Purves guides you through a half-century of the most influential ideas in neuroscience and introduces the extraordinary scientists and physicians who created and tested them. Purves offers a critical assessment of the paths that neuroscience research has taken, their successes and their limitations, and then introduces an alternative approach for thinking about brains. Building on new research on visual perception, he shows why common ideas about brain networks can't be right and uncovers the factors that determine our subjective experience. The resulting insights offer a deeper understanding of what it means to be human. - Why we need a better conception of what brains are trying to do and how they do it Approaches to understanding the brain over the past several decades may be at an impasse - The surprising lessons that can be learned from what we see How complex neural processes owe more to trial-and-error experience than to logical principles - Brains--and the people who think about them Meet some of the extraordinary individuals who've shaped neuroscience - The -ghost in the machine- problem The ideas presented further undermine the concept of free will

    Rich illustrations, systematic resumes, and extensive citations make it a valuable references source.

    The physical examination unit is organized by body system, pedagogically and clinically the most logical and efficient way to learn and perform health assessment. Each chapter has five major sections: (1) Structure and Function (A&P); (2) Subjective Data (history); (3) Objective Data (skills, expected findings, and common variations for healthy people and selected abnormal findings); (4) Abnormal Findings (illustrations of related disorders and conditions in atlas format); and (5) Application and Documentation (sample charting, clinical case studies, nursing diagnoses, and critical thinking questions tied to the Saunders video series).

    Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    The book is organized by body system and covers standard scope and sequence requirements. Its lucid text, strategically constructed art, career features, and links to external learning tools address the critical teaching and learning challenges in the course. The web-based version of Anatomy and Physiology also features links to surgical videos, histology, and interactive diagrams.

    Chapters parallel most standard pathology texts and each chapter ends with a review test. Topics covered include general and basic pathology, major concepts of disease processes, and systemic pathology surveying principal disorders of each organ system. A comprehensive examination at the end of the book contains 500 USMLE-format questions. USMLE questions have all been updated to current USMLE format.The text is written in outline format for effective review. Icons indicate high-yield information that correlates with key pathology concepts.

    This popular Blueprints book has been refined and updated while keeping the concise, organized style and clinical high-yield content of previous editions. Features include USMLE-style questions and answers with full explanations; Key Points in every section; and a color-enhanced design that increases the usefulness of figures and tables.This edition's completely revised art program includes many additional illustrations. Each chapter in this edition ends with evidence-based references (journals) for students to do additional reading/research.

    Here, he leads readers on an unforgettable journey into the bizarre yet oddly beautiful world of parasites. In a narrative that is by turns frightening, disgusting, and laugh-out-loud funny, Kaplan describes how drinking contaminated water can cause a three-foot-long worm to burst from your arm; how he gave birth to a parasite the size and thickness of a pencil while working in Israel; why you should never wave a dead snake in front of your privates; and why fleas are attracted to his wife. Kaplan tells stories about leeches feasting on soldiers in Vietnam; sea cucumbers with teeth in their anuses that seem to encourage the entry of symbiotic fish; the habits of parasites that cause dysentery, river blindness, and other horrifying diseases--and much, much more. Along the way, he explains the underlying science, including parasite evolution and host-parasite physiology.

    We’ll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    The material is based on rigorous reference to ancient and modern Chinese texts, and explains the application of theory in a Western practice context. The new edition features new and updated material, including discussion of 50 additional acupuncture points and more patterns. A redesigned layout complements the accessible writing style and makes the material even easier to follow. Plus, an accompanying CD-ROM contains over 750 self-testing questions in a variety of formats.

    It treats the subject as a coherent whole, complete with numerous logical connections, consequences, and an underlying structure and language. Employing an approach based on mechanism and reaction type, the book empasizes understanding ideas rather than merely memorizing facts. It shows students how to realistically draw molecules and mechanisms to reveal the fundamental chemistry.Using a fresh, accessible writing style as well as examples from everyday life, the authors explain the basics of organic chemistry carefully and thoroughly. A special focus on mechanism, orbitals, and stereochemistry helps students gain a solid comprehension of important factors common to all reactions. The book's innovative design enhances clarity and instruction with boxes that separate summary information and other material from the main text; a variety of colors that draw attention to items such as atoms, molecules, and orbitals; and figures that are drawn in red with significant parts emphasized in black. Early chapters feature carbonyl group reactions, and later chapters systematically develop the chemistry through discussions of spectroscopy, stereochemistry, and chemical reactions.Each chapter opens with a Connections box, divided into three columns:- Building on: Details material from previous chapters that relate to the current chapter- Arriving at: Provides a guide to the content of the chapter- Looking forward to: Previews later chapters, which develop and expand the current material

    But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    It combines the latest findings from the field of neuroscience with expert text and state-of-the-art illustrations and imaging techniques to provide an incomparable insight into every facet of the brain. Layer by layer, it reveals the fascinating details of this remarkable structure, covering all the key anatomy and delving into the inner workings of the mind, unlocking its many mysteries, and helping you to understand what's going on in those millions of little gray and white cells.Tricky concepts are illustrated and explained with clarity and precision, as The Human Brain Book looks at how the brain sends messages to the rest of the body, how we think and feel, how we perform unconscious actions (for example breathing), explores the nature of genius, asks why we behave the way we do, explains how we see and hear things, and how and why we dream. Physical and psychological disorders affecting the brain and nervous system are clearly illustrated and summarized in easy-to-understand terms.The unique DVD brings the subject to life with interactive elements. These include a clickable model of the brain's structure that allows the user to zoom in and discover deeper layers of detail, while complex processes, such as the journey of a nerve impulse, are broken down and simplified through intuitive animations.

    In other words, by all of us."--Dr. Bernie Siegel, author of Love, Medicine and MiraclesRule One for the neurologist in residence: "You ain't never the same when the air hits your brain." In this fascinating book, Dr. Frank Vertosick brings that fact to life through intimate portraits of patients and unsparing yet gripping descriptions of brain surgery.With insight, humor, and poignancy, Dr. Vertosick chronicles his remarkable evolution from naive young intern to world-class neurosurgeon, where he faced, among other challenges, a six week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia, and a minister with a .22 caliber bullet lodged in his skull. In candid detail, WHEN THE AIR HITS YOUR BRAIN illuminates both the mysteries of the mind and the realities of the operating room."Riveting."--Publishers Weekly