The first volume in this annual series of the best writing by Americans, meticulously selected by bestselling author James Gleick, one of the foremost chronicles of scientific social history, debuts with a stellar collection of writers and thinkers.  Many of these cutting-edge essays offer glimpses of new realms of discovery and thought, exploring territory that is unfamiliar to most of us, or finding the unexpected in the midst of the familiar.  Nobel Laureate physicist Steven Weinberg challenges the idea of whether the universe has a designer; Pulitzer Prize winner Natalie Angier reassesses caveman (and-woman) couture; bestselling author and Darwinian theorist Stephen Jay Gould makes a claim for the man whose ideas Darwin discredited; Timothy Ferris proposes a realistic alternative to wrap-speed interseller travel; neurologist and bestselling author Oliver Sacks reminisces about his first loves-chemistry and math.  This diverse, stimulating and accessible collection is required reading for anyone who wants to travel to the frontier of knowledge.

    Gregory Stock, an expert on the implications of recent advances in reproductive biology, has glimpsed the inevitable future of biomedical engineering. Within decades, Stock asserts, technological advances will bring meaningful changes to our offspring; this scientific revolution promises to fundamentally alter the human species. With recent findings presented in a new afterword, Stock's provocative assessment cuts through the debate to envision an age of radical biotechnological advancement and unprecedented human choice.

    Sherwin Nuland, “a gifted and deeply intelligent writer” (San Francisco Chronicle), combines knowledge, compassion, and elegance of expression to shed light on the workings of our bodies from the perspective of a surgeon. Dr. Nuland recounts age-old legends about the functions and "personalities" of the body's organs and, in riveting vignettes of the surgery he has performed, he describes the connections between myth and reality. A brilliant blend of science and folklore, The Mysteries Within reveals the enigmas not only of the body but also of the human imagination.

    Following in the fashion of Stephen Jay Gould and Peter Medawar, one of the world's leading scientists examines how "pure science" is in fact shaped and guided by social and political needs and assumptions.

    Each chapter will review key terms, test for understanding basic concepts, and pose research-based problems. The Problems Book has been designed to correspond with the first twenty chapters of Molecular Biology of the Cell, Fifth Edition.Includes the solutions to the end-of-chapter problems in the textbook Molecular Biology of the Cell, Fifth Edition. Contains over 2,000 problems and their solutions. All of the solutions to the problems in The Problems Book are on the CD-ROM that is packaged with every copy of the book. The problems are organized into the following categories: Terms to Learn, Definitions, True/False, Thought Problems, Calculations, and Data Handling.The Problems Book will be useful for homework assignments and as a basis for class discussion. It could even provide inspiration for exam questions.

    The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

    This text has invited more than 4 million students into the study of this dynamic and essential discipline.The authors have restructured each chapter around a conceptual framework of five or six big ideas. An Overview draws students in and sets the stage for the rest of the chapter, each numbered Concept Head announces the beginning of a new concept, and Concept Check questions at the end of each chapter encourage students to assess their mastery of a given concept. New Inquiry Figures focus students on the experimental process, and new Research Method Figures illustrate important techniques in biology. Each chapter ends with a Scientific Inquiry Question that asks students to apply scientific investigation skills to the content of the chapter.

    Have you ever asked yourself:Are spliced genes the same as mended Levis?Watson and Crick? Aren't they a team of British detectives?Plant sex? Can they do that?Is Genetic Mutation the name of one of those heavy metal bands?Asparagine? Which of the four food groups is that in?Then you need The Cartoon Guide to Genetics to explain the important concepts of classical and modern genetics—it's not only educational, it's funny too!

    An x-ray microscope would do the trick, or since we're dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.

     'A deeply fascinating and rousing book' Mail on Sunday. 'What makes this book a delightful, if unsettling read, is not just O'Mahony's scholarly and witty prose, but also his brutal honesty' The Times. Seamus O'Mahony writes about the illusion of progress, the notion that more and more diseases can be 'conquered' ad infinitum. He punctures the idiocy of consumerism, the idea that healthcare can be endlessly adapted to the wishes of individuals. He excoriates the claims of Big Science, the spending of vast sums on research follies like the Human Genome Project. And he highlights one of the most dangerous errors of industrialized medicine: an over-reliance on metrics, and a neglect of things that can't easily be measured, like compassion.

    Only a small fraction of those affected have been properly diagnosed, leaving many others to suffer in silence or pursue ill-advised conventional treatment methods that fail to address the cause of this painful condition. Tara Grant, a twenty-year sufferer of HS, has become an underground legend to her Internet community of HS victims by presenting a methodical, self-tested action plan to heal naturally. The centerpiece of her holistic approach rests on the understanding that HS is an autoimmune disorder caused by leaky gut syndrome. With a few simple dietary changes that eliminate certain “trigger” foods, you can heal your gut, restore your skin, reclaim your health, and rid yourself of HS symptoms forever. That’s it—no antibiotics, no experimental surgeries, and no more pain, suffering, or confusion.Q&A with Tara1. What was it about the subject you chose to write about in your book that made you feel so passionate about spreading the word and getting your book published? My motivation for writing this book was the overwhelming response I received from people on the Internet when I originally posted about it in March of 2012. It turns out it’s a pretty common condition, but many people (and doctors) don’t know what it is. It’s pretty standard to visit various doctors, and be told that you have “acne,” or to be subjected to butchering surgeries. There is no treatment for HS, according to the doctors. People with it suffer immensely—in fact, HS is acknowledged to be one of most painful conditions in the world. I’ve even received letters from doctors and nurses who suffer from HS, thanking me for telling them what it is that they have—and for offering them hope. The primary motivating factor for writing this book, however, was an email I received from a 12-year old girl, who said she was going to kill herself because of the pain she was in. I immediately wrote her back, but I never heard back from her. I am desperate to know that she’s okay. I don’t want anyone else to go through what I did as a teenager—I myself thought about suicide on more than one occasion. I’ve had many letters from people who say they want to kill themselves since.2. HS is hard to diagnose, and many doctors aren’t even aware of its existence. How did you get a diagnosis? I’ve had HS since I was thirteen years old, but wasn’t diagnosed until I was in my mid-30s. Up until then, I saw over forty doctors from four different countries - none of whom could tell me what was wrong with me. I eventually found the name “Hidradenitis suppurativa” in a book about PCOS (also known as polycystic ovarian syndrome, which I also had) and could finally put a name to the horrible condition I had suffered from for so long. I took that information to a dermatologist. That’s when I finally got a diagnosis—over twenty years later. At that time, I had already changed to a Primal diet and my HS was drastically better, so I declined the antibiotics and Accutane the doctor prescribed. I also refused to believe what she said: “You have to live with this for the rest of your life.” I knew, as a longtime sufferer of HS, that the doctors I had seen had no clue what they were talking about. My journey was extremely frustrating, and I went through it completely alone. Over the years, I was told I had “adult acne,” and also told that they didn’t know what was wrong with me. I was also told that I was overreacting, not keeping clean enough, and told to lose weight. Not a single doctor showed any compassion, or was willing to look into the matter further. I eventually stopped going to the doctors, and didn’t return until I had already made changes and knew I was on the right track. I knew that if I wanted answers, I had to do the research and experimentation myself. I wasn't interested in how I reacted to different drug, I was interested in healing myself naturally.  I knew that I was on the right track with diet, so I started investigating Robb Wolf’s Autoimmune Paleo Protocol, and made specific tweaks for skin conditions. Results I had seen from others (Dr. Terry Wahls, for example) who had healed themselves from crippling autoimmune conditions were the only motivation I needed. When I started treating HS like an autoimmune condition, it went into remission. There are literally thousands of cases of this happening with different autoimmune conditions all over the world. I was also able to induce flare-ups with specific experimentation. This completely checks with autoimmunity. There isn’t a cure—you will always have the predisposition for autoimmunity—but you CAN go into remission. 3. Do you have any relatives or close friends that became diagnosed after you?  There is no one else in my family with this condition. There is a mistaken belief that HS is hereditary. It is not. However, some families have more than one member affected by it. The reason for this is that HS is autoimmune. In order to get an autoimmune condition, you need to have the gene for autoimmunity. The fact that the autoimmune gene manifests as HS in more than one family member is complete coincidence. If you’re suffering from HS, you more than likely have other autoimmune conditions - and so does your family. Family trees littered with Crohn’s, rheumatoid arthritis, multiple sclerosis, restless legs syndrome, diabetes, Lupus, endometriosis, eczema, psoriasis, HS, and more—all of which are autoimmune—are very common. If you have HS, you have the autoimmune gene, which you did inherit. If your gut becomes leaky, then you will eventually develop an autoimmune condition.4. Do you have advice for anyone seeking medical help for this condition? Read my book first. The Western medical community is still under the mistaken belief that HS is caused by bacteria, hence the prescriptions for antibiotics. They will not be able to help you, and will suggest butchering surgeries and heavy hitting drugs, which often make matters worse. You can’t “cut HS out,” like you do with a cancerous tumor. When you remove an organ or tissue that is being ravaged by an autoimmune response, you open up all your other organs and tissues to attack. That’s why there’s over an 80% chance of reoccurrence of HS after surgery, and people will often start flaring-up in areas that had been clear before. Sometimes, they even develop brand new autoimmune conditions. Luckily, you actually hold the key to healing in your hands. You can heal yourself. If you can avoid infection, then you don’t need doctors—or drugs— to help you go into remission.5. What is the one thing you would stress most to anyone unable to get a copy of your book at this time? Many people with HS are on disability and don’t have a lot of disposable income, or they have been taken advantage of in the past. If this is you, go to your local library and ask them to carry the book. Then, you can borrow it for free. How much does a 1-oz jar of EmuAid cost? Turmeric capsules? Surgery? Doctor visits and prescriptions? We’ve all fallen for so much. I bet if you sat down and tallied up how much you’ve spent on Band-Aids alone for your HS over the years, $26 would be a drop in the bucket. The great thing about this book is that if you are not satisfied, you can request your money back. If you get this 300-page manual and find that there is nothing in it that is of any help, you can ask for a refund from the publisher. Try asking for a refund for EmuAid when it doesn’t work. That being said, I would challenge anyone with HS to read this book and find nothing in it that’s helpful.6. Your book is a very important first step in making the public aware of this illness. Besides the book, how do you plan to raise awareness of HS?My goal is to get on the Dr. Oz show. I figure that will give us the biggest bang for the buck. Many people have HS, but are unaware of what it’s called. They’re too embarrassed to go to the doctor about it. I would encourage all of you to write to the Dr. Oz show and ask them to feature me, and ask your local library to carry the book. The only way we’re going to raise awareness is to GO BIG.

    The foods we enjoy, the people we love, the emotions we feel, and the beliefs we hold can all be traced back to our DNA, germs, and environment. This witty, colloquial book is popular science at its best, describing in everyday language how genetics, epigenetics, microbiology, and psychology work together to influence our personality and actions. Mixing cutting-edge research and relatable humor, Pleased to Meet Me is filled with fascinating insights that shine a light on who we really are--and how we might become our best selves.

    What makes you so different to your siblings? Why do you vote a certain way, remain faithful for twenty years, believe in God, love salads, be heterosexual, get cancer or depression, dislike sport or never put on weight? Using fascinating case studies of identical twins, Tim Spector draws gems from his exhaustive research project that has spanned twenty years to show how even real-life 'clones' with the same upbringing turn out in reality to be very different. Based on cutting-edge discoveries that are pushing the frontiers of our knowledge of genetics, he show us that - contrary to recent scientific teaching - nothing is completely hard-wired or pre-ordained. Challenging, enlightening and entertaining, Tim Spector explains theories such as why the Dutch have become the tallest nation in the world, why autism is more heritable than breast cancer and what could cause a fit and healthy man to have a heart attack within weeks of his overweight, heavy drinking, heavy smoking identical twin. Conceptually, he argues, we are not just skin and bones controlled by our genes but minds and bodies made of plastic. This plastic is dynamic - slowly changing shape and evolving, driven by many processes we still cannot comprehend. Many of the subtle differences between us appear now to be due to chance or fate, but as science rapidly evolves and explains current mysteries we will be able to become more active participants in this human moulding process. Then we can really begin to understand why we are who we are and what makes each of us so unique and quintessentially human.

    This was life—but whose?  In his most mind-bending book yet, Ball makes that disconcerting question the focus of a tour through what scientists can now do in cell biology and tissue culture. He shows how these technologies could lead to tailor-made replacement organs for when ours fail, to new medical advances for repairing damage and assisting conception, and to new ways of “growing a human.” For example, it might prove possible to turn skin cells not into neurons but into eggs and sperm, or even to turn oneself into the constituent cells of embryos. Such methods would also create new options for gene editing, with all the attendant moral dilemmas. Ball argues that such advances can therefore never be about “just the science,” because they come already surrounded by a host of social narratives, preconceptions, and prejudices. But beyond even that, these developments raise questions about identity and self, birth and death, and force us to ask how mutable the human body really is—and what forms it might take in years to come.

    The top-selling CS review book written by students and IMGs who recently passed 100+ high-yield minicases by chief complaint 30 complete cases simulate the exam experience Contains new Patient Encounters, including telephone interviews Perfect for group or solo study YOUR COMPLETE CS SURVIVAL GUIDE FROM THE AUTHORS OF FIRST AID FOR THE USMLE STEP 1 INSIDER ADVICE FOR STEP 2 CS SUCCESS New miniguide shows US students and IMGs how best to use this book Revised by test veterans to reflect the 2005--2006 exam experience Each complete case features standardized patient checklists and a recommended clinical approach Minicases represent the major chief complaints and diagnoses seen on the Step 2 CS Proven strategies for the patient encounter and patient note High-yield, must-know facts on patient diagnosis and workup.