As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    So she made a choice that shocked friends, family, and even herself: with only fourteen hours' notice, she adopted a preschooler.Instant Mom is Vardalos's poignant and hilarious true chronicle of trying to become a mother while fielding nosy "frenemies" and Hollywood reporters asking, "Any baby news?" With genuine and frank honesty, she describes how she and husband Ian Gomez eventually found their daughter . . . and what happened next. Vardalos explores innovative ways to conquer the challenges all new moms face, from sleep to personal grooming, and learns that whether via biology, relationship, or adoption—motherhood comes in many forms.The book includes laugh-out-loud behind the scenes Hollywood anecdotes, plus an Appendix on how to adopt worldwide. Vardalos will donate proceeds from the book sales to charities.Vardalos candidly shares her instant motherhood story that is relatable for all new moms (and dads!)

    Anyone who saw an episode of Saturday Night Live between 1999 and 2006 knows Rachel Dratch. She was hilarious! So what happened to her? After a misbegotten part as Jenna on the pilot of 30 Rock, Dratch was only getting offered roles as "Lesbians. Secretaries. Sometimes secretaries who are lesbians."Her career at a low point, Dratch suddenly had time for yoga, dog- sitting, learning Spanish-and dating. After all, what did a forty- something single woman living in New York have to lose? Resigned to childlessness but still hoping for romance, Dratch was out for drinks with a friend when she met John.Handsome and funny, after only six months of dating long-distance, he became the inadvertent father of her wholly unplanned, undreamed-of child, and moved to New York to be a dad. With riotous humor, Dratch recounts breaking the news to her bewildered parents, the awe of her single friends, and the awkwardness of a baby-care class where the instructor kept tossing out the f-word.Filled with great behind-the-scenes anecdotes from Dratch's time on SNL, Girl Walks into a Bar... is a refreshing version of the "happily ever after" story that proves female comics-like bestsellers Tina Fey and Chelsea Handler-are truly having their moment.

    Whether it is with the kind of tweets that led Rolling Stone to name her one of the Funniest People on Twitter, or with pictures of her hilariously adorable family (human and animal), or with something much more serious, like creating the hashtag #NotOkay, where millions of women came together to share their stories of sexual assault, Kelly has a unique, razor-sharp perspective on modern life. As a screen writer, professional sh*t disturber, wife and mother of three, Kelly is about everything but the status quo.Perfect for anyone who ever wished David Sedaris and Mindy Kaling would just finally write a book together already, When You Find Out the World Is Against You is filled with the biting, wise, and laugh-out-loud insights that have won Kelly legions of fans. Whether she’s detailing her obsession with going to camp as an eleven-year-old so she can become a “kissing bandit,” exploring the bittersweet boredom that so often accompanies parenthood, calling out the insanity of a posse of Internet poodle vigilantes, writing bracingly about the anxiety that has plagued her for as long as she can remember or taking us to ride shotgun as she stalks her husband on an accidental date with another man, When You Find Out the World Is Against You is Kelly at her most honest and disarmingly funny best. Her comedic skill, down-to-earth voice and bull’s-eye observations on the absurdity of modern life mean there is nothing quite like seeing the world through Kelly’s eyes.

    Though millions of Little House on the Prairie viewers hated Nellie Oleson and her evil antics, Arngrim grew to love her character—and the freedom and confidence Nellie inspired in her.In Confessions of a Prairie Bitch, Arngrim describes growing up in Hollywood with her eccentric parents: Thor Arngrim, a talent manager to Liberace and others, whose appetite for publicity was insatiable, and legendary voice actress Norma MacMillan, who played both Gumby and Casper the Friendly Ghost. She recalls her most cherished and often wickedly funny moments behind the scenes of Little House: Michael Landon's "unsaintly" habit of not wearing underwear; how she and Melissa Gilbert (who played her TV nemesis, Laura Ingalls) became best friends and accidentally got drunk on rum cakes at 7-Eleven; and the only time she and Katherine MacGregor (who played Nellie's mom)  appeared in public in costume, provoking a posse of elementary schoolgirls to attack them. Arngrim relays all this and more with biting wit, but she also bravely recounts her life's challenges: her struggle to survive a history of traumatic abuse, depression, and paralyzing shyness; the "secret" her father kept from her for twenty years; and the devastating loss of her "Little House husband" and best friend, Steve Tracy, to AIDS, which inspired her second career in social and political activism. Arngrim describes how Nellie Oleson taught her to be bold, daring, and determined, and how she is eternally grateful to have had the biggest little bitch on the prairie to show her the way.

    Louis to his own television show From a young age, Andy Cohen knew one thing: He loved television. Not in the way that most kids do, but in an irrepressible, all-consuming, I-want-to-climb-inside-the-tube kind of way. And climb inside he did. Now presiding over Bravo's reality TV empire, he started out as an overly talkative pop culture obsessive, devoted to "Charlie's Angels" and "All My Children "and to his mother, who received daily letters from Andy at summer camp, usually reminding her to tape the soaps. In retrospect, it's hard to believe that everyone didn't know that Andy was gay; still, he remained in the closet until college. Finally out, he embarked on making a career out of his passion for television.The journey begins with Andy interviewing his all-time idol Susan Lucci for his college newspaper and ends with him in a job where he has a hand in creating today's celebrity icons. In the witty, no-holds-barred style of his show "Watch What Happens Live," Andy tells tales of absurd mishaps during his ten years at CBS News, hilarious encounters with the heroes and heroines of his youth, and the real stories behind "The Real Housewives." Dishy, funny, and full of heart, "Most Talkative" provides a one-of-a-kind glimpse into the world of television, from a fan who grew up watching the screen and is now inside it, both making shows and hosting his own.

    Now he’s opening up for the first time and sharing his behind-the-scenes stories in a warmly endearing, sharply observed, and frankly funny look at life in Hollywood. In 1986, Jon Cryer won over America as Molly Ringwald’s loyal and lovable best friend, Duckie, in the cult classic Pretty in Pink in a role that set the tone for his three-decade-long career in Hollywood. He went on to establish himself as one of the most talented comedic actors in the business, ultimately culminating in his current turn as Alan Harper on the massively popular sitcom Two and a Half Men. With the instincts of a natural storyteller, Cryer charts his extraordinary journey in show business, illuminating his many triumphs and some missteps along the way. Filled with exclusive behind-the-scenes anecdotes, Cryer offers his own endearing perspective on Hollywood, the business at large, and the art of acting. Cryer has worked with some of the biggest and most provocative names in the business, and here, for the first time, he details his experiences with Charlie Sheen, John Hughes, Robert Altman, Molly Ringwald, Demi Moore, Judd Nelson, and Christopher Reeve, among many others. He shares the intimate details of his friendships and relationships, pays tribute to his mentors, and explores the peculiar combination of heart, talent, and wisdom it takes to survive not just the bad times in a notoriously fickle industry but even the good times. In this revealing, humorous, and introspective memoir, Cryer offers readers a front-row seat as he reminisces about his life and experiences in showbiz over the past thirty years.

     Danny Rubin, screenwriter of Groundhog Day. This collection of the most epic, hilarious, and strange Bill Murray stories, many of which have never before been reported, spotlights the star's extraordinary ability to infuse the everyday with surprise, absurdity, and wonder. No one will ever believe you. New York Times bestselling author Gavin Edwards, like the rest of us, has always been fascinated with Bill Murray in particular the beloved actor's adventures off-screen, which rival his filmography for sheer entertainment value. Edwards traveled to the places where Murray has lived, worked, and partied, in search of the most outrageous and hilarious Bill Murray stories from the past four decades, many of which have never before been reported. Bill once paid a child five dollars to ride his bike into a swimming pool. The star convinced Harvard's JV women's basketball team to play with him in a private game of hoops. Many of these surreal encounters ended with Bill whispering, No one will ever believe you into a stranger's ear. But The Tao of Bill Murray is more than just a collection of wacky anecdotes. This volume puts the actor's public clowning into a larger context, as Edwards distills Murray's unique way of being into a set of guiding principles. A sideways mix of comedy and philosophy, full of photo bombs, late-night party crashes, and movie-set antics, this is the perfect book for anyone who calls themselves a Bill Murray fan which is to say, everyone. Praise for The Tao of Bill Murray When confronted by life's challenges and opportunities, we should all be asking ourselves, What would Bill Murray do? This book actually has the answers. Jay Duplass, writer, director, actor, fan of Bill Murray [Gavin Edwards] captures Murray's enigmatic, comic genius. The Washington Post Rib-tickling. Newsday If you are among the multitudes who have a Bill Murray story (viz: I was in the airport bar, and who sat down next to me but Bill Murray? ), The Tao of Bill Murray will speak to you. Elle Murray is an endless delight, and his knack for bons mots and non sequiturs will keep readers laughing before revealing an unexpectedly poignant vision for happiness. . . . A fun and revealing look behind the charm and mythos of Bill Murray that will only strengthen his legend. Kirkus Reviews This book is bursting with anecdotes that underline Murray's unconventional and fun-loving life. . . . Murray's fans are sure to savor [it] and walk away with a deeper appreciation of the actor and his work. Publishers Weekly(starred review) I just can't fathom how anyone could not like the man. He lives as much as possible by his own rules; this is a guy who doesn't buy round-trip airline tickets because he prefers to make decisions on the fly. That old question of the three people you'd most like to have dinner with? I'd pick Bill Murray and leave the other two chairs empty just to see who he pulls over to join us. . . . You will love The Tao of Bill Murray. Period. GeekDad A hilarious read occasionally heartwarming, sometimes head-scratching. . . . Sure to please Murray fans. Library Journal"

    From growing up in a family of firefighters on Staten Island to commuting three hours a day to high school and “seeing the sights” (like watching a Russian woman throw a stroller off the back of a ferry), to attending Harvard while Facebook was created, Jost shares how he has navigated the world like a slightly smarter Forrest Gump.You’ll also discover things about Jost that will surprise and confuse you, like how Jimmy Buffett saved his life, how Czech teenagers attacked him with potato salad, how an insect laid eggs inside his legs, and how he competed in a twenty-five-man match at WrestleMania (and almost won). You’ll go behind the scenes at SNL and Weekend Update (where he’s written some of the most memorable sketches and jokes of the past fifteen years). And you’ll experience the life of a touring stand-up comedian—from performing in rural college cafeterias at noon to opening for Dave Chappelle at Radio City Music Hall.For every accomplishment (hosting the Emmys), there is a setback (hosting the Emmys). And for every absurd moment (watching paramedics give CPR to a raccoon), there is an honest, emotional one (recounting his mother’s experience on the scene of the Twin Towers’ collapse on 9/11). Told with a healthy dose of self-deprecation, A Very Punchable Face reveals the brilliant mind behind some of the dumbest sketches on television, and lays bare the heart and humor of a hardworking guy—with a face you can’t help but want to punch.

    This volume of his diaries reveals how Python emerged and triumphed, how he, John Cleese, Graham Chapman, the two Terrys---Jones and Gilliam---and Eric Idle came together and changed the face of British comedy.But this is but only part of Palin's story. Here is his growing family, his home in a north London Victorian terrace, which grows as he buys the house next door and then a second at the bottom of the garden; here, too, is his solo effort---as an actor, in Three Men in a Boat, his writing endeavours (often in partnership with Terry Jones) that produces Ripping Yarns and even a pantomime.Meanwhile Monty Python refuses to go away: the hugely successful movies that follow the TV (his account of the making of both The Holy Grail and the Life of Brian movies are page-turners), the at times extraordinary goings-on of the many powerful personalities who coalesced to form the Python team, the fight to prevent an American TV network from bleeping out the best jokes on U.S. transmission, and much more---all this makes for funny and riveting reading.The birth and childhood of his three children, his father's growing disability, learning to cope as a young man with celebrity, his friendship with George Harrison, and all the trials of a peripatetic life are also essential ingredients of these diaries. A perceptive and funny chronicle, the diaries are a rich portrait of a fascinating period.

     Rachel Bloom has felt abnormal and out of place her whole life. In this exploration of what she thinks makes her "different," she's come to realize that a lot of people also feel this way; even people who she otherwise thought were "normal."In a collection of laugh-out-loud funny essays, all told in the unique voice (sometimes singing voice) that made her a star; Rachel writes about everything from her love of Disney, OCD and depression, weirdness, and female friendships to the story of how she didn't poop in the toilet until she was four years old; Rachel's pieces are hilarious, smart, and infinitely relatable (except for the pooping thing).

    His profile and reach is lightyears beyond where it was for Chins.Hail to the Chin will be bursting with pictures and the signature humor that Bruce brought to If Chins Could Kill and will be devoured by his legions of fans across the country.

    He is the author of an endless stream of beautiful, insane jokes on Twitter. He is sober. He is sometimes brave. He speaks French. He loves women with abundant pubic hair and saggy naturals. He has bungee jumped off of the Manhattan Bridge. He enjoys antagonizing political figures. He listens to metal while he works out. He likes to fart. He broke into an abandoned mental hospital with his mother. He played Sir Lancelot in Camelot. He has battled depression. He is funny as s***. He cleans up well. He is friends with Margaret Atwood. He is lucky to be alive.   Read these hilarious and heartbreaking true stories and learn how Rob came to be the man he is today.

    What they don’t know is her trailblazing career was a happy accident. In this funny and intimate memoir, Penny takes us from the stage of The Jackie Gleason Show in 1955 to Hollywood’s star-studded sets, offering up some hilarious detours along the way.My Mother Was Nuts is an intimate backstage pass to Penny’s personal life, her breakout role on The Odd Couple, her exploits with Cindy Williams and John Belushi, and her travels across Europe with Art Garfunkel on the back of a motorcycle. We see Penny get married. And divorced. And married again (the second time to Rob Reiner). We meet a young Carrie Fisher, whose close friendship with Penny has spanned decades. And we see Penny at work with Tom Hanks, Mark Wahlberg, Whoopi Goldberg, Robert De Niro, and Whitney Houston.Throughout it all, from her childhood spent tap dancing in the Bronx, to her rise as the star of Laverne & Shirley, Penny lived by simple rules: “try hard, help your friends, don’t get too crazy, and have fun.” With humor and heart, My Mother Was Nuts reveals there’s no one else quite like Penny Marshall.

    At seventeen, in the dark of night, he left the religious settlement, but it was only nine years later that he finally left the church for good. His favorite Bible verse is from Psalm 34: "Delight yourself in the Lord, and He will give you the desires of your heart." In this new memoir, he tells what it was like growing up Old World Amish and what it felt like leaving it for a strange new world. Far more than picturesque; Growing Up Amish conveys one man's heartfelt experience.