government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work.At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.From the Hardcover edition.

    Assuming the reader has little prior knowledge of the subject its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented two-colour illustrations. In addition to a number of informative changes to the text throughout the book, the final four chapters have been significantly updated and extended to reflect the striking advances made in recent years in the applications of gene cloning and DNA analysis in biotechnology: Extended chapter on agriculture including new material on glyphosate resistant plantsNew section on the uses of gene cloning and PCR in archaeologyCoverage of ethical concerns relating to pharming, gene therapy and GM crops Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves. View the Gene Cloning and DNA Analysis webpage at www.blackwellpublishing.com/genecloning

    Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality. In Regenesis, Church and Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took. Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

    The new edition offers a wealth of new information, especially in the areas of taxonomy, genomics, plant hormones, and Arabidopsis research.

    An x-ray microscope would do the trick, or since we're dreaming, perhaps an Asimov-style nanosubmarine (unfortunately, neither is currently feasible). Think of the wonders we could witness firsthand: antibodies atta- ing a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA. Many of the questions puzzling the current cadre of sci- tists would be answered at a glance. But the nanoscale world of molecules is separated from our everyday world of experience by a daunting million-fold difference in size, so the world of molecules is completely invisible. I created the illustrations in this book to help bridge this gulf and allow us to see the molecular structure of cells, if not directly, then in an artistic rendition. I have included two types of illustrations with this goal in mind: watercolor paintings which magnify a small portion of a living cell by one million times, showing the arrangement of molecules inside, and comput- generated pictures, which show the atomic details of individual molecules. In this second edition of The Machinery of Life, these illustrations are presented in full color, and they incorporate many of the exciting scientific advances of the 15 years since the first edition.

    In addition to seven essays on craft, this collection brings together her penetrating and instructive commentaries on a wide variety of individual writers, including Jane Austen, E. M. Forster, Willa Cather, Anton Chekhov, William Faulkner, and Virginia Woolf.

    W. R. Dedekind. The first presents Dedekind's theory of the irrational number-the Dedekind cut idea-perhaps the most famous of several such theories created in the 19th century to give a precise meaning to irrational numbers, which had been used on an intuitive basis since Greek times. This paper provided a purely arithmetic and perfectly rigorous foundation for the irrational numbers and thereby a rigorous meaning of continuity in analysis.The second essay is an attempt to give a logical basis for transfinite numbers and properties of the natural numbers. It examines the notion of natural numbers, the distinction between finite and transfinite (infinite) whole numbers, and the logical validity of the type of proof called mathematical or complete induction.The contents of these essays belong to the foundations of mathematics and will be welcomed by those who are prepared to look into the somewhat subtle meanings of the elements of our number system. As a major work of an important mathematician, the book deserves a place in the personal library of every practicing mathematician and every teacher and historian of mathematics. Authorized translations by "Vooster " V. Beman.

    Author's biography and A Young Girl's Diary in the trial version. Features Navigate from Table of Contents or search for words or phrases Make bookmarks, notes, highlights Searchable and interlinked. Access the e-book anytime, anywhere - at home, on the train, in the subway. Automatic synchronization between the handheld and the desktop PC. You could read half of the book on the handheld, then finish reading on the desktop. Table of Contents Dream Psychology Translated by M. D. EderThe Interpretation of Dreams (3rd edition) Translated by A. A. BrillThree Contributions to the Theory of Sex Translated by A. A. BrillA Young Girl's Diary Translated by Eden and Cedar Paul Appendix:Sigmund Freud BiographySetup and NavigationAbout

    So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of 'systems chemistry' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged.

    But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyondthe selfish gene to consider life on a much wider variety of levels. Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noblesets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in anintricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of thenature of life. Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.

    Morell transports us into the world of these compelling personalities, demonstrating how a small clan of highly talented and fiercely competitive people came to dominate an entire field of science and to contribute immeasurably to our understanding of the origins of humanity.

    He argues that humans have evolved a universal moral instinct, unconsciously propelling us to deliver judgments of right and wrong independent of gender, education, and religion. Experience tunes up our moral actions, guiding what we do as opposed to how we deliver our moral verdicts.For hundreds of years, scholars have argued that moral judgments arise from rational and voluntary deliberations about what ought to be. The common belief today is that we reach moral decisions by consciously reasoning from principled explanations of what society determines is right or wrong. This perspective has generated the further belief that our moral psychology is founded entirely on experience and education, developing slowly and subject to considerable variation across cultures. In his groundbreaking book, Hauser shows that this dominant view is illusory.Combining his own cutting-edge research with findings in cognitive psychology, linguistics, neuroscience, evolutionary biology, economics, and anthropology, he examines the implications of his theory for issues of bioethics, religion, law, and our everyday lives.

    Finding this natural basis of life has proved elusive, but in the eloquent and creative Into the Cool, Eric D. Schneider and Dorion Sagan look for answers in a surprising place: the second law of thermodynamics. This second law refers to energy's inevitable tendency to change from being concentrated in one place to becoming spread out over time. In this scientific tour de force, Schneider and Sagan show how the second law is behind evolution, ecology,economics, and even life's origin.Working from the precept that "nature abhors a gradient," Into the Cool details how complex systems emerge, enlarge, and reproduce in a world tending toward disorder. From hurricanes here to life on other worlds, from human evolution to the systems humans have created, this pervasive pull toward equilibrium governs life at its molecular base and at its peak in the elaborate structures of living complex systems. Schneider and Sagan organize their argument in a highly accessible manner, moving from descriptions of the basic physics behind energy flow to the organization of complex systems to the role of energy in life to the final section, which applies their concept of energy flow to politics, economics, and even human health.A book that needs to be grappled with by all those who wonder at the organizing principles of existence, Into the Cool will appeal to both humanists and scientists. If Charles Darwin shook the world by showing the common ancestry of all life, so Into the Cool has a similar power to disturb—and delight—by showing the common roots in energy flow of all complex, organized, and naturally functioning systems.“Whether one is considering the difference between heat and cold or between inflated prices and market values, Schneider and Sagan argue, we can apply insights from thermodynamics and entropy to understand how systems tend toward equilibrium. The result is an impressive work that ranges across disciplinary boundaries and draws from disparate literatures without blinking.”—Publishers Weekly

    Haraway's discussions of how scientists have perceived the sexual nature of female primates opens a new chapter in feminist theory, raising unsettling questions about models of the family and of heterosexuality in primate research.

    . . Genius of the People is an absorbing look at the incomparable personalities who brought us our Constitution."- Michael BeschlossGenius of the People is a timely account of how America's national government came to be born during the Constitutional Convention of 1787. Charles L. Mee, Jr., vividly describes the personalities, issues, conflicts, and implications of an epoch-making meeting of brilliant and not-so-brilliant political leaders, who had different and often opposed agendas and whose disagreements and compromises, alliances and feuds, vision and shortsightedness create the main storylines of the years to come.Mee sets the events and issues of the Convention against a background of a small but diverse society that had just won its independence and was already wracked with dissension and factionalism as to how it should be governed. The axial line of Mee's account is the ongoing struggle between what he calls the party of liberty and the party of order. On one side was the loose coalition of states' rights and local government people, such as the patrician democrat George Mason, the tenacious Puritan shopkeeper Roger Sherman, and the prototypical Southern politician John Rutledge. Opposed to them and their followers was the coalition of nationalists led by the frail but resourceful James Madison, the arrogant Gouverneur Morris, and the brilliant, aristocratic Alexander Hamilton.These two broad positions roughly organized a myriad of different interests, ideals, and whims. Forced by their disagreements to one unpleasant compromise after another, the delegates finally found themselves compelled to resort to a set of general principles based on the American experience that people are most secure and most free when power is not gathered up in the hands of a few - not the president and his friends, or of a class of businesspeople or landed gentry, or of the military, or of a group of politicians.Without partisanship, Mee has written a history of the Convention for our own time. On virtually every page, his reporting on the proceedings undermines the view of many Americans of the Constitution as a rigidly fixed screed of political fundamentalism. At the same time, Mee invigorates and challenges the reader's faith in American democracy. He shows us our dissatisfied and contentious Founding Fathers entrusting their own class interests and power to the genius of the American people for self-government, knowing fully that only a politically informed and active public could preserve their work.