In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT.David Quammen chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.

    It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and break­ing, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the fric­tion in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.

    Morale had deteriorated, competition was more intense, and technology was changing faster than at any time in the company's history. "I knew there was nothing to be gained from arguing over the past," Iger writes. "The only thing that mattered was the future, and I believed I had a clear idea of the direction Disney needed to go." It came down to three clear ideas: 1) Create the highest quality content Disney could produce. 2) Embrace and adopt technology instead of fighting it. And 3) Think bigger--think global--and turn Disney into a stronger brand in international markets.Twelve years later, Disney is the largest, most respected media company in the world counting Pixar, Marvel, Lucasfilm and 21st Century Fox among its properties. Its value is nearly five times what it was when Iger took over, and Iger is recognized as one of the most innovative and successful CEOs of our time.Now, he's sharing the lessons he's learned while running Disney and leading its 200,000 employees--taking big risks in the face of historic disruption; learning to inspire the people who work for you; leading with fairness and communicating principles clearly. This book is about the relentless curiosity that has driven Iger for forty-five years, since the day he started as a studio supervisor at ABC. It's also about thoughtfulness and respect, and a decency-over-dollars approach that has become the bedrock of every project and partnership Iger pursues, from a deep friendship with Steve Jobs in his final years to an abiding love of the evolving Star Wars myth."Over the past fourteen years, I think I've learned so much about what real leadership is," Iger writes. "But I couldn't have articulated all of this until I lived it. You can't fake it--and that's one of the key lessons in this book."Librarian Note: This is an Advance Reader Copy issued with ISBN 9780399592096. That ISBN has been moved to the final published copy, found here

    But this book is different from all the others.Becoming Steve Jobs takes on and breaks down the existing myth and stereotypes about Steve Jobs. The conventional, one-dimensional view of Jobs is that he was half-genius, half-jerk from youth, an irascible and selfish leader who slighted friends and family alike. Becoming Steve Jobs answers the central question about the life and career of the Apple cofounder and CEO: How did a young man so reckless and arrogant that he was exiled from the company he founded become the most effective visionary business leader of our time, ultimately transforming the daily life of billions of people?Drawing on incredible and sometimes exclusive access, Schlender and Tetzeli tell a different story of a real human being who wrestled with his failings and learned to maximize his strengths over time. Their rich, compelling narrative is filled with stories never told before from the people who knew Jobs best, and who decided to open up to the authors, including his family, former inner circle executives, and top people at Apple, Pixar and Disney, most notably Tim Cook, Jony Ive, Eddy Cue, Ed Catmull, John Lasseter, Robert Iger and many others. In addition, Brent knew Jobs personally for 25 years and draws upon his many interviews with him, on and off the record, in writing the book. He and Rick humanize the man and explain, rather than simply describe, his behavior. Along the way, the book provides rich context about the technology revolution we all have lived through, and the ways in which Jobs changed our world.Schlender and Tetzeli make clear that Jobs's astounding success at Apple was far more complicated than simply picking the right products: he became more patient, he learned to trust his inner circle, and discovered the importance of growing the company incrementally rather than only shooting for dazzling game-changing products.A rich and revealing account that will change the way we view Jobs, Becoming Steve Jobs shows us how one of the most colorful and compelling figures of our times was able to combine his unchanging, relentless passion with a more mature management style to create one of the most valuable and beloved companies on the planet.

    From choreographed carpet figure skating routines to the unavoidable fact that he was Just. So. Gay., Jonathan was an easy target and endured years of judgement, ridicule and trauma—yet none of it crushed his uniquely effervescent spirit.Over the Top uncovers the pain and passion it took to end up becoming the model of self-love and acceptance that Jonathan is today. In this revelatory, raw, and rambunctious memoir, Jonathan shares never-before-told secrets and reveals sides of himself that the public has never seen. JVN fans may think they know the man behind the stiletto heels, the crop tops, and the iconic sayings, but there’s much more to him than meets the Queer Eye.You’ll laugh, you’ll cry, and you’ll come away knowing that no matter how broken or lost you may be, you’re a Kelly Clarkson song, you’re strong, and you’ve got this.

    As the mother of 5 kids -- 6 if you include her husband -- sat in the neurosurgery department in star-covered sweats too whimsical for the seriousness of the situation, all she could think was "Am I going to die?"Thankfully, Jeannie and her family were able to survive their time of crisis, and now she is sharing her deeply personal journey through this miraculous story: the challenging conversations she had with her children; how she came to terms with feeling powerless and ferociously crabby while bedridden and unable to eat for a month; and how she ultimately learned, re-learned and re re-learned to be more present in life.With sincerity and hilarity, Jeannie invites you into her heart (and brain) during this trying time, emphasizing the importance of family, faith and humor as keys to her recovery and leading a more fulfilling life.

    It was a journey that would lead him from a homoerotic Navy initiation ceremony in the jungles of Vietnam to that strangest of strange lands: San Francisco in the early 1970s. Reflecting on the profound impact those closest to him have had on his life, Maupin shares his candid search for his "logical family," the people he could call his own. "Sooner or later, we have to venture beyond our biological family to find our logical one, the one that actually makes sense for us," he writes. "We have to, if we are to live without squandering our lives." From his loving relationship with his palm-reading Grannie who insisted Maupin was the reincarnation of her artistic bachelor cousin, Curtis, to an awkward conversation about girls with President Richard Nixon in the Oval Office, Maupin tells of the extraordinary individuals and situations that shaped him into one of the most influential writers of the last century. Maupin recalls his losses and life-changing experiences with humor and unflinching honesty, and brings to life flesh-and-blood characters as endearing and unforgettable as the vivid, fraught men and women who populate his enchanting novels. What emerges is an illuminating portrait of the man who depicted the liberation and evolution of America’s queer community over the last four decades with honesty and compassion—and inspired millions to claim their own lives.

    She turned to housekeeping to make ends meet, and with a tenacious grip on her dream to provide her daughter the very best life possible, Stephanie worked days and took classes online to earn a college degree, and began to write relentlessly. Maid explores the underbelly of upper-middle class America and the reality of what it’s like to be in service to them. “I’d become a nameless ghost,” Stephanie writes about her relationship with her clients, many of whom do not know her from any other cleaner, but who she learns plenty about. As she begins to discover more about her clients’ lives-their sadness and love, too-she begins to find hope in her own path. Her writing as a journalist gives voice to the "servant" worker, and those pursuing the American Dream from below the poverty line. Maid is Stephanie’s story, but it’s not her alone..

    Or the "Phantom of Fine Hall," a figure many students had seen shuffling around the corridors of the math and physics building wearing purple sneakers and writing numerology treatises on the blackboards. The Phantom was John Nash, one of the most brilliant mathematicians of his generation, who had spiraled into schizophrenia in the 1950s. His most important work had been in game theory, which by the 1980s was underpinning a large part of economics. When the Nobel Prize committee began debating a prize for game theory, Nash's name inevitably came up—only to be dismissed, since the prize clearly could not go to a madman. But in 1994 Nash, in remission from schizophrenia, shared the Nobel Prize in economics for work done some 45 years previously.Economist and journalist Sylvia Nasar has written a biography of Nash that looks at all sides of his life. She gives an intelligent, understandable exposition of his mathematical ideas and a picture of schizophrenia that is evocative but decidedly unromantic. Her story of the machinations behind Nash's Nobel is fascinating and one of very few such accounts available in print (the CIA could learn a thing or two from the Nobel committees).

    Notes about successes and failures, joys and sorrows, things that made me marvel, and things that made me laugh out loud. How to be fair. How to have less stress. How to have fun. How to hurt people less. How to get hurt less. How to be a good man. How to have meaning in life. How to be more me. Recently, I worked up the courage to sit down with those diaries. I found stories I experienced, lessons I learned and forgot, poems, prayers, prescriptions, beliefs about what matters, some great photographs, and a whole bunch of bumper stickers. I found a reliable theme, an approach to living that gave me more satisfaction, at the time, and still: If you know how, and when, to deal with life’s challenges - how to get relative with the inevitable - you can enjoy a state of success I call “catching greenlights.” So I took a one-way ticket to the desert and wrote this book: an album, a record, a story of my life so far. This is fifty years of my sights and seens, felts and figured-outs, cools and shamefuls. Graces, truths, and beauties of brutality. Getting away withs, getting caughts, and getting wets while trying to dance between the raindrops. Hopefully, it’s medicine that tastes good, a couple of aspirin instead of the infirmary, a spaceship to Mars without needing your pilot’s license, going to church without having to be born again, and laughing through the tears. It’s a love letter. To life. It’s also a guide to catching more greenlights - and to realizing that the yellows and reds eventually turn green too. Good luck.

    Through the eyes of a curious scientist, she watched her mind deteriorate whereby she could not walk, talk, read, write, or recall any of her life. Because of her understanding of the brain, her respect for the cells in her body, and an amazing mother, Jill completely recovered. In My Stroke of Insight, she shares her recommendations for recovery and the insight she gained into the unique functions of the two halves of her brain. When she lost the skills of her left brain, her consciousness shifted away from normal reality where she felt "at one with the universe." Taylor helps others not only rebuild their brains from trauma, but helps those of us with normal brains better understand how we can consciously influence the neural circuitry underlying what we think, how we feel and how we react to life's circumstances.

    Anyone who saw an episode of Saturday Night Live between 1999 and 2006 knows Rachel Dratch. She was hilarious! So what happened to her? After a misbegotten part as Jenna on the pilot of 30 Rock, Dratch was only getting offered roles as "Lesbians. Secretaries. Sometimes secretaries who are lesbians."Her career at a low point, Dratch suddenly had time for yoga, dog- sitting, learning Spanish-and dating. After all, what did a forty- something single woman living in New York have to lose? Resigned to childlessness but still hoping for romance, Dratch was out for drinks with a friend when she met John.Handsome and funny, after only six months of dating long-distance, he became the inadvertent father of her wholly unplanned, undreamed-of child, and moved to New York to be a dad. With riotous humor, Dratch recounts breaking the news to her bewildered parents, the awe of her single friends, and the awkwardness of a baby-care class where the instructor kept tossing out the f-word.Filled with great behind-the-scenes anecdotes from Dratch's time on SNL, Girl Walks into a Bar... is a refreshing version of the "happily ever after" story that proves female comics-like bestsellers Tina Fey and Chelsea Handler-are truly having their moment.

    So begins Spinster, a revelatory and slyly erudite look at the pleasures and possibilities of remaining single. Using her own experiences as a starting point, journalist and cultural critic Kate Bolick invites us into her carefully considered, passionately lived life, weaving together the past and present to examine why­ she - along with over 100 million American women, whose ranks keep growing - remains unmarried. This unprecedented demographic shift, Bolick explains, is the logical outcome of hundreds of years of change that has neither been fully understood, nor appreciated. Spinster introduces a cast of pioneering women from the last century whose genius, tenacity, and flair for drama have emboldened Bolick to fashion her life on her own terms: columnist Neith Boyce, essayist Maeve Brennan, social visionary Charlotte Perkins Gilman, poet Edna St. Vincent Millay, and novelist Edith Wharton. By animating their unconventional ideas and choices, Bolick shows us that contemporary debates about settling down, and having it all, are timeless - the crucible upon which all thoughtful women have tried for centuries to forge a good life. Intellectually substantial and deeply personal, Spinster is both an unreservedly inquisitive memoir and a broader cultural exploration that asks us to acknowledge the opportunities within ourselves to live authentically. Bolick offers us a way back into our own lives - a chance to see those splendid years when we were young and unencumbered, or middle-aged and finally left to our own devices, for what they really are: unbounded and our own to savor.

    But through the fog of glamour and gossip, how well do we really know the world’s most famous monarch? Drawing on numerous interviews and never-before-revealed documents, acclaimed biographer Sally Bedell Smith pulls back the curtain to show in intimate detail the public and private lives of Queen Elizabeth II, who has led her country and Commonwealth through the wars and upheavals of the last sixty years with unparalleled composure, intelligence, and grace. In Elizabeth the Queen, we meet the young girl who suddenly becomes “heiress presumptive” when her uncle abdicates the throne. We meet the thirteen-year-old Lilibet as she falls in love with a young navy cadet named Philip and becomes determined to marry him, even though her parents prefer wealthier English aristocrats. We see the teenage Lilibet repairing army trucks during World War II and standing with Winston Churchill on the balcony of Buckingham Palace on V-E Day. We see the young Queen struggling to balance the demands of her job with her role as the mother of two young children. Sally Bedell Smith brings us inside the palace doors and into the Queen’s daily routines—the “red boxes” of documents she reviews each day, the weekly meetings she has had with twelve prime ministers, her physically demanding tours abroad, and the constant scrutiny of the press—as well as her personal relationships: with Prince Philip, her husband of sixty-four years and the love of her life; her children and their often-disastrous marriages; her grandchildren and friends.

    In the wake of rape allegations made against director and actor Nate Parker, Union—a forty-four-year-old actress who launched her career with roles in iconic ’90s movies—instantly became the insightful, outspoken actress that Hollywood has been desperately awaiting. With honesty and heartbreaking wisdom, she revealed her own trauma as a victim of sexual assault: "It is for you that I am speaking. This is real. We are real." In this moving collection of thought provoking essays infused with her unique wisdom and deep humor, Union uses that same fearlessness to tell astonishingly personal and true stories about power, color, gender, feminism, and fame. Union tackles a range of experiences, including bullying, beauty standards, and competition between women in Hollywood, growing up in white California suburbia and then spending summers with her black relatives in Nebraska, coping with crushes, puberty, and the divorce of her parents. Genuine and perceptive, Union bravely lays herself bare, uncovering a complex and courageous life of self-doubt and self-discovery with incredible poise and brutal honesty. Throughout, she compels us to be ethical and empathetic, and reminds us of the importance of confidence, self-awareness, and the power of sharing truth, laughter, and support.