Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    Like its predecessors, this updated Sixth Edition is organized around the periodic table of elements and provides a systematic treatment of the chemistry of all chemical elements and their compounds. It incorporates important recent developments with an emphasis on advances in the interpretation of structure, bonding, and reactivity.From the reviews of the Fifth Edition: "The first place to go when seeking general information about the chemistry of a particular element, especially when up-to-date, authoritative information is desired."--Journal of the American Chemical Society"Every student with a serious interest in inorganic chemistry should have [this book]."-- Journal of Chemical Education "A mine of information . . . an invaluable guide."-- Nature "The standard by which all other inorganic chemistry books are judged."-- Nouveau Journal de Chimie "A masterly overview of the chemistry of the elements."-- The Times of London Higher Education Supplement "A bonanza of information on important results and developments which could otherwise easily be overlooked in the general deluge of publications."-- Angewandte Chemie

    Edited by Drs. Karen Marcdante, Robert M. Kliegman, Hal B. Jenson, and Richard E. Behrman, this edition's content was specifically developed in accordance with the 2009 curriculum guidelines of the Council on Medical Student Education in Pediatrics. It also includes many new and improved clinical photographs and images for enhanced visual reference. A user-friendly full-color format and online access via Student Consult facilitate study and expedite reference.

    Molecular Cell Biology stands out from its peers in this course in that it provides a clear introduction to the techniques and experiments of scientists past and present, not just an "encyclopedia" of information.  This experimental emphasis, together with a solid pedagogical framework in the chapters, provides the clearest, most cutting-edge text available.

    The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel. For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .But all that was about to change. . . . —from The Demon Under the Microscope

    The material is presented in a brief and quick-access format which allows for topic and exam review. It provides enough detailed and specific information to address most all questions and problems that arise in the ICU. Emphasis on fundamental principles in the text should prove useful for patient care outside the ICU as well.New chapters in this edition include hyperthermia and hypothermia syndromes; infection control in the ICU; and severe airflow obstruction. Sections have been reorganized and consolidated when appropriate to reinforce concepts.Purchase The ICU Book, Third Edition and visit TheICUBook.com, which gives you free access to links from references to PubMed, updated regularly; and a directory of Websites handpicked by Dr. Marino.

    The book concisely reviews key physiological principles and includes clinical correlations throughout to emphasize connections between basic physiology and clinical medicine. Numerous illustrations, tables, and flow charts help students visualize material quickly and aid in long-term retention. End-of-chapter USMLE-style questions and a comprehensive end-of-book exam test the student's problem-solving skills, and clearly explained answers guide the student through the correct steps in reasoning. This edition features increased coverage of pathophysiology, new questions, and a new two-color design and artwork.

    Jen Gunter now delivers the definitive book on vaginal health, answering the questions you've always had but were afraid to ask--or couldn't find the right answers to. She has been called Twitter's resident gynecologist, the Internet's OB/GYN, and one of the fiercest advocates for women's health...and she's here to give you the straight talk on the topics she knows best.Does eating sugar cause yeast infections? Does pubic hair have a function? Should you have a vulvovaginal care regimen?Will your vagina shrivel up if you go without sex?What's the truth about the HPV vaccine?So many important questions, so much convincing, confusing, contradictory misinformation! In this age of click bait, pseudoscience, and celebrity-endorsed products, it's easy to be overwhelmed--whether it's websites, advice from well-meaning friends, uneducated partners, and even healthcare providers. So how do you separate facts from fiction? OB-GYN Jen Gunter, an expert on women's health--and the internet's most popular go-to doc--comes to the rescue with a book that debunks the myths and educates and empowers women. From reproductive health to the impact of antibiotics and probiotics, and the latest trends, including vaginal steaming, vaginal marijuana products, and jade eggs, Gunter takes us on a factual, fun-filled journey. Discover the truth about:- The vaginal microbiome - Genital hygiene, lubricants, and hormone myths and fallacies - How diet impacts vaginal health - Stem cells and the vagina - Cosmetic vaginal surgery - What changes to expect during pregnancy, after childbirth, and through menopause - How medicine fails women by dismissing symptomsPlus: - Thongs vs. lace: the best underwear for vaginal health - How to select a tampon - The full glory of the clitoris and the myth of the G Spot... And so much more. Whether you're a twenty-six-year-old worried that her labia are "uncool" or a sixty-six-year-old dealing with painful sex, this comprehensive guide is sure to become a lifelong trusted resource.

    A perfect fit for a lab coat pocket, this book is commonly used as a quick review prior to surgical rounds as well as for board review.Purchasers of this edition will get both the print book and access to MP3 audio files of the entire text. All Q&A material will also be posted online in the form of electronic flashcards for self-quizzing.

    Reflecting the state of the art in medical practice, this edition delivers the latest strategies for understanding, diagnosing and managing disease.

    It is an ideal reference for medical students in ICM courses, house officers, or anyone directly involved in patient care, whether student, teacher, or practitioner.The book features more than 200 facsimiles of EKG strips and numerous case studies and clinical examples. This Fifth Edition includes updated information on pacemakers and myocardial infarction treatment and more practice EKGs.

    The chapters are organized by test type and each chapter begins with a list of the tests covered within the test type, as well as an overview of that category including specimen collection techniques. The tests are presented in a consistent format that includes normal findings, indications, contraindications, potential complications, interfering factors, procedure and patient care, test results and clinical significance, and related tests. This full-color book is easy to use and covers virtually every clinically significant test, including more than 50 new to this edition.

    Under the stewardship of the eminent editorial team, comprising two editors with experience gained over previous editions and a third editor new to this edition, and in response to reader feedback, the content has been sub-divided into parts to ensure a logical sequence and grouping of related chapters throughout while the text features enthusiastically received in the last edition have been retained. The new edition opens with sections devoted to the underlying principles of surgical practice, investigation and diagnosis, and pre-operative care. These are followed by chapters covering all aspects of surgical trauma. The remainder of the book considers each of the surgical specialties in turn, from elective orthopaedics through skin, head and neck, breast and endocrine, cardiothoracic and vascular, to abdominal and genitourinary.Key features: Authoritative: emphasises the importance of effective clinical examination and soundly based surgical principles, while taking into account the latest developments in surgical practice.Updated: incorporates new chapters on a wide variety of topics including metabolic response to injury, shock and blood transfusion, and surgery in the tropics.Easy to navigate: related chapters brought together into clearly differentiated sections for the first time.Readable: preserves the clear, direct writing style, uncluttered by technical jargon, that has proved so popular in previous editions.User-friendly: numerous photographs and explanatory line diagrams, learning objectives, summary boxes, biographical footnotes, memorable anecdotes and full-colour presentation supplement and enhance the text throughout.Bailey and Love has a wide appeal to all those studying surgery, from undergraduate medical students to those in preparation for their postgraduate surgical examinations. In addition, its high standing and reputation for unambiguous advice also make it the first point of reference for many practising surgeons. The changes that have been introduced to the 25th edition will only serve to strengthen support for the text among all these groups.

    Sooner or later, nearly all climbers get injured and it will be injuries that ultimately dictate how far you get in climbing, if you let them. Unfortunately, the data shows it takes over a decade just to get small proportions of medical research adopted in regular practice. Sourcing reliable and up to date advice on preventing and treating finger, elbow, shoulder and other climbing injuries is challenging to say the least. You need to be the expert, because there are so many strands of knowledge and practice to pull together to stay healthy as a climber, and no single source of advice to cover all of these. The book draws together both the cutting edge of peer reviewed sports medicine research, and the subtle concepts of changing your climbing habits and routine to prevent and successfully recover from injuries. It is a handbook on how to take care of yourself as a lifelong climbing athlete. By spanning the fields of climbing coaching, physiotherapy, sports medicine and behavioural science, it goes beyond the general advice on treating symptoms offered by sports medicine textbooks and into much more detail on technique and habits specific to climbing than the existing climbing literature base. You will learn how your current climbing habits are already causing your future injuries and what you can do to change that. If you are already injured, it will prevent you from prolonging your injury with the wrong climbing habits and rehabilitation choices. You will learn how the ingredients of prevention and good recovery come from wildly different sources and how you have been using only a fraction of them. Fully referenced throughout, the practical advice for diagnosis, rehabilitation and prevention of climbing injuries is drawn from up to date peer reviewed sports medicine research.

    Moreover, present-day research on electricity and ion channels has created one of the most exciting fields in science, shedding light on conditions ranging from diabetes and allergies to cystic fibrosis, migraines, and male infertility. With inimitable wit and a clear, fresh voice, award-winning researcher Frances Ashcroft weaves together compelling real-life stories with the latest scientific findings, giving us a spectacular account of the body electric.