Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    Worth reading for both it's historical and current value.

    No longer a fringe extremist cause, it has become a social concern that leading members of society endorse and young people embrace. From Michael Vick's dog fighting scandal to the incredible success of the bestselling Skinny Bitch veggie diet book, animal rights issues have hit the headlines—and are being championed by students and senators, pop stars and producers, and actors and activists.Don't you want to be part of the conversation? In Thanking the Monkey, Karen Dawn covers pets, fur, fashion, food, animal testing, activism, and more. But as the title playfully suggests, this isn't like any previous animal rights book. Thanking the Monkey is light on lectures meant to make you feel guilty if you're not a leather-eschewing vegan. It lets you have fun as you learn about Paul McCartney's love of lambs and why Prince won't wear wool. You'll meet Fall Out Boy's Andy Hurley and Pete Wentz—and their favorite traveling companion, Hemingway, Pete's dog. You'll read why Natalie Portman, Alicia Silverstone, and so many of those skinny but not bitchy actresses won't eat or wear animals. And you'll laugh over dozens of cartoons from Dan Piraro's Bizzaro to other animal-friendly comics.This fun primer for a smart and socially committed generation delivers some serious surprises in the form of facts and figures about the treatment of animals. Yes, it will shock you with tales of primates still used in animal testing on nicotine or killed for oven cleaner. But it will also let you lighten up and laugh a little as we work out how to do a better job of thanking the monkey.

    One of the largest factors in misdiagnosis of Lyme is the presence of other tick-borne infections, which mask or aggravate the symptoms of Lyme disease as well as complicate treatment. Two of the most common and damaging Lyme coinfections are Bartonella and Mycoplasma. Nearly 35 million people in the United States are asymptomatically infected with each of these pathogens, and at least 10 percent will become symptomatic every year--with symptoms ranging from arthritis to severe brain dysfunction. Distilling hundreds of peer-reviewed journal articles on the latest scientific research on Bartonella, Mycoplasma, and Lyme disease, Stephen Buhner examines the complex synergy between these infections and reveals how all three can go undiagnosed or resurface after antibiotic treatment. He explains how these coinfections create cytokine cascades in the body--essentially sending the immune system into an overblown, uncontrolled response in much the same way that rheumatoid arthritis or cancer can. Detailing effective natural holistic methods centered on herbs and supplements, such as the systemic antibacterial herb Sida acuta, which acts to protect blood cells from invading organisms, he reveals how to treat specific symptoms, interrupt the cytokine cascades, and bring the immune system back into balance as well as complement ongoing Lyme disease treatments.

    Did you know...; Almost 50% of supermarket fruit and vegetables contain pesticide residues?* UK supermarkets make 40p on every GBP1 spent on bananas while plantations workers are paid just 1p?* Supermarkets operate a climate of fear amongst their suppliers?* Every time a supermarket opens the local community loses on average 276 jobs?In the 1970s, British supermarkets had only 10% of the UK's grocery spend. Now they swallow up 80%, influencing how we shop, what we eat, how we spend our leisure time, how much rubbish we generate, even the very look of our physical environment. Award-winning food writer Joanna Blythman investigates the enormous impact that these big box retailers are having on our lives. She meets the farmers who are selling food to supermarkets for less than they need to survive, the wholesalers who have been eliminated from the supply chain, travels to suburban retail parks to meet the teenagers and part-timers who stack our shelves and reveals the hoops third world suppliers must jump through to earn supermarket contracts. This thought-provoking, witty and sometimes chilling voyage of discovery is sure to make you think twice before you reach for that supermarket trolley quite so enthusiastically ever again.

    But when fending off bill collectors, begging for salary advances, or borrowing from relatives becomes a way of life, unresolved money problems can lead to enormous stress and destroy relationships, careers, and lives. Do you recognize yourself or someone you love in any of these descriptions?THE COMPULSIVE SPENDERDo you buy things and hide them?THE BIG DEAL CHASERDo you refuse to watch your money because one big deal is going to make everything all right?THE MAINTENANCE MONEY DRUNKIs the pay the only thing you like about your job?THE POVERTY ADDICTDo you feel morally superior to people with money?THE CASH CODEPENDENTAre you afraid to say no to your partner about money?Through their highly effective seminars, Mark Bryan and Julia Cameron have helped many people free themselves from the painful cycle of acting out with money. The Money Drunk offers new perspectives on the real roots of money problems, showing how to dismantle negative family and societal programming about money and how to undo the destructive patterns that sabotage your financial success. The program teaches new, more constructive habits to anyone who has ever had a problem with money.

    Only it didn't. Vic's wife, Jeri, and older daughter, Rachael, were still very much alive, as were his two demanding careers. What did end was his worldview: one based on long-held assumptions and beliefs about life, death, disease, health, risk, and ultimate purpose-subjects on which he had been writing and speaking for years-but the validity of which he now questioned.Vic's experience of being "broken open" (to take bestselling author Elizabeth Lesser's phrase) set him on a life transforming journey through ancient and modern philosophy, literature, psychology, neuroscience, and Egyptology. Along the way, Vic was introduced to an unlikely role model: a six-legged superhero whose unique relationship with a ball of excrement forever altered Vic's outlook. A self-help guide, college lecture, confessional, and time-travel adventure all rolled into one, On Purpose uses a beautiful, fantasy-fueled, graphic novel format to tell a story of self-discovery and personal growth you'll never forget.From the Foreword: "Writing this book has given Vic Strecher a powerful sense of meaning. Reading it may do the same for you. It did for me. The light drives out the darkness and we can experience our world anew, filled with pleasure, joy, and meaning." - Dean Ornish, M.D.

    Bird flu. Unusual concentrations of cancer and other diseases. Massive fish kills from flesh-eating parasites. Recalls of meats, vegetables, and fruits because of deadly E-coli bacterial contamination. Recent public health crises raise urgent questions about how our animal-derived food is raised and brought to market. In Animal Factory, bestselling investigative journalist David Kirby exposes the powerful business and political interests behind large-scale factory farms, and tracks the far-reaching fallout that contaminates our air, land, water, and food. In this thoroughly researched book, Kirby follows three families and communities whose lives are utterly changed by immense neighboring animal farms. These farms (known as “Concentrated Animal Feeding Operations,” or CAFOs), confine thousands of pigs, dairy cattle, and poultry in small spaces, often under horrifying conditions, and generate enormous volumes of fecal and biological waste as well as other toxins. Weaving science, politics, law, big business, and everyday life, Kirby accompanies these families in their struggles against animal factories. A North Carolina fisherman takes on pig farms upstream to preserve his river, his family’s life, and his home. A mother in a small Illinois town pushes back against an out-sized dairy  farm and its devastating impact. And a Washington State grandmother becomes an unlikely activist when her home is invaded by foul odors and her water supply is compromised by runoff from leaking lagoons of cattle waste. Animal Factory is an important book about our American food system gone terribly wrong---and the people who are fighting to restore sustainable farming practices and save our limited natural resources.

    This encouraging change not only has benefited veterans but also provides a blueprint for salvaging America's own deeply troubled healthcare system. "Best Care Anywhere" shows how a government bureaucracy, working with little notice, is setting the standard for best practices and cost reduction while the private sector is lagging in both areas. Author Phillip Longman challenges conventional wisdom by explaining exactly how market forces work to lower quality and raise prices in the healthcare sector, and how U.S. medical practices have a weak basis in science. The book, expanded from a widely praised article in the "Washington Monthly," mixes hard facts with author Philip Longmans' compelling human story of the loss of his wife to cancer. Part manifesto, part moving memoir, "Best Care Anywhere" offers new hope for addressing a major problem of contemporary society that affects all of us.

    Nature as delight. Nature as mother and sister. Nature as victim. Nature as companion and reminder of what is wild in us all. Here, among more than a hundred poets and prose writers, are Diane Ackerman on the opium of sunsets; Ursula K. Le Guin envisioning an alternative world in which human beings are not estranged from their planet; and Julia Butterfly Hill on weathering a fierce storm in the redwood tree where she lived for more than two years. Here, too, are poems, essays, stories, and journal entries by Emily Dickinson, Alice Walker, Terry Tempest Williams, Willa Cather, Gretel Erlich, Adrienne Rich, and others—each offering a vivid, eloquent response to the natural world.This second edition of Sisters of the Earth is fully revised and updated with a new preface and nearly fifty new pieces, including new contributions by Louise Erdrich, Pam Houston, Zora Neale Hurston, Starhawk, Joy Williams, Kathleen Norris, Rita Dove, and Barbara Kingsolver.

    economy has become the driving force behind our expanding waistlines. Blending theory, research, and engaging personal anecdotes the authors discuss how declining food costs--especially for high-calorie, low-nutrient foods--and an increasing usage of technology, which make Americans more sedentary, has essentially led us to eat more calories than we burn off.

    Energy experts are all saying the same thing: solar photovoltaics (PV) is our future. Reports from universities, investment banks, international institutions and large investors agree. It's not about whether the switch from fossil fuels to solar power will happen, but when.Solar panels are being made that will last longer than ever hoped; investors are seeing the benefits of the long-term rewards provided by investing in solar; in the Middle East, a contractor can now offer solar-powered electricity far cheaper than that of a coal-fired power station. The Switch tracks the transition away from coal, oil and gas to a world in which the limitless energy of the sun provides much of the energy the 10 billion people of this planet will need. It examines both the solar future and how we will get there, and the ways in which we will provide stored power when the sun isn't shining. We learn about artificial photosynthesis from a start-up in the US that is making petrol from just CO2 and sunlight; ideas on energy storage are drawn from a company in Germany that makes batteries for homes; in the UK, a small company in Swindon has the story of wind turbines; and in Switzerland, a developer shows how we can use hydrogen to make 'renewable' natural gas for heating.Told through the stories of entrepreneurs, inventors and scientists from around the world, and using the latest research and studies, The Switch provides a positive solution to the climate change crisis, and looks to a brighter future ahead.

    Change is constant. The world is in a continual state of flux. It is a stream of ever-mutating, emergent patterns. Rather than steel ourselves against such change, this book invites us to feel, map, assess, and learn from the swirling patterns around us in order to better understand and influence them as they happen. This is a resolutely materialist “spirituality” based equally on science and science fiction, a visionary incantation to transform that which ultimately transforms us.adrienne maree brown, co-editor of Octavia’s Brood: Science Fiction from Social Justice Movements, is a social justice facilitator, healer, and doula living in Detroit.

    They influence virtually all of the growing individual's characteristics, from determining its sex to controlling the numbers of toes and fingers to shaping intricate details of brain structure.Scientific research over the last 50 years has revealed that this hormonal control of development is vulnerable to disruption by synthetic chemicals. Through a variety of mechanisms, hormone-disrupting chemicals (also known as endocrine disrupting chemicals or endocrine disruptors) interfere with the natural messages and alter the course of development, with potential effects on virtually all aspects of bodily function.Our Stolen Future explores the scientific discovery of endocrine disruption. The investigation begins with wildlife, as it was in animals that the first hints of widespread endocrine disruption appeared. The book then examines a series of experiments examining endocrine disruption of animals in the laboratory which show conclusively that fetal exposure to endocrine disrupting chemicals can wreak life-long damage. These experiments also reveal some of the biological processes by which these chemicals have their effects, and that endocrine disruption effects can be caused by exposure to infinitesimally small amounts of contaminant. Moving from animals to people, Our Stolen Future summarizes a series of well-studied examples where people have been affected by endocrine disrupting chemicals, most notably the synthetic hormone dietheylstilbestrol (DES), to which several million women were exposed through misguided medical attempts to manage difficult pregnancies in the 1950s, '60s and '70s.Our Stolen Future then asks a broader, more difficult and more controversial set of questions. Given what is known from wildlife and laboratory studies, and from examples of well-studied human exposure, and given that exposure to endocrine disrupting chemicals in the real world is widespread at levels comparable to those sufficient to cause animal harm, what effects should health scientists be looking for in people in general? Effects to be expected include declines in fertility and other impacts on the reproductive system of both men and women, impairments in disease resistance, and erosions in intelligence.

    Robbins shares his dispatches from the frontlines of the food revolution: From his undercover investigations of feed lots and slaughterhouses, to the rise of food contamination, the slave trade behind chocolate and coffee, what he calls the sham of "Vitamin Water," and the effects of hormones on animals and animal products.Topics include:The skinny on grassfed beefGreed and salmonellaJunk food marketing to kidsSoy and Alzheimer'sHormones in our milkPlus many more.Robbin's trenchant and provocative observations into the relationships between animals and the humans who raise them remind us of the importance of working for a more compassionate and environmentally responsible world.