Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medical obscurity? The LDN Book explains the drug’s origins, its primary mechanism, and the latest research from practicing physicians and pharmacists as compiled by Linda Elsegood of The LDN Research Trust, the world’s largest LDN charity organization with over 19,000 members worldwide. Featuring ten chapters contributed by medical professionals on LDN’s efficacy and two patient-friendly appendices, The LDN Book is a comprehensive resource for doctors, pharmacists, and patients who want to learn more about how LDN is helping people now, and a clarion call for further research that could help millions more.

    Drawing on her decades of activism and a wide reading of environmental, cultural, and political history, Solnit argues that radicals have a long, neglected history of transformative victories, that the positive consequences of our acts are not always immediately seen, directly knowable, or even measurable, and that pessimism and despair rest on an unwarranted confidence about what is going to happen next.Originally published in 2004, now with a new foreword and afterword, Solnit’s influential book shines a light into the darkness of our time in an unforgettable new edition.

    For well over two centuries now, Americans of all stripes--presidents and activists, writers and soldiers--have turned to Shakespeare's works to address the nation's political fault lines, such as manifest destiny, race, gender, immigration, and free speech. In a narrative arching across the centuries, James Shapiro traces the unparalleled role of Shakespeare's 400-year-old tragedies and comedies in making sense of so many of these issues on which American identity has turned. Reflecting on how Shakespeare has been invoked--and at times weaponized--at pivotal moments in our past, Shapiro takes us from President John Quincy Adams's disgust with Desdemona's interracial marriage to Othello, to Abraham Lincoln's and his assassin John Wilkes Booth's competing obsessions with the plays, up through the fraught debates over marriage and same-sex love at the heart of the celebrated adaptations Kiss Me Kate and Shakespeare in Love. His narrative culminates in the 2017 controversy over the staging of Julius Caesar in Central Park, in which a Trump-like leader is assassinated.Extraordinarily researched, Shakespeare in a Divided America shows that no writer has been more closely embraced by Americans, or has shed more light on the hot-button issues in our history. Indeed, it is by better understanding Shakespeare's role in American life, Shapiro argues, that we might begin to mend our bitterly divided land.

    For, in this stylish, erudite and frequently hilarious book, de Botton dips deeply into Proust’s life and work—his fiction, letter, and conversations—and distills from them that rare self-help manual: one that is actually helpful.Here, tendered in prose almost as luminous as it’s subject’s, is advice on cultivating friendships, suffering successfully, recognizing love and understanding why you should never sleep with someone on the first date. And here, too, is a generously perceptive literary biography that suggests that the master is as relevant today as he was in fin de siècle Paris. At once slyly ironic and genuinely wise, How Proust Can Change Your Life is an unqualified delight.

    In The Poisoner's Handbook Blum draws from highly original research to track the fascinating, perilous days when a pair of forensic scientists began their trailblazing chemical detective work, fighting to end an era when untraceable poisons offered an easy path to the perfect crime. Drama unfolds case by case as the heroes of The Poisoner's Handbook—chief medical examiner Charles Norris and toxicologist Alexander Gettler—investigate a family mysteriously stricken bald, Barnum and Bailey's Famous Blue Man, factory workers with crumbling bones, a diner serving poisoned pies, and many others. Each case presents a deadly new puzzle and Norris and Gettler work with a creativity that rivals that of the most imaginative murderer, creating revolutionary experiments to tease out even the wiliest compounds from human tissue. Yet in the tricky game of toxins, even science can't always be trusted, as proven when one of Gettler's experiments erroneously sets free a suburban housewife later nicknamed "America's Lucretia Borgia" to continue her nefarious work. From the vantage of Norris and Gettler's laboratory in the infamous Bellevue Hospital it becomes clear that killers aren't the only toxic threat to New Yorkers. Modern life has created a kind of poison playground, and danger lurks around every corner. Automobiles choke the city streets with carbon monoxide; potent compounds, such as morphine, can be found on store shelves in products ranging from pesticides to cosmetics. Prohibition incites a chemist's war between bootleggers and government chemists while in Gotham's crowded speakeasies each round of cocktails becomes a game of Russian roulette. Norris and Gettler triumph over seemingly unbeatable odds to become the pioneers of forensic chemistry and the gatekeepers of justice during a remarkably deadly time. A beguiling concoction that is equal parts true crime, twentieth-century history, and science thriller, The Poisoner's Handbook is a page-turning account of a forgotten New York.

    It has been explained as a combination of romance, science and prophecy; as a genre based on an imagined alternative to the reader's environment; and as a form of fantastic fiction and historical literature. It has also been argued that science fiction narratives are the most engaged, socially relevant, and responsive to the modern technological environment. This Very Short Introduction doesn't offer a history of science fiction, but instead ties examples of science fiction to different historical moments, in order to demonstrate how science fiction has evolved over time. David Seed looks not only at literature, but also at drama and poetry, as well as film. Examining recurrent themes in science fiction he looks at voyages into space, the concept of the alien and alternative social identities, the role of technology in science fiction, and its relation to time - in the past, present, and future.

     Stretching between these figures is a cast of artists, writers, and scientists--mostly women, mostly queer--whose public contribution has risen out of their unclassifiable and often heartbreaking private relationships to change the way we understand, experience, and appreciate the universe. Among them are the astronomer Maria Mitchell, who paved the way for women in science; the sculptor Harriet Hosmer, who did the same in art; the journalist and literary critic Margaret Fuller, who sparked the feminist movement; and the poet Emily Dickinson.Emanating from these lives are larger questions about the measure of a good life and what it means to leave a lasting mark of betterment on an imperfect world: Are achievement and acclaim enough for happiness? Is genius? Is love? Weaving through the narrative is a set of peripheral figures--Ralph Waldo Emerson, Charles Darwin, Elizabeth Barrett Browning, Herman Melville, Frederick Douglass, Nathaniel Hawthorne, and Walt Whitman--and a tapestry of themes spanning music, feminism, the history of science, the rise and decline of religion, and how the intersection of astronomy, poetry, and Transcendentalist philosophy fomented the environmental movement.

    She spent most of the next two years on the ward for teenage girls in a psychiatric hospital as renowned for its famous clientele--Sylvia Plath, Robert Lowell, James Taylor, and Ray Charles--as for its progressive methods of treating those who could afford its sanctuary. Kaysen's memoir encompasses horror and razor-edged perception while providing vivid portraits of her fellow patients and their keepers. It is a brilliant evocation of a "parallel universe" set within the kaleidoscopically shifting landscape of the late sixties. Girl, Interrupted is a clear-sighted, unflinching documnet that gives lasting and specific dimension to our definitions of sane and insane, mental illness and recovery.

    After gaining admission to Oxford, and moving to the United States to become a journalist, through several love affairs, then marriage and family, Mead read and reread Middlemarch. The novel, which Virginia Woolf famously described as "one of the few English novels written for grown-up people," offered Mead something that modern life and literature did not.In this wise and revealing work of biography, reporting, and memoir, Rebecca Mead leads us into the life that the book made for her, as well as the many lives the novel has led since it was written. Employing a structure that deftly mirrors that of the novel, My Life in Middlemarch takes the themes of Eliot's masterpiece--the complexity of love, the meaning of marriage, the foundations of morality, and the drama of aspiration and failure--and brings them into our world. Offering both a fascinating reading of Eliot's biography and an exploration of the way aspects of Mead's life uncannily echo that of Eliot herself.

    Here, Wallace turns his critical eye with equal enthusiasm toward Roger Federer and Jorge Luis Borges; Terminator 2 and The Best of the Prose Poem; the nature of being a fiction writer and the quandary of defining the essay; the best underappreciated novels and the English language's most irksome misused words; and much more.Both Flesh and Not restores Wallace's essays as originally written, and it includes a selection from his personal vocabulary list, an assembly of unusual words and definitions.

    I had the urge to poison a monk.' Along the way, it touches on bad books, ideal readers, historical form, and the metaphysics of the detective story.

    In direct, straightforward, and at times strikingly lyrical prose, Jamison looks back at her relationship with her husband, Richard Wyatt, a renowned scientist who battled debilitating dyslexia to become one of the foremost experts on schizophrenia. And with her characteristic honesty, candor, wit, and simplicity, she describes his death, her own long, difficult struggle with grief, and her efforts to distinguish grief from depression.But she also recalls the great joy that Richard brought her during the nearly twenty years they had together. Wryly humorous anecdotes mingle with bittersweet memories of a relationship that was passionate and loving—if troubled on occasion by her manic-depressive (bipolar) illness—as Jamison reveals the ways in which her husband encouraged her to write openly about her mental illness and, through his courage and grace taught her to live fully.A penetrating psychological study of grief viewed from deep inside the experience itself, Nothing Was the Same is also a deeply moving memoir by a superb writer.

    Its presence in nature was dismissed as a desperate response to starvation or other life-threatening circumstances, and few spent time studying it. A taboo subject in our culture, the behavior was portrayed mostly through horror movies or tabloids sensationalizing the crimes of real-life flesh-eaters. But the true nature of cannibalism--the role it plays in evolution as well as human history--is even more intriguing (and more normal) than the misconceptions we've come to accept as fact. In Cannibalism: A Perfectly Natural History, zoologist Bill Schutt sets the record straight, debunking common myths and investigating our new understanding of cannibalism's role in biology, anthropology, and history in the most fascinating account yet written on this complex topic. Schutt takes readers from Arizona's Chiricahua Mountains, where he wades through ponds full of tadpoles devouring their siblings, to the Sierra Nevadas, where he joins researchers who are shedding new light on what happened to the Donner Party--the most infamous episode of cannibalism in American history. He even meets with an expert on the preparation and consumption of human placenta (and, yes, it goes well with Chianti). Bringing together the latest cutting-edge science, Schutt answers questions such as why some amphibians consume their mother's skin; why certain insects bite the heads off their partners after sex; why, up until the end of the twentieth century, Europeans regularly ate human body parts as medical curatives; and how cannibalism might be linked to the extinction of the Neanderthals. He takes us into the future as well, investigating whether, as climate change causes famine, disease, and overcrowding, we may see more outbreaks of cannibalism in many more species--including our own.Cannibalism places a perfectly natural occurrence into a vital new context and invites us to explore why it both enthralls and repels us.

    She was forty-four years old, with a devoted husband and three young children, and she had only one year of health remaining.Susan decided to live that year with joy.She quit her job as a journalist and spent time with her family. She built an outdoor meeting space for friends in her backyard. And she took seven trips with the seven most important people in her life. As her health declined, Susan journeyed to the Yukon, Hungary, the Bahamas, and Cyprus. She took her sons to swim with dolphins, and her teenage daughter, Marina, to Kleinfeld's bridal shop in New York City to see her for the first and last time in a wedding dress.She also wrote this book. No longer able to walk or even to lift her arms, she tapped it out letter by letter on her iPhone using only her right thumb, the last finger still working.However, Until I Say Good-Bye is not angry or bitter. It is sad in parts--how could it not be?--but it is filled with Susan's optimism, joie de vivre, and sense of humor. It is a book about life, not death. One that, like Susan, will make everyone smile.From the Burger King parking lot where she cried after her diagnosis to a snowy hot spring near the Arctic Circle, from a hilarious family Christmas disaster to the decrepit monastery in eastern Cyprus where she rediscovered her heritage, Until I Say Good-Bye is not only Susan Spencer-Wendel's unforgettable gift to her loved ones--a heartfelt record of their final experiences together--but an offering to all of us: a reminder that "every day is better when it is lived with joy."

    P. Lovecraft, the seminal, enigmatic horror writer of the early 20th century. Houellebecq’s insights into the craft of writing illuminate both Lovecraft and Houellebecq’s own work. The two are kindred spirits, sharing a uniquely dark worldview. But even as he outlines Lovecraft’s rejection of this loathsome world, it is Houellebecq’s adulation for the author that drives this work and makes it a love song, infusing the writing with an energy and passion not seen in Houellebecq’s other novels to date.