Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological.The Lady's Handbook for Her Mysterious Illness is a memoir with a mission, to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions.Ramey's pursuit of a diagnosis and cure for her own mysterious illness is a medical mystery that she says reveals a new understanding of today's chronic illnesses as ecological in nature, driven by modern changes to the basic foundations of health, from the quality of our sleep, diet, and social connection to the state of our microbiomes.

    Now comes her highly anticipated first book featuring her signature combination of honesty, humor, and direct, no-nonsense advice.Each chapter of Girl, Wash Your Face begins with a specific lie Hollis once believed that left her feeling overwhelmed, unworthy, or ready to give up. As a working mother, a former foster parent, and a woman who has dealt with insecurities about her body and relationships, she speaks with the insight and kindness of a BFF, helping women unpack the limiting mind-sets that destroy their self-confidence and keep them from moving forward.From her temporary obsession with marrying Matt Damon to a daydream involving hypnotic iguanas to her son's request that she buy a necklace to "be like the other moms," Hollis holds nothing back. With unflinching faith and tenacity, Hollis spurs other women to live with passion and hustle and to awaken their slumbering goals.

    We watch him navigate a fraught relationship with a lonely uncle in jail who—as he degenerates into madness— continues to plead for the support of his conflicted nephew. And we cringe as he gets outed as a “moby” at a Tea Party rally. In moments like these, we can’t help but ask ourselves: How far would we go for our own family members, and when is someone simply too far gone to save? Are there truly “bad people,” and if so, should we change them? With a perfect combination of humor and pathos, these essays, peppered with Kreider’s signature cartoons, leave us with newfound wisdom and a unique prism through which to examine our own chaotic journeys through life.Uncompromisingly candid, sometimes mercilessly so, these comically illustrated essays are rigorous exercises in self-awareness and self-reflection. These are the conversations you have only with best friends or total strangers, late at night over drinks, near closing time.

    It snuck up on me disguised as a healthy diet, a professional attitude. Being as thin as possible was a way to make the job of being an actress easier . . .” Portia de Rossi weighed only 82 pounds when she collapsed on the set of the Hollywood film in which she was playing her first leading role. This should have been the culmination of all her years of hard work—first as a child model in Australia, then as a cast member of one of the hottest shows on American television. On the outside she was thin and blond, glamorous and successful. On the inside, she was literally dying. In this searing, unflinchingly honest book, Portia de Rossi captures the complex emotional truth of what it is like when food, weight, and body image take priority over every other human impulse or action. She recounts the elaborate rituals around eating that came to dominate hours of every day, from keeping her daily calorie intake below 300 to eating precisely measured amounts of food out of specific bowls and only with certain utensils. When this wasn’t enough, she resorted to purging and compulsive physical exercise, driving her body and spirit to the breaking point. Even as she rose to fame as a cast member of the hit television shows Ally McBeal and Arrested Development, Portia alternately starved herself and binged, all the while terrified that the truth of her sexuality would be exposed in the tabloids. She reveals the heartache and fear that accompany a life lived in the closet, a sense of isolation that was only magnified by her unrelenting desire to be ever thinner. With the storytelling skills of a great novelist and the eye for detail of a poet, Portia makes transparent as never before the behaviors and emotions of someone living with an eating disorder. From her lowest point, Portia began the painful climb back to a life of health and honesty, falling in love with and eventually marrying Ellen DeGeneres, and emerging as an outspoken and articulate advocate for gay rights and women’s health issues. In this remarkable and beautifully written work, Portia shines a bright light on a dark subject. A crucial book for all those who might sometimes feel at war with themselves or their bodies, Unbearable Lightness is a story that inspires hope and nourishes the spirit.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    Rahul Jandial is on the cutting edge of the latest advancements in neuroscience. This fascinating book draws on Dr. Jandial’s broad-spectrum expertise and brings together the best of various fields-–surgery, science, brain structure, the conscious mind–-all to explain the bigger picture of brain health and rejuvenation. It is a journey into his operating room, around the world on his surgical missions, inside his laboratory, and to the outer edges of neuroscience to reveal the latest brain breakthroughs that are turning science fiction into reality, translating their implications for everyday life. Busting myths along the way, Jandial helps readers get wired for success at work and school, perform better when the pressure is on, boost memory, control stress and emotions, minimize pain, stick to a healthy eating plan, unleash creativity, raise smarter kids, and stay sharp as they age. Combining the treatment guidelines he gives his patients, the most promising concepts from frontier science, and the smartest super-achiever hacks, he provides practical takeaways for optimizing brain function and leading a healthier, happier, more productive life.

    It’s about how people, organizations and societies can and must hit refresh—transform—in their persistent quest for new energy, new ideas, relevance and renewal. At the core, it’s about us humans and our unique qualities, like empathy, which will become ever more valuable in a world where the torrent of technology will disrupt like never before. As much a humanist as a technologist, Nadella defines his mission and that of the company he leads as empowering every person and every organization on the planet to achieve more.

    No matter where nature has placed him--the club rooms of Brooklyn, the Mafia dives of New York's Lower East Side, the wilds of Alaska, or the hills of Hollywood--he has found a way to put on a show and sell tickets at the door. "All life was a theater and I wanted to put it up on a stage," he writes. "I wanted to set the world under a marquee that read: 'Jerry Weintraub Presents.'"In WHEN I STOP TALKING, YOU'LL KNOW I'M DEAD, we follow Weintraub from his first great success at age twenty-six with Elvis Presley, whom he took on the road with the help of Colonel Tom Parker; to the immortal days with Sinatra and Rat Pack glory; to his crowning hits as a movie producer, starting with Robert Altman and Nashville, continuing with Oh, God!, The Karate Kid movies, and Diner, among others, and summiting with Steven Soderbergh and Ocean's Eleven, Twelve, and Thirteen.Along the way, we'll watch as Jerry moves from the poker tables of Palm Springs (the games went on for days), to the power rooms of Hollywood, to the halls of the White House, to Red Square in Moscow and the Great Palace in Beijing-all the while counseling potentates, poets, and kings, with clients and confidants like George Clooney, Bruce Willis, George H. W. Bush, Armand Hammer, Brad Pitt, Matt Damon, Bob Dylan, Led Zeppelin, John Denver, Bobby Fischer . . .well, the list goes on forever.And of course, the story is not yet over . . .as the old-timers say, "The best is yet to come."As Weintraub says, "When I stop talking, you'll know I'm dead."With wit, wisdom, and the cool confidence that has colored his remarkable career, Jerry chronicles a quintessentially American journey, one marked by luck, love, and improvisation. The stories he tells and the lessons we learn are essential, not just for those who love movies and music, but for businessmen, entrepreneurs, artists . . . everyone.

    You can overcome disease, improve your mental health and physical performance, and even control your physiology so you can thrive in freezing temperatures.” With The Wim Hof Method, this trailblazer of human potential shares a method that anyone can use—not just extreme athletes or spiritual masters—to supercharge your capacity for strength, health, and happiness.Wim Hof has become a modern legend for his astounding achievements, such as withstanding extreme temperatures, breaking world records, and running barefoot marathons over deserts and ice fields. In his gripping and passionate style, Hof shares the story of how he developed his method, along with testimonials and new insights from the university research studies on its amazing results. With guidance suited for any reader—young or old, sick or healthy—you’ll learn how to harness three key elements of Cold, Breathing, and Mindset to take charge of your own mind and metabolism.Yet the most important result of Hof’s method goes beyond improved health or performance—it is a path for reconnecting with your spiritual nature. “With these practices, you awaken to your inner source of power and fulfillment,” he says. “You find you can control your destiny.”

    In college, I ran against Kenyans, and wondered whether endurance genes might have traveled with them from East Africa. At the same time, I began to notice that a training group on my team could consist of five men who run next to one another, stride for stride, day after day, and nonetheless turn out five entirely different runners. How could this be?We all knew a star athlete in high school. The one who made it look so easy. He was the starting quarterback and shortstop; she was the all-state point guard and high-jumper. Naturals. Or were they?The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training?The truth is far messier than a simple dichotomy between nature and nurture. In the decade since the sequencing of the human genome, researchers have slowly begun to uncover how the relationship between biological endowments and a competitor’s training environment affects athleticism. Sports scientists have gradually entered the era of modern genetic research.In this controversial and engaging exploration of athletic success, Sports Illustrated senior writer David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving this great riddle. He investigates the so-called 10,000-hour rule to uncover whether rigorous and consistent practice from a young age is the only route to athletic excellence.Along the way, Epstein dispels many of our perceptions about why top athletes excel. He shows why some skills that we assume are innate, like the bullet-fast reactions of a baseball or cricket batter, are not, and why other characteristics that we assume are entirely voluntary, like an athlete’s will to train, might in fact have important genetic components.This subject necessarily involves digging deep into sensitive topics like race and gender. Epstein explores controversial questions such as:Are black athletes genetically predetermined to dominate both sprinting and distance running, and are their abilities influenced by Africa’s geography?Are there genetic reasons to separate male and female athletes in competition?Should we test the genes of young children to determine if they are destined for stardom?Can genetic testing determine who is at risk of injury, brain damage, or even death on the field?Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

    Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance.Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all.As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.

     It is a remarkable portrait, too, of the life of a psychiatric asylum--the sort of community in which, for better and for worse, hundreds of thousands of people lived out their lives.More than four hundred abandoned suitcases filled with patients’ belongings were found when Willard Psychiatric Center closed in 1995 after 125 years of operation. They are skillfully examined here and compared to the written record to create a moving—and devastating—group portrait of twentieth-century American psychiatric care.

    But the diversity of our philosophies, beliefs, concepts, and views about the soul often leads to confusion. To reconcile the noise that clouds spirituality, Michael Singer combines accounts of his own life journey to enlightenment—from his years as a hippie-loner to his success as a computer program engineer to his work in spiritual and humanitarian efforts—with lessons on how to put aside conflicting beliefs, let go of worries, and transform misdirected desires. Singer provides a road map to a new way of living not in the moment, but to exist in a state of perpetual happiness.

    With three hit shows on television and three children at home, Shonda Rhimes had lots of good reasons to say no when invitations arrived. Hollywood party? No. Speaking engagement? No. Media appearances? No. And to an introvert like Shonda, who describes herself as 'hugging the walls' at social events and experiencing panic attacks before press interviews, there was a particular benefit to saying no: nothing new to fear. Then came Thanksgiving 2013, when Shonda's sister Delorse muttered six little words at her: You never say yes to anything. Profound, impassioned and laugh-out-loud funny, in Year of Yes Shonda Rhimes reveals how saying YES changed -- and saved -- her life. And inspires readers everywhere to change their own lives with one little word: Yes.

    Kennedy tells his extraordinary personal story--of his legendary family, politics, and fifty years at the center of national events.TRUE COMPASSThe youngest of nine children born to Joseph P. Kennedy and Rose Fitzgerald Kennedy, he came of age among siblings from whom much was expected. As a young man, he played a key role in the presidential campaign of his brother John F. Kennedy, recounted here in loving detail. In 1962 he was elected to the U.S. Senate, where he began a fascinating political education and became a legislator.In this historic memoir,Ted Kennedy takes us inside his family, re-creating life with his parents and brothers and explaining their profound impact on him. or the first time, he describes his heartbreak and years of struggle in the wake of their deaths. Through it all, he describes his work in the Senate on the major issues of our time--civil rights, Vietnam, Watergate, the quest for peace in Northern Ireland--and the cause of his life: improved health care for all Americans, a fight influenced by his own experiences in hospitals.His life has been marked by tragedy and perseverance, a love of family, and an abiding faith. There have been controversies, too, and Kennedy addresses them with unprecedented candor. At midlife, embattled and uncertain if he would ever fall in love again, he met the woman who changed his life, Victoria Reggie Kennedy. Facing a tough reelection campaign against an aggressive challenger named Mitt Romney, Kennedy found a new voice and began one of the great third acts in American politics, sponsoring major legislation, standing up for liberal principles, and making the pivotal endorsement of Barack Obama for president.Hundreds of books have been written about the Kennedys. TRUE COMPASS will endure as the definitive account from a member of America's most heralded family, an inspiring legacy to readers and to history, and a deeply moving story of a life like no other.