They are the powerhouses of our cells, essential for the production and management of energy at cell level. Dr Sarah Myhill, together with Dr John McLaren Howard of Acumen Laboratories and Dr Norman Booth of Mansfield College Oxford, has spent many years studying the relationship between their malfunction and the commonest problem seen by GPs in the UK – fatigue. Their research findings have been published in three scientific papers in the International Journal of Clinical and Experimental Medicine, in 2009, 2012 and 2013. These studies showed that poor functioning of the mitochondria is the central problem in CFS. Patients with the worst mitochondrial function had the worst fatigue and vice versa. This is solid scientific evidence that CFS is a problem with mitochondria and has allowed the objective measurement of fatigue for the first time. With the publication of the third study, which showed that mitochondrial function tests and symptoms improved in patients who took measures to address their mitochondrial problems, Dr Myhill was ready to write this book. Here she explains the importance of healthy mitochondria, how we can measure their functioning and what we can do to keep them healthy, or restore them to health if problems arise. CFS is all in our cells, not in our minds!

    This groundbreaking work argues that we cannot define madness as an illness to be cured like any other; that labels such as 'schizophrenia' and 'manic depression' are meaningless, based on nineteenth-century classifications; and that experiences such as delusions and hearing voices are in fact exaggerations of the mental foibles to which we are all vulnerable.We need, Bentall argues, a radically new way of thinking about psychiatric problems - one that does not reduce madness to bain chemistry, but understands and accepts it as part of human nature.'Bentall destroys many of the foundations underlying psychiatric thinking' - Oliver James'A monumental study ... brave, well-researched and accessible' - Scotland on Sunday'Bental demystifies psychosis and restores the patient to a proper place with the rest of humankind' - Aaron T. Beck

    But what should we change and how do we do it? Annabel Streets and Susan Saunders spent their 30s climbing the career ladder, having children and caring for elderly parents - all at the same time. By their 40s, they were exhausted, stressed, sleeping too little and rushing too much. They began to ask whether the prolonged ill health and dementia suffered by their parents was their inevitable future too - could they do anything to avoid requiring their own children to care for them in old age? Thus began THE AGE-WELL PROJECT. With incredible tenacity, Annabel and Susan read 50,000 scientific research papers on all aspects of ageing to find what advice cutting-edge research can offer us on how to ensure the longer lives we're living are healthy and happy. Putting their findings into practice, they found that the lifestyle changes they made were having incredible benefits on their health and wellbeing now - as well as for the future. Told with empathy and humour, in THE AGE-WELL PROJECT Annabel and Susan share the 50 key lessons they learned, the meals they cooked and the experts' tips they uncovered to make the second half of your life the best half of your life - happy, healthy and disease-free. Author BiographyAnnabel was a founder member of an award-winning marketing company, advising the chief executives of companies such as Sony, Reuters and the Financial Times. After four children, and at breaking point, she sold her company. Following a stint studying photography and producing a community cook book, she changed tack and wrote an award-winning novel The Joyce Girl which sold in 14 countries and was selected for the 2017 Berlin Film Festival. Since then she has written regularly for a range of titles including the Daily Telegraph, Psychologies, The Author, the Guardian, The Irish Times, Elle, Australian

    The new edition is thoroughly updated, including most notably a new chapter on innate immunity, a capstone chapter on immune responses in time and space, and many new focus boxes drawing attention to exciting clinical, evolutionary, or experimental connections that help bring the material to life.See what's in the LaunchPad

    Hansen, PhD. Using this interactive coloring workbook, you can trace arteries, veins, and nerves through their courses and bifurcations...reinforce your understanding of muscle origins and insertions from multiple views and dissection layers...and develop a better understanding of the integration of individual organs in the workings of each body system throughout the human form. Online access to Student Consult-where you'll find the complete contents of the book and much more-further enhances your study and exponentially boosts your reference power. Whether you are taking an anatomy course or just curious about how the body works, let the art of Netter guide you!Provides multiple views, magnifications, and dissection layers that strengthen your understanding of 3-D anatomical relationships.Presents each topic in two-page spreads-with Netter anatomical illustrations accompanied by high-yield information-that gives context to the structures.Features illustrations small enough for quick coloring, but large enough to provide you with important details.Offers tips for coloring key structures that emphasize how a coloring exercise can reinforce learning.Uses Key Points to cover functional and clinical relevance and relationships.Contains tables that review muscle attachments, innervation, action, and blood supply.Features Clinical Notes which highlight the importance of anatomy in medicine.Includes online access to Student Consult where you can search the complete contents of the book, print additional copies of the coloring pages, view completed coloring pages for reference, access Integration Links to bonus content in other Student Consult titles...and much more...to further enhance your study and exponentially boost your reference power.

    It includes even more new monographs and the latest FDA approvals. This updated edition is a book that students can count on with vital information for Peds, as well as precautions for all vulnerable populations. From pediatrics to geriatrics and from pregnancy to breast feeding considerations, "Davis's Drug Guide for Nurses" addresses the entire lifespan.

    Gerard, PhD, its chief learning officer, candidly describe the triumphs and stumbles of a seven-year journey to lean healthcare, an effort that continues today and that has slashed medical errors, improved patient outcomes, raised staff morale, and saved $27 million dollars in costs without layoffs. Find out:> How lean techniques of value-stream-mapping and rapid improvement events cut the average “door-to-balloon” time for heart attack patients at two hospitals from 90 minutes to 37.> What ThedaCare leaders did to replace medicine’s “shame and blame” culture with a lean culture based on continuous improvement and respect for people.> How the lean principle of “building in quality at the source” broke down divisions among medical specialties allowing teams to develop patient care plans faster.> Why traditional modern management is the single biggest impediment to lean healthcare.> How the plan-do-study-act cycle coupled with rapid improvement events cut the wait time at a robotic radiosurgery unit from 26 days to six.> How the lean concept of “one piece flow” saved time in treating ischemic stroke patients, increasing the number of patients receiving a CT scan within 25 minutes from 51% to 89%.> How senior leaders at other healthcare organizations can begin their own lean transformations using a nine-step action plan based on what ThedaCare did — and what it would do differently.Toussaint and Gerard prove that lean healthcare does not mean less care. On the Mend shows that when care is truly re-designed around patients, waste and errors are eliminated, quality improves, costs come down, and healthcare professionals have more time to spend with patients, who get even better care.

    These individuals all lost some part of what we think of as our self, but they then offer remarkable, sometimes heart-wrenching insights into what remains. One man cut off his own leg. Another became one with the universe.We are learning about the self at a level of detail that Descartes (“I think therefore I am”) could never have imagined. Recent research into Alzheimer’s illuminates how memory creates your narrative self by using the same part of your brain for your past as for your future. But wait, those afflicted with Cotard’s syndrome think they are already dead; in a way, they believe that “I think therefore I am not.” Who—or what—can say that? Neuroscience has identified specific regions of the brain that, when they misfire, can cause the self to move back and forth between the body and a doppelgänger, or to leave the body entirely. So where in the brain, or mind, or body, is the self actually located? As Ananthaswamy elegantly reports, neuroscientists themselves now see that the elusive sense of self is both everywhere and nowhere in the human brain.

    Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

    . . A tale of love, constancy and groundbreaking research.' --RON SUSKIND, Pulitzer Prize-winning journalist and author of Life, AnimatedHenry Markram is the Elon Musk of neuroscience, the man behind the billion-dollar Blue Brain Project to build a supercomputer model of the brain. He has set the goal of decoding all disturbances of the mind within a generation. This quest is personal for him. The driving force behind his grand ambition has been his son Kai, who suffers from autism. Raising Kai made Henry Markram question all that he thought he knew about neuroscience, and then inspired his groundbreaking research that would upend the conventional wisdom about autism, expressed in his now‑famous theory of Intense World Syndrome.When Kai was first diagnosed, his father consulted studies and experts. He knew as much about the human brain as almost anyone but still felt as helpless as any parent confronted with this condition in his child. What's more, the scientific consensus that autism was a deficit of empathy didn't mesh with Markram's experience of his son. He became convinced that the disorder, which has seen a 657 per cent increase in diagnoses over the past decade, was fundamentally misunderstood. Bringing his world‑class research to bear on the problem, he devised a radical new theory of the disorder: People like Kai don't feel too little; they feel too much. Their senses are too delicate for this world.The theory of Intense World Syndrome could change the way we see autism forever, and it's thanks to Kai, the boy who changed everything.

    The interviewees, ranging from major philosophers to renowned scientists, talk candidly with Blackmore about some of the key philosophical issues confronting us in a series of conversations that are revealing, insightful, and stimulating. They ruminate on the nature of consciousness (is it something apart from the brain?) and discuss if it is even possible to understand the human mind. Some of these thinkers say no, but most believe that we will pierce the mystery surrounding consciousness, and that neuroscience will provide the key. Blackmore goes beyond the issue of consciousness to ask other intriguing questions: Is there free will? (A question which yields many conflicted replies, with most saying yes and no.) If not, how does this effect the way you live your life; and more broadly, how has your work changed the way you live?Paired with an introduction and extensive glossary that provide helpful background information, these provocative conversations illuminate how some of the greatest minds tackle some of the most difficult questions about human nature.

    They will enable you to sculpt your body while improving your flexibility and sense of well-being. The results are visible after only a few sessions.

    Our memory is unreliable; we can't multiply large sums in our heads; advertising manipulates our judgment; we tend to distrust people who are different from us; supernatural beliefs and superstitions are hard to shake; we prefer instant gratification to long-term gain; and what we presume to be rational decisions are often anything but. Drawing on striking examples and fascinating studies, neuroscientist Dean Buonomano illuminates the causes and consequences of these "bugs" in terms of the brain's innermost workings and their evolutionary purposes. He then goes one step further, examining how our brains function-and malfunction-in the digital, predator-free, information-saturated, special effects-addled world that we have built for ourselves. Along the way, Brain Bugs gives us the tools to hone our cognitive strengths while recognizing our inherent weaknesses.

    Recently, however, serious scientists from a range of fields have been uncovering evidence that our thoughts, emotions and beliefs can ease pain, heal wounds, fend off infection and heart disease and even slow the progression of AIDS and some cancers.In Cure, award-winning science writer Jo Marchant travels the world to meet the physicians, patients and researchers on the cutting edge of this new world of medicine. We learn how meditation protects against depression and dementia, how social connections increase life expectancy and how patients who feel cared for recover from surgery faster. We meet Iraq war veterans who are using a virtual arctic world to treat their burns and children whose ADHD is kept under control with half the normal dose of medication. We watch as a transplant patient uses the smell of lavender to calm his hostile immune system and an Olympic runner shaves vital seconds off his time through mind-power alone.Drawing on the very latest research, Marchant explores the vast potential of the mind's ability to heal, lays out its limitations and explains how we can make use of the findings in our own lives. With clarity and compassion, Cure points the way towards a system of medicine that treats us not simply as bodies but as human beings.

    . . on addiction.”—Ezra Klein, New York Times.“Accessible and enjoyable. The Craving Mind brilliantly combines the latest science with universal real-life experiences—from falling in love to spending too much time with our phones.”—Arianna Huffington We are all vulnerable to addiction. Whether it’s a compulsion to constantly check social media, binge eating, smoking, excessive drinking, or any other behaviors, we may find ourselves uncontrollably repeating. Why are bad habits so hard to overcome? Is there a key to conquering the cravings we know are unhealthy for us?   This book provides groundbreaking answers to the most important questions about addiction. Dr. Judson Brewer, a psychiatrist and neuroscientist who has studied the science of addictions for twenty years, reveals how we can tap into the very processes that encourage addictive behaviors in order to step out of them. He describes the mechanisms of habit and addiction formation, then explains how the practice of mindfulness can interrupt these habits. Weaving together patient stories, his own experience with mindfulness practice, and current scientific findings from his own lab and others, Dr. Brewer offers a path for moving beyond our cravings, reducing stress, and ultimately living a fuller life.