But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

    Her fierce, sometimes comic novels and stories reflected the darkly funny, vibrant, and theologically sophisticated woman who wrote them. Brad Gooch brings to life O'Connor's significant friendships -- with Robert Lowell, Elizabeth Hardwick, Walker Percy, and James Dickey among others -- and her deeply felt convictions, as expressed in her communications with Thomas Merton, Elizabeth Bishop, and Betty Hester. Hester was famously known as "A" in O'Connor's collected letters, The Habit of Being, and a large cache of correspondence to her from O'Connor was made available to scholars, including Brad Gooch, in 2006. O'Connor's capacity to live fully -- despite the chronic disease that eventually confined her to her mother's farm in Georgia -- is illuminated in this engaging and authoritative biography. Praise for Flannery: "Flannery O'Connor, one of the best American writers of short fiction, has found her ideal biographer in Brad Gooch. With elegance and fairness, Gooch deals with the sensitive areas of race and religion in O'Connor's life. He also takes us back to those heady days after the war when O'Connor studied creative writing at Iowa. There is much that is new in this book, but, more important, everything is presented in a strong, clear light."-Edmund White "This splendid biography gives us no saint or martyr but the story of a gifted and complicated woman, bent on making the best of the difficult hand fate has dealt her, whether it is with grit and humor or with an abiding desire to make palpable to readers the terrible mystery of God's grace."-Frances Kiernan, author of Seeing Mary Plain: A Life of Mary McCarthy "A good biographer is hard to find. Brad Gooch is not merely good-he is extraordinary. Blessed with the eye and ear of a novelist, he has composed the life that admirers of the fierce and hilarious Georgia genius have long been hoping for."-Joel Conarroe, President Emeritus, John Simon Guggenheim Foundation

    We see the visionary, whose desire for escape honed an innate sense of what people wanted to see on the screen and, when combined with iron determination and obsessive perfectionism, led him to the reinvention of animation. It was Disney, first with Mickey Mouse and then with his feature films - most notably Snow White, Pinocchio, Fantasia, Dumbo, and Bambi - who transformed animation from a novelty based on movement to an art form that presented an illusion of life.We see him reimagine the amusement park with Disneyland, prompting critics to coin the word Disneyfication to describe the process by which reality can be modified to fit one's personal desires. At the same time, he provided a new way to connect with American history through his live-action films and purveyed a view of the country so coherent that even today one can speak meaningfully of "Walt Disney's America." We see how the True-Life Adventure nature documentaries he produced helped create the environmental movement by sensitizing the general public to issues of conservation. And we see how he reshaped the entertainment industry by building a synergistic empire that combined film, television, theme parks, music, book publishing, and merchandise in a way that was unprecedented and was later widely imitated.Gabler also reveals a wounded, lonely, and often disappointed man, who, despite worldwide success, was plagued with financial problems much of his life, suffered a nervous breakdown, and at times retreated into pitiable seclusion in his workshop making model trains. Gabler explores accusations that Disney was a red-baiter, an anti-Semite, an embittered alcoholic. But whatever the characterizations of Disney's personal life, he appealed to the nation by demonstrating the power of wish fulfillment and the triumph of the American imagination. Walt Disney showed how one could impose one's will on the world.This is a masterly biography, a revelation of both the work and the man - of both the remarkable accomplishment and the hidden life.

    Includes a compact disc which is playable on CD-ROM and audio CD players.

    This was the first complete biography of Spinoza in any language and is based on detailed archival research. More than simply recounting the story of Spinoza's life, the book takes the reader right into the heart of Jewish Amsterdam in the seventeenth century and, with Spinoza's exile from Judaism, right into the midst of the tumultuous political, social, intellectual and religious world of the young Dutch Republic. Though the book will be an invaluable resource for philosophers, historians, and scholars of Jewish thought, it has been written for any member of the general reading public with a serious interest in philosophy, Jewish history, seventeenth-century European history, and the culture of the Dutch Golden Age. Spinoza: A Life has recently been awarded the Koret Jewish Book Award."

    Nestled in the Smoky Mountains of eastern Tennessee, the town of Johnson City had always seemed exempt from the anxieties of modern American life. But when the local hospital treated its first AIDS patient, a crisis that had once seemed an urban problem had arrived in the town to stay. Working in Johnson City was Abraham Verghese, a young Indian doctor specializing in infectious diseases. Dr. Verghese became by necessity the local AIDS expert, soon besieged by a shocking number of male and female patients whose stories came to occupy his mind, and even take over his life. Verghese brought a singular perspective to Johnson City: as a doctor unique in his abilities; as an outsider who could talk to people suspicious of local practitioners; above all, as a writer of grace and compassion who saw that what was happening in this conservative community was both a medical and a spiritual emergency."

    Scandalous affairs rage behind closed doors, broken hearts are tossed aside, fires rip through the wings of the house and paparazzi lie in wait outside the front door for the latest tragedy in this never-ending saga. This is the home of the great architect of the twentieth century, a man of extremes in both his work and his private life: at once a force of nature and an avalanche of need and emotion that sweeps aside everything in its path. Sharp, savage and subtle in equal measure, "The Women" plumbs the chaos, horrors and uncontainable passions of a formidable American icon.

    During the years Joan Anderson was a loving wife and supportive mother, she had slowly and unconsciously replaced her own dreams with the needs of her family. With her sons grown, however, she realized that the family no longer centered on the home she provided, and her relationship with her husband had become stagnant. Like many women in her situation, Joan realized that she had neglected to nurture herself and, worse, to envision fulfilling goals for her future. As her husband received a wonderful job opportunity out-of-state, it seemed that the best part of her own life was finished. Shocking both of them, she refused to follow him to his new job and decided to retreat to a family cottage on Cape Cod.At first casting about for direction, Joan soon began to take pleasure in her surroundings and call on resources she didn't realize she had. Over the course of a year, she gradually discovered that her life as an "unfinished woman" was full of possibilities. Out of that magical, difficult, transformative year came A Year by the Sea, a record of her experiences and a treasury of wisdom for readers.This year of self-discovery brought about extraordinary changes in the author's life. The steps that Joan took to revitalize herself and rediscover her potential have helped thousands of woman reveal and release untapped resources within themselves.

    She provides a rare and fascinating insight into a world that has long since vanished. Mollie left school at age fourteen and became a scullery maid for a wealthy gentleman with a mansion house in London’s Knighsbridge and a Tudor manor in Norfolk.            Even though Mollie's days were long and grueling and included endless tasks, such as polishing doorknobs, scrubbing steps, and helping with all of the food prep in the kitchen, she enjoyed her freedom and had a rich life. Like any bright-eyed teenager, Mollie also spent her days daydreaming about boys, dresses, and dances. She became fast friends with the kitchen maid Flo, dated a sweet farmhand, and became secretly involved with a brooding, temperamental footman. Molly eventually rose to kitchen maid for Lord Islington and then cook for the Earl of Leicester's niece at the magnificent Wallington Hall.

    G. Jung undertook the telling of his life story. At regular intervals he had conversations with his colleague and friend Aniela Jaffé, and collaborated with her in the preparation of the text based on these talks. On occasion, he was moved to write entire chapters of the book in his own hand, and he continued to work on the final stages of the manuscript until shortly before his death on June 6, 1961.

    This thinly fictionalized account of Claude Brown's childhood as a hardened, streetwise criminal trying to survive the toughest streets of Harlem has been heralded as the definitive account of everyday life for the first generation of African Americans raised in the Northern ghettos of the 1940s and 1950s. When the book was first published in 1965, it was praised for its realistic portrayal of Harlem -- the children, young people, hardworking parents; the hustlers, drug dealers, prostitutes, and numbers runners; the police; the violence, sex, and humor. The book continues to resonate generations later, not only because of its fierce and dignified anger, not only because the struggles of urban youth are as deeply felt today as they were in Brown's time, but also because the book is affirmative and inspiring. Here is the story about the one who "made it," the boy who kept landing on his feet and became a man.

    He was an icon of rugged individualism who had been to hell and back, telling the tale as never before. In his unforgettable autobiography, Johnny Cash tells the truth about the highs and lows, the struggles and hard-won triumphs, and the people who shaped him.In his own words, Cash set the record straight -- and dispelled a few myths -- as he looked unsparingly at his remarkable life: from the joys of his boyhood in Dyess, Arkansas to superstardom in Nashville, Tennessee, the road of Cash's life has been anything but smooth. Cash writes of the thrill of playing with Elvis, the comfort of praying with Billy Graham; of his battles with addiction and of the devotion of his wife, June; of his gratitude for life, and of his thoughts on what the afterlife may bring. Here, too, are the friends of a lifetime, including Willie Nelson, Roy Orbison, Bob Dylan, and Kris Kristofferson. As powerful and memorable as one of his classic songs, Cash is filled with the candor, wit, and wisdom of a man who truly "walked the line."

    Sexy and shrewd, she quickly went from streetwalker to madam and by 1920 had opened what became a legendary house of prostitution. There she entertained a steady stream of governors, gangsters, and movie stars until she was arrested at last in 1962. Shortly before she died in 1974, she tape—recorded her memories-the scandalous stories of a powerful woman who had the city's politicians in her pocket and whose lovers included the twenty-five-year-old boy next door, whom she married when she was sixty-four. Combining those tapes with original research, Christine Wiltz chronicles not just Norma's rise and fall but also the social history of New Orleans, thick with the vice and corruption that flourished there—and, like Midnight in the Garden of Good and Evil and Philistines at the Hedgerow, resurrects a vanished secret world.

    His Incompleteness Theorem turned not only mathematics but also the whole world of science and philosophy on its head. Equally legendary were Gö's eccentricities, his close friendship with Albert Einstein, and his paranoid fear of germs that eventually led to his death from self-starvation. Now, in the first popular biography of this strange and brilliant thinker, John Casti and Werner DePauli bring the legend to life. After describing his childhood in the Moravian capital of Brno, the authors trace the arc of Gö's remarkable career, from the famed Vienna Circle, where philosophers and scientists debated notions of truth, to the Institute for Advanced Study in Princeton, New Jersey, where he lived and worked until his death in 1978. In the process, they shed light on Gö's contributions to mathematics, philosophy, computer science, artificial intelligence -- even cosmology -- in an entertaining and accessible way.

    Rousey shares hard-won lessons on how to be the best at what you do, including how to find fulfillment in the sacrifices, how to turn limitations into opportunities, and how to be the best on your worst day.Packed with raw emotion, drama, and wisdom this is an unforgettable book by one of the most remarkable women in the world.