With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions.Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick.Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.

    In lively and impassioned prose, she breaks down three key dualisms - sex/gender, nature/nurture, and real/constructed - and asserts that individuals born as mixtures of male and female exist as one of five natural human variants and, as such, should not be forced to compromise their differences to fit a flawed societal definition of normality.

    And many are so, so tired … But women's pain is all too often dismissed, their illnesses misdiagnosed or ignored. In medicine, man is the default human being. Any deviation is atypical, abnormal, deficient.'Fourteen years after being diagnosed with endometriosis, Gabrielle Jackson couldn't believe how little had changed in the treatment and knowledge of the disease. In 2015, her personal story kick-started a worldwide investigation into the disease by The Guardian; thousands of women got in touch to tell their own stories and many more read and shared the material. What began as one issue led Jackson to explore how women - historically and through to the present day - are under-served by the systems that should keep them happy, healthy and informed about their bodies.Pain and Prejudice is a vital testament to how social taboos and medical ignorance keep women sick and in anguish. The stark reality is that women's pain is not taken as seriously as men's. Women are more likely to be disbelieved and denied treatment than men, even though women are far more likely to be suffering from chronic pain.In a potent blend of personal memoir and polemic, Jackson confronts the private concerns and questions women face regarding their health and medical treatment. Pain and Prejudice, finally, explains how we got here, and where we need to go next.

    But in the modern world, the breast is changing. Breasts are getting bigger, arriving earlier, and attracting newfangled chemicals. Increasingly, the odds are stacked against us in the struggle with breast cancer, even among men. What makes breasts so mercurial—and so vulnerable?In this informative and highly entertaining account, intrepid science reporter Florence Williams sets out to uncover the latest scientific findings from the fields of anthropology, biology, and medicine. Her investigation follows the life cycle of the breast from puberty to pregnancy to menopause, taking her from a plastic surgeon’s office where she learns about the importance of cup size in Texas to the laboratory where she discovers the presence of environmental toxins in her own breast milk. The result is a fascinating exploration of where breasts came from, where they have ended up, and what we can do to save them.

    Mythologized. Controversial.A Harvard evolutionary biologist debunks the myths and cultural stereotypes surrounding testosterone and reveals its far-reaching effects on gender and sexuality, sports, relationships, and many more aspects of our everyday lives.The biological source of virility and masculinity has inspired fascination, investigation, and controversy since antiquity. From the eunuchs in the royal courts of ancient China to the booming market for “elixirs” of youth in nineteenth-century Europe, humans have been obsessed with identifying and manipulating what we now know as testosterone. And the trends show no signs of slowing down—the modern market for testosterone supplements is booming. Thanks to this history and the methods of modern science, today we have a rich body of research about testosterone’s effects in both men and women.The science is clear: testosterone is a major, invisible player in our relationships, sex lives, athletic abilities, childhood play, gender transitions, parenting roles, violent crime, and so much more. But there is still a lot of pushback to the idea that it does, in fact, cause sex differences and significantly influence behavior.Carole Hooven argues in T that acknowledging testosterone as a potent force in society doesn’t reinforce stifling gender norms or patriarchal values. Testosterone and evolution work together to produce a huge variety of human behavior, and that includes a multitude of ways to be masculine or feminine. Understanding the science sheds light on how we work and relate to one another, how we express anger and love, and how we can fight bias and problematic behavior to build a more fair society.

    It asks what follows when we make our desires and even our own happiness conditional on the happiness of others: “I just want you to be happy”; “I’m happy if you’re happy.” Combining philosophy and feminist cultural studies, Sara Ahmed reveals the affective and moral work performed by the “happiness duty,” the expectation that we will be made happy by taking part in that which is deemed good, and that by being happy ourselves, we will make others happy. Ahmed maintains that happiness is a promise that directs us toward certain life choices and away from others. Happiness is promised to those willing to live their lives in the right way.Ahmed draws on the intellectual history of happiness, from classical accounts of ethics as the good life, through seventeenth-century writings on affect and the passions, eighteenth-century debates on virtue and education, and nineteenth-century utilitarianism. She engages with feminist, antiracist, and queer critics who have shown how happiness is used to justify social oppression, and how challenging oppression causes unhappiness. Reading novels and films including Mrs. Dalloway, The Well of Loneliness, Bend It Like Beckham, and Children of Men, Ahmed considers the plight of the figures who challenge and are challenged by the attribution of happiness to particular objects or social ideals: the feminist killjoy, the unhappy queer, the angry black woman, and the melancholic migrant. Through her readings she raises critical questions about the moral order imposed by the injunction to be happy.

    Chanda Prescod-Weinstein shares her love for physics, from the Standard Model of Particle Physics and what lies beyond it, to the physics of melanin in skin, to the latest theories of dark matter — all with a new spin informed by history, politics, and the wisdom of Star Trek.One of the leading physicists of her generation, Dr. Chanda Prescod-Weinstein is also one of fewer than one hundred Black American women to earn a PhD from a department of physics. Her vision of the cosmos is vibrant, buoyantly non-traditional, and grounded in Black feminist traditions.Prescod-Weinstein urges us to recognize how science, like most fields, is rife with racism, sexism, and other dehumanizing systems. She lays out a bold new approach to science and society that begins with the belief that we all have a fundamental right to know and love the night sky. The Disordered Cosmos dreams into existence a world that allows everyone to tap into humanity’s wealth of knowledge about the wonders of the universe.

    Just over fifteen years later, he had transformed himself into the charismatic CEO of a company worth $47 billion--at least on paper. With his long hair and feel-good mantras, the 6-foot-five Neumann, who grew up in part on a kibbutz, looked the part of a messianic Silicon Valley entrepreneur. The vision he offered was mesmerizing: a radical reimagining of work space for a new generation, with its fluid jobs and lax office culture. He called it WeWork. Though the company was merely subleasing amenity-filled office space to freelancers and small startups, Neumann marketed it like a revolutionary product--and investors swooned.As billions of funding dollars poured in, Neumann's ambitions grew limitless. WeWork wasn't just an office space provider, he boasted. It would build schools, create WeWork cities, even colonize Mars. Could he, Neumann wondered from the ice bath he'd installed in his office, become the first trillionaire or a world leader? In pursuit of its founder's grandiose vision, the company spent money faster than it could bring it in. From his private jet, sometimes clouded with marijuana smoke, the CEO scoured the globe for more capital. In late 2019, just weeks before WeWork's highly publicized IPO, a Hail Mary effort to raise cash, everything fell apart. Neumann was ousted from his company--but still was poised to walk away a billionaire.Calling to mind the recent demise of Theranos and the hubris of the dotcom era bust, WeWork's extraordinary rise and staggering implosion were fueled by disparate characters in a financial system blind to its risks, from a Japanese billionaire with designs on becoming the Warren Buffet of tech, to leaders at JPMorgan and Goldman Sachs who seemed intoxicated by a Silicon Valley culture where sensible business models lost out to youthful CEOs who promised disruption. Why did some of the biggest names in banking and venture capital buy the hype? And what does the future hold for Silicon Valley unicorns? Wall Street Journal reporters Eliot Brown and Maureen Farrell explore these questions in this definitive account of WeWork's unraveling.

    A human body draped over the limbs of a cactus. Sand scouring the naked flesh every time the wind blows.A shocking death launches Special Agent Victor Loshak on a new investigation with an ominous message: They know everything. He heads to Tucson, Arizona, where a recent murder spree seems to be linked to the human trafficking conspiracy he's been working in secret for months.Loshak still has dreams about the Kansas City case. Nightmares about the team of techs peeling up the floorboards in a suburban home. Finding the rotting bodies face down in the muddy earth of the crawlspace. A grisly discovery that ultimately led to more questions than answers.Now he may be closer than ever to solving the puzzle.If you follow the conspiracy rabbit hole all the way down, you eventually reach the bottom.The task force working the desert murders seems oblivious to the conspiracy link, and Loshak must tread lightly. He doesn't know who to trust, what information to share.The tendrils of the human trafficking ring lead in all directions outward from that Kansas City crawlspace. Their influence reaches the highest levels of government and law enforcement. They have eyes and ears everywhere.Even with the complications, the Tucson case slowly unravels the web of connections behind the crimes, both the murders and the conspiracy.Questions get answered. Names and faces are laid bare. Puzzle pieces snapping into place at long last.But the revelations bring about the gravest danger yet.

    Caroline Knapp addresses the following question: How does a woman know, and then honour, what it is she wants in a culture bent on shaping, defining and controlling women and their desires? She uses her own experiences as a powerful exploration of this issue.

    What we eat has tremendous implications not just for our waistlines, but also for the planet, society, and the global economy. What we do to our bodies, we do to the planet; and what we do to the planet, we do to our bodies.In Food Fix, #1 bestselling author Mark Hyman explains how our food and agriculture policies are corrupted by money and lobbies that drive our biggest global crises: the spread of obesity and food-related chronic disease, climate change, poverty, violence, educational achievement gaps, and more.Pairing the latest developments in nutritional and environmental science with an unflinching look at the dark realities of the global food system and the policies that make it possible, Food Fix is a hard-hitting manifesto that will change the way you think about -- and eat -- food forever, and will provide solutions for citizens, businesses, and policy makers to create a healthier world, society, and planet.

    Nicole Williams presents readers with a much-needed education on the history, science, and attitudes of the most fascinating and misunderstood part of the female anatomy: the vagina. She covers valuable information about sexual function, childbirth, and physiology and provides answers to her patients’ (and probably your) most asked questions. She matter-of-factly dispels the most common myths and misinformation concerning female genitalia, including— • No, your vagina doesn’t need steaming  • Those panty liners are unnecessary—your vagina needs to breathe • It’s actually perfectly normal for your vagina to have an odor—consider it your personal brand This book is an easy-to-understand guide, complete with illustrations, for women to explore and understand their vaginas in a way they never have before. You will learn what's normal and what's not, including that, yes, yours is most certainly normal too.This is How You Vagina is essential reading for anyone who is looking to better understand the form and function of this most majestic and fascinating organ.

    We rely on them every day of our lives. They make us who we are. And yet the truth is they are far from being the accurate record of the past we like to think they are. True, we can all admit to having suffered occasional memory lapses, such as entering a room and immediately forgetting why, or suddenly being unable to recall the name of someone we've met dozens of times. But what if our minds have the potential for more profound errors, that enable the manipulation or even outright fabrication of our memories?In The Memory Illusion, forensic psychologist and memory expert Dr Julia Shaw uses the latest research to show the astonishing variety of ways in which our brains can indeed be led astray. She shows why we can sometimes misappropriate other people's memories, subsequently believing them to be our own. She explains how police officers can imprison an innocent man for life on the basis of many denials and just one confession. She demonstrates the way radically false memories can be deliberately implanted, leading people to believe they had tea with Prince Charles, or committed crimes that never happened. And she reveals how, in spite of all this, we can improve our memory through simple awareness of its fallibility. Fascinating and unnerving in equal measure, The Memory Illusion offers a unique insight into the human brain, challenging you to question how much you can ever truly know about yourself.

    But it wasn't always this way. Seven decades ago, sweating was "unladylike" and girls grew up believing that physical exertion would cause their uterus to "fall out." Most hid their muscle under sleeves and skirts. It was only in the Sixties that, thanks to a few forward-thinking fitness pioneers, women began to move en masse. When they did, journalist Danielle Friedman argues, they were participating in something subversive: the pursuit of physical strength and personal autonomy.In Let's Get Physical, Friedman reveals the fascinating hidden history of contemporary fitness culture, chronicling in vivid, cinematic prose how exercise evolved from a beauty tool sold almost exclusively as a way to "reduce" to one millions have harnessed as a path to mental, emotional, and physical well-being.Inspired by Friedman's viral article in New York Magazine's the Cut that unearthed the little-known origins of the popular barre workout, Let's Get Physical takes us into the workout studios and onto the mats of 20th century America to reclaim these forgotten origins. Each chapter uncovers the birth of an exercise movement that laid the groundwork for working out today: the radical post-war pitch for women to break a sweat, the invention of barre in the Swinging Sixties, jogging's path to liberation in the Seventies, the explosion of aerobic dancing in the Eighties, the rise of weight-training and yoga, and the ongoing push for a more socially just fitness culture--one that is inclusive of every body.Ultimately, Let's Get Physical tells the story of how, with the rise of late 20th century feminism, women discovered the joy of physical competence--and how, by moving together to transform fitness from a privilege into a right, we can create a more powerful sisterhood.

    Animal lovers will feel connected to Murray’s almost spiritual awakening and admire his devotion to following his heart, even in the face of tremendous sacrifice. This touching memoir OVERFLOWS WITH INTENSE EMOTION."—BookLife by Publishers WeeklyIn this unforgettable must read story, Kerk Murray beautifully shares how a few incredible dogs supported him through his experiences of being bullied, battling depression, and overcoming drug abuse. Their role in his redemption inspired him to founding The Lexi's Legacy Foundation, an animal advocacy 501(c)(3) nonprofit organization, who has provided care to over five hundred abused animals to date. As a tribute to those dogs in Kerk's life, 100% of the book's proceeds will be donated toward the nonprofit's mission of ending animal suffering.From the Back CoverPawprints On Our Hearts is a soul-stirring coming-of-age memoir unpacking the journey we experience alongside the animals we love—from forging the unbreakable bonds of friendship to relishing the nostalgia of time passed too quickly. Together scaling the mountaintops of love and courageously descending into the deepest sorrows of loss. Discovering the purpose of our lives as we pause to revel in those extraordinary moments—the ones that changed us forever, leaving behind who we were so that we could arrive at who we were meant to be.You’ll laugh and cry as you reminisce, connecting once more to the joys of loving and being loved by your animal companion. More importantly, you’ll never be the same again.How could you be?Learning what it means to be human is the story of us all. But luckily, we have help along the way from these beautiful creatures who set the bar high and redefine what love ought to be.