Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

    Improper use of antibiotics. Local warfare. Massive refugee migration. Changing social and environmental conditions around the world have fostered the spread of new and potentially devastating viruses and diseases—HIV, Lassa, Ebola, and others. Laurie Garrett takes you on a fifty-year journey through the world's battles with microbes and examines the worldwide conditions that have culminated in recurrent outbreaks of newly discovered diseases, epidemics of diseases migrating to new areas, and mutated old diseases that are no longer curable. She argues that it is not too late to take action to prevent the further onslaught of viruses and microbes, and offers possible solutions for a healthier future.

    Longer training, ever more advanced technologies—neither seems to prevent grievous errors. But in a hopeful turn, acclaimed surgeon and writer Atul Gawande finds a remedy in the humblest and simplest of techniques: the checklist. First introduced decades ago by the U.S. Air Force, checklists have enabled pilots to fly aircraft of mind-boggling sophistication. Now innovative checklists are being adopted in hospitals around the world, helping doctors and nurses respond to everything from flu epidemics to avalanches. Even in the immensely complex world of surgery, a simple ninety-second variant has cut the rate of fatalities by more than a third.In riveting stories, Gawande takes us from Austria, where an emergency checklist saved a drowning victim who had spent half an hour underwater, to Michigan, where a cleanliness checklist in intensive care units virtually eliminated a type of deadly hospital infection. He explains how checklists actually work to prompt striking and immediate improvements. And he follows the checklist revolution into fields well beyond medicine, from disaster response to investment banking, skyscraper construction, and businesses of all kinds.An intellectual adventure in which lives are lost and saved and one simple idea makes a tremendous difference, The Checklist Manifesto is essential reading for anyone working to get things right.

    With this hands-on guide, you'll learn how to write effective, idiomatic Python code by leveraging its best and possibly most neglected features. Author Luciano Ramalho takes you through Python's core language features and libraries, and shows you how to make your code shorter, faster, and more readable at the same time.Many experienced programmers try to bend Python to fit patterns they learned from other languages, and never discover Python features outside of their experience. With this book, those Python programmers will thoroughly learn how to become proficient in Python 3.This book covers:Python data model: understand how special methods are the key to the consistent behavior of objectsData structures: take full advantage of built-in types, and understand the text vs bytes duality in the Unicode ageFunctions as objects: view Python functions as first-class objects, and understand how this affects popular design patternsObject-oriented idioms: build classes by learning about references, mutability, interfaces, operator overloading, and multiple inheritanceControl flow: leverage context managers, generators, coroutines, and concurrency with the concurrent.futures and asyncio packagesMetaprogramming: understand how properties, attribute descriptors, class decorators, and metaclasses work"

    Drawing heavily on the author's own real-world experiences, the book stresses design and analysis. Coverage is divided into two parts, the first being a general guide to techniques for the design and analysis of computer algorithms. The second is a reference section, which includes a catalog of the 75 most important algorithmic problems. By browsing this catalog, readers can quickly identify what the problem they have encountered is called, what is known about it, and how they should proceed if they need to solve it. This book is ideal for the working professional who uses algorithms on a daily basis and has need for a handy reference. This work can also readily be used in an upper-division course or as a student reference guide. THE ALGORITHM DESIGN MANUAL comes with a CD-ROM that contains: * a complete hypertext version of the full printed book. * the source code and URLs for all cited implementations. * over 30 hours of audio lectures on the design and analysis of algorithms are provided, all keyed to on-line lecture notes.

    And through CODE, we see how this ingenuity and our very human compulsion to communicate have driven the technological innovations of the past two centuries. Using everyday objects and familiar language systems such as Braille and Morse code, author Charles Petzold weaves an illuminating narrative for anyone who’s ever wondered about the secret inner life of computers and other smart machines. It’s a cleverly illustrated and eminently comprehensible story—and along the way, you’ll discover you’ve gained a real context for understanding today’s world of PCs, digital media, and the Internet. No matter what your level of technical savvy, CODE will charm you—and perhaps even awaken the technophile within.

    Polya, How to Solve It will show anyone in any field how to think straight. In lucid and appealing prose, Polya reveals how the mathematical method of demonstrating a proof or finding an unknown can be of help in attacking any problem that can be reasoned out--from building a bridge to winning a game of anagrams. Generations of readers have relished Polya's deft--indeed, brilliant--instructions on stripping away irrelevancies and going straight to the heart of the problem.

    Psychiatrist and psychoanalyst, Norman Doidge, M.D., traveled the country to meet both the brilliant scientists championing neuroplasticity and the people whose lives they’ve transformed - people whose mental limitations or brain damage were seen as unalterable. We see a woman born with half a brain that rewired itself to work as a whole, blind people who learn to see, learning disorders cured, IQs raised, aging brains rejuvenated, stroke patients learning to speak, children with cerebral palsy learning to move with more grace, depression and anxiety disorders successfully treated, and lifelong character traits changed. Using these marvelous stories to probe mysteries of the body, emotion, love, sex, culture, and education, Dr. Doidge has written an immensely moving, inspiring book that will permanently alter the way we look at our brains, human nature, and human potential.

    Joining the professional web designers and programmers are new audiences who need to know a little bit of code at work (update a content management system or e-commerce store) and those who want to make their personal blogs more attractive. Many books teaching HTML and CSS are dry and only written for those who want to become programmers, which is why this book takes an entirely new approach. • Introduces HTML and CSS in a way that makes them accessible to everyone—hobbyists, students, and professionals—and it’s full-color throughout • Utilizes information graphics and lifestyle photography to explain the topics in a simple way that is engaging • Boasts a unique structure that allows you to progress through the chapters from beginning to end or just dip into topics of particular interest at your leisureThis educational book is one that you will enjoy picking up, reading, then referring back to. It will make you wish other technical topics were presented in such a simple, attractive and engaging way!

    If we can understand what makes these gatherings effective and memorable, then we can reframe and redirect them to benefit everyone, host and guest alike. Parker defines a gathering as three or more people who come together for a specific purpose. When we understand why we gather, she says -- to acknowledge, to learn, to challenge, to change -- we learn how to organize gatherings that are relevant and memorable: from an effective business meeting to a thought-provoking conference; from a joyful wedding to a unifying family dinner. Drawing on her experience as a strategic facilitator who's worked with such organizations as the World Economic Forum, the Museum of Modern Art, and the retail company Fresh, Parker explains how ordinary people can create remarkable occasions, large and small. In dozens of fascinating examples, she breaks down the alchemy of these experiences to show what goes into the good ones and demonstrates how we can learn to incorporate those elements into all of our gatherings. The result is a book that's both journey and guide, full of big ideas with real-world applications that will change the way you look at a business meeting, a parent-teacher conference, and a backyard barbecue.

    Kathryn Schulz, editor of Grist magazine, argues that error is the fundamental human condition and should be celebrated as such. Guiding the reader through the history and psychology of error, from Socrates to Alan Greenspan, Being Wrong will change the way you perceive screw-ups, both of the mammoth and daily variety, forever.

    Learn You a Haskell for Great Good! introduces programmers familiar with imperative languages (such as C++, Java, or Python) to the unique aspects of functional programming. Packed with jokes, pop culture references, and the author's own hilarious artwork, Learn You a Haskell for Great Good! eases the learning curve of this complex language, and is a perfect starting point for any programmer looking to expand his or her horizons. The well-known web tutorial on which this book is based is widely regarded as the best way for beginners to learn Haskell, and receives over 30,000 unique visitors monthly.

    Joan Bolker, midwife to more than one hundred dissertations and co-founder of the Harvard Writing Center, offers invaluable suggestions for the graduate-student writer. Using positive reinforcement, she begins by reminding thesis writers that being able to devote themselves to a project that truly interests them can be a pleasurable adventure. She encourages them to pay close attention to their writing method in order to discover their individual work strategies that promote productivity; to stop feeling fearful that they may disappoint their advisors or family members; and to tailor their theses to their own writing style and personality needs. Using field-tested strategies she assists the student through the entire thesis-writing process, offering advice on choosing a topic and an advisor, on disciplining one's self to work at least fifteen minutes each day; setting short-term deadlines, on revising and defing the thesis, and on life and publication after the dissertation. Bolker makes writing the dissertation an enjoyable challenge.

    For over half a century, the MLA Handbook is the guide millions of writers have relied on.The seventh edition is a comprehensive, up-to-date guide to research and writing in the online environment. It provides an authoritative update of MLA documentation style for use in student writing, including simplified guidelines for citing works published on the Web and new recommendations for citing several kinds of works, such as digital files and graphic narratives.Every copy of the seventh edition of the MLA Handbook comes with a code for accessing the accompanying Web site. New to this edition, the Web site provides- the full text of the print volume of the MLA Handbook- over two hundred additional examples- several research-project narratives--stories, with sample papers, that illustrate the steps successful students take in researching and writing papers- searching of the entire site, including the full text of the MLA Handbook- continuous access throughout the life of the seventh edition of the MLA Handbook

    Ratey provides insight into the basic structure and chemistry of the brain, and demonstrates how its systems shape our perceptions, emotions, and behavior. By giving us a greater understanding of how the brain responds to the guidance of its user, he provides us with knowledge that can enable us to improve our lives.In A User’s Guide to the Brain, Ratey clearly and succinctly surveys what scientists now know about the brain and how we use it. He looks at the brain as a malleable organ capable of improvement and change, like any muscle, and examines the way specific motor functions might be applied to overcome neural disorders ranging from everyday shyness to autism. Drawing on examples from his practice and from everyday life, Ratey illustrates that the most important lesson we can learn about our brains is how to use them to their maximum potential.