At just two years old, Nic experienced a searing pain that signaled the awakening of a new and deadly disease, one that would hurl Nic and his family up against the limits of modern medicine. For years, through false starts and failed cures, Nic holds on to life, buoyed up by his mother’s fierce drive to get him the care he needs. But when even the world’s experts are stumped by Nic’s illness, his doctors come up with a radical, long-shot plan: a step into the unknown. The next major scientific frontier, following the completion of the Human Genome Project, was to figure out how to use our new knowledge to save lives—to bring genomic or personalized medicine into reality. It’s a quest that is undertaken by researchers around the world. But it is only when geneticist Howard Jacob hears about young Nic that the finish line finally comes into sight: It’s no longer a race to make history. It’s a race to save this boy’s life. One in a Billion is an unforgettable tale of the lives that converged to launch a medical revolution. As pioneering geneticist Mary-Claire King pronounced upon learning Nic’s story: “It was as if one had heard about Case Zero of AIDS and the cure, all at once.”

    Everything about our existence—movement and memory, imagination and reproduction, birth and, ultimately, death—is governed by our cells. They are the basis of all life in the universe, from the tiniest bacteria to the most complex animals. In the tradition of the classic Lives of a Cell, but with the benefit of the latest research, internationally acclaimed embryologist Lewis Wolpert demonstrates how human life derives from a single cell and then grows into a body, an incredibly complex society made up of billions of them. When we age, our cells cannot repair the damage they have undergone; when we get ill, it is because cells are so damaged they stop working and die. Wolpert examines the science behind topics that are much discussed but rarely understood—stem cell research, cloning, DNA, mutating cancer cells—and explains how all life evolved from just one cell. Lively and passionate, this is an accessible guide to understanding the human body and life itself. .

    The book assumes no prior knowledge, taking the student through every stage of their research project in manageable steps. Advice on planning and conducting studies, analyzing data, and writing up practical reports is given, and examples are provided, as well as advice on how to report results in conventional (APA) style. Unlike other introductory texts, there is practical guidance on qualitative research, as well as discussion of issues of bias, interpretation, and variance. Content on qualitative methods has been expanded for the fifth edition and now includes additional material on widely used methods, such as grounded theory, thematic analysis, interpretive phenomenological analysis (IPA), and discourse analysis. The book provides clear coverage of statistical procedures, and includes everything needed at an undergraduate level from nominal level tests, to multi-factorial ANOVA designs, multiple regression, and log linear analysis. In addition, the book provides detailed and illustrated SPSS textbook. Each chapter contains a self-test glossary, key terms, and exercises, ensuring that key concepts have been understood. Students are further supported. Students are further supported by an accompanying website that provides additional exercises, revision flash cards, links to further reading, and data for use with SPSS. The website will also include updated coverage of SPSS should a new version be launched. The bestselling research methods text for over a decade, Research Methods and Statistics in Psychology remains an invaluable resource for students of psychology throughout their studies.

    Filled with resources to guide your study, the Third Edition brings clarity to key concepts as it draws you into the excitement of new research in eating disorders, heart disease, diabetes, and many other topics. Written by an expert author team, this text benefits from a broad range of normal and clinical nutrition expertise from registered dietitians and researchers, meant to help you understand all the major concepts!

    Since the publication of the First Edition over thirty years ago, Div, Grad, Curl, and All That has been widely renowned for its clear and concise coverage of vector calculus, helping science and engineering students gain a thorough understanding of gradient, curl, and Laplacian operators without required knowledge of advanced mathematics.

    Dennett, whom Chet Raymo of The Boston Globe calls "one of the most provocative thinkers on the planet," focuses his unerringly logical mind on the theory of natural selection, showing how Darwin's great idea transforms and illuminates our traditional view of humanity's place in the universe. Dennett vividly describes the theory itself and then extends Darwin's vision with impeccable arguments to their often surprising conclusions, challenging the views of some of the most famous scientists of our day.

    A parable about compassion-and the absence of it-Dark Remedy is a gripping account of thalidomide's extraordinary impact on the lives of individuals and nations over half a century.

    Full of insights, arguments and philosophical perspectives, the book covers an amazing array of topics. Beginning in antiquity with Democritus, it progresses through logic and set theory, computability and complexity theory, quantum computing, cryptography, the information content of quantum states and the interpretation of quantum mechanics. There are also extended discussions about time travel, Newcomb's Paradox, the anthropic principle and the views of Roger Penrose. Aaronson's informal style makes this fascinating book accessible to readers with scientific backgrounds, as well as students and researchers working in physics, computer science, mathematics and philosophy.

    Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

    The 7th edition incorporates the latest advances in molecular diagnostics, the Human Genome Project, and much more. More than 240 dynamic illustrations and high-quality photos help you grasp complex concepts more easily. In addition to the book, you will also receive STUDENT CONSULT, enabling you to access the complete contents of the book online, anywhere you go

    Widely accepted as the authoritative text and reference on electronic circuit design, both analog and digital, this book revolutionized the teaching of electronics by emphasizing the methods actually used by circuit designers -- a combination of some basic laws, rules of thumb, and a large bag of tricks. The result is a largely nonmathematical treatment that encourages circuit intuition, brainstorming, and simplified calculations of circuit values and performance. The new Art of Electronics retains the feeling of informality and easy access that helped make the first edition so successful and popular. It is an ideal first textbook on electronics for scientists and engineers and an indispensable reference for anyone, professional or amateur, who works with electronic circuits.

    This book surveys the most important computer algorithms currently in use and provides a full treatment of data structures and algorithms for sorting, searching, graph processing, and string processing -- including fifty algorithms every programmer should know. In this edition, new Java implementations are written in an accessible modular programming style, where all of the code is exposed to the reader and ready to use.The algorithms in this book represent a body of knowledge developed over the last 50 years that has become indispensable, not just for professional programmers and computer science students but for any student with interests in science, mathematics, and engineering, not to mention students who use computation in the liberal arts.The companion web site, algs4.cs.princeton.edu contains An online synopsis Full Java implementations Test data Exercises and answers Dynamic visualizations Lecture slides Programming assignments with checklists Links to related material The MOOC related to this book is accessible via the "Online Course" link at algs4.cs.princeton.edu. The course offers more than 100 video lecture segments that are integrated with the text, extensive online assessments, and the large-scale discussion forums that have proven so valuable. Offered each fall and spring, this course regularly attracts tens of thousands of registrants.Robert Sedgewick and Kevin Wayne are developing a modern approach to disseminating knowledge that fully embraces technology, enabling people all around the world to discover new ways of learning and teaching. By integrating their textbook, online content, and MOOC, all at the state of the art, they have built a unique resource that greatly expands the breadth and depth of the educational experience.

    Polya, How to Solve It will show anyone in any field how to think straight. In lucid and appealing prose, Polya reveals how the mathematical method of demonstrating a proof or finding an unknown can be of help in attacking any problem that can be reasoned out--from building a bridge to winning a game of anagrams. Generations of readers have relished Polya's deft--indeed, brilliant--instructions on stripping away irrelevancies and going straight to the heart of the problem.

    The principal enhancement in Java 8 was the addition of functional programming constructs to Java's object-oriented roots. Java 7, 8, and 9 also introduced language features, such as the try-with-resources statement, the diamond operator for generic types, default and static methods in interfaces, the @SafeVarargs annotation, and modules. New library features include pervasive use of functional interfaces and streams, the java.time package for manipulating dates and times, and numerous minor enhancements such as convenience factory methods for collections. In this new edition of Effective Java, Bloch updates the work to take advantage of these new language and library features, and provides specific best practices for their use. Java's increased support for multiple paradigms increases the need for best-practices advice, and this book delivers. As in previous editions, each chapter consists of several "items," each presented in the form of a short, standalone essay that provides specific advice, insight into Java platform subtleties, and updated code examples. The comprehensive descriptions and explanations for each item illuminate what to do, what not to do, and why. Coverage includes:Updated techniques and best practices on classic topics, including objects, classes, methods, libraries, and generics How to avoid the traps and pitfalls of commonly misunderstood subtleties of the platform Focus on the language and its most fundamental libraries, such as java.lang and java.util

    This edition introduces Embryologic Notes and includes up-to-date new Clinical Notes, Clinical Problems, and review questions. All illustrations have been recolored, and all Surface Anatomy illustrations are now in color. Upgraded clinical imaging includes radiographs, CT scans, MRIs, and sonograms.A companion Website offers the book's fully searchable text.