The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.Janeway s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout that of the host s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.New in the Eighth EditionInnate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complement has been reworked and reconceived explaining the lectin pathway first making it easier to teach by placing it into the context of innate recognition. Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text. The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways. New references have been added throughout the text.

    Too often, overwhelmed by anatomical detail, students miss out on the functional beauty of the nervous system and its relevance to clinical practice.

    Following an introduction to neural structure and function, all the key methods and procedures of cognitive neuroscience are explained, with a view to helping students understand how they can be used to shed light on the neural basis of cognition.The second part of the book goes on to present an up-to-date overview of the latest theories and findings in all the key topics in cognitive neuroscience, including vision, attention, memory, speech and language, numeracy, executive function and social and emotional behaviour. Throughout, case studies, newspaper reports and everyday examples are used to provide an easy way in to understanding the more challenging ideas that underpin the subject.In addition each chapter includes:Summaries of key terms and points Example essay questions to aid exam preparation Recommended further reading Feature boxes exploring interesting and popular questions and their implications for the subject.Written in an engaging style by a leading researcher in the field, this book will be invaluable as a core text for undergraduate modules in cognitive neuroscience. It can also be used as a key text on courses in cognition, cognitive neuropsychology or brain and behaviour. Those embarking on research will find it an invaluable starting point and reference.We offer CD-ROM-based resources free of charge to instructors who recommend The Student's Guide to Cognitive Neuroscience by Jamie Ward. These resources include:A chapter-by-chapter, illustrated slideshow lecture course An innovative bank of multiple-choice questions, graded according to difficulty and which allow for confidence-weighted answers Comprehensive lecture planning advice tailored to different length courses.Jamie Ward has researched and taught extensively in many areas of cognitive neuroscience. He is a leading authority on the subject of synaesthesia and has contributed to a wider understanding of it in both academic and lay circles.

    Since the publication of the award-winning first edition of Evolutionary Psychology, there has been an explosion of research within the field. In this book, David M. Buss examines human behavior from an evolutionary perspective, providing students with the conceptual tools needed to study evolutionary psychology and apply them to empirical research on the human mind. This edition contains expanded coverage of cultural evolution, with a new section on culture–gene co-evolution, additional studies discussing interbreeding between modern humans and Neanderthals, expanded discussions of evolutionary hypotheses that have been empirically disconfirmed, and much more!

    The brand-new Tenth Edition covers all aspects of embryology of interest to medical students and instructors and includes clinical correlates that provide information on birth defects and other clinical entities directly related to embryologic concepts.This extensively revised edition features new full-color photographs of clinical conditions and updated embryo images/photographs created using newer technologies. It also features new online USMLE-style review questions through Connection / The Point. A new introduction chapter on development includes molecular biology. This edition's larger page size improves readability.A bound-in CD-ROM, Simbryo, presents animations of embryologic system development.

    Now, Erik Sherman, the New York Times bestselling coauthor of Mookie, profiles key players from that infamous Mets team, revealing never-before-exposed details about their lives after that championship year…as well as a look back at the magical season itself.      Darryl Strawberry, Doc Gooden, Keith Hernandez, Lenny Dykstra, Mookie Wilson, Howard Johnson, Doug Sisk, Rafael Santana, Bobby Ojeda, Wally Backman, Kevin Mitchell, Ed Hearn, Danny Heep, and the late Gary Carter were all known for their heroics on the field. For some of them—known as the “Scum Bunch”—their debauchery off the field was even more awe-inspiring. But when that golden season ended, so did their aura of invincibility. Some faced battles with addiction, some were traded, and others struggled just to keep their lives together.    Through interviews with these legendary players, Erik Sherman offers fans a new perspective on a team that will forever be remembered in sports history.INCLUDES PHOTOSFrom the Hardcover edition.

    

    About The Author: Henry Gray, F.R.S., Fellow of the royal college of Surgeons: Lecturer on anatomy at St. George?s Hospital Medical School. Table Of Contents: Descriptive and Surgical Anatomy The Articulations Muscles and Fasclae The Blood-vascular system The Lymphatics The Nervous system The Organs of special sense The Organs of Digestion The Organs of voice and respiration The urinary organs The Male Organs of Generation The Female Organs of Generation The Surgical Anatomy of Hernia Surgical Anatomy of the Perinaeum General Anatomy or Histology Embryology

    There, he fell in with a subculture of young musicians playing some of the most original and brutal music in the world. Turns out the chaos of Pearson’s bands — The Locust, Swing Kids, and Some Girls — is nothing compared to the madness of his life.An icon of the West Coast noise and punk scene, Pearson managed to arrive at adulthood by outsmarting skinheads and dodging equally threatening violence at home. Once there, the struggle continued, with Pearson getting beat up on Jerry Springer and, on more than one occasion, chased out of town by ferociously angry audiences.From the Graveyard of the Arousal Industry is the outrageously candid story of Pearson’s life. In loving, meticulous detail, Pearson gives readers the dirt behind each rivalry, riff, and lineup change.

     Surveys the conceptual problems inherent in many neuroscientific theories. Encourages neuroscientists to pay more attention to conceptual questions. Provides conceptual maps for students and researchers in cognitive neuroscience and psychology. Written by a distinguished philosopher and leading neuroscientist. Avoids the use of philosophical jargon. Constitutes an essential reference work for elucidation of concepts in cognitive neuroscience and psychology.

    It avoids overburdening the reader with topographical detail that is unnecessary for the medical student. Minimum assumptions are made of existing knowledge of the subject.'Key point' boxes for reinforcement and quick revision Glossary of important terms 'Clinical detail' boxes closely integrated with relevant neuroanatomyComplete revision and updating of text. Revision nad expansion of summary chapter, providing overview of entire subject. Clinical material updated to reflect current prevalence of neurological disease. Artwork entirely redrawn for improved clarity and closer integration with text.

    Yet, most hold em players who transition to the heads-up form, especially if they are from full ring no-limit games, do not succeed. Adjusting to the amount of aggression can be difficult since heads-up battles require you to bet and raise with many more hands than what would be considered standard at a full table. Despite this, no-limit heads-up hold em is growing rapidly, especially on the Internet. So mastering this form of poker can be invaluable for those seeking to add a winning loose-aggressive component to their game. In addition, with the increasing number of heads-up matches now available, becoming proficient in them can be highly profitable. This text, written by expert heads-up player Collin Moshman, is the first poker strategy book devoted exclusively to no-limit heads-up play. Through extensive hand examples and accompanying theory, you will learn to: 1. Master expected value, equity, value betting, and the fundamental mathematics of heads-up strategy, 2. Play and exploit each of the most common playing styles, 3. Manipulate the pot size based on your hand and your opponent, 4. Attack button limps, bluff multiple streets, and aggress in the most profitable manner, 5. Distinguish between optimal cash and tournament strategies, 6. Exploit your opponents tendencies and perceptions through metagame mastery, and 7. Maximize your heads-up profits through game theory and fundamental business concepts. So whether you are an aspiring heads-up professional, or want to be ready for the next time you re challenged to a one-on-one battle, Heads Up No-Limit Hold em provides you with the tools you need to succeed.

    It offers superior coverage of all key areas, including descriptive chemistry, MO theory, bonding, and physical inorganic chemistry. Chapter topics are presented in logical order and include: basic concepts; nuclear properties; an introduction to molecular symmetry; bonding in polyatomic molecules; structures and energetics of metallic and ionic solids; acids, bases, and ions in aqueous solution; reduction and oxidation; non-aqueous media; and hydrogen. Four special topic chapters, chosen for their currency and interest, conclude the book. For researchers seeking the latest information in the field of inorganic chemistry.

    Now in paperback, Dr Jeffrey Schwartz and Sharon Begley's groundbreaking work, The Mind and the Brain, argues exactly the opposite: that the mind has a life of its own.Dr Schwartz, a leading researcher in brain dysfunctions, and Wall Street Journal science columnist Sharon Begley demonstrate that the human mind is an independent entity that can shape and control the functioning of the physical brain. Their work has its basis in our emerging understanding of adult neuroplasticity–the brain's ability to be rewired not just in childhood, but throughout life, a trait only recently established by neuroscientists.Through decades of work treating patients with obsessive–compulsive disorder (OCD), Schwartz made an extraordinary finding: while following the therapy he developed, his patients were effecting significant and lasting changes in their own neural pathways. It was a scientific first: by actively focusing their attention away from negative behaviors and toward more positive ones, Schwartz's patients were using their minds to reshape their brains–and discovering a thrilling new dimension to the concept of neuroplasticity.The Mind and the Brain follows Schwartz as he investigates this newly discovered power, which he calls self–directed neuroplasticity or, more simply, mental force. It describes his work with noted physicist Henry Stapp and connects the concept of 'mental force' with the ancient practice of mindfulness in Buddhist tradition. And it points to potential new applications that could transform the treatment of almost every variety of neurological dysfunction, from dyslexia to stroke–and could lead to new strategies to help us harness our mental powers. Yet as wondrous as these implications are, perhaps even more important is the philosophical dimension of Schwartz's work. For the existence of mental force offers convincing scientific evidence of human free will, and thus of man's inherent capacity for moral choice.

    When Arne Cheyenne Johnson stabbed an acquaintance to death with a five-inch folding knife, Johnson presented one of the most shocking legal defenses in history: not guilty by virtue of demonic possession. As the press put it, “the Devil made me do it.”Johnson’s shocking story began months earlier, when his girlfriend’s eleven-year-old brother, David, encountered a spectral figure looming at the foot of the bed and then started showing telltale signs of demonic possession. David suddenly spoke in Latin, levitated, and suffered beatings at the hands of an invisible demon. After a team of Catholic priests failed to drive the demon out, the case was taken up by Ed and Lorraine Warren. The Warrens had fought demons across the globe, but the Connecticut Devil would be one of their greatest challenges, and perhaps their most deadly.Now includes an 8-page photo insert documenting the possession featuring images from the Glatzel family and the Ed and Lorraine Warren collection.