We’ll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.

    Countless behaviors separate us from the rest of the animal kingdom, but all of them can be traced one way or another to six traits that are unique to the human race—our big toe, our opposable thumb, our oddly shaped pharynx, and our ability to laugh, kiss, and cry. At first glance these may not seem to be connected but they are. Each marks a fork in the evolutionary road where we went one way and the rest of the animal kingdom went another. Each opens small passageways on the peculiar geography of the human heart and mind.Walter weaves together fascinating insights from complexity theory, the latest brain scanning techniques, anthropology, artificial intelligence, cognitive psychology, and robotics to explore how the smallest of changes over the past six million years – all shaped by the forces of evolution -- have enabled a primate once on the brink of extinction to evolve into a creature that would one day create all of the grand and exuberant edifices of human culture.As the story of each trait unfolds, Walter explains why our brains grew so large and complex, why we find one another sexually attractive, how toolmaking laid the mental groundwork for language, why we care about what others think, and how we became the creature that laughs and cries and falls in love. Thumbs, Toes and Tears is original, informative, and delightfully thought-provoking.

    New York Times bestselling author Roger Stone lashes out with a blistering indictment, exposing the true history and monumental hypocrisy of the Bushes. In Stone’s usual “go for the jugular” style, this is a no-holds-barred history of the Bush family, comprised of smug, entitled autocrats who both use and hide behind their famous name. They got a long-overdue taste of defeat and public humiliation when Jeb’s 2016 presidential bid went down in flames.Besides detailing the vast litany of Jeb’s misdeeds — including receiving a $4 million taxpayer bailout when his father was vice president as well as his startlingly-close alignment with supposed “enemy” Hillary Clinton — Stone travels back to Bush patriarchs Samuel and Prescott, right on through to presidents George H. W. and George W. Bush to weave an epic story of privilege, greed, corruption, drug profiteering, assassination, and lies. A new preface to this paperback edition features explosive information, including the family’s Machiavellian plan to propel Jeb’s son George Prescott Bush forward as the family’s next political contender.The Bush Crime Family will have readers asking, “Why aren’t these people in prison?”

    

    Earth, born in a nuclear explosion, is a radioactive planet; without radiation, life would not exist. And while radiation can be dangerous, it is also deeply misunderstood and often mistakenly feared. Now Robert Peter Gale, M.D,—the doctor to whom concerned governments turned in the wake of the Chernobyl and Fukushima disasters—in collaboration with medical writer Eric Lax draws on an exceptional depth of knowledge to correct myths and establish facts. Exploring what have become trigger words for anxiety—nuclear energy and nuclear weapons, uranium, plutonium, iodine-131, mammogram, X-ray, CT scan, threats to the food chain—the authors demystify the science and dangers of radiation, and examine its myriad benefits, from safely sterilizing our food to the relatively low-risk fuel alternative of nuclear energy. This is the book for all readers who have asked themselves questions such as: What kinds of radiation, and what degree of exposure, cause cancer? What aftereffects have nuclear accidents and bombs had? Does radiation increase the likelihood of birth defects? And how does radiation work? Hugely illuminating, Radiation is the definitive road map to our post-Chernobyl, post-Fukushima world.

    In 1967, Dr. D.A. Henderson became director of a worldwide campaign to eliminate this disease from the face of the earth.This spellbinding book is Dr. Henderson’s personal story of how he led the World Health Organization’s campaign to eradicate smallpox—the only disease in history to have been deliberately eliminated. Some have called this feat "the greatest scientific and humanitarian achievement of the past century."In a lively, engrossing narrative, Dr. Henderson makes it clear that the gargantuan international effort involved more than straightforward mass vaccination. He and his staff had to cope with civil wars, floods, impassable roads, and refugees as well as formidable bureaucratic and cultural obstacles, shortages of local health personnel and meager budgets. Countries across the world joined in the effort; the United States and the Soviet Union worked together through the darkest cold war days; and professionals from more than 70 nations served as WHO field staff. On October 26, 1976, the last case of smallpox occurred. The disease that annually had killed two million people or more had been vanquished–and in just over ten years.The story did not end there. Dr. Henderson recounts in vivid detail the continuing struggle over whether to destroy the remaining virus in the two laboratories still that held it. Then came the startling discovery that the Soviet Union had been experimenting with smallpox virus as a biological weapon and producing it in large quantities. The threat of its possible use by a rogue nation or a terrorist has had to be taken seriously and Dr. Henderson has been a central figure in plans for coping with it.New methods for mass smallpox vaccination were so successful that he sought to expand the program of smallpox immunization to include polio, measles, whooping cough, diphtheria, and tetanus vaccines. That program now reaches more than four out of five children in the world and is eradicating poliomyelitis.This unique book is to be treasured—a personal and true story that proves that through cooperation and perseverance the most daunting of obstacles can be overcome.

    As Andrew Meier explains in this utterly compelling account, the most recent Chechen war actually broke out on New Year's Eve in 1994 when Boris Yeltsin sent hundreds of tanks to the center of the city of Grozny in an effort to quell popular demands for independence from Russia. Six years later, Meier, braving great personal danger, traveled to the scene of one of the largest civilian massacres carried out by Russian troops, reporting on the carnage in which over 60 Chechen civiliansincluding a pregnant woman and many elderlywere brutally slaughtered in one of the war's most horrific "mop-up" operations. Days after a Chechen woman became the conflict's first female suicide bomber, Meier visited this war-torn province, encountering, among others, kidnappers, Wahhabi Islamists aligned with the Taliban, and a stream of Russian mothers arriving at the morgue to identify their fallen soldier sons. Chechnya is Meier's stunning report from a region where the death toll has already exceeded 100,000 people, and a book that attempts to comprehend what compels men to shoot children in the back.

    In Evolution Impossible, Dr. John Ashton uses discoveries in genetics, biochemistry, geology, radiometric dating, and other scientific disciplines to explain why the theory of evolution is a myth. Regardless of your level of scientific education, you will finish this book able to cite 12 reasons why evolution cannot explain the origin of life.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    Now, America finds itself cash poor, and to a great extent power follows money. In The End of Influence, renowned economic analysts Stephen S. Cohen and J. Bradford DeLong explore the grave consequences this loss will have for America's place in the world. America, Cohen and DeLong argue, will no longer be the world's hyperpower. It will no longer wield soft cultural power or dictate a monolithic foreign policy. More damaging, though, is the blow to the world's ability to innovate economically, financially, and politically. Cohen and DeLong also explore American's complicated relationship with China, the misunderstood role of sovereign wealth funds, and the return of state-led capitalism. An essential read for anyone interested in how global economics and finance interact with national policy, The End of Influence explains the far-reaching and potentially long-lasting but little-noted consequences of our great fiscal crisis.

    In this sharp essay, world-renowned philosopher Bernard-Henri Lévy interrogates the many meanings and metaphors we have assigned to the pandemic—and what they tell us about ourselves.   Drawing on the philosophical tradition from Plato and Aristotle to Lacan and Foucault, Lévy asks uncomfortable questions about reality and mythology: he rejects the idea that the virus is a warning from nature, the inevitable result of global capitalism; he troubles the heroic status of doctors, asking us to think critically about the loci of authority and power; he challenges the panicked polarization that dominates online discourse. Lucid, incisive, and always original, Lévy takes a bird’s-eye view of the most consequential historical event of our time and proposes a way to defend human society from threats to our collective future.

    They are the powerhouses of our cells, essential for the production and management of energy at cell level. Dr Sarah Myhill, together with Dr John McLaren Howard of Acumen Laboratories and Dr Norman Booth of Mansfield College Oxford, has spent many years studying the relationship between their malfunction and the commonest problem seen by GPs in the UK – fatigue. Their research findings have been published in three scientific papers in the International Journal of Clinical and Experimental Medicine, in 2009, 2012 and 2013. These studies showed that poor functioning of the mitochondria is the central problem in CFS. Patients with the worst mitochondrial function had the worst fatigue and vice versa. This is solid scientific evidence that CFS is a problem with mitochondria and has allowed the objective measurement of fatigue for the first time. With the publication of the third study, which showed that mitochondrial function tests and symptoms improved in patients who took measures to address their mitochondrial problems, Dr Myhill was ready to write this book. Here she explains the importance of healthy mitochondria, how we can measure their functioning and what we can do to keep them healthy, or restore them to health if problems arise. CFS is all in our cells, not in our minds!

    It's not likely to be advice you'll hear from anyone else. It is only about an hour to read, but the concepts will ring in your ears for years. [From the Book's Introduction] Many people have been incredibly generous to me throughout the first decade of my career. To return that good karma, I try to pay it forward… to be open and available for people who ask me for insight or advice or just have questions about where to go next. I find myself having many conversations about career decisions. Recently, many of these conversations have repeating many of the same pieces of advice. Over the years I’ve gotten enough positive feedback that publishing these thoughts seems worthwhile. After our conversations I’m often told that this advice was unique, counterintuitive, and valuable. That is a high compliment. And if more people would think the same, then I should put these thought somewhere more scalable and accessible. So, I’ve written them down here.

    Doctors and scientists at prestigious institutions were pressured to produce medical advances to compete with the perceived threats coming from the Soviet Union. In Against Their Will, authors Allen Hornblum, Judith Newman, and Gregory Dober reveal the little-known history of unethical and dangerous medical experimentation on children in the United States. Through rare interviews and the personal correspondence of renowned medical investigators, they document how children—both normal and those termed "feebleminded"—from infants to teenagers, became human research subjects in terrifying experiments. They were drafted as "volunteers" to test vaccines, doused with ringworm, subjected to electric shock, and given lobotomies. They were also fed radioactive isotopes and exposed to chemical warfare agents. This groundbreaking book shows how institutional superintendents influenced by eugenics often turned these children over to scientific researchers without a second thought. Based on years of archival work and numerous interviews with both scientific researchers and former test subjects, this is a fascinating and disturbing look at the dark underbelly of American medical history.

    But as renowned historian Elaine Tyler May reveals in America and the Pill, it was women who embraced it and created change. They used the pill to challenge the authority of doctors, pharmaceutical companies, and lawmakers. They demonstrated that the pill was about much more than family planning—it offered women control over their bodies and their lives. From little-known accounts of the early years to personal testimonies from young women today, May illuminates what the pill did and did not achieve during its half century on the market.