And if other people can laugh at your awful shit as well, then I guess you can officially call yourself a comedian.In Boston, a college student fears leaving her own room—even to use the toilet. In Pennsylvania, a meek personal assistant finally confronts a perpetually enraged gay spiritual guru. In Texas, a rookie high school teacher deals with her male student’s unusually, er, hard personal problem. Sara Benincasa has been that terrified student, that embattled employee, that confused teacher—and so much more. Her hilarious memoir chronicles her attempts to forge a wonderfully weird adulthood in the midst of her lifelong struggle with agoraphobia, depression, and unruly hair.Relatable, unpretentious, and unsentimental, Agorafabulous! celebrates eccentricity, resilience, and the power of humor to light up even the darkest corners of our lives. (There are also some sexy parts, but they’re really awkward. Like really, really awkward.)

    At the same time, he was immersed in street life. Today he is a cutting-edge neuroscientist—Columbia University's first tenured African American professor in the sciences—whose landmark, controversial research is redefining our understanding of addiction.In this provocative and eye-opening memoir, he recalls his journey of self-discovery and weaves his past and present. Hart goes beyond the hype of the antidrug movement as he examines the relationship among drugs, pleasure, choice, and motivation, both in the brain and in society. His findings shed new light on common ideas about race, poverty, and drugs, and explain why current policies are failing.Though Hart escaped neighborhoods that were dominated by entrenched poverty and the knot of problems associated with it, he has not turned his back on his roots. Determined to make a difference, he tirelessly applies his scientific research to help save real lives. But balancing his former street life with his achievements today has not been easy—a struggle he reflects on publicly for the first time.A powerful story of hope and change, of a scientist who has dedicated his life to helping others, High Price will alter the way we think about poverty, race, and addiction—and how we can effect change.

    What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world.Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure.

    Then, slowly, a mist settled deep inside the mind she once knew so well, blurring the world around her. She didn't know it then, but dementia was starting to take hold. In 2014, at age fifty-eight, she was diagnosed with young-onset Alzheimer's.Mitchell shares the heartrending story of her cognitive decline and how she has fought to stave it off. What lay ahead of her after the diagnosis was scary and unknowable, but Mitchell was determined and resourceful, and she vowed to outwit the disease for as long as she could.As Mitchell learned to embrace her new life, she began to see her condition as a gift, a chance to experience the world with fresh eyes and to find her own way to make a difference. Even now, her sunny outlook persists: She devotes her time to educating doctors, caregivers, and other people living with dementia, helping to reduce the stigma surrounding this insidious disease.Still living independently, Mitchell now uses Post-it notes and technology to remind her of her routines and has created a "memory room" where she displays photos--with labels--of her daughters, friends, and special places. It is a room where she feels calm and happy, especially on days when the mist descends.

    But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    The ensuing trial was rife with inconsistencies, false testimony and superstition. Echols was accused of, among other things, practising witchcraft and satanic rituals – a result of the “satanic panic” prevalent in the media at the time. Baldwin and Miskelley were sentenced to life in prison. Echols, deemed the ringleader, was sentenced to death. He was eighteen years old.In a shocking reversal of events, all three were suddenly released in August 2011. This is Damien Echols' story in full: from abuses by prison guards and wardens, to descriptions of inmates and deplorable living conditions, to the incredible reserves of patience, spirituality, and perseverance that kept him alive and sane for nearly two decades. Echols also writes about his complicated and painful childhood. Like Dead Man Walking, Life After Death is destined to be a classic.

    Why then was she driving through Chicago fantasizing about her own death? Why was she envisioning putting an end to the isolation and sadness that still plagued her in spite of her achievements?Enter Dr. Rosen, a therapist who calmly assures her that if she joins one of his psychotherapy groups, he can transform her life. All she has to do is show up and be honest. About everything—her eating habits, childhood, sexual history, etc. Christie is skeptical, insisting that that she is defective, beyond cure. But Dr. Rosen issues a nine-word prescription that will change everything: “You don’t need a cure, you need a witness.So begins her entry into the strange, terrifying, and ultimately life-changing world of group therapy. Christie is initially put off by Dr. Rosen’s outlandish directives, but as her defenses break down and she comes to trust Dr. Rosen and to depend on the sessions and the prescribed nightly phone calls with various group members, she begins to understand what it means to connect.Group is a deliciously addictive read, and with Christie as our guide—skeptical of her own capacity for connection and intimacy, but hopeful in spite of herself—we are given a front row seat to the daring, exhilarating, painful, and hilarious journey that is group therapy—an under-explored process that breaks you down, and then reassembles you so that all the pieces finally fit.

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    The emotional, incredible true story of Neil White, a man who discovers the secret to happiness, leading a fulfilling life, and the importance of fatherhood in the most unlikely of places—the last leper colony in the continental United States.

    A self-assured adman and former all-American lacrosse player (now part-time coach), he shines brightly, and his daughter appears content to live in his reflected glory.Kelly considers herself lucky for this great touchstone in her life, and her dad's can-do spirit becomes her greatest asset when she's diagnosed with breast cancer as a young mother. It is her dad's pluck and resolve that will see her through the oncoming battles -- including the realization that her "cure" will mean the end of her ability to bear children and her dream of having a large family of her own.Though Kelly writes of her husband and daughters, her mother and her brothers, it is her father's love that sustains her. And so, readers fear for her when she reveals that George has been diagnosed with cancer, too. It is at this nadir, facing not only her own mortality but her father's as well, that Kelly finally begins to emerge as a survivor -- a wife, a mother, and more herself. Yet, she will always be her father's daughter.(Spring 2008 Selection)

    It also makes him enormously vulnerable. Eli lacks the innate skepticism that will help his peers navigate adolescence more safely—and vastly more successfully. Journalist Jennifer Latson follows Eli over three critical years of his life as his mother, Gayle, must decide whether to shield Eli entirely from the world and its dangers or give him the freedom to find his own way and become his own person. By intertwining Eli and Gayle’s story with the science and history of Williams syndrome, the book explores the genetic basis of behavior and the quirks of human nature. More than a case study of a rare disorder, however, The Boy Who Loved Too Much is a universal tale about the joys and struggles of raising a child, of growing up, and of being different.

    In this hilarious, high-spirited, sometimes harrowing memoir, Shapiro invites us into his battle with cancer, his romance with an oncology nurse, his journey through graduate school, and his most important life lessons. He tells his story with wit and grace and indomitable spirit, showing us that only when the rhythm of life is stirred violently are able to discover its full beauty.

    Her journey there began when, overwhelmed by anxiety as she completed her doctoral studies in London, England, she found relief by dosing herself with alcohol and tranquillizers. She then embarked on what would turn out to be a decades- long psychoanalysis.The analysis dredged up acutely painful memories of an unhappy and confusing childhood back in Saskatoon. As Taylor struggled to cope with these, she would twice be re-admitted to Friern. She took refuge in day-care institutions and a psychiatric hostel, all the while continuing her therapy, which eventually put her on the road to recovery.This searingly honest, beautifully written memoir is the narrative of the author’s madness years, set inside the wider story of our treatment of psychiatric illness: from the great age of asylums to the current era of community care, ‘Big Pharma’, and quick fixes. It is a meditation on her own experience as well as that of millions of others – both in Europe and in North America – who have suffered, are suffering, and will suffer from mental illness.

    But she knew her man: a famously thoughtful and broad-minded player, he was intrigued by her pitch that she wasn't interested in making money so much as learning about life. She had faced a stretch of personal bad luck, and her reflections on the role of chance had led her to a giant of game theory, who pointed her to poker as the ultimate master class in learning to distinguish between what can be controlled and what can't. And she certainly brought something to the table, including a Ph.D. in psychology and an acclaimed and growing body of work on human behavior and how to hack it. So Seidel was in, and soon she was down the rabbit hole with him, into the wild, fiercely competitive, overwhelmingly masculine world of high-stakes Texas Hold'em, their initial end point the following year's World Series of Poker.But then something extraordinary happened. Under Seidel's guidance, Konnikova did have many epiphanies about life that derived from her new pursuit, including how to better read, not just her opponents but far more importantly herself; how to identify what tilted her into an emotional state that got in the way of good decisions; and how to get to a place where she could accept luck for what it was, and what it wasn't. But she also began to win. And win. In a little over a year, she began making earnest money from tournaments, ultimately totaling hundreds of thousands of dollars. She won a major title, got a sponsor, and got used to being on television, and to headlines like How one writer's book deal turned her into a professional poker player. She even learned to like Las Vegas.But in the end, Maria Konnikova is a writer and student of human behavior, and ultimately the point was to render her incredible journey into a container for its invaluable lessons. The biggest bluff of all, she learned, is that skill is enough. Bad cards will come our way, but keeping our focus on how we play them and not on the outcome will keep us moving through many a dark patch, until the luck once again breaks our way.

    The result is a book so relentlessly funny and frank, it's totally refreshing.