Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    This was life—but whose?  In his most mind-bending book yet, Ball makes that disconcerting question the focus of a tour through what scientists can now do in cell biology and tissue culture. He shows how these technologies could lead to tailor-made replacement organs for when ours fail, to new medical advances for repairing damage and assisting conception, and to new ways of “growing a human.” For example, it might prove possible to turn skin cells not into neurons but into eggs and sperm, or even to turn oneself into the constituent cells of embryos. Such methods would also create new options for gene editing, with all the attendant moral dilemmas. Ball argues that such advances can therefore never be about “just the science,” because they come already surrounded by a host of social narratives, preconceptions, and prejudices. But beyond even that, these developments raise questions about identity and self, birth and death, and force us to ask how mutable the human body really is—and what forms it might take in years to come.

    

    Weaving together anecdotal narratives and preliminary research on the use of small amounts of psychedelics, Microdosing Psychedelics is oriented toward anyone interested in microdosing to improve their general well-being, particularly those in leadership and creative positions. Over the last few years, microdosing has entered the cultural zeitgeist. From bio-hackers in Silicon Valley seeking to improve their focus, to writers and artists looking for a creative edge, to suburban moms struggling with depression, to everyday people who want to achieve emotional balance, microdosing has led the way in mainstreaming and normalizing psychedelics. In the most comprehensive book of its kind, author, public speaker, and microdosing expert Paul Austin provides a thorough overview of how just about anyone can benefit from an intentional, structured microdosing protocol. In Microdosing Psychedelics, Austin provides readers with everything they need to know about microdosing, including: • What exactly is microdosing and how did it become a “thing?” • How to set up a weekly schedule if you want to experiment with microdosing • Three ways microdosing can benefit your professional career • The safest and easiest ways to obtain psychedelics if you wish to experiment with microdosing

    Becoming Ageless presents a three-month, detailed diet and exercise plan to create a leaner, more muscular and happier you. Developed by business mogul and fitness buff Strauss Zelnick--founder of the private equity firm Zelnick Media Capital and president and CEO of Take-Two Interactive, the company behind blockbuster video games such as Grand Theft Auto and NBA2K-- the strategies contained in Becoming Ageless are the same tactics that allowed Zelnick to evolve from a skinny, out-of-shape business executive (a workaholic wunderkind who headed the film studio 20th Century Fox in his early 30s) to one of the world's fittest and most physically active executives who reached his best-ever shape in his late 50s! "If you believe my fitness buddies," Zelnick writes, "I have a body that's aging in reverse...And Becoming Ageless is filled with the amazing tips and unique principles you'd find if you trained with me."

    Whether the ailment is a cold, the flu, diabetes, obesity or certain cancers, the likely cause is germs. Our ancient enemies have four families - bacteria, viruses, fungi, and protozoa - and many names: Ebola, E. coli, salmonella, norovirus, gonorrhea. . . Human beings are engaged in a "war on germs," in which we develop ever-more sophisticated weapons and defensive strategies. But it is a war we can never win. Our best plan for staying as healthy is to choose our battles carefully, and try to co-exist with germs as best we can. The Germ Code is a wise, witty and wonderfully readable guide to our relationship with these infinitesimal but infinitely powerful creatures. Microbiologist Jason Tetro takes us outside the lab and shows the enormous influence of germs upon humanity's past, present and future. He unlocks the mysteries of "the germ code" to reveal how these organisms have exploited our every activity and colonized every corner of the earth. From his own research and personal experience, Tetro relates how the most recent flu pandemic happened, how others may have been averted and how more may come about if we aren't careful. He also explains that not every germ is our foe, and offers advice on harnessing the power of good germs to stay healthy and make our planet a better place. The Germ Code is a fascinating journey through an unseen world, an essential manual to living in harmony with germs and a life-enhancing (as well as life-saving!) good read.

    Si todos debemos movernos para sobrevivir, vale la pena preguntarse: ¿qué factores de nuestro entorno nos impulsan a movernos y cuáles, por el contrario, nos detienen? ¿Por qué algunas personas tienen la oportunidad de moverse hacia donde quieren y otras no? ¿Por qué ciertas sociedades evolucionan y otras no? Para responder a estas interrogantes, los autores del libro estudiaron los códigos culturales y el comportamiento Bio-Lógico de 71 países para desarrollar un índice de que permite medir la movilidad social dentro de estas sociedades.Andrés Roemer y Clotaire Rapaille señalan que las culturas más exitosas son aquellas que han sabido preservar los mejores aspectos de su tradición, al mismo tiempo que han estado dispuestas a innovar y buscar nuevos horizontes. Se trata de sociedades abiertas al cambio y sin temor al statu quo. Otra clave del éxito evolutivo de las sociedades es el equilibrio entre el aspecto biológico (determinado por cuatro factores: supervivencia, sexo, seguridad y superación) y el aspecto cultural. El reto, concluyen los autores, es aprender a armonizar nuestros instintos (nuestro cerebro reptiliano) con nuestras emociones (nuestro cerebro límbico) y nuestra lógica (el neocórtex).ENGLISH DESCRIPTION If we all know we must move to survive, shouldn’t we ask ourselves which factors in our environment propel us and which halt us? Why do certain societies evolve while others don’t? In this book, Andrés Roemer and Clotaire Rapaille point out that the most successful cultures are those that are not afraid of the status quo: they have learned to preserve the best qualities of their traditions while being open to innovation and to uncovering new horizons. Another key to the success of these societies is the equilibrium between biological and the cultural aspects. The challenge is to harmonize our instincts, our emotions, and our logic.

    of Maryland School of Medicine), offers case histories of the health problems of a dozen long-dead famous figures diagnosed from modern medical perspectives. Illustrations depict patients including the odd-looking Pharaoh Akhenaten, C

    She introduces you to an African gray parrot named Alex, a bonobo named Kanzi, and a border collie named Betsy. Each of these animals tells us something interesting about the way they perceive and manipulate their world. The article also looks at what scientists are learning about the intelligence of dolphins and crows, beyond mere communication.   In “Almost Human,” Mary Roach takes us to the savannahs of Senegal to meet a group of 34 chimpanzees, whose behavior and social structures have given scientists some important clues about the nature of their communication and intelligence.   In “The Genius of Swarms,” Peter Miller looks at the collective behavior of ants, bees, and other insects for what they can tell us about social organization and how sometimes intelligence lies outside of the individual brain. This article served as the basis for his book, The Smart Swarm: How Understanding Flocks, Schools, and Colonies Can Make Us Better at Communicating, Decision Making, and Getting Things Done.

    Is luck a cosmic force that we can randomly stumble upon, or is there something real that people we consider lucky have discovered? The Science of Being Lucky is an in-depth look at what all lucky people have in common and how they set themselves up for success time after time.Put success into your own hands, not fate's.The Science of Being Lucky takes you on a science-based journey into what luck is, what we think it is, and how to get more of it in your life. The journey begins by breaking down and defining the lucky breaks, coincidences, and serendipitous events in our lives - then delves into the specific traits, life factors, and perspectives that create lucky outcomes.The Science of Being Lucky will open your eyes to what is behind each moment you would call lucky and give you a concrete action plan to create more of the same. Luck doesn't have to be just fantasy.Become immune to bad luck.Peter Hollins has studied psychology and peak human performance for over a dozen years and is a bestselling author. He has worked with dozens of individuals to unlock their potential and path towards success. His writing draws on his academic, coaching, and research experience. He's no stranger to bad luck, having broken the same toe three times, but he's found ways to reverse his luck and live the good life.Ditch the lucky underwear and rabbit's foot.-The human illusion of control and lucky thinking.-Popular methods for luck - do they work? (One does, one does not)-The downside of probabilities.-Avoiding bad luck internally and externally.Set yourself up for inevitable success.-Coincidence, serendipity, and other "small world" phenomenon.-Three traits that practically manufacture luck.-Max Gunther's famous "strategic luck planning" approach to life.Stack the deck in your favor and live better.The Science of Being Lucky will teach you how to turn lead into gold, a cloudy day into paradise, and your life into the stuff of movies.You will learn to create the conditions for luck and success instead of hoping for them. The more you internalize these mindsets, the luckier you'll get until your friends ask you what your secret is. The secret? It's not actually about luck."Break a leg" TODAY by scrolling up and clicking the BUY NOW button!

    In other words, by all of us."--Dr. Bernie Siegel, author of Love, Medicine and MiraclesRule One for the neurologist in residence: "You ain't never the same when the air hits your brain." In this fascinating book, Dr. Frank Vertosick brings that fact to life through intimate portraits of patients and unsparing yet gripping descriptions of brain surgery.With insight, humor, and poignancy, Dr. Vertosick chronicles his remarkable evolution from naive young intern to world-class neurosurgeon, where he faced, among other challenges, a six week-old infant with a tumor in her brain, a young man struck down in his prime by paraplegia, and a minister with a .22 caliber bullet lodged in his skull. In candid detail, WHEN THE AIR HITS YOUR BRAIN illuminates both the mysteries of the mind and the realities of the operating room."Riveting."--Publishers Weekly

     Early studies of the functions of the human brain used a simple method: wait for misfortune to strike-strokes, seizures, infectious diseases, lobotomies, horrendous accidents-and see how the victim coped. In many cases survival was miraculous, and observers could only marvel at the transformations that took place afterward, altering victims' personalities. An injury to one section can leave a person unable to recognize loved ones; some brain trauma can even make you a pathological gambler, pedophile, or liar. But a few scientists realized that these injuries were an opportunity for studying brain function at its extremes. With lucid explanations and incisive wit, Sam Kean explains the brain's secret passageways while recounting forgotten stories of common people whose struggles, resiliency, and deep humanity made modern neuroscience possible.

    Guyton & Hall's Textbook of Medical Physiology covers all of the major systems in the human body, while emphasizing system interaction, homeostasis, and pathophysiology. This very readable, easy-to-follow, and thoroughly updated, 11th Edition features a new full-color layout, short chapters, clinical vignettes, and shaded summary tables that allow for easy comprehension of the material.The smart way to study!Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.Presents short, easy-to-read chapters in keeping with the Guyton and Hall tradition.Provides shaded summary tables for easy reference.Includes clinical vignettes, which allow readers to see core concepts applied to real-life situations.Offers specific discussions of pathophysiology in most clinical areas of medicine.Ensures a strong grasp of physiology concepts through well-illustrated discussions of the most essential principles.Now in full color! Offers access to the full text and other valuable features online via the STUDENT CONSULT website.Uses full-color illustrations throughout, including 486 figures, 277 charts and graphs, 100 brand-new line drawings, and 36 ECGs.Features a new full-color design that makes information more engaging and even easier to read.Updated throughout to reflect the latest knowledge in the field.

    A who's who of pathology experts delivers the most dependable, current, and complete coverage of today's essential pathology knowledge. At the same time, masterful editing and a practical organization make mastering every concept remarkably easy. Online access via Student Consult includes self-assessment and review questions, interactive case studies, downloadable images, videos, and a virtual microscope that lets you view slides at different magnifications. The result remains the ideal source for an optimal understanding of pathology. Offers the most authoritative and comprehensive, yet readable coverage available in any pathology textbook, making it ideal for USMLE or specialty board preparation as well as for course work. Includes access to the complete contents online via Student Consult, along with self-assessment and review questions, over 100 interactive clinical case studies, videos, and a virtual microscope that lets users view slides at different magnifications.Delivers a state-of-the-art understanding of the pathologic basis of disease through completely updated coverage, including the latest cellular and molecular biology.Demonstrates every concept visually with over 1,600 full-color photomicrographs and conceptual diagrams - many revised for even better quality.Facilitates learning with an outstanding full-color, highly user-friendly design.

    These are only some of the claims made for neurofeedback, a controversial but effective treatment that is revolutionizing the way an incredibly diverse range of medical and psychological conditions are treated. In A Symphony in the Brain, Jim Robbins traces the fascinating, untold story of the development of neurofeedback, from its discovery by a small corps of research psychologists, to its growing application across the country and around the world, to present battles for acceptance in the conservative medical world. Offering a wealth of powerful case studies, accessible scientific explanations, and dramatic personal accounts, Robbins journeys through a remarkable field, which he brings to the public eye for the first time.