Yet there’s a black hole at the heart of biology. We do not know why complex life is the way it is, or, for that matter, how life first began. In The Vital Question, award-winning author and biochemist Nick Lane radically reframes evolutionary history, putting forward a solution to conundrums that have puzzled generations of scientists.For two and a half billion years, from the very origins of life, single-celled organisms such as bacteria evolved without changing their basic form. Then, on just one occasion in four billion years, they made the jump to complexity. All complex life, from mushrooms to man, shares puzzling features, such as sex, which are unknown in bacteria. How and why did this radical transformation happen?The answer, Lane argues, lies in energy: all life on Earth lives off a voltage with the strength of a lightning bolt. Building on the pillars of evolutionary theory, Lane’s hypothesis draws on cutting-edge research into the link between energy and cell biology, in order to deliver a compelling account of evolution from the very origins of life to the emergence of multicellular organisms, while offering deep insights into our own lives and deaths.Both rigorous and enchanting, The Vital Question provides a solution to life’s vital question: why are we as we are, and indeed, why are we here at all?

    But molecules, such as water and sugar, are not alive. So how do our cells--assemblies of otherwise "dead" molecules--come to life, and together constitute a living being? In "Life's Ratchet," physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale. The complex molecules of our cells can rightfully be called "molecular machines," or "nanobots"; these machines, unlike any other, work autonomously to create order out of chaos. Tiny electrical motors turn electrical voltage into motion, tiny factories custom-build other molecular machines, and mechanical machines twist, untwist, separate and package strands of DNA. The cell is like a city--an unfathomable, complex collection of molecular worker bees working together to create something greater than themselves. Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. We are essentially giant assemblies of interacting nanoscale machines; machines more amazing than can be found in any science fiction novel. Incredibly, the molecular machines in our cells function without a mysterious "life force," nor do they violate any natural laws. Scientists can now prove that life is not supernatural, and that it can be fully understood in the context of science. Part history, part cutting-edge science, part philosophy, "Life's Ratchet" takes us from ancient Greece to the laboratories of modern nanotechnology to tell the story of our quest for the machinery of life.

    New findings in molecular biology challenge the gene-centered version of Darwinian theory according to which adaptation occurs only through natural selection of chance DNA variations. In Evolution in Four Dimensions, Eva Jablonka and Marion Lamb argue that there is more to heredity than genes. They trace four dimensions in evolution -- four inheritance systems that play a role in evolution: genetic, epigenetic (or non-DNA cellular transmission of traits), behavioral, and symbolic (transmission through language and other forms of symbolic communication). These systems, they argue, can all provide variations on which natural selection can act. Evolution in Four Dimensions offers a richer, more complex view of evolution than the gene-based, one-dimensional view held by many today. The new synthesis advanced by Jablonka and Lamb makes clear that induced and acquired changes also play a role in evolution. After discussing each of the four inheritance systems in detail, Jablonka and Lamb put Humpty Dumpty together again by showing how all of these systems interact. They consider how each may have originated and guided evolutionary history and they discuss the social and philosophical implications of the four-dimensional view of evolution. Each chapter ends with a dialogue in which the authors engage the contrarieties of the fictional (and skeptical) I.M., or Ifcha Mistabra -- Aramaic for the opposite conjecture -- refining their arguments against I.M.'s vigorous counterarguments. The lucid and accessible text is accompanied by artist-physician Anna Zeligowski's lively drawings, which humorously and effectively illustrate the authors' points.

    Dennett, whom Chet Raymo of The Boston Globe calls "one of the most provocative thinkers on the planet," focuses his unerringly logical mind on the theory of natural selection, showing how Darwin's great idea transforms and illuminates our traditional view of humanity's place in the universe. Dennett vividly describes the theory itself and then extends Darwin's vision with impeccable arguments to their often surprising conclusions, challenging the views of some of the most famous scientists of our day.

    Evo Devo Evolutionary Developmental Biology is the new science that has finally cracked open the box. Within the pages of his rich and riveting book, Sean B. Carroll explains how we are discovering that complex life is ironically much simpler than anyone ever expected.

    . . . Anyone with the slightest interest in biology should read this book."--The New York Times Book Review"A marvelous museum of the past four billion years on earth--capacious, jammed with treasures, full of learning and wide-eyed wonder."--The Boston GlobeFrom its origins on the still-forming planet to the recent emergence of Homo sapiens--one of the world's leading paleontologists offers an absorbing account of how and why life on earth developed as it did. Interlacing the tale of his own adventures in the field with vivid descriptions of creatures who emerged and disappeared in the long march of geologic time, Richard Fortey sheds light upon a fascinating array of evolutionary wonders, mysteries, and debates. Brimming with wit, literary style, and the joy of discovery, this is an indispensable book that will delight the general reader and the scientist alike."A drama bolder and more sweeping than Gone with the Wind . . . a pleasure to read."--Science"A beautifully written and structured work . . . packed with lucid expositions of science."--Natural History

    The book was based on a course of public lectures delivered by Schrödinger in February 1943 at Trinity College, Dublin. Schrödinger's lecture focused on one important question: "how can the events in space and time which take place within the spatial boundary of a living organism be accounted for by physics and chemistry?" In the book, Schrödinger introduced the idea of an "aperiodic crystal" that contained genetic information in its configuration of covalent chemical bonds. In the 1950s, this idea stimulated enthusiasm for discovering the genetic molecule and would give both Francis Crick and James Watson initial inspiration in their research.

    Now, faced with the threat of nuclear weapons and the effects of climate change, it seems our innate tendencies for violence and invention have led us to a crucial fork in our road. Where did these traits come from? Are they part of our species immutable destiny? Or is there hope for our species’ future if we change? With fascinating facts and his unparalleled readability, Diamond intended his book to improve the world that today’s young people will inherit. Triangle Square’s The Third Chimpanzee for Young People is a book for future generation and the future they’ll help build.

    So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of 'systems chemistry' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged.

    Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out.Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.

    The "Theory of Everything" that appears to be emerging includes everything but us: the feelings, meanings, consciousness, and purposes that make us (and many of our animal cousins) what we are. These most immediate and incontrovertible phenomena are left unexplained by the natural sciences because they lack the physical properties—such as mass, momentum, charge, and location—that are assumed to be necessary for something to have physical consequences in the world. This is an unacceptable omission. We need a "theory of everything" that does not leave it absurd that we exist.Incomplete Nature begins by accepting what other theories try to deny: that, although mental contents do indeed lack these material-energetic properties, they are still entirely products of physical processes and have an unprecedented kind of causal power that is unlike anything that physics and chemistry alone have so far explained. Paradoxically, it is the intrinsic incompleteness of these semiotic and teleological phenomena that is the source of their unique form of physical influence in the world. Incomplete Nature meticulously traces the emergence of this special causal capacity from simple thermodynamics to self-organizing dynamics to living and mental dynamics, and it demonstrates how specific absences (or constraints) play the critical causal role in the organization of physical processes that generate these properties.The book's radically challenging conclusion is that we are made of these specific absenses—such stuff as dreams are made on—and that what is not immediately present can be as physically potent as that which is. It offers a figure/background shift that shows how even meanings and values can be understood as legitimate components of the physical world.

    The Panda's Thumb will introduce a new generation of readers to this unique writer, who has taken the art of the scientific essay to new heights.Were dinosaurs really dumber than lizards? Why, after all, are roughly the same number of men and women born into the world? What led the famous Dr. Down to his theory of mongolism, and its racist residue? What do the panda's magical "thumb" and the sea turtle's perilous migration tell us about imperfections that prove the evolutionary rule? The wonders and mysteries of evolutionary biology are elegantly explored in these and other essays by the celebrated natural history writer Stephen Jay Gould.

    The stewards of Earth, these organisms transformed the chemistry of our planet to make it habitable for plants, animals, and us. Life's Engines takes readers deep into the microscopic world to explore how these marvelous creatures made life on Earth possible--and how human life today would cease to exist without them.Paul Falkowski looks "under the hood" of microbes to find the engines of life, the actual working parts that do the biochemical heavy lifting for every living organism on Earth. With insight and humor, he explains how these miniature engines are built--and how they have been appropriated by and assembled like Lego sets within every creature that walks, swims, or flies. Falkowski shows how evolution works to maintain this core machinery of life, and how we and other animals are veritable conglomerations of microbes.A vibrantly entertaining book about the microbes that support our very existence, Life's Engines will inspire wonder about these elegantly complex nanomachines that have driven life since its origin. It also issues a timely warning about the dangers of tinkering with that machinery to make it more "efficient" at meeting the ever-growing demands of humans in the coming century.

    Why do living things and physical phenomena take the forms they do? Analyzing the mathematical and physical aspects of biological processes, this historic work, first published in 1917, has become renowned as well for the poetry of is descriptions.

    Shubin describes how over the last half-century, scientists have been able to explore how genetic recipes build bodies during embryological development--how these inventions and adaptations occur in a nonprogressive manner in different contexts, at different speeds. Paleontology has been transformed over the last 50 years by tools and techniques of molecular biology--and it is that revolution in our understanding of the evolution of life that Shubin traces here. Each of us is a mosaic of precursors that came about at different times and places, with deep rooted connections across species that Darwin, for all he understood, could never even have imagined.