Serotonin is the "contentment" neurotransmitter that tells our brains we don't need any more; yet its deficiency leads to depression. Ideally, both are in optimal supply. Yet dopamine evolved to overwhelm serotonin--because our ancestors were more likely to survive if they were constantly motivated--with the result that constant desire can chemically destroy our ability to feel happiness, while sending us down the slippery slope to addiction. In the last forty years, government legislation and subsidies have promoted ever-available temptation (sugar, drugs, social media, porn) combined with constant stress (work, home, money, Internet), with the end result of an unprecedented epidemic of addiction, anxiety, depression, and chronic disease. And with the advent of neuromarketing, corporate America has successfully imprisoned us in an endless loop of desire and consumption from which there is no obvious escape.With his customary wit and incisiveness, Lustig not only reveals the science that drives these states of mind, he points his finger directly at the corporations that helped create this mess, and the government actors who facilitated it, and he offers solutions we can all use in the pursuit of happiness, even in the face of overwhelming opposition. Always fearless and provocative, Lustig marshals a call to action, with seminal implications for our health, our well-being, and our culture.

    Understand how to use groundbreaking science to improve your health, mood, and more.In just the last few years, scientists have shown how the microscopic ecosystem within our bodies—particularly within our intestines—has an astonishing impact on our lives. Pioneering scientist Rob Knight and award-winning science journalist Brendan Buhler explain—with humor and witty metaphors—why these new findings matters to everyone.You are mostly not you. The human gut is host to trillions of microbes, and evidence shows that small changes in these microbes present (altered by antibiotics, diet, geographic region, and so on) may affect weight, likelihood of disease, and even psychological factors like risk-taking behavior. The evidence for their influence is astonishing. Rob Knight is one of the key figures driving forward this new science. His work demonstrates the startling connection between the presence of certain harmless bacteria and the health benefits we all seek for ourselves and our children.In Follow Your Gut, Knight pairs with Brendan Buhler, an award-winning science writer, to explore the previously unseen world inside our bodies. With a practical eye toward deeper knowledge and better decisions, they lead a detailed tour of our microbiome as well as an exploration of the known effects of antibiotics, probiotics, diet choices, birth method, and access to livestock on our children's lifelong health. Ultimately, this pioneering book explains how to learn about your own micro biome and take steps toward understanding and improving your health, using the latest research as a guide.

    In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America -- heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more -- and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives.The simple truth is that most doctors are good at treating acute illnesses but bad at preventing chronic disease. The fifteen leading causes of death claim the lives of 1.6 million Americans annually. This doesn't have to be the case. By following Dr. Greger's advice, all of it backed up by strong scientific evidence, you will learn which foods to eat and which lifestyle changes to make to live longer.History of prostate cancer in your family? Put down that glass of milk and add flaxseed to your diet whenever you can. Have high blood pressure? Hibiscus tea can work better than a leading hypertensive drug-and without the side effects. Fighting off liver disease? Drinking coffee can reduce liver inflammation. Battling breast cancer? Consuming soy is associated with prolonged survival. Worried about heart disease (the number 1 killer in the United States)? Switch to a whole-food, plant-based diet, which has been repeatedly shown not just to prevent the disease but often stop it in its tracks.In addition to showing what to eat to help treat the top fifteen causes of death, How Not to Die includes Dr. Greger's Daily Dozen -- a checklist of the twelve foods we should consume every day. Full of practical, actionable advice and surprising, cutting edge nutritional science, these doctor's orders are just what we need to live longer, healthier lives.

    Longer training, ever more advanced technologies—neither seems to prevent grievous errors. But in a hopeful turn, acclaimed surgeon and writer Atul Gawande finds a remedy in the humblest and simplest of techniques: the checklist. First introduced decades ago by the U.S. Air Force, checklists have enabled pilots to fly aircraft of mind-boggling sophistication. Now innovative checklists are being adopted in hospitals around the world, helping doctors and nurses respond to everything from flu epidemics to avalanches. Even in the immensely complex world of surgery, a simple ninety-second variant has cut the rate of fatalities by more than a third.In riveting stories, Gawande takes us from Austria, where an emergency checklist saved a drowning victim who had spent half an hour underwater, to Michigan, where a cleanliness checklist in intensive care units virtually eliminated a type of deadly hospital infection. He explains how checklists actually work to prompt striking and immediate improvements. And he follows the checklist revolution into fields well beyond medicine, from disaster response to investment banking, skyscraper construction, and businesses of all kinds.An intellectual adventure in which lives are lost and saved and one simple idea makes a tremendous difference, The Checklist Manifesto is essential reading for anyone working to get things right.

    From the world’s most painful hornet, to the flies that transmit deadly diseases, to millipedes that stop traffic, to the “bookworms” that devour libraries, to the Japanese beetles munching on your roses, Wicked Bugs delves into the extraordinary powers of many-legged creatures. With wit, style, and exacting research, Stewart has uncovered the most terrifying and titillating stories of bugs gone wild. It’s an A to Z of insect enemies, interspersed with sections that explore bugs with kinky sex lives (“She’s Just Not That Into You”), creatures lurking in the cupboard (“Fear No Weevil”), insects eating your tomatoes (“Gardener’s Dirty Dozen”), and phobias that feed our (sometimes) irrational responses to bugs (“Have No Fear”). Intricate and strangely beautiful etchings and drawings by Briony Morrow-Cribbs capture diabolical bugs of all shapes and sizes in this mixture of history, science, murder, and intrigue that begins—but doesn’t end—in your own backyard.

    A series of 24 Lectures on the New England Transcendalist Movement delivered by Ashton Nichols, Professor of English at Dickinson College.

    The good news is that social connection is innate and a cure for loneliness. In Together, the former Surgeon General will address the importance of community and connection and offer viable and actionable solutions to this overlooked epidemic.

    Do you know where your sugar is coming from?Most likely everywhere. Sure, it's in ice cream and cookies, but what scared Eve O. Schaub was the secret world of sugar--hidden in bacon, crackers, salad dressing, pasta sauce, chicken broth, and baby food.With her eyes open by the work of obesity expert Dr. Robert Lustig and others, Eve challenged her husband and two school-age daughters to join her on a quest to eat no added sugar for an entire year.Along the way, Eve uncovered the real costs of our sugar-heavy American diet--including diabetes, obesity, and increased incidences of health problems such as heart disease and cancer. The stories, tips, and recipes she shares throw fresh light on questionable nutritional advice we've been following for years and show that it is possible to eat at restaurants and go grocery shopping--with less and even no added sugar.Year of No Sugar is what the conversation about "kicking the sugar addiction" looks like for a real American family--a roller coaster of unexpected discoveries and challenges.

    (B) Scientific knowledge is always provisional and tells us nothing that is universal, necessary, or certain about the world. Welcome to the science wars—a long-running battle over the status of scientific knowledge that began in ancient Greece, raged furiously among scientists, social scientists, and humanists during the 1990s, and has re-emerged in today's conflict between science and religion over issues such as evolution.Professor Steven L. Goldman, whose Teaching Company course on Science in the 20th Century was praised by customers as "a scholarly achievement of the highest order" and "excellent in every way," leads you on a quest for the nature of scientific reasoning in this intellectually pathbreaking lecture series, Science Wars: What Scientists Know and How They Know It.Those who have taken Professor Goldman's previous course, which is an intensive survey of the revolution in scientific knowledge from 1900 to 2000, may have wondered: if what counts as scientific knowledge can transform so dramatically within only 100 years, what exactly is scientific knowledge? Science Wars addresses this surprisingly difficult question.Five Centuries of the Science WarsIn 24 half-hour lectures, Science Wars explores the history of competing conceptions of scientific knowledge and their implications for science and society from the onset of the Scientific Revolution in the 1600s to the present. It may seem that the accelerating pace of discoveries, inventions, and unexpected insights into nature during this period guarantees the secure foundations of scientific inquiry, but that is far from true. Consider these cases:The scientific method: In the 1600s the English philosopher Francis Bacon defined the scientific method in its classic form: the use of inductive reasoning to draw conclusions from an exhaustive body of facts. But "no scientist has ever been a strict Baconian," says Professor Goldman. "If you followed that, you would get nowhere."A "heated" debate: Around 1800 the dispute over the nature of heat was resolved in favor of the theory that heat is motion and not a substance given off during burning. But then the French mathematical physicist Joseph Fourier wrote a set of equations that accurately described how heat behaves regardless of what it "really" is, which, Fourier contended, was not a scientific question at all.Paradigm shifts: The publication in 1962 of Thomas Kuhn's The Structure of Scientific Revolutions precipitated a radical change in attitudes toward scientific knowledge, prompted by Kuhn's insight that science is not an entirely rational enterprise, and that its well-established theories (or paradigms) are overturned in a revolutionary, nonlogical process.Postmodern putdown: The postmodern attack on science as a privileged mode of inquiry made some headway in the late 20th century. But the credibility of the movement wilted in 1996, when a postmodern journal unwittingly published a spoof by physicist Alan Sokal, purporting to prove that physical theory was socially constructed. Sokal then exposed his piece as a parody.In the penultimate lecture of the course, Professor Goldman considers intelligent design—the argument that evolution can't account for the immense complexity of life and that a master designer must be at work. He approaches this topical debate by asking: What are the minimum criteria that define a hypothesis as scientific, and does intelligent design qualify? Having already covered five centuries of the science wars in the previous lectures, you will analyze this controversy with a set of tools that allows you to see the issues in a sharp, new light.What Is Reality?"Fasten your seatbelts," says Professor Goldman at the outset of Lecture 21—an advisory that applies equally to the whole course, which covers an astonishing array of ideas and thinkers. Throughout, Professor Goldman never loses his narrative thread, which begins 2,400 years ago with Plato's allegorical battle between "the gods" and "the earth giants"—between those for whom knowledge is universal, necessary, and certain; and those for whom it cannot be so and is based wholly on experience.The problem of what constitutes scientific knowledge can be illustrated with one of the most famous and widely accepted scientific theories of all time, Nicolaus Copernicus's heliostatic (stationary sun) theory of the solar system, which has undergone continual change since it was first proposed in 1543: Copernicus called for the planets to move in uniform circular motion around the sun, slightly displaced from the center. Using observations by Tycho Brahe, Johannes Kepler revised the Copernican model, discarding the ancient dogma of circular motion, which did not fit the data. Instead, he guessed that the planets in fact move in elliptical orbits. In his influential work endorsing the Copernican theory, Galileo ignored Kepler's corrections and opted for circular motion. Notoriously, the Catholic Church condemned Galileo for heresy. But the church was actually correct that he had no basis for claiming the heliocentric theory was true, rather than simply an interpretation of experience. Galileo's picture of space was superseded by Newton's and later by Einstein's, which also will doubtless be revised. Even something as basic as the elliptical motion of the planets is a vast oversimplification. There are no closed curves in space, since the solar system is moving around the center of the galaxy; the galaxy is moving within the local cluster; and the local cluster is also moving. Although we still call the conventional picture of the solar system Copernican astronomy, there is effectively no resemblance between astronomy today and Copernicus's 1543 theory of the heavens. The same is also true of other theories, such as the atomic theory of matter. All scientific theories are in a state of ceaseless revision, which raises the question of what reality "really" is. As the contemporary philosopher of science Mary Hesse has pointed out, the lesson of the history of science seems to be that the theories we currently hold to be true are as likely to be overturned as the theories they replaced!Sharpen Your Understanding of What Science IsThe uncertainty about the status of scientific knowledge and about the objectivity of the scientific enterprise led to a broad assault on science in the late 20th century by sociologists, philosophers, and historians, many connected with the postmodern movement. The lectures covering this attack and the ensuing counterattack by scientists are some of the most thrilling in the course and involve a number of figures whom Professor Goldman knows personally.Of one of the firebrands in this conflict, the late Viennese philosopher of science Paul Feyerabend, Professor Goldman says, "I myself took a seminar with Feyerabend when he was teaching at Berkeley in the early 1960s. … Feyerabend was not really off the wall, although he was often depicted that way. … He too recognized, as everyone must, that after all, science does work and science is knowledge of a sort. It's just not the absolute knowledge that scientists and philosophers have historically claimed that it is."By the time you reach the end of this course, you will understand exactly what science is, and you will be enlightened about a fascinating problem that perhaps you didn't even know existed. "There have been a raft of popular books about what scientists know," says Professor Goldman, "but to the best of my knowledge, there is not a single one of these popular books that focuses centrally on the question of how scientists know what they know."This course serves as that book.Course Lecture Titles1. Knowledge and Truth Are Age-Old Problems 2. Competing Visions of the Scientific Method 3. Galileo, the Catholic Church, and Truth 4. Isaac Newtons Theory of the Universe 5. Science vs. Philosophy in the 17th Century 6. Locke, Hume, and the Path to Skepticism 7. Kant Restores Certainty 8. Science, Society, and the Age of Reason 9. Science Comes of Age in the 19th Century 10. Theories Need Not Explain 11. Knowledge as a Product of the Active Mind 12. Trading Reality for Experience 13. Scientific Truth in the Early 20th Century 14. Two New Theories of Scientific Knowledge 15. Einstein and Bohr Redefine Reality 16. Truth, Ideology, and Thought Collectives 17. Kuhn's Revolutionary Image of Science 18. Challenging Mainstream Science from Within 19. Objectivity Under Attack 20. Scientific Knowledge as Social Construct 21. New Definitions of Objectivity 22. Science Wars of the Late 20th Century 23. Intelligent Design and the Scope of Science 24. Truth, History, and Citizenship12 Audio CDs(24 lectures, 30 minutes/lecture)

    No money. No passport. No identity.Taken to a mental hospital by the police, MacLean then started to hallucinate so severely he had to be tied down. Soon he could remember song lyrics, but not his family, his friends, or the woman he was told he loved. All of these symptoms, it turned out, were the result of the commonly prescribed malarial medication he had been taking. Upon his return to the States, he struggled to piece together the fragments of his former life in a harrowing, absurd, and unforgettable journey back to himself.The Answer to the Riddle Is Me, drawn from David MacLean’s award-winning This American Life essay, is a deeply felt, closely researched, and intensely personal book. It asks every reader to confront the essential questions of our age: In our geographically and chemically fluid world, what makes me who I am? And how much can be stripped away before I become someone else entirely?

    Hayes describes it with more depth and clarity than ever before.-Mark Manson, #1 New York Times best-selling author of The Subtle Art of Not Giving a F*ck Life is not a problem to be solved. ACT shows how we can live full and meaningful lives by embracing our vulnerability and turning toward what hurts. In this landmark book, the originator and pioneering researcher into Acceptance and Commitment Therapy (ACT) lays out the psychological flexibility skills that make it one of the most powerful approaches research has yet to offer. These skills have been shown to help even where other approaches have failed. Science shows that they are useful in virtually every area--mental health (anxiety, depression, substance abuse, eating disorders, PTSD); physical health (chronic pain, dealing with diabetes, facing cancer); social processes (relationship issues, prejudice, stigma, domestic violence); and performance (sports, business, diet, exercise).How does psychological flexibility help? We struggle because the problem-solving mind tells us to run from what causes us fear and hurt. But we hurt where we care. If we run from a sense of vulnerability, we must also run from what we care about. By learning how to liberate ourselves, we can live with meaning and purpose, along with our pain when there is pain.Although that is a simple idea, it resists our instincts and programming. The flexibility skills counter those ingrained tendencies. They include noticing our thoughts with curiosity, opening to our emotions, attending to what is in the present, learning the art of perspective taking, discovering our deepest values, and building habits based around what we deeply want.Beginning with the epiphany Steven Hayes had during a panic attack, this book is a powerful narrative of scientific discovery filled with moving stories as well as advice for how we can put flexibility skills to work immediately. Hayes shows how allowing ourselves to feel fully and think freely moves us toward commitment to what truly matters to us. Finally, we can live lives that reflect the qualities we choose.

    Notwithstanding the great strengths of medical science, many people now have concerns about key features of our health-care system-among them, the widespread use of medical drugs and a relative deemphasis on preventive care. But traditional Western medicine is not the only healing system rooted in science. Medical systems from other cultures, including those of India and China, have used natural treatments for centuries, some of which are now directly influencing our own health-care professions. These approaches not only emphasize healing with natural substances, but devote considerable attention to illness prevention and healthful living by considering the whole person rather than just targeting a condition. What is the most effective way to nurture your own optimal health? Are there sound alternatives to the drugs so common in our health-care system, which can carry unwanted consequences and side effects? What about the range of natural methods, such as herbal medications, micronutrients, and the use of food itself as medicine? Are these approaches valid? And, if so, can we integrate the best of Western medicine with the best natural treatments to enjoy prime health and longevity?

    Now, let an expert professor lead you in a panoramic exploration of our monetary and financial systems, their inner workings, and their crucial role and presence in your world. As a guiding theme of these 36 content-rich lectures, you observe the ways in which economies require efficient and evolving financial institutions and markets to fulfill their potential.

    In that short time, many doctors decide on the likely diagnosis and best treatment. Often, decisions made this way are correct, but at crucial moments they can also be wrong -- with catastrophic consequences. In this myth-shattering book, Jerome Groopman pinpoints the forces and thought processes behind the decisions doctors make. Groopman explores why doctors err and shows when and how they can -- with our help -- avoid snap judgments, embrace uncertainty, communicate effectively, and deploy other skills that can profoundly impact our health. This book is the first to describe in detail the warning signs of erroneous medical thinking and reveal how new technologies may actually hinder accurate diagnoses. How Doctors Think offers direct, intelligent questions patients can ask their doctors to help them get back on track.Groopman draws on a wealth of research, extensive interviews with some of the country’s best doctors, and his own experiences as a doctor and as a patient. He has learned many of the lessons in this book the hard way, from his own mistakes and from errors his doctors made in treating his own debilitating medical problems.How Doctors Think reveals a profound new view of twenty-first-century medical practice, giving doctors and patients the vital information they need to make better judgments together.