Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery.The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

    He asked them to disclose something that, for scientific reasons, worries them—particularly scenarios that aren't on the popular radar yet. Encompassing neuroscience, economics, philosophy, physics, psychology, biology, and more—here are 150 ideas that will revolutionize your understanding of the world.Steven Pinker uncovers the real risk factors for war * Mihaly Csikszentmihalyi peers into the coming virtual abyss * Nobel laureate Frank Wilczek laments our squandered opportunities to prevent global catastrophe * Seth Lloyd calculates the threat of a financial black hole * Alison Gopnik on the loss of childhood * Nassim Nicholas Taleb explains why firefighters understand risk far better than economic "experts" * Matt Ridley on the alarming re-emergence of superstition * Daniel C. Dennett and george dyson ponder the impact of a major breakdown of the Internet * Jennifer Jacquet fears human-induced damage to the planet due to "the Anthropocebo Effect" * Douglas Rushkoff fears humanity is losing its soul * Nicholas Carr on the "patience deficit" * Tim O'Reilly foresees a coming new Dark Age * Scott Atran on the homogenization of human experience * Sherry Turkle explores what's lost when kids are constantly connected * Kevin Kelly outlines the looming "underpopulation bomb" * Helen Fisher on the fate of men * Lawrence Krauss dreads what we don't know about the universe * Susan Blackmore on the loss of manual skills * Kate Jeffery on the death of death * plus J. Craig Venter, Daniel Goleman, Virginia Heffernan, Sam Harris, Brian Eno, Martin Rees, and more

    For all of neuroscience's advances, we've made little progress on its biggest question: How do simple cells in the brain create intelligence? Jeff Hawkins and his team discovered that the brain uses maplike structures to build a model of the world-not just one model, but hundreds of thousands of models of everything we know. This discovery allows Hawkins to answer important questions about how we perceive the world, why we have a sense of self, and the origin of high-level thought.

    On March 27, 1964, at 5:36 p.m., the biggest earthquake ever recorded in North America—and the second biggest ever in the world, measuring 9.2 on the Richter scale—struck Alaska, devastating coastal towns and villages and killing more than 130 people in what was then a relatively sparsely populated region. In a riveting tale about the almost unimaginable brute force of nature, New York Times science journalist Henry Fountain, in his first trade book, re-creates the lives of the villagers and townspeople living in Chenega, Anchorage, and Valdez; describes the sheer beauty of the geology of the region, with its towering peaks and 20-mile-long glaciers; and reveals the impact of the quake on the towns, the buildings, and the lives of the inhabitants. George Plafker, a geologist for the U.S. Geological Survey with years of experience scouring the Alaskan wilderness, is asked to investigate the Prince William Sound region in the aftermath of the quake, to better understand its origins. His work confirmed the then controversial theory of plate tectonics that explained how and why such deadly quakes occur, and how we can plan for the next one.

    In order for this to happen, the argument champions eating locally and sustainably and encourages those with the resources to grow their own food. Further examining the question of what to eat from the perspective of both human and environmental health, the account goes beyond health choices and discusses potential moral issues from eating—or not eating—animals. Through the deeply personal narrative of someone who practiced veganism for 20 years, this unique exploration also discusses alternatives to industrial farming, reveals the risks of a vegan diet, and explains why animals belong on ecologically sound farms.

    When temperatures drop below 56°F, tin crumbles into powder. Were the soldiers of the Grande Armée acutee fatally weakened by cold because the buttons of their uniforms fell apart? How different our world might be if tin did not disintegrate at low temperatures and the French had continued their eastward expansion! This fascinating book tells the stories of seventeen molecules that, like the tin of those buttons, greatly influenced the course of history. These molecules provided the impetus for early exploration and made possible the ensuing voyages of discovery. They resulted in grand feats of engineering and spurred advances in medicine; lie behind changes in gender roles, in law, and in the environment; and have determined what we today eat, drink, and wear. Showing how a change as small as the position of an atom can lead to enormous differences in the properties of a substance, the authors reveal the astonishing chemical connections among seemingly unrelated events. Napoleon's Buttons offers a novel way to understand how our contemporary world works and how our civilization has been shaped over time.

    Scientists have discovered that the way cats and dogs lap up liquids can be explained by the laws of surface tension, how ants navigate is due to polarized light, and why pistol shrimps can generate enough force to destroy aquarium glass using their ”elbows”!Each of FURRY LOGIC's six chapters tackles a separate branch of physics and, through more than 30 animal case studies, examines each creature's key features before describing the ways physics is at play in its life, how the connection between physics and animal behavior was discovered, and what remains to be found out. Science journalists Matin Durrani and Liz Kalaugher make the incredible interdisciplinary world of animals accessible to all, in an enthralling and entertaining read.

    Our Big Bang, our distant future, parallel worlds, the sub-atomic and intergalactic - none of them are what they seem. But there is a way to understand this immense strangeness - mathematics. Seeking an answer to the fundamental puzzle of why our universe seems so mathematical, Tegmark proposes a radical idea: that our physical world not only is described by mathematics, but that it is mathematics. This may offer answers to our deepest questions: How large is reality? What is everything made of? Why is our universe the way it is?Table of ContentsPreface 1 What Is Reality? Not What It Seems • What’s the Ultimate Question? • The Journey Begins Part One: Zooming Out 2 Our Place in Space Cosmic Questions • How Big Is Space? • The Size of Earth • Distance to the Moon • Distance to the Sun and the Planets • Distance to the Stars • Distance to the Galaxies • What Is Space? 3 Our Place in TimeWhere Did Our Solar System Come From? • Where Did theGalaxies Come From? • Where Did the Mysterious MicrowavesCome From? • Where Did the Atoms Come From? 4 Our Universe by NumbersWanted: Precision Cosmology • Precision Microwave-Background Fluctuations • Precision Galaxy Clustering • The Ultimate Map of Our Universe • Where Did Our Big Bang Come From? 5 Our Cosmic Origins What’s Wrong with Our Big Bang? • How Inflation Works • The Gift That Keeps on Giving • Eternal Inflation 6 Welcome to the Multiverse The Level I Multiverse • The Level II Multiverse • Multiverse Halftime Roundup Part Two: Zooming In 7 Cosmic Legos Atomic Legos • Nuclear Legos • Particle-Physics Legos • Mathematical Legos • Photon Legos • Above the Law? • Quanta and Rainbows • Making Waves • Quantum Weirdness • The Collapse of Consensus • The Weirdness Can’t Be Confined • Quantum Confusion 8 The Level III Multiverse The Level III Multiverse • The Illusion of Randomness • Quantum Censorship • The Joys of Getting Scooped • Why Your Brain Isn’t a Quantum Computer • Subject, Object and Environment • Quantum Suicide • Quantum Immortality? • Multiverses Unified • Shifting Views: Many Worlds or Many Words? Part Three: Stepping Back 9 Internal Reality, External Reality and Consensus Reality External Reality and Internal Reality • The Truth, the Whole Truth and Nothing but the Truth • Consensus Reality • Physics: Linking External to Consensus Reality 10 Physical Reality and Mathematical Reality Math, Math Everywhere! • The Mathematical Universe Hypothesis • What Is a Mathematical Structure? 11 Is Time an Illusion? How Can Physical Reality Be Mathematical? • What Are You? • Where Are You? (And What Do You Perceive?) • When Are You? 12 The Level IV Multiverse Why I Believe in the Level IV Multiverse • Exploring the Level IV Multiverse: What’s Out There? • Implications of the Level IV Multiverse • Are We Living in a Simulation? • Relation Between the MUH, the Level IV Multiverse and Other Hypotheses •Testing the Level IV Multiverse 13 Life, Our Universe and Everything How Big Is Our Physical Reality? • The Future of Physics • The Future of Our Universe—How Will It End? • The Future of Life •The Future of You—Are You Insignificant? Acknowledgments Suggestions for Further Reading Index

    This discovery dramatically reshaped how humans understood their place in the cosmos, and once and for all laid to rest the idea that the Milky Way galaxy was alone in the universe. Six years later, continuing research by Hubble and others forced Albert Einstein to renounce his own cosmic model and finally accept the astonishing fact that the universe was not immobile but instead expanding. The fascinating story of these interwoven discoveries includes battles of will, clever insights, and wrong turns made by the early investigators in this great twentieth-century pursuit. It is a story of science in the making that shows how these discoveries were not the work of a lone genius but the combined efforts of many talented scientists and researchers toiling away behind the scenes. The intriguing characters include Henrietta Leavitt, who discovered the means to measure the vast dimensions of the cosmos . . . Vesto Slipher, the first and unheralded discoverer of the universe’s expansion . . . Georges Lemaître, the Jesuit priest who correctly interpreted Einstein’s theories in relation to the universe . . . Milton Humason, who, with only an eighth-grade education, became a world-renowned expert on galaxy motions . . . and Harlow Shapley, Hubble’s nemesis, whose flawed vision of the universe delayed the discovery of its true nature and startling size for more than a decade.Here is a watershed moment in the history of astronomy, brought about by the exceptional combination of human curiosity, intelligence, and enterprise, and vividly told by acclaimed science writer Marcia Bartusiak.

    But this is not the whole story.Shedding light on controversial research and investigating the ferocious gender wars in biology, psychology and anthropology, Angela Saini takes readers on an eye-opening journey to uncover how women are being rediscovered. She explores what these revelations mean for us as individuals and as a society, revealing an alternative view of science in which women are included, rather than excluded.

    And yet for many years it was equally baffling for scientists themselves. Manjit Kumar gives a dramatic and superbly-written history of this fundamental scientific revolution, and the divisive debate at its heart.For 60 years most physicists believed that quantum theory denied the very existence of reality itself. Yet Kumar shows how the golden age of physics ignited the greatest intellectual debate of the twentieth century.Quantum sets the science in the context of the great upheavals of the modern age. In 1925 the quantum pioneers nearly all hailed from upper-middle-class academic families; most were German; and their average age was 24. But it was their irrational, romantic spirit, formed in reaction to the mechanised slaughter of the First World War that inspired their will to test science to its limits.The essential read for anyone fascinated by this complex and thrilling story and by the band of young men at its heart.

    The bedrock, the topsoil, and everything in between that generates the health of your local watershed. In his new book, Nick takes a humorous, inspiring, and elucidating trip to America's trails, farms, and frontier to celebrate the people, landscape, and stories, both historical and fresh, that have made it great.The seeds of this book were planted in 2019, when Nick took two memorable journeys with friends--a hiking trip to Glacier National Park with his friends Jeff Tweedy and George Saunders, as well as an extended visit to his friend James Rebanks, the author of A Shepherd's Life and English Pastoral. He followed that up with an excursion that could only have come about in 2020--Nick and his wife, Megan Mullally, bought an Airstream trailer to drive across the US in late 2020. All three journeys inspired some "deep-ish thinking from Nick, about the history and philosophy of our relationship with nature in our national parks, in our farming, and in our wildlife; what we mean when we talk about conservation; the importance of outdoor recreation; and the healthy building of both local and national communities across party lines, all subjects very close to Nick's heart.With witty, heartwarming stories, and a keen insight into the problems we all confront, this is both a ramble through and celebration of the land we all love.

    But as Ocean Guardian founder William McKeever reveals, sharks are evolutionary marvels essential to maintaining a balanced ecosystem. We can learn much from sharks, he argues, and our knowledge about them continues to grow. The first book to reveal in full the hidden lives of sharks, Emperors of the Deep examines four species—Mako, Tiger, Hammerhead, and Great White—as never before, and includes fascinating details such as:Sharks are 50-million years older than trees;Sharks have survived five extinction level events, including the one that killed off the dinosaurs;Sharks have electroreception, a sixth-sense that lets them pick up on electric fields generated by living things;Sharks can dive 4,000 feet below the surface;Sharks account for only 6 human fatalities per year, while humans kill 100 million sharks per year.McKeever goes back through time to probe the shark’s pre-historic secrets and how it has become the world’s most feared and most misunderstood predator, and takes us on a pulse-pounding tour around the world and deep under the water’s surface, from the frigid waters of the Arctic Circle to the coral reefs of the tropical Central Pacific, to see sharks up close in their natural habitat. He also interviews ecologists, conservationists, and world-renowned shark experts, including the founders of Greenpeace’s Rainbow Warrior, the head of the Massachusetts Shark Research Program, and the self-professed “last great shark hunter.”At once a deep-dive into the misunderstood world of sharks and an urgent call to protect them, Emperors of the Deep celebrates this wild species that hold the key to unlocking the mysteries of the ocean—if we can prevent their extinction from climate change and human hunters.

    The author uses two of his Midwestern hometown grocery chains, Heinen's and Fazio's, and his memories of his father's love of food and grocery shopping as the foundation for this engaging narrative. While he notes that many other writers have covered the history of the grocery store, the broken industrial food production system, and the nutritional benefits of various foods, Ruhlman delivers -a reported reflection on the grocery store in America,

    Gates says, "we can work on a local, national, and global level to build the technologies, businesses, and industries to avoid the worst impacts of climate change." His interest in climate change is a natural outgrowth of the efforts by his foundation to reduce poverty and disease. Climate change, according to Gates, will have the biggest impact on the people who have done the least to cause it. As a technologist, he has seen first-hand how innovation can change the world. By investing in research, inventing new technologies, and by deploying them quickly at large scale, Gates believes climate change can be addressed in meaningful ways. According to Gates, "to prevent the worst effects of climate change, we have to get to net-zero emissions of greenhouse gases. This problem is urgent, and the debate is complex, but I believe we can come together to invent new carbon-zero technologies, deploy the ones we have, and ultimately avoid a climate catastrophe."