They are the powerhouses of our cells, essential for the production and management of energy at cell level. Dr Sarah Myhill, together with Dr John McLaren Howard of Acumen Laboratories and Dr Norman Booth of Mansfield College Oxford, has spent many years studying the relationship between their malfunction and the commonest problem seen by GPs in the UK – fatigue. Their research findings have been published in three scientific papers in the International Journal of Clinical and Experimental Medicine, in 2009, 2012 and 2013. These studies showed that poor functioning of the mitochondria is the central problem in CFS. Patients with the worst mitochondrial function had the worst fatigue and vice versa. This is solid scientific evidence that CFS is a problem with mitochondria and has allowed the objective measurement of fatigue for the first time. With the publication of the third study, which showed that mitochondrial function tests and symptoms improved in patients who took measures to address their mitochondrial problems, Dr Myhill was ready to write this book. Here she explains the importance of healthy mitochondria, how we can measure their functioning and what we can do to keep them healthy, or restore them to health if problems arise. CFS is all in our cells, not in our minds!

    Written in a clear and accessible narrative, the 7th Edition focuses on fundamental principles and their applications to solving real circuit analysis problems, and devotes six chapters to examining electronic devices. With an eye-catching visual program and practical exercises, this book provides readers with the problem-solving experience they need in a style that makes complex material thoroughly understandable. For professionals with a career in electronics, engineering, technical sales, field service, industrial manufacturing, service shop repair, and/or technical writing.

    These children grow up between two cultures, the Hearing and the Deaf, forever balancing the worlds of sound and silence. Paul Preston, one of these children, takes us to the place where Deaf and Hearing cultures meet, where families like his own embody the conflicts and resolutions of two often opposing world views. Based on 150 interviews with adult hearing children of deaf parents throughout the United States, Mother Father Deaf examines the process of assimilation and cultural affiliation among a population whose lives incorporate the paradox of being culturally "Deaf" yet functionally hearing. It is rich in anecdote and analysis, remarkable for its insights into a family life normally closed to outsiders.

    Public concern about infectious disease is on the rise as newspapers trumpet the arrivals of new germs and the reemergence of old ones.In A Field Guide to Germs, Pulitzer Prize-winning science writer Wayne Biddle brings readers face to face with nearly one hundred of the best-known (in terms of prevalence, power, historical importance, or even literary interest) of the myriad pathogens that live in and around the human population. Along with physical descriptions of the organisms and the afflictions they cause, the author provides folklore, philosophy, history, and such illustrations as nineteenth century drawings of plague-induced panic, microscopic photographs of HIV and Ebola, and wartime posters warning servicemen against syphilis and gonorrhea.From cholera to chlamydia, TB to HIV, bubonic plague to Lyme disease, rabies to Congo-Crimean encephalitis, anthrax to Zika fever, and back to good old rhinitis (the common cold), A Field Guide to Germs is both a handy reference work to better understand today's headlines and a fascinating look at the astonishing impact of micro-organisms on social and political history.

      Making art does not necessarily mean painting a gallery-worthy still life or belting out a Grammy-winning song. It simply means finding a way to give your inner muse a voice in this world. Sure, there’s drawing, dancing, singing, and writing. But there’s also art to be made from creating your own pair of angel wings or inventing a new toy or curating your own at-home film festival.   Each week features a project of self-examination, an inspirational message, a real-world example of a celebrity who has addressed similar obstacles, and three zany activities to awaken your infinite creativity.   It’s time to declare the beat of your own drum.

    Provides a review of introductory noncalculus-based physics for those who do not have a strong background in mathematics.

    With engaging stories and keen insights the authors delve into the fundamental aspects of leadership to help students keep pace with our ever-changing world.

    His assignment is to program the complex lunar landing phase in the Lunar Module's onboard computer. As he masters his art the reader learns about the computer, the mission, and a bit about spacecraft navigation and meets a cast of interesting characters along the way. As Apollo 11 approaches, the author flies lunar landings in simulators and meets the astronauts who will fly the LM for real. He explains the computer alarms that almost prevented Neil Armstrong from landing and describes a narrow escape from another dangerous problem. He helps Pete Conrad achieve a pinpoint landing on Apollo 12, and works with Apollo 16 commander John Young on a technique for landing even more precisely. On Apollo 14 he devises a workaround when a faulty pushbutton threatens Alan Shepard's mission, earning a NASA award, a story in Rolling Stone, and a few lines in the history books. Along the way the author hits the high points of his eclectic personal life, as he enters adulthood in the 1960s. He writes for students of the Apollo project, for whom the development of the flight software is still largely unexplored territory, but also for the young coders of the current digital culture, who will get the author's observations on the art of programming and who may identify as he explores sex, drugs, and the other excitements of the era. The underlying thesis is that the American space program in the 1960s was successful not in spite of, but in large measure because of the idealism, the freedom of thought, and the sense of exploration, inner and outer, that prevailed in the culture during that period. The memoir concludes in a party atmosphere at the spectacular night launch of Apollo 17 before a glittery crowd an occasion that marked the high water mark, so far, of human space exploration.

    This revision provides a step-by-step approach to making the thesis or dissertation process easier and more manageable.

    Yet the staff who set up and administer these programs often lack skills for the very task that is so critical to the success of their efforts--the planning of the programs themselves. Drawing on the tremendous success of the first edition, Planning Programs for Adult Learners, Second Edition covers the development of adult education programs in clear, specific detail. This popular guide contains information on every area of program planning for adult learners, from understanding the purpose of educational programs to obtaining suitable facilities. Thoroughly expanded and revised, the book contains a wealth of new material and examples, and features new information on incorporating technology into the development and practice of adult education programs. Educators and practitioners alike will find this guide to be an essential tool.

    There is a major emphasis on study design, with separate chapt

    For it is but the record of the public and official acts of human beings. It is our object, therefore, to humanize our history and deal with people past and present; people who ate and possibly drank; people who were born, flourished, and died. And if we cannot laugh at ourselves, then we are condemned to repeat the very same deeds of the past.

    It covers areas such as fundamentals, logic, counting, relations and digraphs, trees, topics in graph theory, languages and finite-state machines, and groups and coding.

    The creator of expansive tableaus of fantastic and hellish scenes—where any devil not dancing is too busy eating human souls—he has been as equally misunderstood by history as his paintings have. In this book, Nils Büttner draws on a wealth of historical documents—not to mention Bosch’s paintings—to offer a fresh and insightful look at one of history’s most peculiar artists on the five-hundredth anniversary of his death.             Bosch’s paintings have elicited a number a responses over the centuries. Some have tried to explain them as alchemical symbolism, others as coded messages of a secret cult, and still others have tried to psychoanalyze them. Some have placed Bosch among the Adamites, others among the Cathars, and others among the Brethren of the Free Spirit, seeing in his paintings an occult life of free love, strange rituals, mysterious drugs, and witchcraft. As Büttner shows, Bosch was—if anything—a hardworking painter, commissioned by aristocrats and courtesans, as all painters of his time were. Analyzing his life and paintings against the backdrop of contemporary Dutch culture and society, Büttner offers one of the clearest biographical sketches to date alongside beautiful reproductions of some of Bosch’s most important work. The result is a smart but accessible introduction to a unique artist whose work transcends genre.

    This book covers all the important aspects of plant tissue culture viz. nutrition media, micropropagation, organ culture, cell suspension culture, haploid culture, protoplast isolation and fusion, secondary metabolite production, somaclonal variation and cryopreservation. For good understanding of recombinant DNA technology, chapters on genetic material, organization of DNA in the genome and basic techniques involved in recombinant DNA technology have been added. Different aspects on rDNA technology covered gene cloning, isolation of plant genes, transposons and gene tagging, in vitro mutagenesis, PCR, molecular markers and marker assisted selection, gene transfer methods, chloroplast and mitochondrion DNA transformation, genomics and bioinformatics. Genomics covers functional and structural genomics, proteomics, metabolomics, sequencing status of different organisms and DNA chip technology. Application of biotechnology has been discussed as transgenics in crop improvement and impact of recombinant DNA technology mainly in relation to biotech crops.