But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime.Miraculously, Fajgenbaum survived--only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself.More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide.

    In her work for New York, The Baffler, The New York Times Magazine, and The Atlantic, as well as in her advice column for The Cut, "Ask Polly," she dispenses a singular, cutting wisdom--an ability to inspire, provoke, and put a name to our most insidious cultural delusions.What If This Were Enough? is a mantra and a clarion call. In its chapters--many of them original to the book, others expanded from their initial publication--Havrilesky takes on those cultural forces that shape us. From the enforced cheer of American life to the celebration of survivalism, from the allure of materialism to our misunderstandings of romance and success, Havrilesky deconstructs some of the most poisonous and misleading messages we ingest today, all the while suggesting new ways we might navigate our increasingly bewildering world.Through her incisive and witty inquiries, Havrilesky emphasizes the importance of locating the miraculous within the mundane. In these timely, provocative, and often hilarious chapters, she urges readers to embrace the flawed--to connect with what already is, who we already are, what we already have. She asks us to consider: What if this were enough? Our salvation, Havrilesky asserts, can be found right here, right now, in this imperfect moment.The smile factory --The happiest place on earth --To infinity and beyond --Playing house --Delusion at the gastropub --Adults only --Stuffed --Running on empty --Lost treasure --Land of heroic villains --The popularity contest --Tag and release --Haunted --Bravado --Survival fantasies --True romance --A scourge of gurus --My mother's house --Miracle of the mundane

    With every birth, she encounters another woman-turned-goddess: Catherine rides out her labor in a car careening down a mountain road. Sofia spends hers trying to keep her hyper doctor-father from burning down the house. Susannah gives birth so quietly that neither husband nor midwife notice until there's a baby in the room. More than a collection of birth stories, however, Baby Catcher is a provocative account of the difficulties that midwives face in the United States. With vivid portraits of courage, perseverance, and love, this is an impassioned call to rethink technological hospital births in favor of more individualized and profound experiences in which mothers and fathers take center stage in the timeless drama of birth.

    Hoping to explore the “real ground of literature,” she reads her way through a somewhat randomly chosen shelf of fiction, from LEQ to LES.The shelf has everything Rose could wish for—a classic she has not read, a remarkable variety of authors, and a range of literary styles. The early nineteenth-century Russian classic A Hero of Our Time by Mikhail Lermontov is spine by spine with The Phantom of the Opera by Gaston Leroux. Stories of French Canadian farmers sit beside those about aristocratic Austrians. California detective novels abut a picaresque novel from the seventeenth century. There are several novels by a wonderful, funny, contemporary novelist who has turned to raising dogs because of the tepid response to her work.In The Shelf, Rose investigates the books on her shelf with exuberance, candor, and wit while pondering the many questions her experiment raises and measuring her discoveries against her own inner shelf—those texts that accompany us through life. “Fairly sure that no one in the history of the world has read exactly this series of novels,” she sustains a sense of excitement as she creates a refreshingly original and generous portrait of the literary enterprise.

    A stunning collection of personal observations that uses images of the American West to probe larger concerns in lyrical, evocative prose that is a true celebration of the region.

    Pure Drivel is a collection of pieces, most of them written for the New Yorker, that demonstrate Martin's playful way with words and his unerring ability to create a feeling of serendipitous improvisation even on the printed page. Here's a passage from a piece that announces a shortage of periods in the Times Roman font: "Most vulnerable are writers who work in short, choppy sentences," said a spokesperson for Times Roman, who continued, "We are trying to remedy the situation and have suggested alternatives, like umlauts, since we have plenty of umlauts--and, in fact, have more umlauts than we could possibly use in a lifetime! Don't forget, umlauts can really spice up a page with their delicate symmetry--resting often midway in a word, letters spilling on either side--and not only indicate the pronunciation of a word but also contribute to a writer's greater glory because they're fancy, not to mention that they even look like periods, indeed, are indistinguishable from periods, and will lead casual readers to believe that the article actually contains periods!" Although some of these pieces flirted with topicality when they first appeared, Martin is most successful when he leaves the real world behind and gives his wit free rein. This collection preserves the best (so far) of his glorious improvisations. --Simon Leake

    From the thawing tundra linking a Yup'ik village in Alaska to its hunter-gatherer past to the shifting sand dunes revealing the impressively preserved homes of neolithic farmers in Scotland, Jamie explores how the changing natural world can alter our sense of time. Most movingly, she considers, as her father dies and her children leave home, the surfacing of an older, less tethered sense of herself. In precise, luminous prose, Surfacing offers a profound sense of time passing and an antidote to all that is instant, ephemeral, unrooted.

    He enjoyed a successful career and drew happiness from his wife, children, family and close friends. Then in May 2005, Gene was diagnosed with late-stage brain cancer. This is his account of his final journey.

    But, at forty-eight years old, having spent decades in San Francisco, he craved change. Grieving over the death of his partner, he quickly discovered the profound consolations of the city's incessant rhythms, the sight of the Empire State Building against the night sky, and New Yorkers themselves, kindred souls that Hayes, a lifelong insomniac, encountered on late-night strolls with his camera.And he unexpectedly fell in love again, with his friend and neighbor, the writer and neurologist Oliver Sacks, whose exuberance--"I don't so much fear death as I do wasting life," he tells Hayes early on--is captured in vignettes throughout. What emerges is a portrait of Sacks at his most personal and endearing, from falling in love for the first time at age seventy-five to facing illness and death (Sacks died of cancer in August 2015).

    In a series of coruscating set pieces, Greif asks why we put ourselves through the pains of exercise, what shopping in organic supermarkets does for our sense of self-worth, what the political identity of the hipster might be, and what happens to us when we listen to too much Radiohead. From such counter-intuitive observations, Greif exposes the fundamental contradictions between our actions, desires and the excuses that we make to ourselves in hope of consolation. With the wit and seriousness of David Foster Wallace, Against Everything is the most thought-provoking study and essential guide to everyday life under 21st-century capitalism.

    Yet she spent much of her life disassociated from her own body—a disconnection brought on by her father’s sexual abuse and her mother’s remoteness. “Because I did not, could not inhabit my body or the Earth,” she writes, “I could not feel or know their pain.”But Ensler is shocked out of her distance. While working in the Congo, she is shattered to encounter the horrific rape and violence inflicted on the women there. Soon after, she is diagnosed with uterine cancer, and through months of harrowing treatment, she is forced to become first and foremost a body—pricked, punctured, cut, scanned. It is then that all distance is erased. As she connects her own illness to the devastation of the earth, her life force to the resilience of humanity, she is finally, fully—and gratefully—joined to the body of the world.Unflinching, generous, and inspiring, Ensler calls on us all to embody our connection to and responsibility for the world.http://us.macmillan.com/inthebodyofth...

    Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance.Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all.As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.

    Rowling delivered a deeply affecting commencement speech at Harvard University. Now published for the first time in book form, VERY GOOD LIVES presents J.K. Rowling's words of wisdom for anyone at a turning point in life. How can we embrace failure? And how can we use our imagination to better both ourselves and others?Drawing from stories of her own post-graduate years, the world famous author addresses some of life's most important questions with acuity and emotional force.

    We follow Strauss as he explores his startling past-collision life - the funeral, the queasy drama of a high-stakes court case? and what starts as a personal tale of a tragic event opens into the story of how to live with a very hard fact: we can try our human best in the crucial moment, and it might not be good enough. Half a Life is a nakedly honest, ultimately hopeful examination of guilt, responsibility, and living with the past.

    And with a thump, down came Father Iggy.From shoot-outs at funerals to dead men screaming and runaway corpses, undertakers have plenty of unusual stories to tell--and a special way of telling them.In this macabre and moving compilation, funeral directors across the country share their most embarrassing, jaw-dropping, irreverent, and deeply poignant stories about life at death's door. Discover what scares them and what moves them to tears. Learn about rookie mistakes and why death sometimes calls for duct tape.Enjoy tales of the dearly departed spending eternity naked from the waist down and getting bottled and corked--in a wine bottle. And then meet their families--the weepers, the punchers, the stolidly dignified, and the ones who deliver their dead mother in a pickup truck.If there's one thing undertakers know, it's that death drives people crazy. These are the best "bodies of work" from America's darkest profession."Sick, funny, and brilliant! I love this book." --Jonathan Maberry