The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including  the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept;  the central, underappreciated evolutionary importance of viruses; the origin of eukaryotes as a result of endosymbiosis; the concomitant origin of cells and viruses on the primordial earth; universal dependences between genomic and molecular-phenomic variables; and the evolving landscape of constraints that shape the evolution of genomes and molecular phenomes.

    In this lively and groundbreaking new book, economist Ian Ayres shows how today's best and brightest organizations are analyzing massive databases at lightening speed to provide greater insights into human behavior. They are the Super Crunchers. From internet sites like Google and Amazon that know your tastes better than you do, to a physician's diagnosis and your child's education, to boardrooms and government agencies, this new breed of decision makers are calling the shots. And they are delivering staggeringly accurate results. How can a football coach evaluate a player without ever seeing him play? Want to know whether the price of an airline ticket will go up or down before you buy? How can a formula outpredict wine experts in determining the best vintages? Super crunchers have the answers. In this brave new world of equation versus expertise, Ayres shows us the benefits and risks, who loses and who wins, and how super crunching can be used to help, not manipulate us.Gone are the days of solely relying on intuition to make decisions. No businessperson, consumer, or student who wants to stay ahead of the curve should make another keystroke without reading Super Crunchers.

    Based on the abstract, general style of mathematical exposition favored by research mathematicians, its goal was to teach students not just to manipulate numbers and formulas, but to grasp the underlying mathematical concepts. The result, at least at first, was a great deal of confusion among teachers, students, and parents. Since then, the negative aspects of "new math" have been eliminated and its positive elements assimilated into classroom instruction.In this charming volume, a noted English mathematician uses humor and anecdote to illuminate the concepts underlying "new math": groups, sets, subsets, topology, Boolean algebra, and more. According to Professor Stewart, an understanding of these concepts offers the best route to grasping the true nature of mathematics, in particular the power, beauty, and utility of pure mathematics. No advanced mathematical background is needed (a smattering of algebra, geometry, and trigonometry is helpful) to follow the author's lucid and thought-provoking discussions of such topics as functions, symmetry, axiomatics, counting, topology, hyperspace, linear algebra, real analysis, probability, computers, applications of modern mathematics, and much more.By the time readers have finished this book, they'll have a much clearer grasp of how modern mathematicians look at figures, functions, and formulas and how a firm grasp of the ideas underlying "new math" leads toward a genuine comprehension of the nature of mathematics itself.

    Selected for originality, general interest, or because they demonstrate valuable techniques, the problems are ideal as a supplement to courses in probability or statistics, or as stimulating recreation for the mathematically minded. Detailed solutions. Illustrated.

    Drawing on their hugely popular BBC Radio 4 show More or Less,, journalist Michael Blastland and internationally known economist Andrew Dilnot delight, amuse, and convert American mathphobes by showing how our everyday experiences make sense of numbers. The radical premise of The Numbers Game is to show how much we already know, and give practical ways to use our knowledge to become cannier consumers of the media. In each concise chapter, the authors take on a different theme—such as size, chance, averages, targets, risk, measurement, and data—and present it as a memorable and entertaining story. If you’ve ever wondered what “average” really means, whether the scare stories about cancer risk should convince you to change your behavior, or whether a story you read in the paper is biased (and how), you need this book. Blastland and Dilnot show how to survive and thrive on the torrent of numbers that pours through everyday life. It’s the essential guide to every cause you love or hate, and every issue you follow, in the language everyone uses.

    We nevertheless muddle through even in the absence of theories of how to act. But how do we do it?In Probably Approximately Correct, computer scientist Leslie Valiant presents a masterful synthesis of learning and evolution to show how both individually and collectively we not only survive, but prosper in a world as complex as our own. The key is “probably approximately correct” algorithms, a concept Valiant developed to explain how effective behavior can be learned. The model shows that pragmatically coping with a problem can provide a satisfactory solution in the absence of any theory of the problem. After all, finding a mate does not require a theory of mating. Valiant’s theory reveals the shared computational nature of evolution and learning, and sheds light on perennial questions such as nature versus nurture and the limits of artificial intelligence.Offering a powerful and elegant model that encompasses life’s complexity, Probably Approximately Correct has profound implications for how we think about behavior, cognition, biological evolution, and the possibilities and limits of human and machine intelligence.

    From randomized clinical trials in medical research, to statistical models of risk in banking and hedge fund industries, to the statistical tools used to probe vast astronomical databases, the field of statistics has become centrally important to how we understand our world. But the discipline underlying all these is not the dull statistics of the popular imagination. Long gone are the days of manual arithmetic manipulation. Nowadays statistics is a dynamic discipline, revolutionized by the computer, which uses advanced software tools to probe numerical data, seeking structures, patterns, and relationships. This Very Short Introduction sets the study of statistics in context, describing its history and giving examples of its impact, summarizes methods of gathering and evaluating data, and explains the role played by the science of chance, of probability, in statistical methods. The book also explores deep philosophical issues of induction--how we use statistics to discern the true nature of reality from the limited observations we necessarily must make.About the Series: Combining authority with wit, accessibility, and style, Very Short Introductions offer an introduction to some of life's most interesting topics. Written by experts for the newcomer, they demonstrate the finest contemporary thinking about the central problems and issues in hundreds of key topics, from philosophy to Freud, quantum theory to Islam.

    Requiring essentially no background apart from mathematical maturity, the book can be used as a reference for self-study for anyone interested in complexity, including physicists, mathematicians, and other scientists, as well as a textbook for a variety of courses and seminars. More than 300 exercises are included with a selected hint set.

    The new edition includes the most up-to-date research developments and many more examples and problems.

    In writing the book James Stewart asked himself: What is essential for a three-semester calculus course for scientists and engineers? Stewart's ESSENTIAL CALCULUS offers a concise approach to teaching calculus that focuses on major concepts and supports those concepts with precise definitions, patient explanations, and carefully graded problems. Essential Calculus is only 850 pages-two-thirds the size of Stewart's other calculus texts (CALCULUS, Fifth Edition and CALCULUS, EARLY TRANSCENDENTALS, Fifth Edition)-and yet it contains almost all of the same topics. The author achieved this relative brevity mainly by condensing the exposition and by putting some of the features on the website, www.StewartCalculus.com. Despite the reduced size of the book, there is still a modern flavor: Conceptual understanding and technology are not neglected, though they are not as prominent as in Stewart's other books. ESSENTIAL CALCULUS has been written with the same attention to detail, eye for innovation, and meticulous accuracy that have made Stewart's textbooks the best-selling calculus texts in the world.

    However, most discussions of Bayesian inference rely on intensely complex mathematical analyses and artificial examples, making it inaccessible to anyone without a strong mathematical background. Now, though, Cameron Davidson-Pilon introduces Bayesian inference from a computational perspective, bridging theory to practice-freeing you to get results using computing power. Bayesian Methods for Hackers illuminates Bayesian inference through probabilistic programming with the powerful PyMC language and the closely related Python tools NumPy, SciPy, and Matplotlib. Using this approach, you can reach effective solutions in small increments, without extensive mathematical intervention. Davidson-Pilon begins by introducing the concepts underlying Bayesian inference, comparing it with other techniques and guiding you through building and training your first Bayesian model. Next, he introduces PyMC through a series of detailed examples and intuitive explanations that have been refined after extensive user feedback. You'll learn how to use the Markov Chain Monte Carlo algorithm, choose appropriate sample sizes and priors, work with loss functions, and apply Bayesian inference in domains ranging from finance to marketing. Once you've mastered these techniques, you'll constantly turn to this guide for the working PyMC code you need to jumpstart future projects. Coverage includes - Learning the Bayesian "state of mind" and its practical implications - Understanding how computers perform Bayesian inference - Using the PyMC Python library to program Bayesian analyses - Building and debugging models with PyMC - Testing your model's "goodness of fit" - Opening the "black box" of the Markov Chain Monte Carlo algorithm to see how and why it works - Leveraging the power of the "Law of Large Numbers" - Mastering key concepts, such as clustering, convergence, autocorrelation, and thinning - Using loss functions to measure an estimate's weaknesses based on your goals and desired outcomes - Selecting appropriate priors and understanding how their influence changes with dataset size - Overcoming the "exploration versus exploitation" dilemma: deciding when "pretty good" is good enough - Using Bayesian inference to improve A/B testing - Solving data science problems when only small amounts of data are available Cameron Davidson-Pilon has worked in many areas of applied mathematics, from the evolutionary dynamics of genes and diseases to stochastic modeling of financial prices. His contributions to the open source community include lifelines, an implementation of survival analysis in Python. Educated at the University of Waterloo and at the Independent University of Moscow, he currently works with the online commerce leader Shopify.

    G. Wells predicted that statistical thinking would be as necessary for citizenship in a technological world as the ability to read and write. But in the twenty-first century, we are often overwhelmed by a baffling array of percentages and probabilities as we try to navigate in a world dominated by statistics. Cognitive scientist Gerd Gigerenzer says that because we haven't learned statistical thinking, we don't understand risk and uncertainty. In order to assess risk -- everything from the risk of an automobile accident to the certainty or uncertainty of some common medical screening tests -- we need a basic understanding of statistics.Astonishingly, doctors and lawyers don't understand risk any better than anyone else. Gigerenzer reports a study in which doctors were told the results of breast cancer screenings and then were asked to explain the risks of contracting breast cancer to a woman who received a positive result from a screening. The actual risk was small because the test gives many false positives. But nearly every physician in the study overstated the risk. Yet many people will have to make important health decisions based on such information and the interpretation of that information by their doctors.Gigerenzer explains that a major obstacle to our understanding of numbers is that we live with an illusion of certainty. Many of us believe that HIV tests, DNA fingerprinting, and the growing number of genetic tests are absolutely certain. But even DNA evidence can produce spurious matches. We cling to our illusion of certainty because the medical industry, insurance companies, investment advisers, and election campaigns have become purveyors of certainty, marketing it like a commodity.To avoid confusion, says Gigerenzer, we should rely on more understandable representations of risk, such as absolute risks. For example, it is said that a mammography screening reduces the risk of breast cancer by 25 percent. But in absolute risks, that means that out of every 1,000 women who do not participate in screening, 4 will die; while out of 1,000 women who do, 3 will die. A 25 percent risk reduction sounds much more significant than a benefit that 1 out of 1,000 women will reap.This eye-opening book explains how we can overcome our ignorance of numbers and better understand the risks we may be taking with our money, our health, and our lives.

    

    Along the way we’ll learn how selection bias can explain why your boss doesn’t know he sucks (even when everyone else does); how to use Bayes’ Theorem to decide if your partner is cheating on you; and why Mark Zuckerberg should never be used as an example for anything. See the world in a whole new light, and make better decisions and judgements without ever going near a t-test. Think. Think Statistically.