Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    They are not the victims of ruthless enemy warfare, but of their own military commanders. These soldiers, afflicted with rare cancers and respiratory diseases, were sickened from the smoke and ash swirling out of the “burn pits” where military contractors incinerated mountains of trash, including old stockpiles of mustard and sarin gas, medical waste, and other toxic material.This shocking work includes: Illustration of the devastation in one soldier’s intimate storyA plea for helpConnection between the burn pits and Major Biden’s unfortunate suffering and deathThe burn pits’ effects on native citizens of Iraq: mothers, fathers, and childrenDenial from the Department of Defense and othersWarning signs that were ignoredand much moreBased on thousands of government documents, over five hundred in-depth medical case studies, and interviews with more than one thousand veterans and active-duty GIs, The Burn Pits will shock the nation. The book is more than an explosive work of investigative journalism—it is the deeply moving chronicle of the many young men and women who signed up to serve their country in the wake of 9/11, only to return home permanently damaged, the victims of their own armed forces’ criminal negligence.

    But this book will help you to do something that humans have only recently understood how to do: to count to regions that no animal has ever reached. By the end of this book you'll be able to count to infinity... and beyond. On our way to infinity we'll discover how the ancient Babylonians used their bodies to count to 60 (which gave us 60 minutes in the hour), how the number zero was only discovered in the 7th century by Indian mathematicians contemplating the void, why in China going into the red meant your numbers had gone negative and why numbers might be our best language for communicating with alien life.But for millennia, contemplating infinity has sent even the greatest minds into a spin. Then at the end of the nineteenth century mathematicians discovered a way to think about infinity that revealed that it is a number that we can count. Not only that. They found that there are an infinite number of infinities, some bigger than others. Just using the finite neurons in your brain and the finite pages in this book, you'll have your mind blown discovering the secret of how to count to infinity.Do something amazing and learn a new skill thanks to the Little Ways to Live a Big Life books!

    Too bad. Because medicine isn't an industry, it's practically witchcraft. Despite the growth of big pharma, HMOs, and hospital chains, medicine remains the isolated work of individual doctors—and the system is going broke fast.So why is Andy Kessler—the man who told you outrageous stories of Wall Street analysts gone bad in Wall Street Meat and tales from inside a hedge fund in Running Money—poking around medicine for the next big wave of technology?It's because he smells change coming. Heart attacks, strokes, and cancer are a huge chunk of medical spending, yet there's surprisingly little effort to detect disease before it's life threatening. How lame is that—especially since the technology exists today to create computer-generated maps of your heart and colon?Because it's too expensive—for now. But Silicon Valley has turned computing, telecom, finance, music, and media upside down by taking expensive new technologies and making them ridiculously cheap. So why not the $1.8 trillion health care business, where the easiest way to save money is to stop folks from getting sick in the first place?Join Kessler's bizarre search for the next big breakthrough as he tries to keep from passing out while following cardiologists around, cracks jokes while reading mammograms, and watches twitching mice get injected with radioactive probes. Looking for a breakthrough, Kessler even selflessly pokes, scans, and prods himself.CT scans of your heart will identify problems before you have a heart attack or stroke; a nanochip will search your blood for cancer cells--five years before they grow uncontrollably and kill you; and baby boomers can breathe a little easier because it's all starting to happen now.Your doctor can't be certain what's going on inside your body, but technology will. Embedding the knowledge of doctors in silicon will bring a breakout technology to health care, and we will soon see an end of medicine as we know it.

    Focused on helping students understand and construct proofs and expanding their mathematical maturity, this best-selling text is an accessible introduction to discrete mathematics. Johnsonbaugh's algorithmic approach emphasizes problem-solving techniques. The Seventh Edition reflects user and reviewer feedback on both content and organization.

    It provides explanations of biological, psychological and social factors in health issues, reinforced with case studies.

    Students will master the central concepts of psychology with the new 10th edition of Psychology from Benjamin Lahey. A new chapter on the Interplay of Nature and Nurture highlights the 10th edition's new organization and streamlined content . Lahey weaves scholarship based on empirical research throughout the text, ensuring an accurate portrait of contemporary psychology. The text's student-friendly writing, new chapter openers, and fresh applications make the material more relevant to students than ever before, and the proven learning system ensures that all students will grasp the concepts presented in the book. Lahey's hallmark emphasis on diversity and culture remains integrated throughout the text, making this the text for a well rounded introduction to all areas of psychology.

    Do you want your students to just take psychology or to experience psychology? Laura King's approach to introductory psychology embodies a balanced consideration of functioning behavior as well as dysfunction and a view of psychology as an integrated whole.

    ANATOMY AND PHYSIOLOGY FOR SPEECH, LANGUAGE, AND HEARING is a core course for all Speech Pathology and Audiology students. In 2004, 239 colleges and universities offered graduate programs in speech-language pathology that are accredited by the Council on Academic Accreditation in Audiology and Speech-Language Pathology. Total undergraduate enrollment: 16,397. (Source: CAPCS, June 2006.) Total graduate enrollment: 7,389. (Source: CAPCS, June 2006.)

    Devlin's Textbook of Biochemistry with Clinical Correlations presents the biochemistry of mammalian cells, relates events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to humans. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this sixth edition is an indispensable tool for students and professionals in the medical or health sciences. Key Features of the Sixth Edition Over 250 Clinical Correlations highlighting the significance of the biochemistry to clinical conditions and diseases MCAT-Style Questions with annontated answers in every chapter - in a format similar to that used by the National Board of Medical Examiners More than 1,200 high-quality, full-color illustrations A concise appendix reviewing important Organic Chemistry Concepts New to the Sixth Edition: Fully Updated with a significant revision of all chapters and major topics Two new chapters: Fundamentals of Signal Transduction and Cell Cycle, Programmed Cell Death, and Cancer A Glossary that explains important biochemical terms New sections on the Basal Lamina Protein Complex and Molecular Motors

    As he wanders the land year upon year, Raymo gathers the revelations embedded in the geological and cultural history of this wild and ancient place. "When I called out for the Absolute, I was answered by the wind," Raymo writes. "If it was God's voice in the wind, then I heard it." In poetic prose grounded in a mind trained to discover fact, Honey from Stone enters the wonder of the material world in search of our deepest nature.

    Darwin’s theory has withstood 150 years of scientific scrutiny, and today it not only explains the origin and design of living things, but highlights the importance of a scientific understanding in our culture and in our lives.Recently the movement known as “Intelligent Design” has attracted the attention of journalists, educators, and legislators. The scientific community is puzzled and saddened by this trend–not only because it distorts modern biology, but also because it diverts people from the truly fascinating ideas emerging from the real science of evolution. Here, join fifteen of our preeminent thinkers whose clear, accessible, and passionate essays reveal the fact and power of Darwin’s theory, and the beauty of the scientific quest to understand our world.

    The authors make these subjects accessible through carefully worked examples illustrating the technical aspects of the subject, and intuitive explanations of what is going on behind the mathematics. After presenting the basics of quantum electrodynamics, the authors discuss the theory of renormalization and its relation to statistical mechanics, and introduce the renormalization group. This discussion sets the stage for a discussion of the physical principles that underlie the fundamental interactions of elementary particle physics and their description by gauge field theories.

    A Key Strength Of This Text Is Zill'S Emphasis On Differential Equations As Mathematical Models, Discussing The Constructs And Pitfalls Of Each. The Third Edition Is Comprehensive, Yet Flexible, To Meet The Unique Needs Of Various Course Offerings Ranging From Ordinary Differential Equations To Vector Calculus. Numerous New Projects Contributed By Esteemed Mathematicians Have Been Added. Key Features O The Entire Text Has Been Modernized To Prepare Engineers And Scientists With The Mathematical Skills Required To Meet Current Technological Challenges. O The New Larger Trim Size And 2-Color Design Make The Text A Pleasure To Read And Learn From. O Numerous NEW Engineering And Science Projects Contributed By Top Mathematicians Have Been Added, And Are Tied To Key Mathematical Topics In The Text. O Divided Into Five Major Parts, The Text'S Flexibility Allows Instructors To Customize The Text To Fit Their Needs. The First Eight Chapters Are Ideal For A Complete Short Course In Ordinary Differential Equations. O The Gram-Schmidt Orthogonalization Process Has Been Added In Chapter 7 And Is Used In Subsequent Chapters. O All Figures Now Have Explanatory Captions. Supplements O Complete Instructor'S Solutions: Includes All Solutions To The Exercises Found In The Text. Powerpoint Lecture Slides And Additional Instructor'S Resources Are Available Online. O Student Solutions To Accompany Advanced Engineering Mathematics, Third Edition: This Student Supplement Contains The Answers To Every Third Problem In The Textbook, Allowing Students To Assess Their Progress And Review Key Ideas And Concepts Discussed Throughout The Text. ISBN: 0-7637-4095-0

    In the new edition of Biochemistry, instructors will see the all the hallmark features that made this a consistent bestseller for the undergraduate biochemistry course: exceptional clarity and concision, a more biological focus, cutting-edge content, and an elegant, uncluttered design.  Accomplished in both the classroom and the laboratory, coauthors Jeremy Berg and John Tymoczko draw on the field's dynamic research to illustrate its fundamental ideas.