And yet, the 1949 discovery of lithium as a cure for bipolar disorder is perhaps one of the most important—yet largely unsung—breakthroughs of the modern era. In Lithium, Walter Brown, a practicing psychiatrist and professor at Brown, reveals two unlikely success stories: that of John Cade, the physician whose discovery would come to save an untold number of lives and launch a pharmacological revolution, and that of a miraculous metal rescued from decades of stigmatization.From insulin comas and lobotomy to incarceration to exile, Brown chronicles the troubling history of the diagnosis and (often ineffective) treatment of bipolar disorder through the centuries, before the publication of a groundbreaking research paper in 1949. Cade’s “Lithium Salts in the Treatment of Psychotic Excitement” described, for the first time, lithium’s astonishing efficacy at both treating and preventing the recurrence of manic-depressive episodes, and would eventually transform the lives of patients, pharmaceutical researchers, and practicing physicians worldwide. And yet, as Brown shows, it would be decades before lithium would overcome widespread stigmatization as a dangerous substance, and the resistance from the pharmaceutical industry, which had little incentive to promote a naturally occurring drug that could not be patented.With a vivid portrait of the story’s unlikely hero, John Cade, Brown also describes a devoted naturalist who, unlike many modern medical researchers, did not benefit from prestigious research training or big funding sources (Cade’s “laboratory” was the unused pantry of an isolated mental hospital). As Brown shows, however, these humble conditions were the secret to his historic success: Cade was free to follow his own restless curiosity, rather than answer to an external funding source. As Lithium makes tragically clear, medical research—at least in America—has transformed in such a way that serendipitous discoveries like Cade’s are unlikely to occur ever again.Recently described by the New York Times as the “Cinderella” of psychiatric drugs, lithium has saved countless of lives and billions of dollars in healthcare costs. In this revelatory biography of a drug and the man who fought for its discovery, Brown crafts a captivating picture of modern medical history—revealing just how close we came to passing over this extraordinary cure.

    Tiffany Watt Smith covers the globe and draws on history, anthropology, science, art, literature, music and popular culture to explore them. Each emotion has its own story, and reveals the strange forces which shape our rich and varied internal worlds. You’ll discover feelings you never knew you had (like basorexia, the sudden urge to kiss someone), uncover secret histories of boredom and confidence, and gain unexpected insights into why we feel the way we do.

    In Mad House we have an account of the devastating effects of mental illness on the lives of those who share their world?the healthy siblings of those afflicted. Clea Simon was shattered when her older brother, Daniel, a freshman at Harvard, began hearing voices, making it impossible for him to function. He later committed suicide. Schizophrenia next claimed her sister, Katherine, who has moved from one institution to another after refusing any help from her family. Simon, who spoke with hundreds of other siblings of the mentally ill and with experts in the field, confronts the issues healthy siblings face, from guilt (Why do I deserve to be okay?) to fear (Will illness claim me or my children next?) to anger at being neglected by parents overwhelmed by the needs of the mad child. Part memoir, part practical guide, Mad House is a compelling and compassionate book destined to help many people come to terms, as Simon has, with the unique pain of living with a sibling?s mental illness.

    Applying the same objective criteria to legal and illegal substances, an argument is made that legality is not a clear measure for harm. Tackling a variety of questions, such as Which is more harmful—Ecstasy or alcohol? Can addiction be cured? and Does the "War on Drugs" have serious unintended effects that can hurt children?, this analysis equips readers with the ability to make educated decisions regarding drugs both personally and in their communities. Broadening the scope of the discussion, a framework is explored for formulating national drug policies that will minimize a myriad of harms—social, medical, criminal, financial, and environmental.

    While on set, Mark met the women of Ward 81, the only locked hospital security ward for women in the state: the inmates were considered dangerous to themselves or to others. In February of 1976, just before the ward closed (it ceased to exist in November of 1977, when it became the female section of a coeducational treatment ward), Mark and Karen Folger Jacobs, a writer and social scientist, were given permission to make a more extended stay, living on the ward in order to photograph and interview the women. They spent 36 days on Ward 81, photographing and documenting. Jacobs recalls their slow, inevitable assimilation: "We felt the degeneration of our own bodies and the erosion of our self-confidence. We were horrified at the thought of what we might become after a year or two of confinement and therapy on Ward 81." This new hardcover edition adds 10 new pictures to the original. Ward 81 is a sobering investigation into the lives and treatment of the mentally ill.

    . . A riveting and anxiety-inducing read. Mike Pond tells his story of recovery from alcoholism with a brutally honest, warts-and-all approach that makes you want cheer for him and simultaneously slap him upside the head.” – Vancouver SunPsychotherapist Michael Pond is no stranger to the devastating consequences of alcoholism. He has helped hundreds of people conquer their addictions, but this knowledge did not prevent his own near-demise. In this riveting memoir, he recounts how he lost his Penticton-based practice, his home, and his family—all because of his drinking. After scores of visits to the ER, a tour of hellish recovery homes, a stint in intensive care for end-stage alcoholism, and jail, Pond devised his own personal plan for recovery. He met Maureen Palmer and together they investigated scientific alternatives to the rigid abstinence doctrine pushed by Alcoholics Anonymous.

    Why does music evoke such powerful moods? The answers are at last be- coming clear, thanks to revolutionary neuroscience and the emerging field of evolutionary psychology. Both a cutting-edge study and a tribute to the beauty of music itself, This Is Your Brain on Music unravels a host of mysteries that affect everything from pop culture to our understanding of human nature, including: • Are our musical preferences shaped in utero? • Is there a cutoff point for acquiring new tastes in music? • What do PET scans and MRIs reveal about the brain’s response to music? • Is musical pleasure different from other kinds of pleasure?This Is Your Brain on Music explores cultures in which singing is considered an essential human function, patients who have a rare disorder that prevents them from making sense of music, and scientists studying why two people may not have the same definition of pitch. At every turn, this provocative work unlocks deep secrets about how nature and nurture forge a uniquely human obsession.

    Hours of her life simply disappeared. She'd hear voices shouting at her, telling her she was useless. And the nightmares that had haunted her since early childhood, scenes of men abusing her, became more detailed . . . more real. Staring at herself in the mirror she'd catch her face changing, as if someone else was looking out through her eyes.In this work she describes her journey from a teenage girl battling anorexia and OCD, drowning the voices with alcohol, to a young woman slipping further and further into mental illness. It was only after years lost in institutions that she was correctly diagnosed with multiple personality disorder. When her alternative personalities were revealed in therapy she discovered how each one had their own memories of abuse and a full picture of her childhood finally emerged. As she learned to live with her many 'alters', she set out to confront the man who had caused her unbearable pain.Moving and ultimately inspiring, this is a gripping account of a rare condition, and the remarkable story of a courageous woman.

    Joel Gold had seen before was admitted to his unit at Bellevue Hospital. This man claimed he was being filmed constantly and that his life was being broadcast around the world like The Truman Show—the 1998 film depicting a man who is unknowingly living out his life as the star of a popular soap opera. Over the next few years, Dr. Gold saw a number of patients suffering from what he and his brother, Dr. Ian Gold, began calling the “Truman Show delusion,” launching them on a quest to understand the nature of this particular phenomenon, of delusions more generally, and of madness itself.The current view of delusions is that they are the result of biology gone awry, of neurons in the brain misfiring. In contrast, the Golds argue that delusions are the result of the interaction between the brain and the social world. By exploring the major categories of delusion through fascinating case studies and marshaling the latest research in schizophrenia, the brothers reveal the role of culture and the social world in the development of psychosis—delusions in particular. Suspicious Minds presents a groundbreaking new vision of just how dramatically our surroundings can influence our brains.

     A Million Little Pieces was the first Oprah Book Club pick by a living author in over two years. It instantly became a #1 New York Times bestseller, a #1 USA Today bestseller, and a #1 Publishers Weekly bestseller, with over 1.7 million copies in print. My Friend Leonard picks up right where Pieces leaves off. A New York Times bestseller in its own right before the Oprah pick, My Friend Leonard is James Frey's story of his friendship with Leonard, the larger-than-life mobster who "adopted" James as he left rehab. Leonard, who offers James lucrative-if illegal, mysterious, and slightly dangerous-employment when he needs it. Leonard, of the secret deals, of the surprising passions that belie his violent career choice, of fantastic generosity and ferocious loyalty. Leonard, who has been holding on to some remarkable secrets, and who has invested in their friendship more than James could ever imagine. My Friend Leonard is, at its core, about the responsibility that comes with loving someone and going out on any number of limbs to care for them. And it is a book that proves that one of the most provocative literary voices of his generation is also one of the most emphatically human.

    As the cancer progressed and was treated, the author experienced behavioral and cognitive symptoms connected to a range of mental disorders, including her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, recalled her experience and, through her knowledge of neuroscience, identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist McArdle, shows that strength and courage but also a encouraging support network are vital to recovery

    Understand how to use groundbreaking science to improve your health, mood, and more.In just the last few years, scientists have shown how the microscopic ecosystem within our bodies—particularly within our intestines—has an astonishing impact on our lives. Pioneering scientist Rob Knight and award-winning science journalist Brendan Buhler explain—with humor and witty metaphors—why these new findings matters to everyone.You are mostly not you. The human gut is host to trillions of microbes, and evidence shows that small changes in these microbes present (altered by antibiotics, diet, geographic region, and so on) may affect weight, likelihood of disease, and even psychological factors like risk-taking behavior. The evidence for their influence is astonishing. Rob Knight is one of the key figures driving forward this new science. His work demonstrates the startling connection between the presence of certain harmless bacteria and the health benefits we all seek for ourselves and our children.In Follow Your Gut, Knight pairs with Brendan Buhler, an award-winning science writer, to explore the previously unseen world inside our bodies. With a practical eye toward deeper knowledge and better decisions, they lead a detailed tour of our microbiome as well as an exploration of the known effects of antibiotics, probiotics, diet choices, birth method, and access to livestock on our children's lifelong health. Ultimately, this pioneering book explains how to learn about your own micro biome and take steps toward understanding and improving your health, using the latest research as a guide.

    From A Child Called “It” to The Lost Boy, from A Man Named Dave to Help Yourself, Dave Pelzer’s inspirational books have helped countless others triumph over hardship and misfortune.  In The Privilege of Youth, he shares the missing chapter of his life: as a boy on the threshold of adulthood.  With sensitivity and insight, he recounts the relentless taunting he endured from bullies; but he also describes the thrill of making his first real friends—some of whom he still shares close relationships with today.  He writes about the simple pleasures of exploring his neighborhood, while trying to forget the hell waiting for him at home.From high school to a world beyond the four walls that were his prison for so many years, The Privilege of Youth bravely and compassionately charts this crucial turning point in Dave Pelzer’s life and will inspire a whole new generation of readers.

    It helped thousands by giving clear instructions to doctors, nurses, and families on how to handle a patient's request for euthanasia.In the wake of court cases and legislative mandates, this revised and updated third edition goes far beyond the original to provide new information about the legality of euthanasia and assisted suicide, and a thoughtful examination of the personal issues involved. It has become the essential source to help loved ones and supportive doctors remain within existing laws and keep a person's dying intimate, private, and dignified.With deep compassion and sensitivity, it spells out why a living will may not be sufficient to have a person's wishes carried out—and what document is a better alternative. It updates where to get proper drugs and exactly how to carry out the quickest, most peaceful way to make a final exit. Finally, it gently talks to a person considering self-deliverance about alternatives, planning, and the means to make every death a "good death" at our time of greatest need.

    Despite distressing statistics that show suicide rates rising, the subject, long a taboo, is infrequently talked about. In this sweeping intellectual and cultural history, poet and historian Jennifer Michael Hecht channels her grief for two friends lost to suicide into a search for history’s most persuasive arguments against the irretrievable act, arguments she hopes to bring back into public consciousness. From the Stoics and the Bible to Dante, Shakespeare, Wittgenstein, and such twentieth-century writers as John Berryman, Hecht recasts the narrative of our “secular age” in new terms. She shows how religious prohibitions against self-killing were replaced by the Enlightenment’s insistence on the rights of the individual, even when those rights had troubling applications. This transition, she movingly argues, resulted in a profound cultural and moral loss: the loss of shared, secular, logical arguments against suicide. By examining how people in other times have found powerful reasons to stay alive when suicide seems a tempting choice, she makes a persuasive intellectual and moral case against suicide.