In The Compatibility Gene, one of our foremost immunologists tells the remarkable history of these genes' discovery and the unlocking of their secrets. Davis shows how the compatibility gene is radically transforming our knowledge of the way our bodies work - and is having profound consequences for medical research and ethics. Looking to the future, he considers the startling possibilities of what these wondrous discoveries might mean for you and me.

    But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    Their first intimation of our existence might well be a Super Bowl broadcast or a stray transmission from the Playboy channel. But, of course, they might seem equally strange to us. How strange? Their senses could be entirely different from ours—they might see in the infrared or “hear” radio waves.What would aliens look like? An intelligent octopus-like creature is certainly plausible. What about odd numbers of limbs—a three-legged alien with three arms and three eyes? What about an entire planet of immobile, silicon-based “trees” that communicate with each other via electrical signals?The Science of Aliens gets weirder still. Could a giant interstellar cloud be “alive” and intelligent? Could creatures live at extremely high pressures and temperatures? And which of these many possibilities would be similar enough to us that they could communicate with them, or they with us? Would they have any interest in abducting us? Would they want to have sex with us?In classic Pickover style, here is speculation at the far edge of knowledge—and beyond.

    But Vidal was also a terrific conversationalist; indeed Dick Cavett once described him as “the best talker since Oscar Wilde.” Vidal was never more eloquent, or caustic, than when let loose on his favorite topic: the history and politics of the United States.This book is made up from four interviews conducted with his long-time interlocutor, the writer and radio host Jon Wiener, in which Vidal grapples with matters evidently close to his heart: the history of the American Empire, the rise of the National Security State, and his own life in politics, both as a commentator and candidate.The interviews cover a twenty-year span, from 1988 to 2008, when Vidal was at the height of his powers. His extraordinary facility for developing an argument, tracing connections between past and present, and drawing on an encyclopedic knowledge of America’s place in the world, are all on full display. And, of course, it being Gore Vidal, an ample sprinkling of gloriously acerbic one-liners is also provided.

    Wade case shares the fascinating and highly controversial story of her struggle to obtain a legal abortion 20 years ago and what has happened to her since. "A powerful and important American document".--New York Times.

    All animals, human or otherwise, thrive when they mimic key elements of life in their natural habitat. From diet to movement to sleep, this evolutionary perspective sheds light on some of our most pressing health concerns. What is causing the rise of chronic conditions, such as obesity, diabetes, and depression? Is eating red meat going to kill you? Is avoiding the sun actually the best way to avoid skin cancer? Durant takes readers on a thrilling ride to the Paleolithic and beyond, unlocking the health secrets of our ancient ancestors. What do obese gorillas teach us about weight loss? How can Paleolithic skulls contain beautiful sets of teeth? Why is the Bible so obsessed with hygiene? What do NASA astronauts teach us about getting a good night’s sleep? And how are Silicon Valley techies hacking the human body? Blending science and culture, anthropology and philosophy, John Durant distills the lessons from his adventures and shows how to apply them to day-to-day life, teaching people how to construct their own personal “habitat” that will enable them to thrive. The book doesn’t just address what we eat, but why we eat it; not just how to exercise, but the purpose of functional movement; not just being healthy, but leading a purposeful life. Combining the best of ancient wisdom with cutting edge science, Durant crafts a vision of health that is both fresh and futuristic.

    Revised to reflect the latest research in the field, this book emphasizes the relationships and concepts that link cell and tissue structures with their functions. A bonus image library CD-ROM featuring all the photos and illustrations from the text with "zoom in" and "zoom out" capability is also included.

    We have long been told to breakfast like kings and dine like paupers. In the wake of his own type 2 diabetes diagnosis, Professor Terence Kealey was given the same advice. He soon noticed that his glucose levels were unusually high after eating in the morning, but if he fasted until lunchtime they fell. Professor Kealey began to question how much evidence there was to support the advice he’d been given, and whether there might be an advantage to not eating breakfast after all.Breakfast is a Dangerous Meal asks:What is the reliable scientific and medical evidence for eating breakfast?Who should consider intermittent fasting by removing breakfast from their daily routine?From weight loss to reduced blood pressure, what are the potential benefits of missing breakfast?

    In the third edition, all the chapters have been thoroughly revised and the concepts updated. A new chapter on the spectral analysis of heart rate variability has been added. This is the first textbook in medicine to introduce this topic as a text for medical students. Apart from this, the feedback received from students and teachers has been given due importance and is reflected in this edition.

    The first small cities formed not only the cradle of civilization, but the spawning ground for the earliest viral epidemics, the first opportunity for viruses to find a home in the human herd. This is a story of fear and ignorance, as everything from demons and the wrath of the gods to minority groups have been blamed for epidemics from smallpox to yellow fever to AIDS. It is a story of grief and heartbreak, as hundreds of thousands, sometimes millions, are wiped out in a single year. And it is a story of great bravery and sacrifice, as doctors and nurses put themselves in harm's way to combat yellow fever in Memphis and Ebola in Zaire, and as researchers risk their own lives to test theories of vaccines and the transmission of disease. Now, in Viruses, Plagues, and History, Michael B. A. Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented humanity.Oldstone focuses his tale on a few of the most famous viruses humanity has battled, beginning with some we have effectively defeated, such as smallpox, polio, and measles. Nearly 300 million people were killed by smallpox in this century alone -- more than were killed in all the wars of the twentieth century combined. The author presents a vivid account of the long campaign against the virus, the insightful work of Edward Jenner, who created the smallpox vaccine from cowpox virus in 1796, and the monumental efforts of D. A. Henderson and an army of W.H.O. health care workers to finally eradicate smallpox. The smallpox virus remains the only organism that we have deliberately pushed to complete extinction in the wild.Oldstone then describes the fascinating viruses that have captured headlines in more recent years: Ebola and other hemorrhagic fevers, which literally turn their victims' organs to a bloody pulp; the Hantavirus outbreaks in the southwestern United States and elsewhere; mad cow disease, a frightening illness made worse by government mishandling and secrecy; and, of course, AIDS, often called the plague of our time. And he tells us of the many scientists watching and waiting even now for the next great plague, monitoring influenza strains to see whether the deadly variant from 1918 -- a viral strain that killed over 20 million people in 1918-1919, more than twice the military and civilian casualties of the First World War -- will make a comeback.Viruses have enormous power. They have wiped out cities, brought down dynasties, and helped destroy civilizations. But, as Michael Oldstone reveals, scientific research has given us the power to tame many of these viruses as well. Viruses, Plagues, and History shows us the panorama of humanity's long-standing conflict with our unseen viral enemies, from our successes to our continuing struggles. Oldstone's book is a vivid history of a fascinating field, and a highly reliable dispatch from a worker on the frontiers of this ongoing campaign.

    Our garbage has become a massive and exponentially growing problem in modern society. Eco-entrepreneur Tom Szaky explores why this crisis exists and explains how can we solve it by eliminating the very idea of garbage. To outsmart waste, he says, we first have to understand it, then change how we create it, and finally rethink what we do with it.By mimicking nature and focusing on the value inherent in our by-products, we can transform the waste we can’t avoid creating from useless trash to a useful resource. Szaky demonstrates that there is value in every kind of garbage, from used chewing gum to juice pouches to cigarette butts. After reading this mind-expanding book, you will never think about garbage the same way again.

    Now DK brings this ancient practice into the 21st century, explaining how to grow and care for bonsai trees with a clear step-by-step approach.Offering easy-to-follow advice and simple photography, Bonsai demystifies the art of bonsai with sequences covering the traditional styles of Chokkan, Moyogi, Shakan, and Kengai, as well as deadwood bonsai styles such as Ishizuki, Yose Uye, and Sharimiki.For bonsai enthusiasts in search of fresh ideas, innovative techniques, and new ways to display their living art, Bonsai is the must-have book of the season.

    An individual's Decision Tree begins with genomics, where $400 and a test tube of spit provides a peek at how your DNA influences your health. It taps self-monitoring and collaborative health tools, where iPhone applications and next-generation monitoring gadgets can help individuals successfully change their behavior, once and for all. And it turns to new screening techniques that detect diseases like cancer and diabetes far earlier and with far better prospects for our health. Full of thoughtful, groundbreaking reporting on the impact personalized medicine will have on the average patient, The Decision Tree will show you how to take advantage of this new frontier in health care.

    With reference to the Indian scene.

    Your colleagues, family, and friends may be tired of your moods, your chronic fatigue, and your various aches and illnesses--none of which seem to have a clear cause. You get the jitters, you're nervous, and you can get edgy and irritable at the drop of a hat, especially if you haven't eaten in a while. Now there's a book to give you a better understanding of hypoglycemia and an easy-to-follow program for recovery. Hypoglycemia For Dummies sorts through the confusion surrounding this condition, presenting expert information on diagnosis, risk factors, and treatment options for anyone who suffers from this disease--or knows someone who does. You'll discover the different types of hypoglycemia, the most common symptoms, and the link between hypoglycemia and diabetes. This p lain-English guide shows you how to:Diagnose low blood sugar Choose the best form of treatment for your condition Create a practical, healthy, doable diet Develop a enjoyable exercise regimen Deal with depression and anxiety Achieve and maintain your ideal weight You'll find step-by-step guidelines to help you get your blood sugar under control, as well as advice on finding the right doctor and setting up a support network.Hypoglycemia For Dummies also covers:Overlapping syndromes, such as fibromyalgia and candidasis Glucose tolerance tests Easy ways to keep your diet in balance Easing symptoms and energizing with aerobics, yoga, and weights Vitamins and supplements Dealing with hypoglycemia in the workplace and in relationships Stress-reduction through breathing exercises, meditating, and self-hypnosis Featuring delicious, healthy recipes that will ease your symptoms, tips for tackling temptation, and a list of helpful resources, Hypoglycemia For Dummies provides the information you need to get a handle on the disease, make changes in your lifestyle, and improve your well-being.