But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought - just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportionof DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'?Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact ofits 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes ofNeanderthals as well as that of chimps about the development our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

    The first volume in this annual series of the best writing by Americans, meticulously selected by bestselling author James Gleick, one of the foremost chronicles of scientific social history, debuts with a stellar collection of writers and thinkers.  Many of these cutting-edge essays offer glimpses of new realms of discovery and thought, exploring territory that is unfamiliar to most of us, or finding the unexpected in the midst of the familiar.  Nobel Laureate physicist Steven Weinberg challenges the idea of whether the universe has a designer; Pulitzer Prize winner Natalie Angier reassesses caveman (and-woman) couture; bestselling author and Darwinian theorist Stephen Jay Gould makes a claim for the man whose ideas Darwin discredited; Timothy Ferris proposes a realistic alternative to wrap-speed interseller travel; neurologist and bestselling author Oliver Sacks reminisces about his first loves-chemistry and math.  This diverse, stimulating and accessible collection is required reading for anyone who wants to travel to the frontier of knowledge.

    In Dirk Gently's Holistic Detective Agency, Dirk finds himself on the trail of a gruesome murderer who is somehow involved with the works of Coleridge, quantum physics, and the enigmatic study of the Cambridge Professor of Chronology. Ultimately, the stakes of the case are far greater than a single murder, but go to the fate of life on Earth. Confused? Don't be - everything is connected.

    An individual's Decision Tree begins with genomics, where $400 and a test tube of spit provides a peek at how your DNA influences your health. It taps self-monitoring and collaborative health tools, where iPhone applications and next-generation monitoring gadgets can help individuals successfully change their behavior, once and for all. And it turns to new screening techniques that detect diseases like cancer and diabetes far earlier and with far better prospects for our health. Full of thoughtful, groundbreaking reporting on the impact personalized medicine will have on the average patient, The Decision Tree will show you how to take advantage of this new frontier in health care.

    Our beginners guide contains all the essential information you need in order to succeed. It covers the basic techniques, well illustrated with over a hundred images, and explains everything you need to know in an understandable way. Bonsai Empire is the world's most visited Bonsai website and has provided beginners with quality information for over a decade. We have developed this guide to help you get a taste of this fascinating and living art, and hope you'll enjoy it as much as we do! This book includes: - Over 100 stunning images - Over 80 pages - Explanations of the basic techniques - Care guides on the 10 most popular tree species - Background on the history, definition and styles Walter Pall: "Now here is the ultimate book to lead beginners. I am happy to have been able to contribute to this" Mauro Stemberger "Very clear" and "With great quality drawings and pics"

    Soon Gen Xers will be the only cohort of Americans who remember life as it was lived before the arrival of the Internet. They are, as Hennessey dubs them, “the last adult generation,” the sole remaining link to a time when childhood was still a bit dangerous but produced adults who were naturally resilient. More than a decade into the social media revolution, the American public is waking up to the idea that the tech sector’s intentions might not be as pure as advertised. The mountains of money being made off our browsing habits and purchase histories are used to fund ever-more extravagant and utopian projects that, by their very natures, will corrode the foundations of free society, leaving us all helpless and digitally enslaved to an elite crew of ultra-sophisticated tech geniuses. But it’s not too late to turn the tide. There’s still time for Gen X to write its own future. A spirited defense of free speech, eye contact, and the virtues of patience, Zero Hour for Gen X is a cultural history of the last 35 years, an analysis of the current social and historical moment, and a generational call to arms.

    Written with Barnard’s cooperation and with input from dozens of associates, drivers and rivals, this biography tells the entire story, both personal and professional, of a British design genius. Barnard’s technical achievements are explored in detail — and in accessible language — with special emphasis on his brilliant initiatives while at McLaren (the first carbon-fibre composite chassis) and Ferrari (the first semi-automatic gearbox). The Perfect Car is also a human-interest story, telling a tale of innovation under intense pressure while Barnard endeavoured to maintain a stable family life. This is a landmark book that will be relished by anyone interested in motorsport and design.

    The Golden Retriever's personality is as golden as his outer coat. He was bred to please, and please he does. He started out as a hunting partner who delivered birds to hand and has evolved into modern times delivering whatever suits his owner's fancy. Because Golden Retrievers were originally bred to work in tandem with humans, they are also highly trainable. Golden Retrievers For Dummies is intended for busy 21st century dog owners who don't have time to sit down and read through 300 pages at a crack. This is a reference you can jump in and out of as dog questions rear their furry heads. This handy guide is also for you ifYou own a Golden Retriever or thinking about getting one. You've just brought home a Golden pup. You want to find the best way to raise and train your Golden. You want to help your Golde n to not just survive but to thrive. Find out what it takes to own this active, intelligent, and friendly dog. Explore the Golden's personality traits and living requirements. Discover which diseases are hereditary. This reference guide covers all the aspects of dog ownership, including:Looking at breeders, rescue groups, and animal shelters Adopting and caring for older dogs Selecting a puppy with help from an established testing process Dog-proofing your house and yard Crate training, housetraining, and obedience training Canine communication and growing pains Feeding, exercising, and playing with your Golden Dealing with illness, problem behavior, and treatment Grooming for health and beauty If you're serious about this Golden business and not just caving in to the kids or some other wild impulse, follow the advice of responsible dog owners and breeders. Look deep into your dog-loving soul and carefully consider the big picture. Love alone is not enough.

    Although molecular topics are presented first, instructors can assign the chapters in any sequence. Pedagogical features such as chapter-opening “Key Questions” and strategically placed “Keynotes” help readers to efficiently master genetic concepts. The Genetics Place Companion Website contains interactive iActivities and narrated animations that help readers visualize and understand processes and concepts that are illustrated in the book. Genetics: An Introduction, DNA: The Genetic Material, DNA Replication, Gene Control of Proteins, Gene Expression: Transcription,Gene Expression: Translation, DNA Mutation, DNA Repair, and Transposable Elements, Structural Genomics, Functional and Comparative Genomics, Recombinant DNA Technology, Mendelian Genetics, Chromosomal Basis of Inheritance, Extensions of and Deviations from Mendelian Genetic Principles, Genetic Mapping in Eukaryotes, Genetics of Bacteria and Bacteriophages, Variations in Chromosome Structure and Number, Regulation of Gene Expression in Bacteria and Bacteriophages, Regulation of Gene Expression in Eukaryotes, Genetic Analysis of Development, Genetics of Cancer, Quantitative Genetics, Population Genetics, Molecular Evolution Intended for those interested in learning the basics of genetics

    A space vessel called Schrodinger's Box discovers the creature, brings it back to life, and analyzes its intellectual and physical capabilities. It's not long before the scientists realize the creature is able to manipulate the make-up of objects, including organic matter, at a molecular level. The eyes of the scientific world are on Schrodinger's Box, but not everyone is pleased with the discovery. A group of terrorists attempts to intercept the ship and destroy it.

    Conway Morris is one of the few paleontologists ever to explore the Burgess Shale, having been involved in the dig since 1972, and thus he is an ideal guide to this amazing discovery. Indeed, he provides a complete overview of this remarkable find, ranging from an informative, basic discussion of the origins of life and animals on earth, to a colorful description of Charles Walcott's discovery of the Burgess Shale and of the painstaking scientific work that went on there (as well as in Burgess collections held at Harvard and the Smithsonian), to an account of similar fossil finds in Greenland and in China. The heart of the book is an imaginative trip in a time machine, back to the Cambrian seas, where the reader sees first-hand the remarkable diversity of life as it existed then. And perhaps most important, Conway Morris examines the lessons to be learned from the Burgess Shale, especially as they apply to modern evolutionary thinking. In particular, he critiques the ideas of Stephen Jay Gould, whose best-selling book Wonderful Life drew on Conway Morris's Burgess Shale work. The author takes a fresh look at the evidence and draws quite different conclusions from Gould on the nature of evolution. This finely illustrated volume takes the reader to the forefront of paleontology as it provides fresh insights into the nature of evolution and of life on earth.

    The ultimate reference to 355 dinosaurs from the Triassic, Jurassic and Cretaceous periods, including more than 900 watercolors, maps, timelines and photographs.Includes the best-known non-dinosaurs such as sea-living placodonts, nothosaurs, plesiosaurs, mosasaurs and ichthyosaurs, as well as the airborne pterosaurs.With informative descriptions, technically accurate profiles, anatomical illustrations, depictions of dinosaur habitats, and maps of fossil sites.

    This thorough revision provides a survey by groups, emphasizing adaptive morphology and physiology, while covering anatomical ground plans and basic developmental patterns. New co-author Richard Fox brings to the revision his expertise as an ecologist, offering a good balance to Ruppert's background as a functional morphologist. Rich illustrations and extensive citations make the book extremely valuable as a teaching tool and reference source.

    In The Horse, the journalist and equestrienne Wendy Williams brings that story brilliantly to life.Williams chronicles the 56-million-year journey of horses as she visits with horse experts around the world, revealing what our biological affinities and differences can tell us about the bond between horses and humans, and what our noble companion may think and feel. Indeed, recent scientific breakthroughs regarding the social and cognitive capacities of the horse and its ability to adapt to changing ecosystems indicate that this animal is a major evolutionary triumph.Williams charts the course that leads to our modern Equus-from the protohorse to the Dutch warmbloods, thoroughbreds, and miniature horses of the twenty-first century. She observes magnificent ancient cave art that signals a deep respect and admiration for horses well before they were domesticated, visits the mountains of Wyoming with an expert in equine behavior to understand the dynamics of free-roaming mustangs, witnesses the fluid gracefulness of the famous Lipizzaners of Vienna, contemplates what life is like for the sure-footed, mustachioed Garrano horses who thrive on the rugged terrain of Galicia, celebrates the Takhi horses of Mongolia, and more. She blends profound scientific insights with remarkable stories to create a unique biography of the horse as a sentient being with a fascinating past and a finely nuanced mind.The Horse is a revelatory account of the animal who has been at our side through the ages, carrying us into battle and traveling with us across the plains. Enriched by Wendy Williams's own experience with horses, The Horse is a masterful work of narrative nonfiction that pays tribute to this champion of the natural world.

    How we react to a beautiful painting or symphony draws upon instincts laid down long before humans existed. Now, in this enhanced edition of the highly popular The Artful Universe, Barrow further explores the close ties between our aesthetic appreciation and the basic nature of the Universe. Barrow argues that the laws of the Universe have imprinted themselves upon our thoughts and actions in subtle and unexpected ways. Why do we like certain types of art or music? What games and puzzles do we find challenging? Why do so many myths and legends have common elements? In this eclectic and entertaining survey, Barrow answers these questions and more as he explains how the landscape of the Universe has influenced the development of philosophy and mythology, and how millions of years of evolutionary history have fashioned our attraction to certain patterns of sound and color. Barrow casts the story of human creativity and thought in a fascinating light, considering such diverse topics as our instinct for language, the origins and uses of color in nature, why we divide time into intervals as we do, the sources of our appreciation of landscape painting, and whether computer-generated fractal art is really art. Drawing on a wide variety of examples, from the theological questions raised by St. Augustine and C.S. Lewis to the relationship between the pure math of Pythagoras and the music of the Beatles, The Artful Universe Expanded covers new ground and enters a wide-ranging debate about the meaning and significance of the links between art and science.