With great compassion and erudition, Gabor Maté demystifies medical science and, as he did in Scattered Minds, invites us all to be our own health advocates.

    It’s so bound up with our deepest feelings that emotional trauma causes it to change shape.Practising cardiologist Sandeep Jauhar beautifully weaves his own experiences with the defining discoveries of the past to tell the story of our most vital organ. He looks at some of the pioneers who risked their careers and their patients’ lives to better understand the heart. People like Daniel Hale Williams, who performed the world’s first documented heart surgery, and Wilson Greatbatch, who accidentally invented the pacemaker.Amid gripping scenes from the operating theatre, Jauhar interweaves stories about the patients he’s treated with the moving tale of his family’s own history of heart problems, from his grandfather’s sudden death in India – an event that sparked his life-long obsession – to the ominous signs of how he himself might die.He also confronts the limits of medical technology and argues that future progress will be determined more by how we choose to live rather than by any device we invent.

    In 2013, the New York Times published an obituary for Yvonne Brill. It began: “She made a mean beef stroganoff, followed her husband from job to job, and took eight years off from work to raise three children.” It wasn’t until the second paragraph that readers discovered why the Times had devoted several hundred words to her life: Brill was a brilliant rocket scientist who invented a propulsion system to keep communications satellites in orbit, and had recently been awarded the National Medal of Technology and Innovation. Among the questions the obituary—and consequent outcry—prompted were, Who are the role models for today’s female scientists, and where can we find the stories that cast them in their true light?      Headstrong delivers a powerful, global, and engaging response. Covering Nobel Prize winners and major innovators, as well as lesser-known but hugely significant scientists who influence our every day, Rachel Swaby’s vibrant profiles span centuries of courageous thinkers and illustrate how each one’s ideas developed, from their first moment of scientific engagement through the research and discovery for which they’re best known. This fascinating tour reveals these 52 women at their best—while encouraging and inspiring a new generation of girls to put on their lab coats.

    Joshua Mezrich creates life from loss, transplanting organs from one body to another. In this intimate, profoundly moving work, he illuminates the extraordinary field of transplantation that enables this kind of miracle to happen every day.When Death Becomes Life is a thrilling look at how science advances on a grand scale to improve human lives. Mezrich examines more than one hundred years of remarkable medical breakthroughs, connecting this fascinating history with the inspiring and heartbreaking stories of his transplant patients. Combining gentle sensitivity with scientific clarity, Mezrich reflects on his calling as a doctor and introduces the modern pioneers who made transplantation a reality—maverick surgeons whose feats of imagination, bold vision, and daring risk taking generated techniques and practices that save millions of lives around the world.Mezrich takes us inside the operating room and unlocks the wondrous process of transplant surgery, a delicate, intense ballet requiring precise timing, breathtaking skill, and at times, creative improvisation. In illuminating this work, Mezrich touches the essence of existence and what it means to be alive. Most physicians fight death, but in transplantation, doctors take from death. Mezrich shares his gratitude and awe for the privilege of being part of this transformative exchange as the dead give their last breath of life to the living. After all, the donors are his patients, too.When Death Becomes Life also engages in fascinating ethical and philosophical debates: How much risk should a healthy person be allowed to take to save someone she loves? Should a patient suffering from alcoholism receive a healthy liver? What defines death, and what role did organ transplantation play in that definition? The human story behind the most exceptional medicine of our time, Mezrich’s riveting book is a beautiful, poignant reminder that a life lost can also offer the hope of a new beginning.

    A group of young scientists, under the guidance of Dr. George Church, the most brilliant geneticist of our time, works to make fantasy reality by sequencing the DNA of a frozen woolly mammoth harvested from above the Arctic circle, and splicing elements of that sequence into the DNA of a modern elephant. Will they be able to turn the hybrid cells into a functional embryo and bring the extinct creatures to life in our modern world?Along with Church and his team of Harvard scientists, a world-famous conservationist and a genius Russian scientist plan to turn a tract of the Siberian tundra into Pleistocene Park, populating the permafrost with ancient herbivores as a hedge against an environmental ticking time bomb.

    Yet, as a species, humans have lost the ability to breathe correctly, with grave consequences.Journalist James Nestor travels the world to figure out what went wrong and how to fix it. The answers aren't found in pulmonology labs, as we might expect, but in the muddy digs of ancient burial sites, secret Soviet facilities, New Jersey choir schools, and the smoggy streets of Sao Paulo. Nestor tracks down men and women exploring the hidden science behind ancient breathing practices like Pranayama, Sudarshan Kriya, and Tummo and teams up with pulmonary tinkerers to scientifically test long-held beliefs about how we breathe.Modern research is showing us that making even slight adjustments to the way we inhale and exhale can jump-start athletic performance; rejuvenate internal organs; halt snoring, asthma, and autoimmune disease; and even straighten scoliotic spines. None of this should be possible, and yet it is.Drawing on thousands of years of medical texts and recent cutting-edge studies in pulmonology, psychology, biochemistry, and human physiology, Breath turns the conventional wisdom of what we thought we knew about our most basic biological function on its head. You will never breathe the same again.

    Antonio Damasio makes clear that we descend biologically, psychologically, and even socially from a long lineage that begins with single living cells; that our minds and cultures are linked by an invisible thread to the ways and means of ancient unicellular life and other primitive life-forms; and that inherent in our very chemistry is a powerful force, a striving toward life maintenance that governs life in all its guises, including the development of genes that help regulate and transmit life. In The Strange Order of Things, Damasio gives us a new way of comprehending the world and our place in it.www.antoniodamasio.com

    Why We Get Sick compels readers to reexamine the age-old attitudes toward sickness. Line drawings.

    November 2015 is the 100th anniversary of Einstein’s discovery of the General Theory of Relativity.Levenson, head of MIT’s Science Writing Program, tells the captivating, unusual, and nearly-forgotten backstory behind Einstein’s invention of the Theory of Relativity, which completely changed the course of science forever. For over 50 years before Einstein developed his theory, the world’s top astronomers spent countless hours and energy searching for a planet, which came to be named Vulcan, that had to exist, it was thought, given Isaac Newton’s theories of gravity. Indeed, in the two centuries since Newton’s death, his theory had essentially become accepted as fact. It took Einstein’s genius to realize the mystery of the missing planet wasn’t a problem of measurements or math but of Newton’s theory of gravity itself. Einstein’s Theory of Relativity proved that Vulcan did not and could not exist, and that the decades-long search for it had merely been a quirk of operating under the wrong set of assumptions about the universe. Thomas Levenson tells this unique story, one of the strangest episodes in the history of science, with elegant simplicity, fast-paced drama, and lively characters sure to capture the attention of a wide group of readers.

    But, Alex Bellos says, "math can be inspiring and brilliantly creative. Mathematical thought is one of the great achievements of the human race, and arguably the foundation of all human progress. The world of mathematics is a remarkable place."Bellos has traveled all around the globe and has plunged into history to uncover fascinating stories of mathematical achievement, from the breakthroughs of Euclid, the greatest mathematician of all time, to the creations of the Zen master of origami, one of the hottest areas of mathematical work today. Taking us into the wilds of the Amazon, he tells the story of a tribe there who can count only to five and reports on the latest findings about the math instinct--including the revelation that ants can actually count how many steps they've taken. Journeying to the Bay of Bengal, he interviews a Hindu sage about the brilliant mathematical insights of the Buddha, while in Japan he visits the godfather of Sudoku and introduces the brainteasing delights of mathematical games.Exploring the mysteries of randomness, he explains why it is impossible for our iPods to truly randomly select songs. In probing the many intrigues of that most beloved of numbers, pi, he visits with two brothers so obsessed with the elusive number that they built a supercomputer in their Manhattan apartment to study it. Throughout, the journey is enhanced with a wealth of intriguing illustrations, such as of the clever puzzles known as tangrams and the crochet creation of an American math professor who suddenly realized one day that she could knit a representation of higher dimensional space that no one had been able to visualize. Whether writing about how algebra solved Swedish traffic problems, visiting the Mental Calculation World Cup to disclose the secrets of lightning calculation, or exploring the links between pineapples and beautiful teeth, Bellos is a wonderfully engaging guide who never fails to delight even as he edifies. "Here's Looking at Euclid "is a rare gem that brings the beauty of math to life.

     It was an ancient puzzle that stymied history's greatest minds: How did the fossils of seashells find their way far inland, sometimes high up into the mountains? Fossils only made sense in a world old enough to form them, and in the seventeenth century, few people could imagine such a thing. Texts no less authoritative than the Old Testament laid out very clearly the timescale of Earth's past; in fact one Anglican archbishop went so far as to calculate the exact date of Creation...October 23, 4004, B.C. A revolution was in the making, however, and it was started by the brilliant and enigmatic Nicholas Steno, the man whom Stephen Jay Gould called "the founder of geology." Steno explored beyond the pages of the Bible, looking directly at the clues left in the layers of the Earth. With his groundbreaking answer to the fossil question, Steno would not only confound the religious and scientific thinking of his own time, he would set the stage for the modern science that came after him. He would open the door to the concept of "deep time," which imagined a world with a history of millions or billions of years. And at the very moment his expansive new ideas began to unravel the Bible's authoritative claim as to the age of the Earth, Steno would enter the priesthood and rise to become a bishop, ultimately becoming venerated as a saint and beatified by the Catholic Church in 1988. Combining a thrilling scientific investigation with world-altering history and the portrait of an extraordinary genius, "The Seashell on the Mountaintop" gives us new insight into the very old planet on which we live, revealing how we learned to read the story told to us by the Earth itself, written in rock and stone.

    "If you want to change the world in some big way," he says, "that's where you should start-biological molecules." The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In "Biopunk," Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.

    Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging.Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely--technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future--is now within reach.In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage.  As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars.  We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage.  By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

    A favorite of Tesla and SpaceX founder Elon Musk, listeners will want to tune into this "really good book on rocket[s]," available for the first time in audio. Ignition! is the story of the search for a rocket propellant which could be trusted to take man into space. This search was a hazardous enterprise carried out by rival labs who worked against the known laws of nature, with no guarantee of success or safety. Acclaimed scientist and sci-fi author John Drury Clark writes with irreverent and eyewitness immediacy about the development of the explosive fuels strong enough to negate the relentless restraints of gravity. The resulting volume is as much a memoir as a work of history, sharing a behind-the-scenes view of an enterprise that eventually took men to the moon, missiles to the planets, and satellites to outer space. A classic work in the history of science, listeners will want to get their hands on this influential classic, available for the first time in decades.

    We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise.So we've all heard of genes, but how do they actually work?According to legend, Ernest Hemingway was once given a six-toed cat by an old sea captain, and her distinctive descendants still roam the writer's Florida estate today. Scientists now know that the fault driving this profusion of digits lies in a tiny genetic control switch, miles away (in molecular terms) from the gene that 'makes' toes. And it's the same mistake that gives rise to multi-toed humans too.There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. And figuring out how it all works – how your genes make you, you – is a major challenge for researchers around the world.Drawing on stories ranging from six-toed cats and stickleback hips to wobbly worms and zombie genes, geneticist Kat Arney explores the how our genes work, creating a companion reader to the book of life itself.