Moreover, present-day research on electricity and ion channels has created one of the most exciting fields in science, shedding light on conditions ranging from diabetes and allergies to cystic fibrosis, migraines, and male infertility. With inimitable wit and a clear, fresh voice, award-winning researcher Frances Ashcroft weaves together compelling real-life stories with the latest scientific findings, giving us a spectacular account of the body electric.

    Communities where heroin had never been seen before—from Charlotte, NC and Huntington, WVA, to Salt Lake City and Portland, OR—were overrun with it. Local police and residents were stunned. How could heroin, long considered a drug found only in the dense, urban environments along the East Coast, and trafficked into the United States by enormous Colombian drug cartels, be so incredibly ubiquitous in the American heartland? Who was bringing it here, and perhaps more importantly, why were so many townspeople suddenly eager for the comparatively cheap high it offered?With the same dramatic drive of El Narco and Methland, Sam Quinones weaves together two classic tales of American capitalism: The stories of young men in Mexico, independent of the drug cartels, in search of their own American Dream via the fast and enormous profits of trafficking cheap black-tar heroin to America’s rural and suburban addicts; and that of Purdue Pharma in Stamford, Connecticut, determined to corner the market on pain with its new and expensive miracle drug, Oxycontin; extremely addictive in its own right. Quinones illuminates just how these two stories fit together as cause and effect: hooked on costly Oxycontin, American addicts were lured to much cheaper black tar heroin and its powerful and dangerous long-lasting high. Embroiled alongside the suppliers and buyers are DEA agents, local, small-town sheriffs, and the US attorney from eastern Virginia whose case against Purdue Pharma and Oxycontin made him an enemy of the Bush-era Justice Department, ultimately stalling and destroying his career in public service.Dreamland is a scathing and incendiary account of drug culture and addiction spreading to every part of the American landscape.

    Seven artists. Seven girls and women reading. A young orphan poses nervously for a Renaissance maestro in medieval Siena, and an artist's servant girl in 17th-century Amsterdam snatches a moment away from her work to lose herself in tales of knights and battles. A young woman reading in a Shoreditch bar catches the eye of a young man who takes her picture, and a Victorian medium holds a book that she barely acknowledges while she waits for the exposure. Each chapter of this richly textured debut takes us into a perfectly imagined tale of how each portrait came to be, and as the connections accumulate, the narrative leads us into the present and beyond - an inspired celebration of women reading and the artists who have caught them in the act.

    Packed with the most effective skills for assessing and treating anxiety, this workbook can be used alone or as a supplement to therapy to help you develop a full arsenal of skills for quieting worried thoughts and putting yourself back in control.This new edition has been thoroughly updated with the latest anxiety research and medications, and also includes new therapeutic techniques that have been proven effective for the treatment of anxiety and anxiety-related conditions. Each worksheet in this book will help you learn the skills you need to manage your anxiety and start living more freely than you ever thought possible. With this workbook, you'll learn a range of proven methods for overcoming anxiety, such as relaxation and breathing techniques, challenging negative self-talk and mistaken beliefs, and imagery and real-life desensitization. In addition, you will learn how to make lifestyle, nutrition, and exercise changes and cultivate skills for preventing and coping with and preventing panic attacks.

    Serotonin is the "contentment" neurotransmitter that tells our brains we don't need any more; yet its deficiency leads to depression. Ideally, both are in optimal supply. Yet dopamine evolved to overwhelm serotonin--because our ancestors were more likely to survive if they were constantly motivated--with the result that constant desire can chemically destroy our ability to feel happiness, while sending us down the slippery slope to addiction. In the last forty years, government legislation and subsidies have promoted ever-available temptation (sugar, drugs, social media, porn) combined with constant stress (work, home, money, Internet), with the end result of an unprecedented epidemic of addiction, anxiety, depression, and chronic disease. And with the advent of neuromarketing, corporate America has successfully imprisoned us in an endless loop of desire and consumption from which there is no obvious escape.With his customary wit and incisiveness, Lustig not only reveals the science that drives these states of mind, he points his finger directly at the corporations that helped create this mess, and the government actors who facilitated it, and he offers solutions we can all use in the pursuit of happiness, even in the face of overwhelming opposition. Always fearless and provocative, Lustig marshals a call to action, with seminal implications for our health, our well-being, and our culture.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Twenty astonishing stories from acclaimed author Ursula K. Le Guin that carry us to worlds of wonder and horror, desire and destiny, enchantment and doom.

    It begins with Sally’s visionary crack-up on the streets of Greenwich Village, and continues, among other places, in the out-of-time world of a Manhattan psychiatric ward during the city’s most sweltering months. “I feel like I’m traveling and traveling with nowhere to go back to,” Sally says in a burst of lucidity while hurtling away toward some place her father could not dream of or imagine. Hurry Down Sunshine is the chronicle of that journey, and its effect on Sally and those closest to her–her brother and grandmother, her mother and stepmother, and, not least of all, the author himself. Among Greenberg’s unforgettable gallery of characters are an unconventional psychiatrist, an Orthodox Jewish patient, a manic Classics professor, a movie producer, and a landlord with literary dreams. Unsentimental, nuanced, and deeply humane, Hurry Down Sunshine holds the reader in a mesmerizing state of suspension between the mundane and the transcendent.

    But in a Scarborough subdivision populated by newcomers from all over the world, a series of sudden catastrophic events reveals that not everyone’s dreams come true. Moving from house to house, Carrianne Leung explores the inner lives behind the tidy front gardens and picture-perfect windows, always returning to June, an irrepressible adolescent Chinese-Canadian coming of age in this shifting world. Through June and her neighbours, Leung depicts the fine line where childhood meets the realities of adult life, and examines, with insight and sharp prose, how difficult it is to be true to ourselves at any age.

    Rick Strassman conducted US DEA-approved clinical research at the University of New Mexico in which he injected 60 volunteers with DMT, one of the most powerful psychedelics known. His detailed account of those sessions is an inquiry into the nature of the human mind and the therapeutic potential of psychedelics. DMT, a plant-derived chemical that is also manufactured by the human brain, consistently produced near-death and mystical experiences. Many volunteers reported convincing encounters with intelligent nonhuman presences, especially "aliens." Nearly all felt that the sessions were among the most profound experiences of their lives.Strassman's research connects DMT with the pineal gland, considered by Hindus to be the site of the seventh chakra and by René Descartes to be the seat of the soul. DMT: The Spirit Molecule makes the case that DMT, naturally released by the pineal gland, facilitates the soul's movement in and out of the body and is an integral part of the birth and death experiences, as well as the highest states of meditation and even sexual transcendence. Strassman also believes that alien abduction experiences are brought on by accidental releases of DMT. If used wisely, DMT could trigger a period of remarkable progress in the scientific exploration of the most mystical regions of the human mind and soul.

    A potter's assistant by day and dress lodger by night, Gustine sells herself for necessity in a rented gown, scrimping to feed and protect her only love: her fragile baby boy. She holds a glimmer of hope after meeting Dr. Henry Chiver, a prisoner of his own dark past. But in a world where suspicion of medicine runs rampant like a fever, these two lost souls will become irrevocably linked, as each crosses lines between rich and destitute, decorum and abandon, damnation and salvation. By turns tender and horrifying, The Dress Lodger is a captivating historical thriller charged with a distinctly modern voice. . . .

    But is it possible America's most troubling impact on the globalizing world has yet to be accounted for? In "Crazy Like Us," Ethan Watters reveals that the most devastating consequence of the spread of American culture has not been our golden arches or our bomb craters but our bulldozing of the human psyche itself: We are in the process of homogenizing the way the world goes mad. America has been the world leader in generating new mental health treatments and modern theories of the human psyche. We export our psychopharmaceuticals packaged with the certainty that our biomedical knowledge will relieve the suffering and stigma of mental illness. We categorize disorders, thereby defining mental illness and health, and then parade these seemingly scientific certainties in front of the world. The blowback from these efforts is just now coming to light: It turns out that we have not only been changing the way the world talks about and treats mental illness -- we have been changing the mental illnesses themselves.For millennia, local beliefs in different cultures have shaped the experience of mental illness into endless varieties." Crazy Like Us" documents how American interventions have discounted and worked to change those indigenous beliefs, often at a dizzying rate. Over the last decades, mental illnesses popularized in America have been spreading across the globe with the speed of contagious diseases. Watters travels from China to Tanzania to bring home the unsettling conclusion that the virus is us: As we introduce Americanized ways of treating mental illnesses, we are in fact spreading the diseases.In post-tsunami Sri Lanka, Watters reports on the Western trauma counselors who, in their rush to help, inadvertently trampled local expressions of grief, suffering, and healing. In Hong Kong, he retraces the last steps of the teenager whose death sparked an epidemic of the American version of anorexia nervosa. Watters reveals the truth about a multi-million-dollar campaign by one of the world's biggest drug companies to change the Japanese experience of depression -- literally marketing the disease along with the drug.But this book is not just about the damage we've caused in faraway places. Looking at our impact on the psyches of people in other cultures is a gut check, a way of forcing ourselves to take a fresh look at our own beliefs about mental health and healing. When we examine our assumptions from a farther shore, we begin to understand how our own culture constantly shapes and sometimes creates the mental illnesses of our time. By setting aside our role as the world's therapist, we may come to accept that we have as much to learn from other cultures' beliefs about the mind as we have to teach.

    Topics covered include Bi-polar disorder, self harming, suicide, depression and theauthor also shows how for some famous people mental disorders were part of what may have made them great. Frank, hard hitting and moving.

    It is the story of an American Army Lieutenant Philip Nolan, who gets entangled with Aaron Burr in 1807, and renounces his country during his trial for treason, saying he never wanted to hear about the United States again. The Judge asks him to recant but Nolan doesn't. So the Judge granted his request and the rest of his life Nolan spent on Navy ships around the world. The officers and crew were not allowed to mention the United States.This story came out during the height of the Civil War and served to help the Union recruit soldiers and people to their cause. It is noteworthy that Edward Everett Hale's Uncle, Edward Everett, than man he was named after, gave the two hour featured address at Gettysburg just before Lincoln's speech of 209 words and two minutes, that became the best acknowledged speech in American life. Everett, like Hale, was a total patriot and honest man, and immediately congratulated Lincoln on his fine accomplishment, "You have done far better in your two minutes than I did in my 2 hours.""The Man without a Country" is still considered a major American work and read widely in American schools.. A quiet calm read letting the story speak for itself.

    A brief, but insightful look at history shows the evolution of combat, the development of the physical and psychological leverage that enables humans to kill other humans, followed by an objective examination of domestic violence in America. The authors reveal the nature of the warrior, brave men and women who train their minds and bodies to go to that place from which others flee. After examining the incredible impact of a few true warriors in battle, On Combat presents new and exciting research as to how to train the mind to become inoculated to stress, fear and even pain.