As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    In this riveting work of true crime, he spotlights four of the most diabolical criminals he’s confronted, interviewed and learned from. Going deep into each man’s life and crimes, he outlines the factors that led them to murder and how he used his interrogation skills to expose their means, motives, and true evil. Like the hit Netflix show, The Killer Across the Table is centered around Douglas’ unique interrogation and profiling process. With his longtime collaborator Mark Olshaker, Douglas recounts the chilling encounters with these four killers as he experienced them—revealing for the first time his profile methods in detail. Going step by step through his interviews, Douglas explains how he connects each killer’s crimes to the specific conversation, and contrasts these encounters with those of other deadly criminals to show what he learns from each one. In the process, he returns to other famous cases, killers and interviews that have shaped his career, describing how the knowledge he gained from those exchanges helped prepare him for these.A glimpse into the mind of a man who has pierced the heart of human darkness, The Killer Across the Table unlocks the ultimate mystery of depravity and the techniques and approaches that have countered evil in the name of justice.

    These other subjects include...Caffeine | Ghostbusters | Being Poor | Twitter | Caravans | Obama | Wales | Paul McCartney | The Welfare State | Sherlock | David Cameron Looking Like Ham | Amy Winehouse | ‘The Big Society’ | Big Hair | Nutter-letters | Michael Jackson's funeral | Failed Nicknames | Wolverhampton | Squirrels’ Testicles | Sexy Tax | Binge-drinking | Chivalry | Rihanna’s Cardigan | Party Bags | Hot People| Transsexuals | The Gay Moon Landings

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Though the world at first recoiled at the notion of a woman studying medicine, her intelligence and intensity ultimately won her the acceptance of the male medical establishment. In 1849, she became the first woman in America to receive an M.D. She was soon joined in her iconic achievement by her younger sister, Emily, who was actually the more brilliant physician.Exploring the sisters’ allies, enemies, and enduring partnership, Janice P. Nimura presents a story of trial and triumph. Together, the Blackwells founded the New York Infirmary for Indigent Women and Children, the first hospital staffed entirely by women. Both sisters were tenacious and visionary, but their convictions did not always align with the emergence of women’s rights—or with each other. From Bristol, Paris, and Edinburgh to the rising cities of antebellum America, this richly researched new biography celebrates two complicated pioneers who exploded the limits of possibility for women in medicine. As Elizabeth herself predicted, "a hundred years hence, women will not be what they are now."

    Illuminating, completely engaging—it's essential reading for all since we all know someone whose life, family or friends are touched by the disease that directly afflicts a fifth of Canadians. In her early twenties, while outwardly thriving in her dream job and enjoying warm familial support and a strong social network, award-winning journalist Anna Mehler Paperny found herself trapped by feelings of failure and despair. Her first suicide attempt—ingesting a deadly mix of sleeping pills and antifreeze—landed her in the ICU, followed by weeks of enforced detention that ran the gamut of horrifying, boring, hilarious, and absurd. This was Anna's entry into the labyrinthine psychiatric care system responsible for providing care to millions of Canadians.As she struggled to survive the psych ward and as an outpatient—enduring the "survivor's" shame of facing concerned family, friends, and co-workers; finding (or not) the right therapist, the right meds; staying healthy, insured, and employed—Anna could not help but turn her demanding journalist's eye on her condition and on the system in which she found herself. She set off on a quest to "know her enemy," interviewing leading practitioners in the field across Canada and the US—from psychiatrists to neurological experts, brain-mapping pioneers to heroic family practitioners, and others dabbling in novel hypotheses. She reveals in courageously frank detail her own experiences with the pharmacological pitfalls and side effects of long-term treatment, and offers moving case studies of conversations with others, opening wide a window into how we treat (and fail to treat) the disease that accounts for more years swallowed up by disability than any other in the world.

    It’s a journey deep within, in a way that’s respectful and non-invasive; a journey for which we will all pay a heavy price, even if you’ve waited for the smaller paperback edition.Ayoade argues for the canonisation of this brutal masterpiece, a film that celebrates capitalism in all its victimless glory; one we might imagine Donald Trump himself half-watching on his private jet’s gold-plated flat screen while his other puffy eye scans the cabin for fresh, young prey."

    First diagnosed when he was only ten years old, she was the model of resilience throughout his childhood, fighting her disease with tenacity and a mouth foul enough to make a sailor blush. But just as she faces a relapse, her husband —a successful businessman and devoted father—is diagnosed with ALS. He is told that in a few months' time, he be unable to walk, eat, or breathe on his own. Dan, a recent college graduate living the good life in Los Angeles, has no choice but to return home to help. Reinstalled in his parents' basement (in one of the only non-Mormon homes in a Salt Lake City subdivision) Dan is reunited with his siblings. His older sister Tiffany is resentful, having stayed closer to home to bear the brunt of their mother's illness. Younger brother Greg comes to lend a hand, giving up a journalism career and evenings cruising Chicago gay bars. Younger sister Michelle is a sullen teenager experimenting with drinking and flirting with her 35-year-old soccer coach. And baby sister Chelsea—the oddest duck in a family of misfits—can only think about dance. Together they form Team Terminal, going to battle against their parents' illnesses and cracking plenty of jokes along the way. As Dan steps into his role as caregiver, wheelchair wrangler, and sibling referee, he watches pieces of his previous life slip away, and comes to realize that you don't get to choose when it's time to grow up.

    . . or it might have been last night, when you watched three episodes in a row. But either way, fifteen years after the show first aired, it's more popular than ever, and fans have only one problem--what to watch, or read, next.Fortunately, Rolling Stone writer Andy Greene has that answer. In his brand-new oral history, The Office: The Untold Story of the Greatest Sitcom of the 2000s, Greene will take readers behind the scenes of their favorite moments and characters. Greene gives us the true inside story behind the entire show, from its origins on the BBC through its impressive nine-season run in America, with in-depth research and exclusive interviews. Fans will get the inside scoop on key episodes from "The Dundies" to "Threat Level Midnight" and "Goodbye, Michael," including behind-the-scenes details like the battle to keep it on the air when NBC wanted to pull the plug after just six episodes and the failed attempt to bring in James Gandolfini as the new boss after Steve Carell left, spotlighting the incredible, genre-redefining show created by the family-like team, who together took a quirky British import with dicey prospects and turned it into a primetime giant with true historical and cultural significance.Hilarious, heartwarming, and revelatory, The Office gives fans and pop culture buffs a front-row seat to the phenomenal sequence of events that launched The Office into wild popularity, changing the face of television and how we all see our office lives for decades to come.

    Imprisoned in the Buchenwald concentration camp, they miraculously survive the Nazis’ murderous brutality.Then Gustav learns he is being sent to Auschwitz—and certain death.For Fritz, letting his father go is unthinkable. Desperate to remain together, Fritz makes an incredible choice: he insists he must go too. To the Nazis, one death camp is the same as another, and so the boy is allowed to follow. Throughout the six years of horror they witness and immeasurable suffering they endure as victims of the camps, one constant keeps them alive: their love and hope for the future. Based on the secret diary that Gustav kept as well as meticulous archival research and interviews with members of the Kleinmann family, including Fritz’s younger brother Kurt, sent to the United States at age eleven to escape the war, The Boy Who Followed His Father into Auschwitz is Gustav and Fritz’s story—an extraordinary account of courage, loyalty, survival, and love that is unforgettable.

    Gawky, socially awkward and totally unqualified, his first reaction to this exciting opportunity was panic. But he'd always been drawn to off-beat characters, so maybe his enthusiasm would carry the day. Or, you know, maybe it wouldn't...In Gotta Get Theroux This, Louis takes the reader on a joyous journey through his life and unexpectedly successful career. Nervously accepting the BBC's offer of his own series, he went on to create an award-winning documentary style that has seen him immersed in worlds as diverse as racist US militias and secretive pro-wrestlers, the violent gangs of Johannesburg and extreme drinkers in London.Arguably his biggest challenge was corralling celebrities in his When Louis Met series, with Jimmy Savile proving most elusive. Blindsided when the revelations about Savile came to light, Louis was to reflect again on the nature of evil he had spent decades uncovering.Filled with wry observation, larger-than-life characters, and self-deprecating humour, this is Louis at his insightful and honest best.

    She woke up one morning and her entire history—the life she had lived—crumbled beneath her.Inheritance is a book about secrets—secrets within families, kept out of shame or self-protectiveness; secrets we keep from one another in the name of love. It is the story of a woman’s urgent quest to unlock the story of her own identity, a story that has been scrupulously hidden from her for more than fifty years, years she had spent writing brilliantly, and compulsively, on themes of identity and family history. It is a book about the extraordinary moment we live in—a moment in which science and technology have outpaced not only medical ethics but also the capacities of the human heart to contend with the consequences of what we discover.

    It was a decision her mother railed against from the moment the idea was raised. Win had very little agency in the world, every choice was determined by the men in her life. And strangely, she wanted the same for her daughter. Attending university wasn't for the likes of the Orr family. Worse still, it would mean leaving Win behind - and Win wanted Deborah with her at all times, rather like she wanted her arm with her at all times. But while she managed to escape, Deborah's severing from her family was only superficial. She continued to travel back to Motherwell, fantasizing about the day that Win might come to accept her as good enough. Though of course it was never meant to be.Motherwell is a sharp, candid and often humorous memoir about the long shadow that can be cast when the core relationship in your life compromises every effort you make to become an individual. It is about what we inherit - the good and the very bad - and how a deeper understanding of the place and people you have come from can bring you towards redemption.

    Her first book is a revelatory treatise on plant life—but it is also so much more. Lab Girl is a book about work, love, and the mountains that can be moved when those two things come together. It is told through Jahren’s stories: about her childhood in rural Minnesota with an uncompromising mother and a father who encouraged hours of play in his classroom’s labs; about how she found a sanctuary in science, and learned to perform lab work done “with both the heart and the hands”; and about the inevitable disappointments, but also the triumphs and exhilarating discoveries, of scientific work.Yet at the core of this book is the story of a relationship Jahren forged with a brilliant, wounded man named Bill, who becomes her lab partner and best friend. Their sometimes rogue adventures in science take them from the Midwest across the United States and back again, over the Atlantic to the ever-light skies of the North Pole and to tropical Hawaii, where she and her lab currently make their home.

    But it's not, perhaps, the story you expect.Gavin Francis is a GP who works in both urban and rural communities, splitting his time between Edinburgh and the islands of Orkney. When the pandemic ripped through our society he saw how it affected every walk of life: the anxious teenager, the isolated care home resident, the struggling furloughed worker and homeless ex-prisoner, all united by their vulnerability in the face of a global disaster. And he saw how the true cost of the virus was measured not just in infections, or deaths, or ITU beds, but in the consequences of the measures taken against it.In this deeply personal account of nine months spent caring for a society in crisis, Francis will take you from rural village streets to local clinics and communal city stairways. And in telling this story, he reveals others: of loneliness and hope, illness and recovery, and of what we can achieve when we care for each other.