Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    In this title, the treatment is made easy-to-follow by giving step-by-step derivations, explanations and by avoiding advanced mathematics unfamiliar to students. It covers: math and physics thorough review sections; and worked examples, followed by a practice exercise.

    We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    

    As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020.

    For millions, the Galápagos Islands represent nature at its most unspoiled, an inviolate place famed for its rare flora and fauna. But soon today’s 30,000 human residents could surpass 50,000. Add invasive species, floods of tourists, and unresolved conflicts between Ecuadorian laws and local concerns, and it’s easy to see why the Galápagos were recently added to UNESCO’s World Heritage in Danger list. Each chapter in this provocative, perceptive book focuses on a specific person or group with a stake in the Galápagos’ natural resources—from tour companies whose activities are often illegal and not always green, to creationist guides who lead tours with no mention of evolution, from fishermen up in arms over lobster quotas, to modern-day pirates who poach endangered marine species. Bassett presents a perspective as readable as it is sensible. Told with wit, passion, and grace, the Galápagos story serves as a miniature model of Earth itself, a perfect example of how an environment can be destroyed-- and what is being done to preserve these islands before it's too late.

    This claim is not only false, but its presence in the debate is an insult to science." With these words, the authors begin a detailed analysis of one of the most controversial topics of the day. The authors make a compelling case against claims of a scientific consensus. The purported proof of such a consensus consists of sloppy research by nonscientists, college students, and a highly partisan Australian blogger. Surveys of climate scientists, even those heavily biased in favor of climate alarmism, find extensive disagreement on the underlying science and doubts about its reliability. The authors point to four reasons why scientists disagree about global warming: a conflict among scientists in different and often competing disciplines; fundamental scientific uncertainties concerning how the global climate responds to the human presence; failure of the United Nations Intergovernmental Panel on Climate Change (IPCC) to provide objective guidance to the complex science; and bias among researchers. The authors offer a succinct summary of the real science of climate change based on their previously published comprehensive review of climate science in a volume titled Climate Change Reconsidered II: Physical Science. They recommend that policymakers resist pressure from lobby groups to silence scientists who question the authority of the IPCC to claim to speak for climate science. More than 50,000 copies of the first edition were sold or given away in five months to elected officials, civic and business leaders, scientists, and other opinion leaders. The response from the science community and experts on climate change has been overwhelmingly positive. To meet demand for more copies, we have produced this second revised edition. Changes include a foreword by Marita Noon, at the time executive director of Energy Makes America Great, Inc. Some of the discussion in Chapter 1 has been revised and expanded thanks to feedback from readers of the first edition. Graphs in Chapters 4, 5, and 6 are now full color, and new graphs have been added.

    In the third edition of this best-selling guide, you'll find these topics:- 83 exercises for free weights, machines, bands, and balls- 30 workouts for increasing size, endurance, and strength- Sport-specific programs for tennis, golf, cycling, running, and more- Eating plans and nutrition advice for adding lean muscle and losing fatStrength Training Past 50 will keep you active, healthy, and looking great with workouts and programs designed just for you.

    Scott guides readers through the latest advances in stem cell research in clear, accessible language, telling the stories of the researchers who are exploring the potential of stem cells to cure cancer, grow new organs, and repair the immune system. He also leads readers through a discussion of the question at the heart of the explosive ethical debate: How, as a society, do we balance our responsibilities to the unborn and the sick? Stem Cell Now is essential reading for anyone who wants to build an informed opinion on stem cell research.

    The calls to ban it were more or less instant.Re:cyclists is the tale of what happened next, of how we have spent two centuries wheeling our way about town and country on bikes--or on two-wheeled things that vaguely resembled what we now call bikes. Michael Hutchinson picks his way through those 200 years, discovering how cycling became a kinky vaudeville act for Parisians, how it became an American business empire, and how it went on to find a unique home in the British Isles. He considers the penny-farthing riders exploring the abandoned and lonely coaching roads during the railway era, and the Victorian high-society cyclists of the 1890s bicycle craze--a time when no aristocratic house party was without bicycles and when the Prince of Wales used to give himself an illicit thrill on a weekday afternoon by watching the women's riding-school in the Royal Albert Hall.Re:cyclists looks at how cycling became the sport, the pastime and the social life of millions of ordinary people, how it grew and how it suffered through the 1960s and '70s, and how at the dawn of the twenty-first century it rose again, much changed but still ultimately just someone careering along on two wheels.

    In Musicophilia, he shows us a variety of what he calls “musical misalignments.” Among them: a man struck by lightning who suddenly desires to become a pianist at the age of forty-two; an entire group of children with Williams syndrome, who are hypermusical from birth; people with “amusia,” to whom a symphony sounds like the clattering of pots and pans; and a man whose memory spans only seven seconds-for everything but music. Illuminating, inspiring, and utterly unforgettable, Musicophilia is Oliver Sacks’ latest masterpiece.

    Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

    This exciting new book, from a leading expert in working with expectant dads, doesn’t sideline or speak down to men. Instead it provides an array of targeted information to fully prepare men for their new roles – as both birth partners and fathers.The Expectant Dad’s Handbook is a one-stop guide for men on their path to fatherhood. It provides practical answers to all the questions on the mind of a dad-to-be – from what to expect at each stage of pregnancy to how to cope with any worries and fears about becoming a dad. It also reveals unique insights into a dad’s role during labour, showing key strategies for improving the birth.Both practical and accessible, this guide will provide all the information and advice fathers need for the journey ahead.

    Acid reflux, heartburn, gastritis, ulcers, lactose intolerance, and food allergies are among the many ailments caused by faulty digestion. Digestive Wellness was designed to help you understand the complex relationships between gastrointestinal physiology, diet, and health. Written by noted nutritionist Elizabeth Lipski, this accessible third edition of the popular resource has been thoroughly updated to reflect the latest information and research on digestive disorders. Here, you will find practical advice on implementing a wellness program to promote health and alleviate a wide range of problems caused by faulty digestion.