These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    Alongside Louis C.K., Tig Notaro, John Turturro, and Meg Wolitzer, readers will encounter: an astronomer gazing at the surface of Pluto for the first time, an Afghan refugee learning how much her father sacrificed to save their family, a hip-hop star coming to terms with being a one-hit wonder, a young female spy risking everything as part of Churchill's secret army during World War II, and more. High-school student and neuroscientist alike, the storytellers share their ventures into uncharted territory and how their lives were changed indelibly by what they discovered there. With passion, and humor, they encourage us all to be more open, vulnerable, and alive."

    Today he is the director of the Center for Compassion and Altruism Research and Education (CCARE) at Stanford University, of which the Dalai Lama is a founding benefactor. But back then his life was at a dead end until at twelve he wandered into a magic shop looking for a plastic thumb. Instead he met Ruth, a woman who taught him a series of exercises to ease his own suffering and manifest his greatest desires. Her final mandate was that he keep his heart open and teach these techniques to others. She gave him his first glimpse of the unique relationship between the brain and the heart.Doty would go on to put Ruth’s practices to work with extraordinary results—power and wealth that he could only imagine as a twelve-year-old, riding his orange Sting-Ray bike. But he neglects Ruth’s most important lesson, to keep his heart open, with disastrous results—until he has the opportunity to make a spectacular charitable contribution that will virtually ruin him. Part memoir, part science, part inspiration, and part practical instruction, Into the Magic Shop shows us how we can fundamentally change our lives by first changing our brains and our hearts.

    Each piece compels readers to rethink not only how they have arrived at their own personal beliefs but also the extent to which they share them with others. Featuring a well-known list of contributors--including Isabel Allende, Colin Powell, Gloria Steinem, William F. Buckley Jr., Penn Jillette, Bill Gates, and John Updike--the collection also contains essays by a Brooklyn lawyer; a part-time hospital clerk from Rehoboth, Massachusetts; a woman who sells Yellow Pages advertising in Fort Worth, Texas; and a man who serves on the state of Rhode Island's parole board. The result is a stirring and provocative trip inside the minds and hearts of a diverse group of people whose beliefs--and the incredibly varied ways in which they choose to express them--reveal the American spirit at its best.

    Difficulty breathing. Overwhelming dread. Andrea Petersen was first diagnosed with an anxiety disorder at the age of twenty, but she later realized that she had been experiencing panic attacks since childhood. With time her symptoms multiplied. She agonized over every odd physical sensation. She developed fears of driving on highways, going to movie theaters, even licking envelopes. Although having a name for her condition was an enormous relief, it was only the beginning of a journey to understand and master it—one that took her from psychiatrists’ offices to yoga retreats to the Appalachian Trail. Woven into Petersen’s personal story is a fascinating look at the biology of anxiety and the groundbreaking research that might point the way to new treatments. She compares psychoactive drugs to non-drug treatments, including biofeedback and exposure therapy. And she explores the role that genetics and the environment play in mental illness, visiting top neuroscientists and tracing her family history—from her grandmother, who, plagued by paranoia, once tried to burn down her own house, to her young daughter, in whom Petersen sees shades of herself. Brave and empowering, this is essential reading for anyone who knows what it means to live on edge.

    Taking us back to her adolescence, when she was diagnosed with depression at fourteen, Kat speaks eloquently with pathos and humor about her skin picking, hand flapping, “nervousness” that made her the recipient of many a harsh taunt. With her mother also gripped by depression and health issues throughout her life, Kat came to live in a constant state of unease—that she would fail, that she would never find love . . . that she would end up just like her mother.Now, as a successful media personality, Kat still battles anxiety every day. That anxiety manifests in strange, and deeply personal ways. But as she found when she started to write about her struggles, Kat is not alone in feeling like the simple act of leaving the house, or getting a haircut can be crippling. And though periodic medication, counseling, a successful career and a happy marriage have brought her relief, the illness, because that is what anxiety is, remains.Exploring how millions are affected anxiety, Hi, Anxiety is a clarion call for everyone—but especially women—struggling with this condition. Though she is a strong advocate for seeking medical intervention, Kinsman implores those suffering to come out of the shadows—to talk about their battle openly and honestly. With humor, bravery, and writing that brings bestsellers like Laurie Notaro and Jenny Lawson to mind, Hi, Anxiety tackles a difficult subject with amazing grace.

    They fell in love at eighteen, married at twenty-four, and were living their dream life in San Francisco. When Giulia was twenty-seven, she suffered a terrifying and unexpected psychotic break that landed her in the psych ward for nearly a month. One day she was vibrant and well-adjusted; the next she was delusional and suicidal, convinced that her loved ones were not safe.Eventually, Giulia fully recovered, and the couple had a son. But, soon after Jonas was born, Giulia had another breakdown, and then a third a few years after that. Pushed to the edge of the abyss, everything the couple had once taken for granted was upended.A story of the fragility of the mind, and the tenacity of the human spirit, My Lovely Wife in the Psych Ward is, above all, a love story that raises profound questions: How do we care for the people we love? What and who do we live for? Breathtaking in its candor, radiant with compassion, and written with dazzling lyricism, Lukach’s is an intensely personal odyssey through the harrowing years of his wife’s mental illness, anchored by an abiding devotion to family that will affirm readers’ faith in the power of love.

    How she faces her joy, grief, anxiety, impending motherhood, and conflicted truce with the world results in a moving meditation on the nature, rapture, and perils of crying―from the history of tear-catching gadgets (including the woman who designed a gun that shoots tears) to the science behind animal tears (including moths who drink them) to the fraught role of white women's tears in racist violence.Told in short, poetic snippets, The Crying Book delights and surprises, as well as rigorously examines how mental illness can affect a family across generations and how crying can express women’s agency―or lack of agency―in everyday life. Christle’s gift is the freshness of her voice and honesty of her approach, both of which create an intimacy with readers as she explores a human behavior broadly experienced but rarely questioned. A beautiful tribute to the power of crying, and to working through despair to tears of joy.

    When the online storytelling magazine SMITH asked readers to submit six-word memoirs, they proved a whole, real life can be told this way, too. The results are fascinating, hilarious, shocking, and moving. From small sagas of bittersweet romance ("Found true love, married someone else") to proud achievements and stinging regrets ("After Harvard, had baby with crackhead"), these terse true tales relate the diversity of human experience in tasty bite-size pieces. The original edition of Not Quite What I Was Planning spent six weeks on the New York Times bestseller list, and thanks to massive media attention—from NPR to the The New Yorker—the six-word memoir concept spread to classrooms, dinner tables, churches, synagogues, and tens of thousands of blogs. This deluxe edition has been revised and expanded to include more than sixty never-before-seen memoirs. From authors Elizabeth Gilbert, Richard Ford, and Joyce Carol Oates to celebrities Stephen Colbert, Mario Batali, and Joan Rivers to ordinary folks around the world, everyone has a six-word story to tell.

    The result is an extraordinary, complex portrait of "white girls," as Als dubs them—an expansive but precise category that encompasses figures as diverse as Truman Capote and Louise Brooks, Malcolm X and Flannery O’Connor. In pieces that hairpin between critique and meditation, fiction and nonfiction, high culture and low, the theoretical and the deeply personal, Als presents a stunning portrait of a writer by way of his subjects, and an invaluable guide to the culture of our time.

    Despair and uncertainty surround us: in the news, in our families, and in ourselves. But even when life is at its bleakest--when we are, as she puts it, "doomed, stunned, exhausted, and over-caffeinated"--the seeds of rejuvenation are at hand. "All truth is paradox," Lamott writes, "and this turns out to be a reason for hope. If you arrive at a place in life that is miserable, it will change." That is the time when we must pledge not to give up but "to do what Wendell Berry wrote: 'Be joyful, though you have considered all the facts.'"In this profound and funny book, Lamott calls for each of us to rediscover the nuggets of hope and wisdom that are buried within us that can make life sweeter than we ever imagined. Divided into short chapters that explore life's essential truths, Almost Everything pinpoints these moments of insight as it shines an encouraging light forward.

    Four years later, she and her mother joined her father in Stillwater, Oklahoma —a move that would be anxiety ridden for any child, but especially for Bassey. Her early years in America would come to be defined by tension: an assimilation further complicated by bipolar II and anxiety that would go undiagnosed for decades.By the time she was in her early twenties, Bassey was a spoken word artist and traveling with HBO's Russell Simmons Def Poetry Jam, channeling her experiences into art. But something wasn’t right—beneath the façade of the confident performer, Bassey’s mental health was in a precipitous decline, culminating in a breakdown that resulted in hospitalization and a diagnosis of Bipolar II.Determined to learn from her experiences—and share them with others—Bassey became a mental health advocate and has spent the fourteen years since her diagnosis examining the ways mental health is inextricably intertwined with every facet of ourselves and our lives. Viscerally raw and honest, the result is an exploration of the stories we tell ourselves to make sense of who we are—and the ways, as honest as we try to be, each of these stories can also be a lie.

    He was told—like his entire generation—that his problem was caused by a chemical imbalance in his brain. As an adult, trained in the social sciences, he began to investigate this question—and he learned that almost everything we have been told about depression and anxiety is wrong. Across the world, Hari discovered social scientists who were uncovering the real causes—and they are mostly not in our brains, but in the way we live today. Hari’s journey took him from the people living in the tunnels beneath Las Vegas, to an Amish community in Indiana, to an uprising in Berlin—all showing in vivid and dramatic detail these new insights. They lead to solutions radically different from the ones we have been offered up until now.Just as Chasing the Scream transformed the global debate about addiction, with over twenty million views for his TED talk and the animation based on it, Lost Connections will lead us to a very different debate about depression and anxiety—one that shows how, together, we can end this epidemic.

    Perry Baird was a rising medical star in the late 1920s and 1930s. Early in his career, ahead of his time, he grew fascinated with identifying the biochemical root of manic depression, just as he began to suffer from it himself. By the time the results of his groundbreaking experiments were published, Dr. Baird had been institutionalized multiple times, his medical license revoked, and his wife and daughters estranged. He later received a lobotomy and died from a consequent seizure, his research incomplete, his achievements unrecognized.Mimi Baird grew up never fully knowing this story, as her family went silent about the father who had been absent for most of her childhood. Decades later, a string of extraordinary coincidences led to the recovery of a manuscript which Dr. Baird had worked on throughout his brutal institutionalization, confinement, and escape. This remarkable document, reflecting periods of both manic exhilaration and clear-headed health, presents a startling portrait of a man who was a uniquely astute observer of his own condition, struggling with a disease for which there was no cure, racing against time to unlock the key to treatment before his illness became impossible to manage.Fifty years after being told her father would forever be “ill” and “away,” Mimi Baird set off on a quest to piece together the memoir and the man. In time her fingers became stained with the lead of the pencil he had used to write his manuscript, as she devoted herself to understanding who he was, why he disappeared, and what legacy she had inherited. The result of his extraordinary record and her journey to bring his name to light is He Wanted the Moon, an unforgettable testament to the reaches of the mind and the redeeming power of a determined heart.Soon to be a major motion picture, from Brad Pitt and Tony Kushner

    Alvarez, "has permeated Western culture like a dye that cannot be washed out." Although the aims of this compelling, compassionate work are broadly cultural and literary, the narrative is rooted in personal experience: it begins with a long memoir of Sylvia Plath, and ends with an account of the author's own suicide attempt. Within this dramatic framework, Alvarez launches his enquiry into the final taboo of human behavior, and traces changing attitudes towards suicide from the perspective of literature. He follows the black thread leading from Dante through Donne and the romantic agony, to the Savage God at the heart of modern literature.