Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

     “You’re about as useful as a windshield wiper on a goat’s butt.” Keep this book handy, someday you’ll be glad you have it. “Let's play horse. I'll be the front end and you just be yourself.” Pick any of the many jaw-dropping insults then laugh at the look on your adversary’s face when you whip one out and use it on them. You’ll leave no doubt in their mind that you are a master of sarcastic insults! ADDED BONUS: In addition to the fresh and hilarious insults in this book, you’ll also find great sarcastic observations about life hidden inside this book’s pages, like… “I think the reason so many people have smart phones is because opposites attract!” You’re no idiot, so you need this book to start your new life as the master of sarcastic insults and put-downs! “Hey! Who left the Idiot Box open? Now they're everywhere!”

    Full of advice on how surgeons should use their heads as well as their hands - how to think, plan, and improvise - when, for example, operating on a massively bleeding trauma patient. Starts with general principles, continues with specific injuries to abdomen, chest, neck, and peripheral vessels. Generously illustrated throughout, with drawings produced specifically for this book. For residents, general surgeons with an interest in trauma, and for surgeons operating on badly wounded patients in isolated military, rural, or humanitarian settings. Asher Hirshberg and Kenneth L Mattox are trauma surgeons at the Ben Taub General Hospital, Houston, and professors at the Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, USA. Kenneth L Maddox is famous as the lead editor of McGraw Hill's classic text, Trauma, now in its fifth edition. This is going to be a GREAT book!

    At his death last spring, Roueche left behind seven new narratives that have never been published in book form. This book collects these works along with one earlier classic--all relating true tales of strange illnesses, rare diseases, and the brilliant minds who race to understand and conquer them.

    Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance.Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all.As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.

    K. C. Cole's "Fun with Physics" is a profile of astrophysicist Janet Conrad that blends her personal life with professional activity. In "Desperate Measures," the doctor and writer Atul Gawande profiles the surgeon Francis Daniels Moore, whose experiments in the 1940s and '50s pushed medicine harder and farther than almost anyone had contemplated. Also included is a poem by the legendary John Updike, "Mars as Bright as Venus." The collection ends with Diane Ackerman's "ebullient" essay "We Are All a Part of Nature."Together these twenty-three articles on a wide range of today's most current topics in science -- from biology, physics, biotechnology, and astronomy, to anthropology, genetics, evolutionary theory, and cognition‚ represent the full spectrum of scientific writing from America's most prominent science authors, proving once again that "good science writing is evidently plentiful" (Scientific American).

    Hodgkinson offer you a wry look inside the mirrored palaces of high culture.Read this book and you'll never again mistake Hegel for Engels, you'll know when precisely to drop Foucault's name into a conversation and how to pronounce "Borgesian," and you'll learn many more essential pointers for the intellectual life.

    The most current information on the mechanisms, manifestations, and treatments of disease are clearly and concisely presented. Accessible writing, numerous illustrations in full-color, and complete and separate treatment of pediatric pathophysiology are the hallmarks of this popular and respected text. The new third edition features extensively revised and updated content and an enhanced art program.The book is divided into two parts. Part One presents the general principles of pathophysiology, including cell injury and repair; genetics; fluids and electrolytes, acids and bases; immunity, inflammation, and infection; stress; and cancer. Part Two is organized by body system, and for each system it covers normal anatomy and physiology, alterations of function in adults, and alterations of function in children.• Complete but concise coverage provides a thorough discussion of general pathophysiology and specific disease processes. • Outstanding full-color art program illustrates normal anatomy and physiology, disease processes, and clinical manifestations of disease. • Pediatric content is presented in 9 separate chapters to provide thorough coverage of how disease processes specifically affect children. • Health Alert boxes present brief discussions of new research, diagnostic studies, preventative care, treatments, or other developments related to health or specific diseases. • Quick Check questions appear at the end of major sections of text and are designed to promote critical thinking. Suggested answers to the questions are found on the CD companion included with the text. • Risk Factor boxes illustrate how certain risk factors are associated with specific diseases. • Did You Understand? chapter summaries provide students with a comprehensive review of the major concepts presented in each chapter. • Aging content is identified with a special icon within the adult chapters. • Algorithms are used throughout the text to illustrate normal and compensatory physiology and pathophysiology. • Key terms are boldface in text and listed with page numbers at the end of each chapter for easy reference and chapter review.• Approximately 250 new full-color drawings have been added. • An Introduction to Pathophysiology included in the front matter defines pathophysiology — and related terms such as etiology and epidemiology — and explains why it is important. • Extensive updates, based on the most current research, have been made throughout the book. • To reflect the latest developments, the Biology of Cancer chapter has been completely rewritten. • Several chapters, including Fluids and Electrolytes, Acids and Bases and Alterations of the Reproductive Systems have been extensively edited.

    Aimed at undergraduate/MBA-level courses in business ethics in the departments of philosophy or business, this comprehensive text provides a balanced and up-to-date treatment of some of the most prominent issues of business ethics.

    A reference for health care clinicians and students, that takes account of the integration of alternative and complementary approaches into standard western medical care, defining terms relating to herbal remedies and traditional cures from other cultures.

     Free BONUS Inside! Voltaire, born François-Marie Arouet in Paris, France, was a writer and leading figure of the Enlightenment. His insistence that all authority could and must be questioned was so radical, he ended up in prison several times and was ultimately exiled. Voltaire’s writings were instrumental in influencing the American and French revolutions. Man as a being with natural rights was a radical concept at the time, but one which the American founding fathers embraced. Voltaire’s anger was specifically directed at the arbitrary powers of the state and the church. The French legal system treated aristocrats differently than ordinary citizens. The Catholic church, too, wielded its dictatorial power. Voltaire incurred the wrath of both kings and bishops with his unrelenting attacks on such abuses of freedom. Unwilling to be silenced, Voltaire continued his demand for individual freedom throughout the span of his entire life. Only after his death was he officially welcomed back to Paris, and Voltaire’s remains now rest in the Parisian Panthéon, the burial place for the country’s national heroes. Discover a plethora of topics such as Literary Success and Financial Failure Émilie: The Love of His Life Years in Exile Candide and Morality Voltaire’s Final Year and Death And much more! So if you want a quick and easy to read book on Voltaire, simply scroll up and click the "Buy now" button for instant access!

    We currently see no evidence of any kind indicating that extraterrestrials exist outside of our solar system. But at this moment, millions of engineers, scientists, corporations, universities and entrepreneurs are racing to create the second intelligent species right here on planet earth. And we can see the second intelligent species coming from all directions in the form of self-driving cars, automated call centers, chess-playing and Jeopardy-playing computers that beat all human players, airport kiosks, restaurant tablet systems, etc. The frightening thing is that these robots will soon be eliminating human jobs in startling numbers. The first wave of unemployed workers is likely to be a million truck drivers who are replaced by self-driving trucks. Pilots will be eliminated soon as well. Then, as new computer vision systems come online, we will see tens of millions of workers in retail stores, fast food restaurants and construction sites replaced by robots. Unless we take steps now to change the economy, we will soon have tens of millions of workers who are unemployed and seeking welfare because they will have no other choice. Marshall Brain's new book "The Second Intelligent Species: How Humans Will Become as Irrelevant as Cockroaches" explores how the future will unfold as the second intelligent species emerges. The book answers questions like: - How will new computer vision systems affect the job market? - How many people will become unemployed by the second intelligent species? - What will happen to millions of newly unemployed workers? - How can modern society and modern economies cope with run-away unemployment caused by robots? - What will happen when the first sentient, conscious computer appears? - What moral and ethical principles will guide the second intelligent species? - Why do we see no extraterrestrials in our universe? "The Second Intelligent Species" offers a unique and fascinating look at the future of the human race, and the choices we will need to make to avoid massive unemployment and poverty worldwide as intelligent machines start eliminating millions of jobs.

    In the majority of cases individuals diagnosed as "brain dead" are the source of the organs without which transplants could not take place. In this compelling and provocative examination, Margaret Lock traces the discourse over the past thirty years that contributed to the locating of a new criterion of death in the brain, and its routinization in clinical practice in North America. She compares this situation with that in Japan where, despite the availability of the necessary technology and expertise, brain death was legally recognized only in 1997, and then under limited and contested circumstances. Twice Dead explores the cultural, historical, political, and clinical reasons for the ready acceptance of the new criterion of death in North America and its rejection, until recently, in Japan, with the result that organ transplantation has been severely restricted in that country. This incisive and timely discussion demonstrates that death is not self-evident, that the space between life and death is historically and culturally constructed, fluid, multiple, and open to dispute. In addition to an analysis of that professional literature on and popular representations of the subject, Lock draws on extensive interviews conducted over ten years with physicians working in intensive care units, transplant surgeons, organ recipients, donor families, members of the general public in both Japan and North America, and political activists in Japan opposed to the recognition of brain death. By showing that death can never be understood merely as a biological event, and that cultural, medical, legal, and political dimensions are inevitably implicated in the invention of brain death, Twice Dead confronts one of the most troubling questions of our era.

    or House, or been absorbed by a piece in The New Yorker by Gawande, Groopman, or Nuland, or sat on that exam table wondering what's really going on in your doctor's head, then this book is for you. Expertise versus commonsense practice; moral judgments on young patients or their parents; asking tough questions; death and physician-assisted suicide; daily life with a doctor's job (yours or a family member's); doctors as patients- Klass addresses the primary issues in the life of any doctor and, by extension, the lives of those for whom they care. Perri Klass, M.D., is a writer, teacher, pediatrician, and mentor. In her frequent contributions to the New York Times, she takes on a host of issues particular to the life of a doctor-secrecy, ethics, fear, grief, and competition-with a warmth and wit her readers have come to love. Now, in the newest addition to Basic's Art of Mentoring Series, she offers her guidance, and her stories, to a new generation of doctors and readers.

    Originally published in 1996 and later chosen by World magazine as one of the top 100 books of the twentieth century, Gilbert Meilaender’s Bioethics covers a wide range of pressing bioethical issues and offers discerning guidance on how Christians ought to think about them.In admirably clear language Meilaender discusses abortion, assisted reproduction, genetic advance and prenatal screening, care for the dying and euthanasia, human experimentation, and more. This new edition of his Bioethics features updated information throughout, a fuller discussion of human embryos — including stem cell research — and a thorough rewrite of the chapter on organ donation.