Armstrong writes about her experience as one of only a few people to participate in an experimental treatment for depression involving ten rounds of a chemically induced coma approximating brain death.For years, Heather B. Armstrong has alluded to her struggle with depression on her website. But in 2016, Heather found herself in the depths of a depression she just couldn’t shake, an episode darker and longer than anything she had previously experienced. This book recalls the torturous eighteen months of suicidal depression she endured and the month-long experimental study in which doctors used propofol anesthesia to quiet all brain activity for a full fifteen minutes before bringing her back from a flatline. Ten times. The experience wasn’t easy. Not for Heather or her family. But a switch was flipped, and Heather hasn’t experienced a single moment of suicidal depression since. The Valedictorian of Being Dead brings to light a groundbreaking new treatment for depression.

    After 3.8 billion years humankind is about to start evolving by new rules...From leading geopolitical expert and technology futurist Jamie Metzl comes a groundbreaking exploration of the many ways genetic-engineering is shaking the core foundations of our lives -- sex, war, love, and death.At the dawn of the genetics revolution, our DNA is becoming as readable, writable, and hackable as our information technology. But as humanity starts retooling our own genetic code, the choices we make today will be the difference between realizing breathtaking advances in human well-being and descending into a dangerous and potentially deadly genetic arms race.Enter the laboratories where scientists are turning science fiction into reality. Look towards a future where our deepest beliefs, morals, religions, and politics are challenged like never before and the very essence of what it means to be human is at play. When we can engineer our future children, massively extend our lifespans, build life from scratch, and recreate the plant and animal world, should we?

    Eilene Zimmerman noticed that her ex-husband looked thin, seemed distracted, and was frequently absent from activities with their children. She thought he looked sick and needed to see a doctor, and indeed, he told her he had been diagnosed with an autoimmune disorder. Yet in many ways, Peter also seemed to have it all: a beautiful house by the beach purchased after their divorce, expensive cars, and other luxuries that came with an affluent life. Eilene assumed his odd behavior was due to stress and overwork--he was a senior partner at a prominent law firm and had been working more than 60 hours a week for the last 20 years.Although they were divorced, Eilene and Peter had been partners and friends for decades, so, when her calls to Peter were not returned for several days, Eilene went to his house to see if he was OK.So begins Smacked, a brilliant, moving memoir of Eilene's shocking discovery, one that sets her on a journey to find out how a man she knew for nearly 30 years became a drug addict, and hid it so well that neither she nor anyone else in his life suspected what was happening. Eilene discovers that Peter led a secret life, one that started with pills and ended with opioids, cocaine and methamphetamine. Peter was also addicted to work; the last call he ever made was to dial into a conference call.Eilene is determined to learn all she can about Peter's hidden life, and also about drug addiction among ambitious and high achieving professionals like him. Through extensive research and interviews, she presents a picture of drug dependence today in that moneyed, upwardly mobile world. She also embarks on a journey to recreate her life in the wake of loss, both of the person--and the relationship--that profoundly defined the woman she had become.Smacked takes readers on an intimate journey into a little-known part of the drug epidemic, through the story of one man, one woman and one family.

    The daughter they secreted away made all the difference.Joe and Rose Kennedy’s strikingly beautiful daughter Rosemary attended exclusive schools, was presented as a debutante to the Queen of England, and traveled the world with her high-spirited sisters. And yet, Rosemary was intellectually disabled — a secret fiercely guarded by her powerful and glamorous family.  Major new sources — Rose Kennedy’s diaries and correspondence, school and doctors' letters, and exclusive family interviews — bring Rosemary alive as a girl adored but left far behind by her competitive siblings. Kate Larson reveals both the sensitive care Rose and Joe gave to Rosemary and then — as the family’s standing reached an apex — the often desperate and duplicitous arrangements the Kennedys made to keep her away from home as she became increasingly intractable in her early twenties. Finally, Larson illuminates Joe’s decision to have Rosemary lobotomized at age twenty-three, and the family's complicity in keeping the secret.  Rosemary delivers a profoundly moving coda: JFK visited Rosemary for the first time while campaigning in the Midwest; she had been living isolated in a Wisconsin institution for nearly twenty years. Only then did the siblings understand what had happened to Rosemary and bring her home for loving family visits. It was a reckoning that inspired them to direct attention to the plight of the disabled, transforming the lives of millions.

    Or April, the Neo-Nazi bringing up her twin daughters Lamb and Lynx (who have just formed a white-power folk group for kids called Prussian Blue), and her youngest daughter, Dresden. For a decade now, Louis Theroux has been making programs about offbeat characters on the fringes of U.S. society. Now he revisits the people who have most intrigued him to try to discover what motivates them, and why they believe the things they believe. From his Las Vegas base (where else?), Theroux calls on these assorted dreamers, schemers, and outlaws--and in the process finds out a little about the workings of his own mind. What does it mean, after all, to be weird, or "to be yourself"? Do we choose our beliefs or do our beliefs choose us? And is there something particularly weird about Americans? America, prepare yourself for a hilarious look in the mirror that has already taken the rest of the English-speaking world by storm: "Paul Theroux's son writes with just as clear an eye for character and place as his father.... And he's funny.... Theroux's final analysis of American weirdness is true and new." -- Literary Review (England)

    Two people newly in love—Teresa Butz and Jennifer Hopper, who spent many years trying to find themselves and who eventually found each other—and a young man on a dangerous psychological descent: Isaiah Kalebu, age twenty-three, the son of a distant, authoritarian father and a mother with a family history of mental illness. All three paths forever altered by a violent crime, all three stories a wake-up call to the system that failed to see the signs.   In this riveting, probing, compassionate account of a murder in Seattle, Eli Sanders, who won a Pulitzer Prize for his newspaper coverage of the crime, offers a deeply reported portrait in microcosm of the state of mental health care in this country—as well as an inspiring story of love and forgiveness. Culminating in Kalebu’s dangerous slide toward violence—observed by family members, police, mental health workers, lawyers, and judges, but stopped by no one—While the City Slept is the story of a crime of opportunity and of the string of missed opportunities that made it possible. It shows what can happen when a disturbed member of society repeatedly falls through the cracks, and in the tradition of The Other Wes Moore and The Short and Tragic Life of Robert Peace, is an indelible, human-level story, brilliantly told, with the potential to inspire social change.

    Though the world at first recoiled at the notion of a woman studying medicine, her intelligence and intensity ultimately won her the acceptance of the male medical establishment. In 1849, she became the first woman in America to receive an M.D. She was soon joined in her iconic achievement by her younger sister, Emily, who was actually the more brilliant physician.Exploring the sisters’ allies, enemies, and enduring partnership, Janice P. Nimura presents a story of trial and triumph. Together, the Blackwells founded the New York Infirmary for Indigent Women and Children, the first hospital staffed entirely by women. Both sisters were tenacious and visionary, but their convictions did not always align with the emergence of women’s rights—or with each other. From Bristol, Paris, and Edinburgh to the rising cities of antebellum America, this richly researched new biography celebrates two complicated pioneers who exploded the limits of possibility for women in medicine. As Elizabeth herself predicted, "a hundred years hence, women will not be what they are now."

    It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine.  ​Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book.

    In only a few decades, the medical system has been overrun by organizations seeking to exploit for profit the trust that vulnerable and sick Americans place in their healthcare. Our politicians have proven themselves either unwilling or incapable of reining in the increasingly outrageous costs faced by patients, and market-based solutions only seem to funnel larger and larger sums of our money into the hands of corporations. Impossibly high insurance premiums and inexplicably large bills have become facts of life; fatalism has set in. Very quickly Americans have been made to accept paying more for less. How did things get so bad so fast?Breaking down this monolithic business into the individual industries--the hospitals, doctors, insurance companies, and drug manufacturers--that together constitute our healthcare system, Rosenthal exposes the recent evolution of American medicine as never before. How did healthcare, the caring endeavor, become healthcare, the highly profitable industry? Hospital systems, which are managed by business executives, behave like predatory lenders, hounding patients and seizing their homes. Research charities are in bed with big pharmaceutical companies, which surreptitiously profit from the donations made by working people. Patients receive bills in code, from entrepreneurial doctors they never even saw.The system is in tatters, but we can fight back. Dr. Elisabeth Rosenthal doesn't just explain the symptoms, she diagnoses and treats the disease itself. In clear and practical terms, she spells out exactly how to decode medical doublespeak, avoid the pitfalls of the pharmaceuticals racket, and get the care you and your family deserve. She takes you inside the doctor-patient relationship and to hospital C-suites, explaining step-by-step the workings of a system badly lacking transparency. This is about what we can do, as individual patients, both to navigate the maze that is American healthcare and also to demand far-reaching reform. An American Sickness is the frontline defense against a healthcare system that no longer has our well-being at heart.

    Text Me When You Get Home is a personal and sociological perspective - and ultimately a celebration - of the evolution of the modern female friendship.Kayleen Schaefer has experienced (and occasionally, narrowly survived) most every iteration of the modern female friendship. First there was the mean girl cliques of the '90s; then the teenage friendships that revolved around constant discussion of romantic interests and which slowly morphed into Sex and the City spin-offs; the disheartening loneliness of "I'm not like other girls" friendships with only men; the discovery of a platonic soul mate; and finally, the overwhelming love of a supportive female squad (#squad).And over the course of these friendships, Schaefer made a startling discovery: girls make the best friends. And she isn't the only one to realize this. Through interviews with friends, mothers, authors, celebrities, businesswomen, doctors, screenwriters, and historians (a list that includes Judy Blume, Megan Abbott, The Fug Girls, and Kay Cannon), Schaefer shows a remarkable portrait of what female friendships can help modern women accomplish in their social, personal, and work lives.A validation of female friendship unlike any that's ever existed before, this book is a mix of historical research, the author's own personal experience, and conversations about friendships across the country. Everything Schaefer uncovers leads to - and makes the case for - the eventual conclusion that these ties among women are making us (both as individuals and as society as a whole) stronger than ever before.

    In the 1940s, a bored heiress began creating dollhouse crime scenes depicting murders, suicides, and accidental deaths. Known as the “Mother of Forensic Science,” she revolutionized the field of what was then called legal medicine. In the aftermath of the Manson Family murders, a young woman moved into Sharon Tate’s guesthouse and, over the next two decades, entwined herself with the Tate family. In the mid-nineties, a landscape architect in Brooklyn fell in love with a convicted murderer, the supposed ringleader of the West Memphis Three, through an intense series of letters. After they married, she devoted her life to getting him freed from death row. And in 2015, a teenager deeply involved in the online fandom for the Columbine killers planned a mass shooting of her own.Each woman, Monroe argues, represents and identifies with a particular archetype that provides an entryway into true crime. Through these four cases, she traces the history of American crime through the growth of forensic science, the evolving role of victims, the Satanic Panic, the rise of online detectives, and the long shadow of the Columbine shooting. In a combination of personal narrative, reportage, and a sociological examination of violence and media in the twentieth and twenty-first century, Savage Appetites scrupulously explores empathy, justice, and the persistent appeal of violence.

    Nestled in the Appalachian mountains, Owsley County is one of the poorest counties in both Kentucky and the country. Buildings are crumbling and fields sit vacant, as tobacco farming and coal mining decline. But strong women are finding creative ways to subsist in their hollers in the hills. Cassie Chambers grew up in these hollers and, through the women who raised her, she traces her own path out of and back into the Kentucky mountains. Chambers’s Granny was a child bride who rose before dawn every morning to raise seven children. Despite her poverty, she wouldn’t hesitate to give the last bite of pie or vegetables from her garden to a struggling neighbor. Her two daughters took very different paths: strong-willed Ruth—the hardest-working tobacco farmer in the county—stayed on the family farm, while spirited Wilma—the sixth child—became the first in the family to graduate from high school, then moved an hour away for college. Married at nineteen and pregnant with Cassie a few months later, Wilma beat the odds to finish school. She raised her daughter to think she could move mountains, like the ones that kept her safe but also isolated her from the larger world. Cassie would spend much of her childhood with Granny and Ruth in the hills of Owsley County, both while Wilma was in college and after. With her “hill women” values guiding her, Cassie went on to graduate from Harvard Law. But while the Ivy League gave her knowledge and opportunities, its privileged world felt far from her reality, and she moved back home to help her fellow rural Kentucky women by providing free legal services. Appalachian women face issues that are all too common: domestic violence, the opioid crisis, a world that seems more divided by the day. But they are also community leaders, keeping their towns together in the face of a system that continually fails them. With nuance and heart, Chambers uses these women’s stories paired with her own journey to break down the myth of the hillbilly and illuminate a region whose poor communities, especially women, can lead it into the future.

    This book is about them, the so-called "mole people" living alone and in communities, in the frescoed waiting rooms of long-forgotten subway tunnels and in pick-axed compartments below busway platforms. It is about how and why people move underground, who they are, and what they have to say about their lives and the treacherous "topside" world they've left behind. There are even the voices of young children taken down to the tunnels by parents who are determined to keep their families together, although as one tunnel dweller explains, "once you go down there, you can't be a child anymore." Though they maintain an existence hidden from the world aboveground, tunnel dwellers form a large and growing sector of the homeless population. They are a diverse group, and they choose to live underground for many reasonssome rejecting society and its values, others reaffirming those values in what they view as purer terms, and still others seeking shelter from the harsh conditions on the streets. Their enemies include government agencies and homeless organizations as well as wandering crack addicts and marauding gangs. In communities underground, however, many homeless people find not only a place but also an identity. On these pages Jennifer Toth visits underground New York with various straight-talking guides, from outreach workers and transit police to vetern tunnel dwellers, graffiti artists, and even the "mayor" of a large, highly structured community several levels down. In addition to chilling and poignant firsthand accounts of tunnel life, she describes the fascinating and labryrinthine physical world beneath the city and discusses the literary allusions and historical points of view that prejudice our culture against those who "go underground". Toth has gained unprecedented access to a strange and frightening world, but The Mole People is not a daredevil jo

    But as Jane Mayer shows in this powerful, meticulously reported history, a network of exceedingly wealthy people with extreme libertarian views bankrolled a systematic, step-by-step plan to fundamentally alter the American political system.The network has brought together some of the richest people on the planet. Their core beliefs—that taxes are a form of tyranny; that government oversight of business is an assault on freedom—are sincerely held. But these beliefs also advance their personal and corporate interests: Many of their companies have run afoul of federal pollution, worker safety, securities, and tax laws.The chief figures in the network are Charles and David Koch, whose father made his fortune in part by building oil refineries in Stalin’s Russia and Hitler’s Germany. The patriarch later was a founding member of the John Birch Society, whose politics were so radical it believed Dwight Eisenhower was a communist. The brothers were schooled in a political philosophy that asserted the only role of government is to provide security and to enforce property rights.When libertarian ideas proved decidedly unpopular with voters, the Koch brothers and their allies chose another path. If they pooled their vast resources, they could fund an interlocking array of organizations that could work in tandem to influence and ultimately control academic institutions, think tanks, the courts, statehouses, Congress, and, they hoped, the presidency. Richard Mellon Scaife, the mercurial heir to banking and oil fortunes, had the brilliant insight that most of their political activities could be written off as tax-deductible “philanthropy.”These organizations were given innocuous names such as Americans for Prosperity. Funding sources were hidden whenever possible. This process reached its apotheosis with the allegedly populist Tea Party movement, abetted mightily by the Citizens United decision—a case conceived of by legal advocates funded by the network.The political operatives the network employs are disciplined, smart, and at times ruthless. Mayer documents instances in which people affiliated with these groups hired private detectives to impugn whistle-blowers, journalists, and even government investigators. And their efforts have been remarkably successful. Libertarian views on taxes and regulation, once far outside the mainstream and still rejected by most Americans, are ascendant in the majority of state governments, the Supreme Court, and Congress. Meaningful environmental, labor, finance, and tax reforms have been stymied.Jane Mayer spent five years conducting hundreds of interviews-including with several sources within the network-and scoured public records, private papers, and court proceedings in reporting this book. In a taut and utterly convincing narrative, she traces the byzantine trail of the billions of dollars spent by the network and provides vivid portraits of the colorful figures behind the new American oligarchy.Dark Money is a book that must be read by anyone who cares about the future of American democracy.

    When Matt Haig developed panic disorder, anxiety, and depression as an adult, it took him a long time to work out the ways the external world could impact his mental health in both positive and negative ways. Notes on a Nervous Planet collects his observations, taking a look at how the various social, commercial and technological "advancements" that have created the world we now live in can actually hinder our happiness. Haig examines everything from broader phenomena like inequality, social media, and the news; to things closer to our daily lives, like how we sleep, how we exercise, and even the distinction we draw between our minds and our bodies.