Some of these drugs are truly transformative, offering major improvements in how long patients live or how they feel--but what is often missing from the popular narrative is that, far too often, these new drugs have marginal or minimal benefits. Some are even harmful. In Malignant, hematologist-oncologist Dr. Vinayak K. Prasad writes about the many sobering examples of how patients are too often failed by cancer policy and by how oncology is practiced. Throughout this work, Prasad illuminates deceptive practices which- promote novel cancer therapies long before credible data are available to support such treatment; and- exaggerate the potential benefits of new therapies, many of which cost thousands and in some cases hundreds of thousands of dollars.Prasad then critiques the financial conflicts of interest that pervade the oncology field, the pharmaceutical industry, and the US Food and Drug administration.This is a book about how the actions of human beings--our policies, our standards of evidence, and our drug regulation--incentivize the pursuit of marginal or unproven therapies at lofty and unsustainable prices. Prasad takes us through how cancer trials are conducted, how drugs come to market, and how pricing decisions are made, asking how we can ensure that more cancer drugs deliver both greater benefit and a lower price. Ultimately, Prasad says,- more cancer clinical trials should measure outcomes that actually matter to people with cancer;- patients on those trials should look more like actual global citizens;- we need drug regulators to raise, not perpetually lower, the bar for approval; and- we need unbiased patient advocates and experts.This well-written, opinionated, and engaging book explains what we can do differently to make serious and sustained progress against cancer--and how we can avoid repeating the policy and practice mistakes of the past.

    . . full of intellectual treats and tricks, of whimsy and deep scientific philosophy. It is highbrow entertainment at its best, a teasing challenge to all who aspire to think about the universe." — New York Herald TribuneOne of the world's foremost nuclear physicists (celebrated for his theory of radioactive decay, among other accomplishments), George Gamow possessed the unique ability of making the world of science accessible to the general reader.He brings that ability to bear in this delightful expedition through the problems, pleasures, and puzzles of modern science. Among the topics scrutinized with the author's celebrated good humor and pedagogical prowess are the macrocosm and the microcosm, theory of numbers, relativity of space and time, entropy, genes, atomic structure, nuclear fission, and the origin of the solar system.In the pages of this book readers grapple with such crucial matters as whether it is possible to bend space, why a rocket shrinks, the "end of the world problem," excursions into the fourth dimension, and a host of other tantalizing topics for the scientifically curious. Brimming with amusing anecdotes and provocative problems, One Two Three . . . Infinity also includes over 120 delightful pen-and-ink illustrations by the author, adding another dimension of good-natured charm to these wide-ranging explorations.Whatever your level of scientific expertise, chances are you'll derive a great deal of pleasure, stimulation, and information from this unusual and imaginative book. It belongs in the library of anyone curious about the wonders of the scientific universe. "In One Two Three . . . Infinity, as in his other books, George Gamow succeeds where others fail because of his remarkable ability to combine technical accuracy, choice of material, dignity of expression, and readability." — Saturday Review of Literature

    Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it–on some level–restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer.A healthy young man suddenly loses his memory–making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment–only to have their symptoms mysteriously return. A young woman lies dying in the ICU–bleeding, jaundiced, incoherent–and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness–the diagnosis–revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.

    Today there is just one. Us. Homo sapiens. How did our species succeed in the battle for dominance? Why did our foraging ancestors come together to create cities and kingdoms? How did we come to believe in gods, nations and human rights; to trust money, books and laws; and to be enslaved by bureaucracy, timetables and consumerism? And what will our world be like in the millennia to come? In Sapiens, Dr Yuval Noah Harari spans the whole of human history, from the very first humans to walk the earth to the radical – and sometimes devastating – breakthroughs of the Cognitive, Agricultural and Scientific Revolutions. Drawing on insights from biology, anthropology, paleontology and economics, he explores how the currents of history have shaped our human societies, the animals and plants around us, and even our personalities. Have we become happier as history has unfolded? Can we ever free our behaviour from the heritage of our ancestors? And what, if anything, can we do to influence the course of the centuries to come? Bold, wide-ranging and provocative, Sapiens challenges everything we thought we knew about being human: our thoughts, our actions, our power ... and our future.

    Psychologist Geoffrey Miller offers the most convincing-and radical-explanation for how and why the human mind evolved.Consciousness, morality, creativity, language, and art: these are the traits that make us human. Scientists have traditionally explained these qualities as merely a side effect of surplus brain size, but Miller argues that they were sexual attractors, not side effects. He bases his argument on Darwin's theory of sexual selection, which until now has played second fiddle to Darwin's theory of natural selection, and draws on ideas and research from a wide range of fields, including psychology, economics, history, and pop culture. Witty, powerfully argued, and continually thought-provoking, The Mating Mind is a landmark in our understanding of our own species.

    He also happens to have a Ph.D. in zoology and wrote his dissertation on evolution, atheism and naturalism. Preston Jones is a history professor at a Christian college and a fan of Bad Religion's music. One day, on a whim, Preston sent Greg an appreciative e-mail. That was the start of an extraordinary correspondence. For several months, Preston and Greg sent e-mails back and forth on big topics like God, religion, knowledge, evil, evolution, biology, destiny and the nature of reality. Preston believes in God; Greg sees insufficient evidence for God's existence. Over the course of their friendly debate, they tackle such cosmic questions as: Is religion rational or irrational? Does morality require belief in God? Do people only believe in God because they are genetically predisposed toward religion? How do you make sense of suffering in the world? Is this universe all there is? And what does it all matter? In this engaging book, Preston and Greg's actual e-mail correspondence is reproduced, along with bonus materials that provide additional background and context. Each makes his case for why he thinks his worldview is more compelling and explanatory. While they find some places to agree, neither one convinces the other. They can't both be right. So which worldview is more plausible? You decide.

    QFT is the only physics theory that makes sense and that dispels or resolves the paradoxes of relativity and quantum mechanics that have confused and mystified so many people.

    Why We Get Sick compels readers to reexamine the age-old attitudes toward sickness. Line drawings.

    Originally published in 1996 and later chosen by World magazine as one of the top 100 books of the twentieth century, Gilbert Meilaender’s Bioethics covers a wide range of pressing bioethical issues and offers discerning guidance on how Christians ought to think about them.In admirably clear language Meilaender discusses abortion, assisted reproduction, genetic advance and prenatal screening, care for the dying and euthanasia, human experimentation, and more. This new edition of his Bioethics features updated information throughout, a fuller discussion of human embryos — including stem cell research — and a thorough rewrite of the chapter on organ donation.

    Book by Benson, Ezra T.

    Medicine, anatomy, astronomy, mathematics and cosmology were all invented in their world. Plato, Aristotle, Pythagoras, Archimedes and Hippocrates were amongst its stars, master architects all of the modern as well as the ancient.

    Napolitano, Fox News Channel's Senior Judicial Analyst, holds a straightforward "conversation" with the American voter, in which he asks questions and gives answers that no one else will:Why do our taxes continue to rise, government services stay worse than ever, and we just pay the taxes and re-elect those who raised them?Why do people in government never acknowledge a mistake, and why do we accept that?Why does the government continue to regulate private behavior?Why do both Republicans and Democrats bring about bigger and more expensive government?Whatever happened to our individual inalienable rights to life, liberty, and the pursuit of happiness, that are guaranteed by the Declaration of Independence, yet ignored by the governments elected to protect them?Why does Congress keep telling the States what to do?Why does every public office holder swear allegiance to the Constitution, yet very few follow it?Why are we afraid of the governments we have hired to protect our freedoms?

    In How Many Friends Does One Person Need? Robin Dunbar uses groundbreaking experiments that have forever changed the way evolutionary biologists explain how the distant past underpins our current ­behavior.We know so much more now than Darwin ever did, but the core of modern evolutionary theory lies firmly in Darwin’s elegantly simple idea: organisms behave in ways that enhance the frequency with which genes are passed on to future generations. This idea is at the heart of Dunbar’s book, which seeks to explain why humans behave as they do. Stimulating, provocative, and immensely enjoyable, his book invites you to explore the number of friends you have, whether you have your father’s brain or your mother’s, whether morning sickness might actually be good for you, why Barack Obama’s 2008 victory was a foregone conclusion, what Gaelic has to do with frankincense, and why we laugh. In the process, Dunbar examines the role of religion in human evolution, the fact that most of us have unexpectedly famous ancestors, and why men and women never seem able to see eye to eye on color.