We like to imagine that it’s based on evidence and the results of fair tests. In reality, those tests are often profoundly flawed. We like to imagine that doctors are familiar with the research literature surrounding a drug, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality much of their education is funded by industry. We like to imagine that regulators let only effective drugs onto the market, when in reality they approve hopeless drugs, with data on side effects casually withheld from doctors and patients.All these problems have been protected from public scrutiny because they’re too complex to capture in a sound bite. But Dr. Ben Goldacre shows that the true scale of this murderous disaster fully reveals itself only when the details are untangled. He believes we should all be able to understand precisely how data manipulation works and how research misconduct on a global scale affects us. In his own words, “the tricks and distortions documented in these pages are beautiful, intricate, and fascinating in their details.” With Goldacre’s characteristic flair and a forensic attention to detail, Bad Pharma reveals a shockingly broken system and calls for something to be done. This is the pharmaceutical industry as it has never been seen before.

    This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the co-evolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brains fundamental organizer of neuronal information. The small world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive metastable state and provide energy-efficient synchronizing mechanisms via weak links.In a sequence of cycles, Gy�rgy Buzs�ki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing accessible to any reader with some scientific knowledge is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

    This book integrates clinical examples throughout each chapter and covers important physiologic concepts. It includes 630 multiple choice questions. It covers topics such as: Regulation of food intake; Mitochondria and molecular motors; Renal function; and, Estrogen receptors.

    Devlin's Textbook of Biochemistry with Clinical Correlations presents the biochemistry of mammalian cells, relates events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of human diseases derived from aberrant biochemical processes. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to humans. Loaded with new material and chapters and brimming with detailed, full-color illustrations that clearly explain associated concepts, this sixth edition is an indispensable tool for students and professionals in the medical or health sciences. Key Features of the Sixth Edition Over 250 Clinical Correlations highlighting the significance of the biochemistry to clinical conditions and diseases MCAT-Style Questions with annontated answers in every chapter - in a format similar to that used by the National Board of Medical Examiners More than 1,200 high-quality, full-color illustrations A concise appendix reviewing important Organic Chemistry Concepts New to the Sixth Edition: Fully Updated with a significant revision of all chapters and major topics Two new chapters: Fundamentals of Signal Transduction and Cell Cycle, Programmed Cell Death, and Cancer A Glossary that explains important biochemical terms New sections on the Basal Lamina Protein Complex and Molecular Motors

    Countless behaviors separate us from the rest of the animal kingdom, but all of them can be traced one way or another to six traits that are unique to the human race—our big toe, our opposable thumb, our oddly shaped pharynx, and our ability to laugh, kiss, and cry. At first glance these may not seem to be connected but they are. Each marks a fork in the evolutionary road where we went one way and the rest of the animal kingdom went another. Each opens small passageways on the peculiar geography of the human heart and mind.Walter weaves together fascinating insights from complexity theory, the latest brain scanning techniques, anthropology, artificial intelligence, cognitive psychology, and robotics to explore how the smallest of changes over the past six million years – all shaped by the forces of evolution -- have enabled a primate once on the brink of extinction to evolve into a creature that would one day create all of the grand and exuberant edifices of human culture.As the story of each trait unfolds, Walter explains why our brains grew so large and complex, why we find one another sexually attractive, how toolmaking laid the mental groundwork for language, why we care about what others think, and how we became the creature that laughs and cries and falls in love. Thumbs, Toes and Tears is original, informative, and delightfully thought-provoking.

    Too often, overwhelmed by anatomical detail, students miss out on the functional beauty of the nervous system and its relevance to clinical practice.

    Designed primarily for undergraduates, this self-help manual offers straightforward solutions to common problems and an overview of the diversity of writing tasks faced by professional biologists.

    Our biology predisposes us to see and understand the world in different ways, not always reason and the careful consideration of facts. These predispositions are in turn responsible for a significant portion of the political and ideological conflict that marks human history.With verve and wit, renowned social scientists John Hibbing, Kevin Smith, and John Alford--pioneers in the field of biopolitics--present overwhelming evidence that people differ politically not just because they grew up in different cultures or were presented with different information. Despite the oft-heard longing for consensus, unity, and peace, the universal rift between conservatives and liberals endures because people have diverse psychological, physiological, and genetic traits. These biological differences influence much of what makes people who they are, including their orientations to politics.Political disputes typically spring from the assumption that those who do not agree with us are shallow, misguided, uninformed, and ignorant. Predisposed suggests instead that political opponents simply experience, process, and respond to the world differently. It follows, then, that the key to getting along politically is not the ability of one side to persuade the other side to see the error of its ways but rather the ability of each side to see that the other is different, not just politically, but physically. Predisposed will change the way you think about politics and partisan conflict.As a bonus, the book includes a "Left/Right 20 Questions" game to test whether your predispositions lean liberal or conservative.

    Unlike traditional empirical psychology, it is more oriented toward the how than the what. An experiment in mind design is more likely to be an attempt to build something and make it work--as in artificial intelligence--than to observe or analyze what already exists. Mind design is psychology by reverse engineering.When Mind Design was first published in 1981, it became a classic in the then-nascent fields of cognitive science and AI. This second edition retains four landmark essays from the first, adding to them one earlier milestone (Turing's Computing Machinery and Intelligence) and eleven more recent articles about connectionism, dynamical systems, and symbolic versus nonsymbolic models. The contributors are divided about evenly between philosophers and scientists. Yet all are philosophical in that they address fundamental issues and concepts; and all are scientific in that they are technically sophisticated and concerned with concrete empirical research.ContributorsRodney A. Brooks, Paul M. Churchland, Andy Clark, Daniel C. Dennett, Hubert L. Dreyfus, Jerry A. Fodor, Joseph Garon, John Haugeland, Marvin Minsky, Allen Newell, Zenon W. Pylyshyn, William Ramsey, Jay F. Rosenberg, David E. Rumelhart, John R. Searle, Herbert A. Simon, Paul Smolensky, Stephen Stich, A.M. Turing, Timothy van Gelder

    Written for both the casual reader and the science buff hungry for new information, The Vision Revolution is a resource that dispels commonly believed perceptions about sight and offers answers drawn from the field’s most recent research.Changizi focuses on four “why” questions:1. Why do we see in color?2. Why do our eyes face forward?3. Why do we see illusions?4. Why does reading come so naturally to us?Why Do We See in Color?It was commonly believed that color vision evolved to help our primitive ancestors identify ripe fruit. Changizi says we should look closer to home: ourselves. Human color vision evolved to give us greater insights into the mental states and health of other people. People who can see color changes in skin have an advantage over their color-blind counterparts; they can see when people are blushing with embarrassment, purple-faced with exertion or the reddening of rashes. Changizi’s research reveals that the cones in our eyes that allow us to see color are exquisitely designed exactly for seeing color changes in the skin. And it’s no coincidence that the primates with color vision are the ones with bare spots on their faces and other body parts; Changizi shows that the development of color vision in higher primates closely parallels the loss of facial hair, culminating in the near hairlessness and highly developed color vision of humans.Why Do Our Eyes Face Forward?Forward-facing eyes set us apart from most mammals, and there is much dispute as to why we have them. While some speculate that we evolved this feature to give us depth perception available through stereo vision, this type of vision only allows us to see short distances, and we already have other mechanisms that help us to estimate distance. Changizi’s research shows that with two forward-facing eyes, primates and humans have an x-ray ability. Specifically, we’re able to see through the cluttered leaves of the forest environment in which we evolved. This feature helps primates see their targets in a crowded, encroached environment. To see how this works, hold a finger in front of your eyes. You’ll find that you’re able to look “through” it, at what is beyond your finger. One of the most amazing feats of two forward-facing eyes? Our views aren’t blocked by our noses, beaks, etc.Why Do We See Illusions?We evolved to see moving objects, not where they are, but where they are going to be. Without this ability, we couldn’t catch a ball because the brain’s ability to process visual information isn’t fast enough to allow us to put our hands in the right place to intersect for a rapidly approaching baseball. “If our brains simply created a perception of the way the world was at the time light hit the eye, then by the time that perception was elicited—which takes about a tenth of a second for the brain to do—time would have marched on, and the perception would be of the recent past,” Changizi explains. Simply put, illusions occur when our brain is tricked into thinking that a stationary two-dimensional picture has an element that is moving. Our brains project the “moving” element into the future and, as a result, we don’t see what’s on the page, but what our brain thinks will be the case a fraction of a second into the future.Why Does Reading Come So Naturally to Us?We can read faster than we can hear, which is odd, considering that reading is relatively recent, and we’ve evolved to process speech for millions of years. Changizi’s research reveals that language has been carefully designed to tap in to elements of the visual processing center that have evolved for tens of millions of years. Visual signs of all languages are shaped like objects in nature, Changizi says, because we have evolved to see nature easily. “People have noticed letters in nature for some time, and there are artists who have a spent a lot of time photographing Latin letters in natural scenes or on butterfly wings,” Changizi says. “For example, if you look at an upper corner of the room you are in, you will see three contours meeting at a point, making a shape close to that of a ‘Y.’“ The Vision Revolution expands upon how our ancestors found the shapes of Latin letters and delves into how visual signs can have similar shapes even though their inspirations come from very different environments.In addition to these four areas, The Vision Revolution explores other phenomena such as cyclopses, peeking and many more you hadn’t even thought to wonder about. Changizi shows how deeply involved these evolutionary aspects of our vision are in why we see the way we do—and what the future holds for us.“…to understand how culture interacts with vision, one must understand not just the eye’s design, but the actual mechanisms we have evolved,” Changizi says, “for culture can tap in to both the designed responses of our brains and the unintended responses.”The Vision Revolution is a book that finally gives attention to what before has been largely neglected by other works on human vision—a book that looks at the “why.”

    How to approach complex normal and abnormal behaviors through biology. How to integrate disciplines including sociobiology, ethology, neuroscience, and endocrinology to examine behaviors such as aggression, sexual behavior, language use, and mental illness.36 hours lectures

    About The Author: Henry Gray, F.R.S., Fellow of the royal college of Surgeons: Lecturer on anatomy at St. George?s Hospital Medical School. Table Of Contents: Descriptive and Surgical Anatomy The Articulations Muscles and Fasclae The Blood-vascular system The Lymphatics The Nervous system The Organs of special sense The Organs of Digestion The Organs of voice and respiration The urinary organs The Male Organs of Generation The Female Organs of Generation The Surgical Anatomy of Hernia Surgical Anatomy of the Perinaeum General Anatomy or Histology Embryology

    He studied physics and philosophy at the University of Tübingen in Germany and was awarded his Ph.D. in biophysics in 1982. He is now the Lois and Victor Troendle Professor of Cognitive and Behavioral Biology at the California Institute of Technology. The author of several books, Dr. Koch studies the biophysics of computation, and the neuronal basis of visual perception, attention, and consciousness. Together with Francis Crick, his long-time collaborator, he has pioneered the scientific study of consciousness.

    Each chapter integrates coverage of both human memory and animal learning, with separate sections specifically devoted to behavioral processes, brain systems, and clinical perspectives.

    From the "phantom pain" experienced by people who have lost their limbs to the uncanny faculty of "blindsight," Humphrey argues that raw sensations are central to all conscious states and that consciousness must have evolved, just like all other mental faculties, over time from our ancestors' bodily responses to pain and pleasure. '