When a small vial arrives in her mailbox from "Lewis Carroll," Ayelet Waldman is at a low point. Her mood storms have become intolerably severe; she has tried nearly every medication possible; her husband and children are suffering with her. So she opens the vial, places two drops on her tongue, and joins the ranks of an underground but increasingly vocal group of scientists and civilians successfully using therapeutic microdoses of LSD. As Waldman charts her experience over the course of a month--bursts of productivity, sleepless nights, a newfound sense of equanimity--she also explores the history and mythology of LSD, the cutting-edge research into the drug, and the byzantine policies that control it. Drawing on her experience as a federal public defender, and as the mother of teenagers, and her research into the therapeutic value of psychedelics, Waldman has produced a book that is eye-opening, often hilarious, and utterly enthralling.

    Braided with that history is the moving story of Powers's beloved son Kevin--spirited, endearing, and gifted--who triumphed even while suffering from schizophrenia until finally he did not, and the story of his courageous surviving son Dean, who is also schizophrenic.A blend of history, biography, memoir, and current affairs ending with a consideration of where we might go from here, this is a thought-provoking look at a dreaded illness that has long been misunderstood.

    That he emerged to write this funny and true book and then moved on to find the meaningful life that for a while had seemed beyond reach is what ultimately happens in The Eden Express. But the real story here is that throughout his harrowing experience his sense of humor let him see the humanity of what he was going through, and his gift of language let him describe it in such a moving way that others could begin to imagine both its utter ordinariness as well as the madness we all share.

    These “psychosurgeons,” as they called themselves, occupied a gray zone between medical research and medical practice, and ended up subjecting untold numbers of people to the types of surgical experiments once limited to chimpanzees.The most important test subject to emerge from this largely untold chapter in American history was a twenty-seven-year-old factory worker named Henry Molaison. In 1953, Henry—who suffered from severe epilepsy—received a radical new version of the lobotomy, one that targeted the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry left the operating room profoundly amnesic, unable to create new long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.Luke Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world. Throughout, Dittrich delves into the enduring mysteries of the mind while exposing troubling stories of just how far we’ve gone in our pursuit of knowledge. It is also, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

    in the fall of 2016, Chelsea Handler daydreams about what life will be like with a woman in the White House. And then Donald Trump happens. In a torpor of despair, she decides that she's had enough of the privileged bubble she's lived in--a bubble within a bubble--and that it's time to make some changes, both in her personal life and in the world at large.At home, she embarks on a year of self-sufficiency--learning how to work the remote, how to pick up dog shit, where to find the toaster. She meets her match in an earnest, brainy psychiatrist and enters into therapy, prepared to do the heavy lifting required to look within and make sense of a childhood marked by love and loss and to figure out why people are afraid of her. She becomes politically active--finding her voice as an advocate for change, having difficult conversations, and energizing her base. In the process, she develops a healthy fixation on Special Counsel Robert Mueller and, through unflinching self-reflection and psychological excavation, unearths some glittering truths that light up the road ahead.

    The top-selling American musical act of the 1970s, they delivered the love songs that defined a generation. Karen’s velvety voice on a string of 16 consecutive Top 20 hits from 1970 to 1976—including “Close to You,” “We’ve Only Just Begun,” “Rainy Days and Mondays,” “Superstar,” and “Hurting Each Other”—propelled the duo to worldwide stardom and record sales of more than 100 million. During their short musical career, the Carpenters released ten studio albums, toured more than 200 days a year, taped five television specials, and won three Grammys and an American Music Award.            But that’s only a part of Karen’s story. Little Girl Blue reveals Karen’s heartbreaking struggles with her mother, brother, and husband; the intimate disclosures she made to her closest friends; her love for playing drums and her frustrated quest for solo stardom; and the ups and downs of her treatment for anorexia nervosa. After her shocking death at 32 years of age in 1983, she became the proverbial poster child for that disorder; but the other causes of her decline are laid bare for the first time in this moving account.            Little Girl Blue is Karen Carpenter’s definitive biography, based on exclusive interviews with her innermost circle of girlfriends and nearly 100 others, including professional associates, childhood friends, and lovers. It tells a story as touching, warm, and involving as any of Karen’s greatest songs.

    Dr. Manheimer describes the plights of twelve very different patients--from dignitaries at the nearby UN, to supermax prisoners at Riker's Island, to illegal immigrants, and Wall Street tycoons.Manheimer was not only the medical director of the country's oldest public hospital for over 13 years, but he was also a patient. As the book unfolds, the narrator is diagnosed with cancer, and he is forced to wrestle with the end of his own life even as he struggles to save the lives of others.

    In the tradition of Joan Baez and Joni Mitchell (she has been compared to both), a singer-songwriter of her kind had not emerged in decades. Now, with over 30 million albums sold worldwide, Jewel tells the story of her life and the lessons learned from her experience and her music.Living on a homestead in Alaska, Jewel learned to yodel at age three and joined her parents' act, working in hotels, honky-tonks, and biker bars. Behind a strong-willed and independent family life, with an emphasis on music and artistic talent, was also instability, abuse, and trauma.At age 15 Jewel was accepted into the prestigious Interlochen Arts Academy in Michigan, where she began writing her own songs as a means of expression. She was 18, homeless, and living out of her car in San Diego when a radio DJ aired a bootleg version of one of her songs. It was requested in the top-10 countdown, something unheard of for an unsigned artist. By age 21, her debut album went multiplatinum.There is so much more to Jewel's story, one complicated by family and financial woes, by crippling fear and insecurity, by parents who forced a child to grow up far too quickly, and by the extraordinary circumstances in which she became a world-famous singer and songwriter. Here Jewel reflects on how she survived and how writing songs, poetry, and prose have saved her life many times over. She writes beautifully about the natural wonders of Alaska, about pain and childhood trauma, and about discovering her own identity years after the entire world had discovered the beauty of her songs.

    Fox.The entire world knows Michael J. Fox as Marty McFly, the teenage sidekick of Doc Brown in Back to the Future; as Alex P. Keaton in Family Ties; as Mike Flaherty in Spin City; and through numerous other movie roles and guest appearances on shows such as The Good Wife and Curb Your Enthusiasm. Diagnosed at age 29, Michael is equally engaged in Parkinson’s advocacy work, raising global awareness of the disease and helping find a cure through The Michael J. Fox Foundation for Parkinson’s Research, the world’s leading non-profit funder of PD science. His two previous bestselling memoirs, Lucky Man and Always Looking Up, dealt with how he came to terms with the illness, all the while exhibiting his iconic optimism. His new memoir reassesses this outlook, as events in the past decade presented additional challenges.In No Time Like the Future: An Optimist Considers Mortality, Michael shares personal stories and observations about illness and health, aging, the strength of family and friends, and how our perceptions about time affect the way we approach mortality. Thoughtful and moving, but with Fox’s trademark sense of humor, his book provides a vehicle for reflection about our lives, our loves, and our losses.Running through the narrative is the drama of the medical madness Fox recently experienced, that included his daily negotiations with the Parkinson’s disease he’s had since 1991, and a spinal cord issue that necessitated immediate surgery. His challenge to learn how to walk again, only to suffer a devastating fall, nearly caused him to ditch his trademark optimism and “get out of the lemonade business altogether.”

    Kim Miller is an immaculately put-together woman with a great career, a loving boyfriend, and a beautifully tidy apartment in Brooklyn. You would never guess that she spent her childhood hiding behind the closed doors of her family’s idyllic Long Island house, navigating between teetering stacks of aging newspaper, broken computers, and boxes upon boxes of unused junk festering in every room—the product of her father’s painful and unending struggle with hoarding. In this coming-of-age story, Kim brings to life her experience of growing up in a rat-infested home, concealing her father’s shameful secret from friends for years, and of the emotional burden that ultimately led to an attempt to take her own life. And in beautiful prose, Miller sheds light on her complicated yet loving relationship with her parents that has thrived in spite of the odds. Coming Clean is a story about recognizing where we come from and the relationships that define us—and about finding peace in the homes we make for ourselves.

    But he was alive and trapped inside his own body for ten years.In January 1988 Martin Pistorius, aged twelve, fell inexplicably sick. First he lost his voice and stopped eating. Then he slept constantly and shunned human contact. Doctors were mystified. Within eighteen months he was mute and wheelchair-bound. Martin's parents were told an unknown degenerative disease left him with the mind of a baby and less than two years to live.Martin was moved to care centers for severely disabled children. The stress and heartache shook his parents’ marriage and their family to the core. Their boy was gone. Or so they thought.Ghost Boy is the heart-wrenching story of one boy’s return to life through the power of love and faith. In these pages, readers see a parent’s resilience, the consequences of misdiagnosis, abuse at the hands of cruel caretakers, and the unthinkable duration of Martin’s mental alertness betrayed by his lifeless body.We also see a life reclaimed—a business created, a new love kindled—all from a wheelchair. Martin's emergence from his own darkness invites us to celebrate our own lives and fight for a better life for others.

    From miraculous pregnancies to dirty protests, and from violent attacks on prisoners to heartbreaking acts of self-harm, she has witnessed it all. In this memoir, Amanda reveals the stories, the patients and the cases that have shaped a career helping those most of us would rather forget.

    But her story has had its obstacles, including being her own parent, living in her car as a teenager, and moving to New York City to pursue her dreams. Through it all, she looked to movies, TV, and music as the family and support systems she never had.From spending the holidays alone to having better “stranger luck” than with those closest to her to feeling like the last hopeless romantic on earth, Lane reveals her powerful and entertaining journey in all its candor, anxiety, and ultimate acceptance—with humor always her bolstering force and greatest gift.How to Be Alone is a must-read for anyone whose childhood still feels unresolved, who spends more time pretending to have friends online than feeling close to anyone in real life, who tries to have genuine, deep conversations in a roomful of people who would rather you not. Above all, it’s a book for anyone who desperately wants to feel less alone and a little more connected through reading her words.

    This was the world of medicine when Thomas Dent Mütter began his trailblazing career as a plastic surgeon in Philadelphia during the middle of the nineteenth century.Although he died at just forty-eight, Mütter was an audacious medical innovator who pioneered the use of ether as anesthesia, the sterilization of surgical tools, and a compassion-based vision for helping the severely deformed, which clashed spectacularly with the sentiments of his time.   Brilliant, outspoken, and brazenly handsome, Mütter was flamboyant in every aspect of his life. He wore pink silk suits to perform surgery, added an umlaut to his last name just because he could, and amassed an immense collection of medical oddities that would later form the basis of Philadelphia’s Mütter Museum. Cristin O’Keefe Aptowicz chronicles how Mütter’s efforts helped establish Philadelphia as a global mecca for medical innovation—despite intense resistance from his numerous rivals.

    Jacobs undergoes a hilarious, heartfelt quest to understand what constitutes family—where it begins and how far it goes—and attempts to untangle the true meaning of the “Family of Humankind.”A.J. Jacobs has received some strange emails over the years, but this note was perhaps the strangest: “You don’t know me, but I’m your eighth cousin. And we have over 80,000 relatives of yours in our database.” That’s enough family members to fill Madison Square Garden four times over. Who are these people, A.J. wondered, and how do I find them? So began Jacobs’s three-year adventure to help build the biggest family tree in history. Jacobs’s journey would take him to all seven continents. He drank beer with a US president, found himself singing with the Mormon Tabernacle Choir, and unearthed genetic links to Hollywood actresses and real-life scoundrels. After all, we can choose our friends, but not our family. “Whether he’s posing as a celebrity, outsourcing his chores, or adhering strictly to the Bible, we love reading about the wacky lifestyle experiments of author A.J. Jacobs” (Entertainment Weekly). Now Jacobs upends, in ways both meaningful and hilarious, our understanding of genetics and genealogy, tradition and tribalism, identity and connection. It’s All Relative is a fascinating look at the bonds that connect us all.