Provies basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

    Today's outliers in revenue growth and value creation are winning with a new set of rules. They are dominating by managing the information that surrounds people, organizations, processes, and products--what authors Malcolm Frank, Paul Roehrig, and Ben Pring call Code Halos. This is far beyond "Big Data" and analytics. Code Halos spark new commercial models that can dramatically flip market dominance from industry stalwarts to challengers. In this new book, the authors show leaders how digital innovators and traditional companies can build Code Halo solutions to drive success. The book:Examines the explosion of digital information that now surrounds us and describes the profound impact this is having on individuals, corporations, and societies; Shows how the Crossroads Model can help anticipate and navigate this market shift; Provides examples of traditional firms already harnessing the power of Code Halos including GE's Brilliant Machines, Disney's theme park Magic Band, and Allstate's mobile devices and analytics that transform auto insurance. With reasoned insight, new data, real-world cases, and practical guidance, Code Halos shows seasoned executives, entrepreneurs, students, line-of-business owners, and technology leaders how to master the new rules of the Code Halo economy.

    Hardcover published by Quadragle/The New York Times Book Co., third printing, August 1977, copyright 1975.

    In this fast-paced investigation into the adrenaline-pumping world of NASCAR, a physicist with a passion uncovers what happens when the rubber hits the road and 800- horsepower vehicles compete at 190 miles per hour only inches from one another. Diandra Leslie-Pelecky reveals how and why drivers trust the engineering and science their teams literally build around them not only to get them across the finish line in first place, but also to keep them alive. Professor Leslie-Pelecky is a physicist in love with the sport’s beauty and power and is uniquely qualified to explain exactly how physics translates into winning races. Based on the author’s extensive access to race shops, pit crews, crew chiefs and mechanics, this book traces the life cycle of a race car from behind the scenes at top race shops to the track. The Physics of NASCAR takes readers right into the ultra competitive world of NASCAR, from the champion driver’s hot seat behind the detachable steering wheel to the New Zealander nicknamed Kiwi in charge of shocks for the No. 19 car. Diandra Leslie-Pelecky tells her story in terms anyone who drives a car--and maybe occasionally looks under the hood--can understand. How do drivers walk away from serious crashes? How can two cars travel faster together than either car can on its own? How do you dress for a 1800°F gasoline fire? In simple yet detailed, high-octane prose, this is the ultimate thrill ride for armchair speed demons, auto science buffs, and NASCAR fans at every level of interest. Readers, start your engines.

    It was also a weapon.Simplicity isn’t just a design principle at Apple—it’s a value that permeates every level of the organization. The obsession with Simplicity is what separates Apple from other technology companies. It’s what helped Apple recover from near death in 1997 to become the most valuable company on Earth in 2011.Thanks to Steve Jobs’s uncompromising ways, you can see Simplicity in everything Apple does: the way it’s structured, the way it innovates, and the way it speaks to its customers.It’s by crushing the forces of Complexity that the company remains on its stellar trajectory.As ad agency creative director, Ken Segall played a key role in Apple’s resurrection, helping to create such critical marketing campaigns as Think different. By naming the iMac, he also laid the foundation for naming waves of i-products to come.Segall has a unique perspective, given his years of experience creating campaigns for other iconic tech companies, including IBM, Intel, and Dell. It was the stark contrast of Apple’s ways that made Segall appreciate the power of Simplicity—and inspired him to help others benefit from it.In Insanely Simple, you’ll be a fly on the wall inside a conference room with Steve Jobs, and on the receiving end of his midnight phone calls. You’ll understand how his obsession with Simplicity helped Apple perform better and faster, sometimes saving millions in the process. You’ll also learn, for example, how to:• Think Minimal: Distilling choices to a minimum brings clarity to a company and its customers—as Jobs proved when he replaced over twenty product models with a lineup of four.• Think Small: Swearing allegiance to the concept of “small groups of smart people” raises both morale and productivity.• Think Motion: Keeping project teams in constant motion focuses creative thinking on well-defined goals and minimizes distractions.• Think Iconic: Using a simple, powerful image to symbolize the benefit of a product or idea creates a deeper impression in the minds of customers.• Think War: Giving yourself an unfair advantage—using every weapon at your disposal—is the best way to ensure that your ideas survive unscathed.Segall brings Apple’s quest for Simplicity to life using fascinating (and previously untold) stories from behind the scenes. Through his insight and wit, you’ll discover how companies that leverage this power can stand out from competitors—and individuals who master it can become critical assets to their organizations.

    But often their solutions fall far short of what they want to accomplish and what is truly needed. Moreover, the answers they propose and fund often produce the opposite of what they want over time. We end up with temporary shelters that increase homelessness, drug busts that increase drug-related crime, or food aid that increases starvation. How do these unintended consequences come about and how can we avoid them? By applying conventional thinking to complex social problems, we often perpetuate the very problems we try so hard to solve, but it is possible to think differently, and get different results. Systems Thinking for Social Change enables readers to contribute more effectively to society by helping them understand what systems thinking is and why it is so important in their work. It also gives concrete guidance on how to incorporate systems thinking in problem solving, decision making, and strategic planning without becoming a technical expert. Systems thinking leader David Stroh walks readers through techniques he has used to help people improve their efforts to end homelessness, improve public health, strengthen education, design a system for early childhood development, protect child welfare, develop rural economies, facilitate the reentry of formerly incarcerated people into society, resolve identity-based conflicts, and more. The result is a highly readable, effective guide to understanding systems and using that knowledge to get the results you want.

    Just about everyone thinks they know how they got there. Just about everyone is wrong. For all that's been written about the Four over the last two decades, no one has captured their power and staggering success as insightfully as Scott Galloway.Instead of buying the myths these compa-nies broadcast, Galloway asks fundamental questions. How did the Four infiltrate our lives so completely that they're almost impossible to avoid (or boycott)? Why does the stock market forgive them for sins that would destroy other firms? And as they race to become the world's first trillion-dollar company, can anyone chal-lenge them?In the same irreverent style that has made him one of the world's most celebrated business professors, Galloway deconstructs the strategies of the Four that lurk beneath their shiny veneers. He shows how they manipulate the fundamental emotional needs that have driven us since our ancestors lived in caves, at a speed and scope others can't match. And he reveals how you can apply the lessons of their ascent to your own business or career.Whether you want to compete with them, do business with them, or simply live in the world they dominate, you need to understand the Four.

    Late fees were ubiquitous, video-streaming unheard was of, and widespread DVD adoption seemed about as imminent as flying cars. Indeed, these were the widely accepted laws of the land in 1997, when Marc Randolph had an idea. It was a simple thought—leveraging the internet to rent movies—and was just one of many more and far worse proposals, like personalized baseball bats and a shampoo delivery service, that Randolph would pitch to his business partner, Reed Hastings, on their commute to work each morning.But Hastings was intrigued, and the pair—with Hastings as the primary investor and Randolph as the CEO—founded a company. Now with over 150 million subscribers, Netflix's triumph feels inevitable, but the twenty first century's most disruptive start up began with few believers and calamity at every turn. From having to pitch his own mother on being an early investor, to the motel conference room that served as a first office, to server crashes on launch day, to the now-infamous meeting when Netflix brass pitched Blockbuster to acquire them, Marc Randolph's transformational journey exemplifies how anyone with grit, gut instincts, and determination can change the world—even with an idea that many think will never work.What emerges, though, isn't just the inside story of one of the world's most iconic companies. Full of counter-intuitive concepts and written in binge-worthy prose, it answers some of our most fundamental questions about taking that leap of faith in business or in life: How do you begin? How do you weather disappointment and failure? How do you deal with success? What even is success?From idea generation to team building to knowing when it's time to let go, That Will Never Work is not only the ultimate follow-your-dreams parable, but also one of the most dramatic and insightful entrepreneurial stories of our time.

    

    Used in university courses and professional seminars all over the world, the text has proven its ability to open minds and sharpen thinking.Originally published in 1975 and reprinted more than twenty times over a quarter century -- and now available for the first time from Dorset House Publishing -- the text uses clear writing and basic algebraic principles to explore new approaches to projects, products, organizations, and virtually any kind of system.Scientists, engineers, organization leaders, managers, doctors, students, and thinkers of all disciplines can use this book to dispel the mental fog that clouds problem-solving. As author Gerald M. Weinberg writes in the new preface to the Silver Anniversary Edition, "I haven’t changed my conviction that most people don’t think nearly as well as they could had they been taught some principles of thinking.”Now an award-winning author of nearly forty books spanning the entire software development life cycle, Weinberg had already acquired extensive experience as a programmer, manager, university professor, and consultant when this book was originally published.With helpful illustrations, numerous end-of-chapter exercises, and an appendix on a mathematical notation used in problem-solving, An Introduction to General Systems Thinking may be your most powerful tool in working with problems, systems, and solutions.

    As they helped grow Google from a young start-up to a global icon, they relearned everything they knew about management. How Google Works is the sum of those experiences distilled into a fun, easy-to-read primer on corporate culture, strategy, talent, decision-making, communication, innovation, and dealing with disruption.The authors explain how the confluence of three seismic changes - the internet, mobile, and cloud computing - has shifted the balance of power from companies to consumers. The companies that will thrive in this ever-changing landscape will be the ones that create superior products and attract a new breed of multifaceted employees whom the authors dub 'smart creatives'. The management maxims ('Consensus requires dissension', 'Exile knaves but fight for divas', 'Think 10X, not 10%') are illustrated with previously unreported anecdotes from Google's corporate history.'Back in 2010, Eric and I created an internal class for Google managers,' says Rosenberg. 'The class slides all read 'Google confidential' until an employee suggested we uphold the spirit of openness and share them with the world. This book codifies the recipe for our secret sauce: how Google innovates and how it empowers employees to succeed.'

    Lawson carefully and succinctly examines all aspects of the global warming issue: the science, the economics, the politics, and the ethics. He concludes that the conventional wisdom on the subject is suspect on a number of grounds, that global warming is not the devastating threat to the planet it is widely alleged to be, and that the remedy that is currently being proposed, which is in any event politically unattainable, would be worse that the threat it is supposed to avert. Argued with logic, common sense, and even wit, and thoroughly sourced and referenced, Lawson has written a long overdue corrective to the barrage of spin and hype to which the politicians and media have been subjecting the public on this important issue.

    Half a century later, only robots have been to the Red Planet and our astronauts rarely venture beyond Earth orbit.Now Mars is back With everyone from Elon Musk to Ridley Scott and Donald Trump talking about it, interplanetary exploration is back on the agenda and Mars is once again the prime destination for future human expansion and colonisation. In Destination Mars, astrophysicist and science writer Andrew May traces the history of our fascination with the Red Planet and explores the science upon which a crewed mission would be based, from assembling a spacecraft in Earth orbit to surviving solar storms. With expert insight, he analyses the new space race and assesses what the future holds for human life on Mars.

    Based on numerous interviews, this book reveals exclusive new information about how Apple innovates, deals with its suppliers, and is handling the transition into the post Jobs era.

    . .Our health care system is in critical condition. Each year, fewer Americans can afford it, fewer businesses can provide it, and fewer government programs can promise it for future generations.We need a cure, and we need it now.Harvard Business School's Clayton M. Christensen--whose bestselling The Innovator's Dilemma revolutionized the business world--presents The Innovator's Prescription, a comprehensive analysis of the strategies that will improve health care and make it affordable.Christensen applies the principles of disruptive innovation to the broken health care system with two pioneers in the field--Dr. Jerome Grossman and Dr. Jason Hwang. Together, they examine a range of symptoms and offer proven solutions.YOU'LL DISCOVER HOW"Precision medicine" reduces costs and makes good on the promise of personalized careDisruptive business models improve quality, accessibility, and affordability by changing the way hospitals and doctors workPatient networks enable better treatment of chronic diseasesEmployers can change the roles they play in health care to compete effectively in the era of globalizationInsurance and regulatory reforms stimulate disruption in health care