Growing understanding of the immune system, and especially the creation of immune memory (long lasting protection), which can be harnessed in the design of vaccines, have been major breakthroughs in medicine.In this Very Short Introduction, Paul Klenerman describes the immune system, and how it works in health and disease. In particular he focuses on the human immune system, considering how it evolved, the basic rules that govern its behavior, and the major health threats where it is important. Theimmune system comprises a series of organs, cells and chemical messengers which work together as a team to provide defence against infection. Klenerman discusses these components, the critical signals that trigger them and how they exert their protective effects, including so-called innate immuneresponses, which react very fast to infection, and adaptive immune responses, which have huge diversity and a capacity to recognize and defend against a massive array of micro-organisms. Klenerman also considers what happens when our immune systems fail to be activated effectively, leading toserious infections, problems with inherited diseases, and also HIV/AIDS. At the opposite extreme, as Klenerman shows, an over-exaggerated immune response leads to inflammatory diseases such as Multiple Sclerosis and Rheumatoid Arthritis, as well as allergy and asthma. Finally he looks at the Immunesystem v2.o - how immune therapies and vaccines can be advanced to protect us against the major diseases of the 21st century.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, andenthusiasm to make interesting and challenging topics highly readable.

    One in ten people in developed countries take antidepressants. Millions of boys who can't sit still in school are prescribed methamphetamines. Modern medicine has been overused. Skyrocketing global healthcare costs render this overuse of medicine increasingly unaffordable. The wonders of modern medicine have also obscured the body's ability to heal itself. Your body produces its own drugs that can treat pain as well as drugs, cure some joint problems as well as a surgeon, and treat most mild depression as well as a psychologist. We've all heard of endorphins, but did you know 'endorphin' literally means 'morphine made by your body'? Besides the body's self-healing abilities, latest evidence clearly show that states of mind affect our health. Relaxing, positive thinking, and comfortable social environments can all improve our health as much as blockbuster drugs.Written using the latest, high quality, conventional evidence Doctor You arms you with knowledge that will empower you to make the right choices about what drugs to take, what drugs to give your children, and when you should let your body do its thing.

    . . Sanghavi is a vivid and effortless teller of human tales and quite evidently a special doctor, too." —Atul Gawande, author of ComplicationsIn this compelling book, Dr. Darshak Sanghavi takes the reader on a dramatic tour of a child's eight vital organs, beginning with the lungs and proceeding through the heart, blood, bones, brain, skin, gonads, and gut.Along the way, we meet children and families in extraordinary circumstances—a premature baby named Adam Flax who was born with undeveloped lungs, a teenage boy with a positive pregnancy test, and a young girl who keeps losing weight despite her voracious appetite. In a deeply personal narrative, Sanghavi provides a richly detailed—and humanized—portrait of how the pediatric body functions in both sickness and health.

    Dozens of key charts, tables, and graphs, including updated steam tables and two new charts of LMTD heat exchanger correction factors, make it possible to work most exam problems using the Reference Manual alone. A complete, easy-to-use index saves you valuable time during the exam as it helps you quickly locate important information needed to solve problems._____________________________Since 1975 more than 2 million people preparing for their engineering, surveying, architecture, LEED®, interior design, and landscape architecture exams have entrusted their exam prep to PPI. For more information, visit us at www.ppi2pass.com.

    This text provides a basic treatment of discrete-event simulation, including the proper collection and analysis of data, the use of analytic techniques, verification and validation of models, and designing simulation experiments. It offers an up-to-date treatment of simulation of manufacturing and material handling systems, computer systems, and computer networks. Students and instructors will find a variety of resources at the associated website, www.bcnn.net, including simulation source code for download, additional exercises and solutions, web links and errata.

    It covers treatment of common diseases as well as other medical, therapeutic and patient related issues. Written by both pharmacists and clinicians to reflect a team approach, it offers an in-depth analysis of drug therapy in the treatment of disease, relying on input from the pharmacist as a member of the team in hospital and community settings. Information is easy to locate in a logical format organized primarily by systems and disorders.A logical organization and format for each chapter provides consistent features including key points, epidemiology, aetiology, disease, clinical manifestations, investigations and treatment, drugs used in treatment.Convenient tables and boxes highlight supplementary information in the text such as risk factors and dietary guidelines.All chapters close with an evidence-based practice box and case studies that solidify applications of chapter content.More up-to-date information is provided on: rational antibiotic prescribing and the institution of policies; advances in therapy for chronic renal failure and transplants; changes in asthma treatment; and new drugs for epilepsy and Parkinson's.The neurology section has been expanded to include a new chapter on multiple sclerosis, dementia and Alzheimer's disease, and treatment.More information has been added related to infertility treatment and menopause.New two-color illustrations make the text more readable and accessible.A greater emphasis on treatment of the patient rather than the diagnosis reflects a shift in focus toward patient-centered care.

     Many people remember the beaming face of Christiaan Barnard, the South African surgeon, after he performed the first human heart transplant, and captured the world's imagination. It was a stunning achievement, but he was not alone. In truth it was a four-way race, a fierce struggle fraught with passionate rivalry. The other three surgeons-Adrian Kantrowitz, Norman Shumway, and Richard Lower-were giants in the field, and by early December 1967 they and Barnard were each poised to snatch the victor's laurels. Each had spent years perfecting techniques that would lead to a successful heart transplant; each had monitored his chosen patient's condition, watching the clock, hoping a donor would be found in time. Some of these men were friends; others were enemies. Only one of them would be the first. From a dank, underequipped hospital in Cape Town to a cramped lab in San Francisco, the surgeons worked their own individual miracles to prolong their patients' lives, testing the limits of science, and nature itself. Like the classics of medical adventure-from James Watson's The Double Helix to John Barry's The Great Influenza-Every Second Counts is an unforgettable story of not only competition and fame, but of life and death.

    But I was just a naive Wisconsin boy, fresh out of medical school and new to Oakland, California. I chose Highland Hospital for my surgical internship: an entire year filled with sick patients, brutal work hours, more brutal staff surgeons, and flawed attempts to maintain a long-distance relationship. Yet, somehow, it’s a work of nonfictional comedy.I take on many roles throughout the story. I’m a kid who still plays Tetris, a guy who can’t commit to his girlfriend, an untrained doctor who finds himself cutting open people’s skulls, and a fish out of water who is called to the ER to drain the blood from a cocaine-engorged penis.But this adventure isn’t just crazy hospital anecdotes or what it takes to become a surgeon. It's a coming of age tale about learning what it means to be a caregiver. Sure, I worked 40 hours without sleep, but that is only one of the ways They tried to kill me. Their real evil was crushing the enthusiasm and compassion of their trainees. I struggled to remain a “normal” human while joining a fraternity of holier-than-thou surgeons, and nothing grounded me more than trying to cope with the illnesses within my own family.If this book proves anything, it's that "Laughter is the best medicine, but surgery is a close second."Enjoy.A dollar of every Kindle book sold will benefit the charity Operation Access.

    C. Walton Lillehei, who, along with colleagues at University Hospital in Minneapolis and a small band of pioneers elsewhere, accomplished what many experts considered to be an impossible feat: He opened the heart, repaired fatal defects, and made the miraculous routine.Acclaimed author G. Wayne Miller draws on archival research and exclusive interviews with Lillehei and legendary pioneers such as Michael DeBakey and Christiaan Barnard, taking readers into the lives of these doctors and their patients as they progress toward their landmark achievement. In the tradition of works by Richard Rhodes and Tracy Kidder, King of Hearts tells the story of an important and gripping piece of forgotten science history.From the Hardcover edition.

    This best-selling, student-friendly book contains clear, step-by-step explanations with comprehensive, stimulating, and challenging material that prepares users for real on-the-job situations. Featuring case studies, state-of-the-art scans, algorithms, protocols, and the inclusion of areas above and beyond the DOT protocols, the tenth edition effectively prepares students for success. The assessment and emergency care sections provide the most up-to-date strategies for providing competent care; and the enrichment sections further enhance students ability to assess and manage ill and injured patients in prehospital environments. The text s table of contents is organized to follow the National EMS Educational Standards."

    The chapters are organized by test type and each chapter begins with a list of the tests covered within the test type, as well as an overview of that category including specimen collection techniques. The tests are presented in a consistent format that includes normal findings, indications, contraindications, potential complications, interfering factors, procedure and patient care, test results and clinical significance, and related tests. This full-color book is easy to use and covers virtually every clinically significant test, including more than 50 new to this edition.

    Emerging from these compelling stories and provocative insights is a powerful case for change-by policymakers, hospitals, doctors, nurses, and even patients and their families. Wachter & Shojania underscore the depth and breadth of dangers in medical care; more important, they suggest basic safety procedures and hard-nosed remedies that could make erratic systems fail-safe and save countless lives.

    Vivid, hilarious and often alarming, his columns have found a cult following among doctors and patients alike. Now these pieces are available in one volume.

     Former practicing psychiatrist Mark Rubinstein opens the door and takes the reader deep into the world of mental illness. From the chaos of a psychiatric emergency room to the bowels of a maximum security prison, the stories range from bizarre to poignant and the people from noble to callously uncaring. Bedlam's Door depicts the challenges mental illness poses for patients, their families, health-care professionals, and society. More importantly, it demystifies the subject while offering real hope.

    Dr Kendrick, a well-known statin sceptic and author of the bestselling The Great Cholesterol Con, has returned to the diet-heart-cholesterol battlefield to warn that people are being conned.In relaxed and humorous style, he lifts the rock to allow the reader to peer underneath. He points out that statins, even in high-risk individuals, increase life expectancy by a mere four days after five years of treatment. Yet adverse effects have been swept under the carpet by researchers who are closely tied to the industry.The way to avoid heart disease, and strokes, is simple - but, as this riveting book shows, it has nothing to do with lowering cholesterol levels.