Prusiner received a Nobel Prize, the world's most prestigious award for achievement in physiology or medicine. That he was the sole recipient of the award for the year was entirely appropriate, for his struggle to identify the agent responsible for ravaging the brains of animals suffering from scrapie and mad cow disease, and of humans with Creutzfeldt-Jakob disease, had been waged largely alone and in some cases in the face of strenuous disagreement.   In this book, Prusiner tells the remarkable story of his discovery of prions—infectious proteins that replicate and cause disease but surprisingly contain no genetic material—and reveals how superb and meticulous science is actually practiced using talented teams of researchers who persevere. He recounts the frustrations and rewards of years of research and offers fascinating portraits of his peers as they raced to discover the causes of fatal brain diseases. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and the basis for developing diagnoses and eventual cures. He closes with a meditation on the legacy of his discovery: What will it take to cure Alzheimer’s, Parkinson’s, Lou Gehrig’s and other devastating diseases of the brain?

    It presents historical perspectives on the development of nursing theory, assessments of concept and theory development and theory evaluation, middle-range theories, and shared theories from other disciplines in the sociologic, behavioral, and biomedical sciences, focusing on the application of theory. Learning features found throughout the text include case studies and end-of-chapter summaries that help to reinforce essential concepts.

    Although molecular topics are presented first, instructors can assign the chapters in any sequence. Pedagogical features such as chapter-opening “Key Questions” and strategically placed “Keynotes” help readers to efficiently master genetic concepts. The Genetics Place Companion Website contains interactive iActivities and narrated animations that help readers visualize and understand processes and concepts that are illustrated in the book. Genetics: An Introduction, DNA: The Genetic Material, DNA Replication, Gene Control of Proteins, Gene Expression: Transcription,Gene Expression: Translation, DNA Mutation, DNA Repair, and Transposable Elements, Structural Genomics, Functional and Comparative Genomics, Recombinant DNA Technology, Mendelian Genetics, Chromosomal Basis of Inheritance, Extensions of and Deviations from Mendelian Genetic Principles, Genetic Mapping in Eukaryotes, Genetics of Bacteria and Bacteriophages, Variations in Chromosome Structure and Number, Regulation of Gene Expression in Bacteria and Bacteriophages, Regulation of Gene Expression in Eukaryotes, Genetic Analysis of Development, Genetics of Cancer, Quantitative Genetics, Population Genetics, Molecular Evolution Intended for those interested in learning the basics of genetics

    It is one of many awe-inspiring, magical processes that have evolved among the fungi, yet this group remains the least studied and most poorly understood kingdom of organisms. In Mushroom, NicholasMoney offers a vibrant introduction to the world of mushrooms, investigating the science behind these organisms as well as their enduring cultural and imaginative appeal. Beginning with the basics of mushroom biology, Money leads us through a history of mushroom research, painting portraits of thecolorful characters involved in their study--among them, Beatrix Potter, the celebrated author and creator of Peter Rabbit, and Captain Charles McIlvaine, a Civil War veteran who engaged in a dangerous quest to determine the edibility of every mushroom in North America. Money also discusses the usesof mushrooms today, exploring their importance as food and medicine, their use as recreational drugs, and as the cause of horrific poisonings. A cultural, natural, and scientific history in one, Mushroom is a must-read for mycophiles, mushroom gatherers, and nature lovers alike.

    Ignatavicius and M. Linda Workman cover all the latest trends, evidence-based treatment guidelines, and additional updated information needed for safe clinical practice in medical-surgical nursing. This seventh edition features an expanded emphasis on patient safety and NCLEX? Examination preparation, new ties to the QSEN priorities for patient safety, and a greater alignment with the language and focus of clinical practice. A new chapter on evidence-based practice and a wealth of effective online learning tools help solidify your mastery of medical-surgical nursing.

    The 7th edition incorporates the latest advances in molecular diagnostics, the Human Genome Project, and much more. More than 240 dynamic illustrations and high-quality photos help you grasp complex concepts more easily. In addition to the book, you will also receive STUDENT CONSULT, enabling you to access the complete contents of the book online, anywhere you go

    The set includes thirty-one 30-minute MCAT practice exams with answers and explanations and more than 1,600 MCAT questions.

    It fulfils the requirements of various competitive examinations and university courses, and serves as a ready reckoner for students and teachers.

    A team of fossil hunters... A desperate fight to survive.... In book 5, Hannah and the other survivors arrive in the ice world of the Pleistocene, bare of trees and with almost no animal life. Starving, with no other game to hunt, they must take on the mighty Mammoth and his wicked tusks. Can they survive the freeze long enough to jump back to modern times?

    At each stage, students are asked to apply critical thinking skills as they learn key concepts. Accounts of real researchers designing and analysing experiments are punctuated by questions and exercises.

    Assuming the reader has little prior knowledge of the subject its importance, the principles of the techniques used and their applications are all carefully laid out, with over 250 clearly presented two-colour illustrations. In addition to a number of informative changes to the text throughout the book, the final four chapters have been significantly updated and extended to reflect the striking advances made in recent years in the applications of gene cloning and DNA analysis in biotechnology: Extended chapter on agriculture including new material on glyphosate resistant plantsNew section on the uses of gene cloning and PCR in archaeologyCoverage of ethical concerns relating to pharming, gene therapy and GM crops Gene Cloning and DNA Analysis remains an essential introductory text to a wide range of biological sciences students; including genetics and genomics, molecular biology, biochemistry, immunology and applied biology. It is also a perfect introductory text for any professional needing to learn the basics of the subject. All libraries in universities where medical, life and biological sciences are studied and taught should have copies available on their shelves. View the Gene Cloning and DNA Analysis webpage at www.blackwellpublishing.com/genecloning

    The Seventh Edition updates and revises material to reflect current advances in respiratory science but does not stray from the proven formula students and faculty have enjoyed since 1974.New updates include physiology of pulmonary capillaries, hypoxic pulmonary vasoconstriction, pulmonary edema, surface tension, elastic properties of the lung and chest wall, metabolic functions of the lung, and perinatal respiration. Ample illustrations and pedagogical features help clarify important equations and concepts. USMLE-style review questions at the end of each chapter help students review for class or boards.

    We’ll look at what identical twins can teach us about the epigenetic effects of our environment and experiences, why certain genes are 'switched on' or off at various stages of embryonic development, and how scientists have reversed the specialization of cells to clone frogs from a single gut cell. In Introducing Epigenetics, Cath Ennis and Oliver Pugh pull apart the double helix, examining how the epigenetic building blocks and messengers that interpret and edit our genes help to make us, well, us.

    Drawing on new translations of Mutis's nearly forgotten writings, this fascinating story of scientific adventure in eighteenth-century South America retrieves Mutis's contributions from obscurity.In 1760, the 28-year-old Mutis—newly appointed as the personal physician of the Viceroy of the New Kingdom of Granada—embarked on a 48-year exploration of the natural world of northern South America. His thirst for knowledge led Mutis to study the region's flora, become a professor of mathematics, construct the first astronomical observatory in the Western Hemisphere, and amass one of the largest scientific libraries in the world. He translated Newton's writings and penned essays about Copernicus; lectured extensively on astronomy, geography, and meteorology; and eventually became a priest. But, as two-time Pulitzer Prize–winner Edward O. Wilson and Spanish natural history scholar José M. Gómez Durán reveal in this enjoyable and illustrative account, one of Mutis's most magnificent accomplishments involved ants.Acting at the urging of Carl Linnaeus—the father of taxonomy—shortly after he arrived in the New Kingdom of Granada, Mutis began studying the ants that swarmed everywhere. Though he lacked any entomological training, Mutis built his own classification for the species he found and named at a time when New World entomology was largely nonexistent. His unorthodox catalog of army ants, leafcutters, and other six-legged creatures found along the banks of the Magdalena provided a starting point for future study.Wilson and Durán weave a compelling, fast-paced story of ants on the march and the eighteenth-century scientist who followed them. A unique glance into the early world of science exploration, Kingdom of Ants is a delight to read and filled with intriguing information.

    The Grand Question of Lifes Origins 2. The Historical Setting of Origins Research 3. What Is Life? 4. Is There Life on Mars? 5. Earths Oldest Fossils 6. Fossil Isotopes 7. Molecular Biosignatures 8. Emergence 9. The Miller-Urey Experiment 10. Life from the Bottom of the Sea 11. The Deep, Hot Biosphere 12. Experiments at High Pressure 13. More Experiments Under Pressure 14. Deep Space Dust, Molten Rock, and Zeolite 15. Macromolecules and the Tree of Life 16. Lipids and Membrane Self-Organization 17. Life on Clay, Clay as Life 18. Lifes Curious Handedness 19. Self-Replicating Molecular Systems 20. Günter Wächtershäusers Grand Hypothesis 21. The RNA World 22. The Pre-RNA World 23. Natural Selection and Competition 24. Three Scenarios for the Origin of Life