An epic, first-of-its-kind book, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize–winning New York Times journalist.A terminal cancer patient rises from the grave. A medical marvel defies HIV. Two women with autoimmunity discover their own bodies have turned against them. Matt Richtel's An Elegant Defense uniquely entwines these intimate stories with science’s centuries-long quest to unlock the mysteries of sickness and health, and illuminates the immune system as never before.The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. Its legion of microscopic foot soldiers—from T cells to “natural killers”—patrols our body, linked by a nearly instantaneous communications grid. It has been honed by evolution over millennia to face an almost infinite array of threats.For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.Richtel effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to the cutting-edge laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. The foundation that Richtel builds makes accessible revelations about cancer immunotherapy, the microbiome, and autoimmune treatments that are changing millions of lives. An Elegant Defense also captures in vivid detail how these powerful therapies, along with our behavior and environment, interact with the immune system, often for the good but always on a razor’s edge that can throw this remarkable system out of balance.Drawing on his groundbreaking reporting for the New York Times and based on extensive new interviews with dozens of world-renowned scientists, Matt Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

    In the months that followed, she realized that the one thing helping her process her grief and begin to heal was comedy. So she began making YouTube videos as a form of creative expression and as a way to connect with others. Ten years later, Anna has more than a million subscribers who watch her smart, honest vlogs on her YouTube channel. Her most popular videos, including "How to Put On Your Face" and "Why Girls Should Ask Guys Out," are comical and provocative, but they all share a deeper message: Your worth is determined by you and you alone. You must learn to love yourself.In So Much I Want to Tell You, Anna opens up about her own struggles with poor self-esteem and reveals both the highs and lows of coming-of-age. She offers fresh, funny, hard-won advice for young women on everything from self-care to money to sex, and she is refreshingly straightforward about the realities of dating, female friendship, and the hustle required to make your dreams come true. This is Anna's story, but, as she says, it belongs just as much to Kristina and to every other girl who must learn that growing up can be hard to do. Witty and real, Anna breaks things down in a way only a big sister can.Advance praise for So Much I Want to Tell You"This book is filled with the kind of honesty, vulnerability, and determination that makes Anna such a captivating person. One warning: You'll want to hug her a lot while reading this."--Natalie Tran, actress and comedian"As a woman working in entertainment, Anna Akana is accustomed to feeling vulnerable. Which means that she's used to being brave. This book is a tribute to the duality of bravery and fear as told through Anna's experiences to date."--Hannah Hart, New York Times bestselling author of Buffering: Unshared Tales of a Life Fully Loaded"Frank advice on how to live a productive, happy life . . . written in tribute to a 'fearless, talented, and bold' sister."--Kirkus Reviews

    In Well Designed Life, you will learn that the solution to this stumbling block resides in coupling two disciplines: brain science and design thinking. Brain and behavior sciences have exploded in recent years. This catalyzes new insights into why we do what we do--and how we can change.Meanwhile, major advances in consumer technology, service industries, and public health are rapidly changing how we live. This boom of innovation has been fueled by a creative approach to solving problems called design thinking. We are living in the age of design--and designers are the new rock stars.Dr. Kyra Bobinet brings together over 25 years of successfully designing interventions, products, and experiences that change lives--to empower you as the designer of your life. Dr. Bobinet has gathered her top ten key concepts from psychology, behavior and neuroscience and shows you how to apply each of them to changing your health, relationships, and well-being. Bobinet insists that the success or failure of changing our lives hinges on both understanding what's going on inside our head and applying the flexible mindset of a designer.She writes, "Designing behavior is equal parts art and science. Steve Jobs once said, "Design is not just what it looks like or feels like. Design is how it works." Adopting the mindset of a designer puts you in the driver's seat of making life work. Grounding yourself in the science of how we see the world and how our brain responds helps you design behaviors that work--in real life, for real people. This is 100 percent about you acting on what you always wished you would do. It's about stepping out of any areas of helplessness and into creative self-direction. You have a choice: design your life or let it design you!"Infused with relatable narratives that are at once witty and gripping, professional and personal, Bobinet takes you on a journey through the origins of your self-image, motivations, decisions, and unconscious behaviors--leaving you with the keys to free yourself from your conditioning and lead a well-designed life.

    She was married with children and a good career. So why did she feel miserable? And why did it seem that other Generation X women were miserable, too?Calhoun decided to find some answers. She looked into housing costs, HR trends, credit card debt averages, and divorce data. At every turn, she saw a pattern: sandwiched between the Boomers and the Millennials, Gen X women were facing new problems as they entered middle age, problems that were being largely overlooked.Speaking with women across America about their experiences as the generation raised to “have it all,” Calhoun found that most were exhausted, terrified about money, under-employed, and overwhelmed. Instead of being heard, they were told instead to lean in, take “me-time,” or make a chore chart to get their lives and homes in order.In Why We Can’t Sleep, Calhoun opens up the cultural and political contexts of Gen X’s predicament and offers solutions for how to pull oneself out of the abyss—and keep the next generation of women from falling in. The result is reassuring, empowering, and essential reading for all middle-aged women, and anyone who hopes to understand them.

    But if you want your metabolism to burn faster than ever before; if you want to shape the body you've always wanted; then The Eat-Clean Diet Workout is for you.Think fitness comes only with hour upon hour of exercise? Nope! Tosca will show you that you can have a better body than you ever dreamed possible, in 30 minutes a day, four days a week. Don't believe it? You will, 'cause Tosca's workout will get you there.

    There really are no ultimate authority figures-no one has the secret and there is no place to look up the definitive answers to our questions (not even Google). But, by thinking skeptically and logically, we can combat sloppy reasoning, bad arguments and superstitious thinking. It's difficult, and takes a lot of vigilance, but it's worth the effort.In this tie-in to their incredibly popular "The Skeptics Guide to the Universe" podcast, Steven Novella, MD along with "Skeptical Rogues" Bob Novella, Cara Santa Maria, Jay Novella, and Evan Bernstein will explain the tenets of skeptical thinking and debunk some of the biggest scientific myths, fallacies and conspiracy theories (Anti-vaccines, homeopathy, UFO sightings, etc.) They'll help us try to make sense of what seems like an increasingly crazy world using powerful tools like science and philosophy. THE SKEPTICS' GUIDE TO THE UNIVERSE is your guide through this maze of modern life. It covers essential critical thinking skills, as well as giving insight into how your brain works and how to avoid common pitfalls in thinking. They discuss the difference between science and pseudoscience, how to recognize common science news tropes, how to discuss conspiracy theories with that crazy coworker of yours, and how to apply all of this to everyday life.So, are you ready to join them on an epic scientific quest, one that has taken us from huddling in dark caves to stepping foot on the Moon? (Yes, we really did that.) Like all adventures, this one is foremost a journey of self discovery. The monsters you will slay and challenges you will face are mostly constructs of your own mind. With the SKEPTIC'S GUIDE TO THE UNIVERSE, we can do this together.

    In the third edition of this best-selling guide, you'll find these topics:- 83 exercises for free weights, machines, bands, and balls- 30 workouts for increasing size, endurance, and strength- Sport-specific programs for tennis, golf, cycling, running, and more- Eating plans and nutrition advice for adding lean muscle and losing fatStrength Training Past 50 will keep you active, healthy, and looking great with workouts and programs designed just for you.

    It's not just a list of "superfoods" or trendy exercises; the course takes a rigorous scientific approach to human vitality. Energy is a limited resource; learn to allocate yours in the best way possible to make the most of each day.

    Yet all too often, we're exposed to information and techniques that promise quick and easy results but can be harmful to your overall health: crash diets, experimental medications, ever-changing studies on what you should eat more or less of, and more. It can be confusing to dig through the mass of hype, myth, and misconceptions about good nutrition habits. So in the face of potentially misleading information and aids, where can you find the key to nutritional success?The answer: in understanding the concepts, practices, and science behind good nutrition. Once you master the intricate—and undeniably captivating—interaction between what you eat and its effect on your body and mind, you unlock a powerful and scientifically proven tool to use in the quest for maintaining or improving your personal health.Nutrition Made Clear is your opportunity to finally sort through nutrition misconceptions and replace them with hard science you can understand. In 36 in-depth lectures taught by dietitian and award-winning Professor Roberta H. Anding, you explore the fundamentals of good nutrition and get a practical and personal guide to applying these fundamentals to your unique lifestyle. Designed to appeal to anyone at any age, this course is an invaluable source of medically backed, statistically proven information about the guidelines for healthy eating and living.

    His life is about being bold and risky. So when Jesse felt himself drifting on autopilot, he hired a rather unconventional trainer to live with him for a month-an accomplished Navy SEAL widely considered to be "the toughest man on the planet"! Living With a Seal is like a buddy movie if it starred the Fresh Prince of Bel- Air. . .and Rambo. Jesse is about as easy-going as you can get. SEAL is. . . not. Jesse and SEAL's escapades soon produce a great friendship, and Jesse gains much more than muscle. At turns hilarious and inspiring, Living With a Seal ultimately shows you the benefits of stepping out of your comfort zone.

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    In the office or at study we are ‘mind workers’, with superfluous bodies. In the gym we stretch, run and lift, but our minds are idle. Damon Young challenges this idea, revealing how fitness can develop our bodies and minds, together. Exploring exercises and sports with the help of ancient and modern philosophy, he uncovers the pleasures, virtues and big ideas of fitness. By exercising intelligently, we are committing to wholeness: enjoying and enhancing our full humanity.

    Dr Julie Smith's expert advice and powerful coping techniques will help you stay resilient, whether you want to manage anxiety, deal with criticism, cope with depression, build self-confidence, find motivation, or learn to forgive yourself. The book tackles everyday issues and offers practical solutions in bite-sized, easy-to-digest entries which make it easy to quickly find specific information and guidance.Your mental well-being is just as important as your physical well-being. Packed with proven strategies, Dr Smith's empathetic guide offers a deeper understanding of how your mind works and gives you the insights and help you need to nurture your mental health every day. Wise and practical, Why Has Nobody Told Me This Before? might just change your life.

    . . a great read,"" and that has been praised as ""a delightful dance through science"" ("New York Times "bestselling author Mark Hyman, M.D.) and as a ""remarkable and insightful book [that] offers you the chance to achieve the best health of your life"" (Mark Liponis, M.D., Medical Director, Canyon Ranch).Written by bestselling author Gene Stone, "The Secrets of People Who Never Get Sick "arose from his desire to discover what might actually prevent him from getting sick himself. This book, the result of that exploration, tells the stories of twenty-five people who each possess a different secret of excellent health--a secret that makes sense and that Stone discovered has a true scientific underpinning. There are food secrets--why to take garlic and vitamin C, eat more probiotics, becomea vegan, drink a tonic of brewer's yeast. Exercise secrets--the benefits of lifting weights, the power of stretching. Environmental secrets--living in a Blue Zone, understanding the value of germs. Emotional secrets--seek out and stay in touch with friends, cultivate your spirituality. Physical secrets--nap more, take cold showers in the morning. And the wisdom that goes back generations: Yes, chicken soup works.The stories make it personal, the research makes it real, and the do-it-yourself information shows how to integrate each secret into your own life, and become the next person who never gets sick.

    In fact, our bodies are hardwired against it. But each time our diets fail, instead of considering that maybe our ridiculously low-carb diet is the problem, we wonder what’s wrong with us. Why can’t we stick to our simple plan of grapefruit and tuna fish??? Why are we so hungry? What is wrong with us??? We berate ourselves for being lazy and weak, double down on our belief that losing weight is the key to our everlasting happiness, and resolve to do better tomorrow. But it’s time we called a spade a spade: Constantly trying to eat the smallest amount possible is a miserable way to live, and it isn’t even working. So fuck eating like that. In The F*ck It Diet, Caroline Dooner tackles the inherent flaws of dieting and diet culture, and offers readers a counterintuitively simple path to healing their physical, emotional, and mental relationship with food. What’s the secret anti-diet? Eat. Whatever you want. Honor your appetite and listen to your hunger. Trust that your body knows what it is doing. Oh, and don’t forget to rest, breathe, and be kind to yourself while you’re at it.  Once you get yourself out of survival mode, it will become easier and easier to eat what your body really needs—a healthier relationship with food ultimately leads to a healthier you.An ex-yo-yo dieter herself, Dooner knows how terrifying it can be to break free of the vicious cycle, but with her signature sharp humor and compassion, she shows readers that a sustainable, easy relationship with food is possible.Irreverent and empowering, The F*ck It Diet is call to arms for anyone who feels guilt or pain over food, weight, or their body. It’s time to give up the shame and start thriving. Welcome to the F*ck It Diet. Let’s Eat.