A decade later, the price for any of us to order our own personal genome sequence—a comprehensive map of the 3 billion letters in our DNA—is rapidly and inevitably dropping to just $1,000. Dozens of men and women—scientists, entrepreneurs, celebrities, and patients—have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer’s or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions—and many more—by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure. Indeed, many experts are advocating that all newborns have a complete genome analysis done so that preventive measures and preemptive medicine can begin early in life. How has this astonishing achievement been accomplished? And what will it mean for our lives? To research the story of this unfolding revolution, critically acclaimed science writer Kevin Davies has spent the past few years traveling to the leading centers and interviewing the entrepreneurs and pioneers in the race to achieve the $1,000 genome. He vividly brings to life the extraordinary drama of this grand scientific achievement, revealing the masterful ingenuity that has transformed the process of decoding DNA and delivering the information it possesses to the public at large. Davies also profiles the future of genomic medicine and thoughtfully explores the many pressing issues raised by the tidal wave of personal genetic information. Will your privacy be protected? Will you be pressured, by insurance companies or by your employer, to get your genome sequenced? What psychological toll might there be to discovering you are at risk for certain diseases like Alzheimer’s? And will the government or the medical establishment come between you and your genome?One thing that is not in question is that we are moving swiftly into the personalized medicine era, and The $1,000 Genome is an essential guide to this brave new future.

    Now in its fourth edition, the work has been extensively revised, with entirely new artwork, updated examples and new pedagogical features. An interactive CD-ROM with worked examples is included. Alternatively, the material on from the CD-ROM can be down-loaded from a website (see supplements section). Twentieth-century developments such as quantum mechanics are introduced early on, so that students can appreciate their importance and see how they fit into the bigger picture.

    Leptin is your body’s natural weight-loss mechanism: it curbs your appetite, jump-starts your metabolism, and when working properly makes you literally fat resistant—you will lose weight effortlessly and efficiently and never gain those pounds back.If you’re struggling to lose weight, chances are you are “leptin resistant”—your body no longer responds to leptin, making it impossible for you to slim down. The Fat Resistance Diet is the first and only eating plan designed specifically to combat leptin resistance and reprogram your body to start melting away the pounds. Using a breakthrough combination of anti-inflammatory and hormone-balancing foods, the three-phase regimen delivers:A loss of six to ten pounds in the first two weeks.A loss of at least two pounds a week thereafter. Fun, flavorful meals that make sticking with the plan a breeze.An easy maintenance program that keeps you fat resistant for life.With over 100 delicious recipes designed for maximum satisfaction and eating pleasure, the Fat Resistance Diet is the only diet you’ll ever need—a brand new way to eat that will transform your body into a lean, fat-fighting machine.

    The text teaches the basics of solving problems using its trademark clear discussions and new art-enhanced format. The text moves students beyond rote quantitative problem solving, encouraging them to visualize and think about a problem before beginning to solve it; it conveys the key concepts being discussed to help students truly understand the chemistry by using unique, proven features. The clean, interesting writing style talks directly to students with a minimum of distractions. Molecular illustrations are abundant and are placed where they are referenced for maximum effectiveness with students. The well-integrated McMurry/Fay media program includes the IRCD, PH GradeAssist, a CW/CD suite and more.

    Discover more than 250 ancient species, many of which have only just been unearthed. Accompanied by spectacular double-page illustrations, the encyclopedia is packed full of extra information on the anatomy, behavior, diet, and habitat of prehistoric creatures.Find out about the very first dinosaurs and their descendants, the giant herbivores, the fierce meat-eaters and the reptiles that ruled the seas and skies. And read about the amazing quest of the fossil hunters who have gradually revealed a hidden world.

    In Where There's a Will, Stephen M. Silverman shows just how different with a peek at the wills of the richest, most celebrated people of all time, and he provides the intimate scoop on what their heirs had to say about it. Discover what secret pact Clark Gable made in 1942 and took to his grave - only to be exposed when his will was read. Learn why it took more than a year for Liza Minnelli to raise the $37,500 needed to bury the ashes of her mother, Judy Garland, and what treasures were left to the heirs of Babe Ruth, James Dean, John Jacob Astor, Ernest Hemingway, and Ayn Rand once those wills cleared probate. From Marilyn Monroe and Andy Warhol to John Lennon, Jim Morrison, John Steinbeck, Rita Hayworth, and Jack Dempsey, Where There's a Will . . . is an utterly engrossing read sure to captivate tycoons and gossip addicts alike with its fascinating tales of how the other half bequeaths.

    Phages are also being used to detect and remove pathogens from our food supplies, both plant and animal. Also exciting is the use of phages as vehicles to delivery DNA vaccines, often directly to mammalian immune system cells. Recent work also suggests possible antitumor effects of phages. We stand on the edge of a whole new world of exploration and applications of microbiology. For over 20 years, and through five editions, Black's Microbiology: Principles and Explorations has captured students' imaginations. Her enthusiasm, passion, and knack for memorable stories and anecdotes bring the study of microbiology to life in a way few other texts can match. Now updated to reflect the latest topics in the field (e.g., SARS, bioterrorism, GMO's, geomicrobiology) and accompanied by state-of-the-art animations of key concepts, this new edition is sure to help inspire a new generation of enthusiasts for the dynamic science of microbiology. Critical Acclaim "I continue to find Black's text an excellent contribution to undergraduate Microbiology education." --Karen Messley, Rock Valley College "I like the conversational and informal style Black adopts throughout the book. This is a book, which could very well engage even the most reluctant student. It is comprehensive, nicely detailed, and incorporates many aids to teaching and learning..."--Iris Cook, Westchester CC "[The text] is a wonderful introduction into the world of microorganisms for students from a wide variety of backgrounds."--Jeff G. Leid, Northern Arizona University ..".I have found it [the book] accurate to a fault, brilliant at getting students motivated and interested in microbiology, and a great practical training book."--Gerard O'Donovan, University of North Texas Also available Laboratory Exercises in Microbiology, 2nd Edition Robert A. Pollack, et al. ISBN: 0-471-42082-4, 264 pages, paper, (c)2005 Written specifically for allied health students, this lab manual presents a variety of highly engaging activities and experiments that convey the basic concepts of microbiology.

    In Feral Cities, Tristan Donovan digs below the urban gloss to uncover the wild creatures that we share our streets and homes with, and profiles the brave and fascinating people who try to manage them. Along the way readers will meet the wall-eating snails that are invading Miami, the boars that roam Berlin, and the monkey gangs of Cape Town. From feral chickens and carpet-roaming bugs to coyotes hanging out in sandwich shops and birds crashing into skyscrapers, Feral Cities takes readers on a journey through streets and neighborhoods that are far more alive than we often realize, shows how animals are adjusting to urban living, and asks what messages the wildlife in our metropolises have for us.

    The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.In Pandemics: What Everyone Needs to Know�, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know� series.What Everyone Needs to Know� is a registered trademark of Oxford University Press.